HUE071059T2 - Alfa 2,3- és alfa 2,6-szalizációt tartalmazó rekombináns FSH - Google Patents

Alfa 2,3- és alfa 2,6-szalizációt tartalmazó rekombináns FSH

Info

Publication number
HUE071059T2
HUE071059T2 HUE21212873A HUE21212873A HUE071059T2 HU E071059 T2 HUE071059 T2 HU E071059T2 HU E21212873 A HUE21212873 A HU E21212873A HU E21212873 A HUE21212873 A HU E21212873A HU E071059 T2 HUE071059 T2 HU E071059T2
Authority
HU
Hungary
Prior art keywords
alpha
sialylation
recombinant fsh
fsh including
including alpha
Prior art date
Application number
HUE21212873A
Other languages
English (en)
Hungarian (hu)
Inventor
Ian Cottingham
Daniel Plaksin
Richard Boyd White
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39717519&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE071059(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of HUE071059T2 publication Critical patent/HUE071059T2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99006—N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HUE21212873A 2008-04-16 2009-04-16 Alfa 2,3- és alfa 2,6-szalizációt tartalmazó rekombináns FSH HUE071059T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4542408P 2008-04-16 2008-04-16
EP08251528 2008-04-25

Publications (1)

Publication Number Publication Date
HUE071059T2 true HUE071059T2 (hu) 2025-07-28

Family

ID=39717519

Family Applications (9)

Application Number Title Priority Date Filing Date
HUE21212873A HUE071059T2 (hu) 2008-04-16 2009-04-16 Alfa 2,3- és alfa 2,6-szalizációt tartalmazó rekombináns FSH
HUE16179121A HUE068565T2 (hu) 2008-04-16 2009-04-16 Alfa-2,3- és alfa-2,6 szializációt tartalmazó rekombináns FSH
HUE16158141A HUE033830T2 (en) 2008-04-16 2009-04-16 Recombinant FSH containing alpha-2,3 and alpha-2,6
HUE14178729A HUE030652T4 (en) 2008-04-16 2009-04-16 Recombinant FSH containing alpha-2,3 and alpha-2,6
HUS1700024C HUS1700024I1 (hu) 2008-04-25 2017-05-30 Rekombináns, alfa-2,3- és alfa-2,6-szializációt tartalmazó FSH
HUS1700025C HUS1700025I1 (hu) 2008-04-25 2017-05-31 Rekombináns, alfa-2,3- és alfa-2,6-szializációt tartalmazó FSH
HUS1700036C HUS1700036I1 (hu) 2008-04-25 2017-09-27 Rekombináns, alfa-2,3- és alfa-2,6-szializációt tartalmazó FSH
HUS2500008C HUS2500008I1 (hu) 2008-04-25 2025-01-28 Alfa-2,3- és alfa-2,6 szializációt tartalmazó rekombináns FSH
HUS2500029C HUS2500029I1 (hu) 2008-04-25 2025-07-07 Alfa 2,3- és alfa 2,6-szalizációt tartalmazó rekombináns FSH

Family Applications After (8)

Application Number Title Priority Date Filing Date
HUE16179121A HUE068565T2 (hu) 2008-04-16 2009-04-16 Alfa-2,3- és alfa-2,6 szializációt tartalmazó rekombináns FSH
HUE16158141A HUE033830T2 (en) 2008-04-16 2009-04-16 Recombinant FSH containing alpha-2,3 and alpha-2,6
HUE14178729A HUE030652T4 (en) 2008-04-16 2009-04-16 Recombinant FSH containing alpha-2,3 and alpha-2,6
HUS1700024C HUS1700024I1 (hu) 2008-04-25 2017-05-30 Rekombináns, alfa-2,3- és alfa-2,6-szializációt tartalmazó FSH
HUS1700025C HUS1700025I1 (hu) 2008-04-25 2017-05-31 Rekombináns, alfa-2,3- és alfa-2,6-szializációt tartalmazó FSH
HUS1700036C HUS1700036I1 (hu) 2008-04-25 2017-09-27 Rekombináns, alfa-2,3- és alfa-2,6-szializációt tartalmazó FSH
HUS2500008C HUS2500008I1 (hu) 2008-04-25 2025-01-28 Alfa-2,3- és alfa-2,6 szializációt tartalmazó rekombináns FSH
HUS2500029C HUS2500029I1 (hu) 2008-04-25 2025-07-07 Alfa 2,3- és alfa 2,6-szalizációt tartalmazó rekombináns FSH

Country Status (29)

Country Link
US (5) US8951967B2 (cg-RX-API-DMAC7.html)
EP (7) EP3098234B1 (cg-RX-API-DMAC7.html)
JP (7) JP2011519359A (cg-RX-API-DMAC7.html)
KR (5) KR20180095140A (cg-RX-API-DMAC7.html)
CN (3) CN105906703A (cg-RX-API-DMAC7.html)
AR (1) AR071479A1 (cg-RX-API-DMAC7.html)
AU (5) AU2009237479B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0910461B8 (cg-RX-API-DMAC7.html)
CA (1) CA2725257A1 (cg-RX-API-DMAC7.html)
CY (1) CY1115413T1 (cg-RX-API-DMAC7.html)
DK (6) DK4015527T3 (cg-RX-API-DMAC7.html)
ES (5) ES2989729T3 (cg-RX-API-DMAC7.html)
FI (4) FI3098234T3 (cg-RX-API-DMAC7.html)
FR (3) FR17C1020I2 (cg-RX-API-DMAC7.html)
HR (5) HRP20241187T1 (cg-RX-API-DMAC7.html)
HU (9) HUE071059T2 (cg-RX-API-DMAC7.html)
IL (2) IL208538A (cg-RX-API-DMAC7.html)
LT (8) LT2808340T (cg-RX-API-DMAC7.html)
MX (3) MX355457B (cg-RX-API-DMAC7.html)
NO (4) NO2017025I1 (cg-RX-API-DMAC7.html)
NZ (1) NZ588381A (cg-RX-API-DMAC7.html)
PL (6) PL2268666T3 (cg-RX-API-DMAC7.html)
PT (6) PT3098234T (cg-RX-API-DMAC7.html)
RU (3) RU2682270C2 (cg-RX-API-DMAC7.html)
SA (1) SA109300228B1 (cg-RX-API-DMAC7.html)
SI (6) SI3098234T1 (cg-RX-API-DMAC7.html)
TW (1) TWI488640B (cg-RX-API-DMAC7.html)
WO (1) WO2009127826A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201007373B (cg-RX-API-DMAC7.html)

