KR20180044433A - 진피 및 섬유증성 적응증에서의 rna 간섭 - Google Patents
진피 및 섬유증성 적응증에서의 rna 간섭 Download PDFInfo
- Publication number
- KR20180044433A KR20180044433A KR1020187010