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TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
WO2012016576A1 (en) * 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
DK2621517T4 (da) 2010-09-29 2023-11-20 Ferring Bv Sammensætning til anvendelse i behandlingen af infertilitet
JP5918697B2 (ja) 2010-10-15 2016-05-18 Ｊｃｒファーマ株式会社 糖鎖の非還元末端がマンノース残基である糖蛋白質の製造方法
ES2693273T3 (es) * 2011-03-31 2018-12-10 Ferring B.V. Preparación farmacéutica
WO2012168680A1 (en) 2011-06-06 2012-12-13 Ferring B.V. Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) * 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
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JP2018500934A (ja) * 2014-12-22 2018-01-18 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｃｍｐ依存性シアリダーゼ活性
HUE054300T2 (hu) 2015-04-17 2021-08-30 Ferring Bv FSH-t tartalmazó, meddõség kezelésére szolgáló készítmény
WO2016207353A1 (en) 2015-06-26 2016-12-29 Ferring B.V. Methods of purification and/or viral inactivation
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GB201603280D0 (en) 2016-02-24 2016-04-13 Ferring Bv Stable liquid gonadotropin formulation
EP3382014A1 (en) 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation
EP3441471A1 (en) 2017-08-08 2019-02-13 CEVEC Pharmaceuticals GmbH Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines
DK3973982T3 (da) 2017-09-01 2024-09-23 Ferring Bv Sammensætning til kontrolleret ovariestimulation
HUE071268T2 (hu) 2018-04-30 2025-08-28 Ferring Bv Készítmény szabályozott petefészek-stimuláláshoz
TWI846743B (zh) 2018-10-17 2024-07-01 荷蘭商菲林公司 用於控制性卵巢刺激之組成物及方法
WO2021081670A1 (en) * 2019-11-01 2021-05-06 The University Of British Columbia Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins
TW202237173A (zh) 2020-12-09 2022-10-01 荷蘭商菲林公司 用於受控的卵巢刺激之組成物及方法
AU2022451605A1 (en) 2022-04-01 2024-09-26 Ferring B.V. Mixed protocol for treatment of infertility
CA3255772A1 (en) 2022-05-26 2023-11-30 Ferring B.V. Compositions and methods of treating infertility in men
KR20250033230A (ko) 2022-07-08 2025-03-07 훼링 비.브이. 자궁내 인공수정(iui)을 위한 조성물 및 방법
AR133300A1 (es) 2023-07-20 2025-09-17 Ferring Bv Micropartículas cargadas con fármaco de liberación prolongada

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ES2693273T3 (es) 2011-03-31 2018-12-10 Ferring B.V. Preparación farmacéutica
WO2012168680A1 (en) 2011-06-06 2012-12-13 Ferring B.V. Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
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Also Published As

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LTPA2025525I1 (cg-RX-API-DMAC7.html) 2025-07-25
LTPA2017029I1 (lt) 2017-10-10
PT3098234T (pt) 2024-10-21
FI4015527T3 (fi) 2025-04-29
KR20170110741A (ko) 2017-10-11
NO2025032I1 (no) 2025-07-14
AU2017225020A1 (en) 2017-09-28
KR20190092608A (ko) 2019-08-07
BRPI0910461B8 (pt) 2021-05-25
PT3144318T (pt) 2020-11-04
EP2268666A1 (en) 2011-01-05
SA109300228B1 (ar) 2014-04-08
EP4015527B1 (en) 2025-01-22
PL3045471T3 (pl) 2017-10-31
NZ588381A (en) 2012-05-25
SI2808340T1 (sl) 2016-12-30
KR20160056960A (ko) 2016-05-20
US9771407B2 (en) 2017-09-26
AU2014203277A1 (en) 2014-07-24
LT3098234T (lt) 2024-09-10
JP2011519359A (ja) 2011-07-07
MX2010011343A (es) 2011-01-20
PL4015527T3 (pl) 2025-05-26
FIC20250025I1 (fi) 2025-07-11
MX355457B (es) 2018-04-19
DK4015527T3 (da) 2025-04-14
ES3023526T3 (en) 2025-06-02
HK1199039A1 (en) 2015-06-19
US20240327487A1 (en) 2024-10-03
DK2268666T3 (da) 2014-05-12
HK1146284A1 (en) 2011-05-20
ES2610277T3 (es) 2017-04-26
HRP20140535T1 (hr) 2014-07-18
US8951967B2 (en) 2015-02-10
US20180079794A1 (en) 2018-03-22
HUE030652T2 (en) 2017-05-29
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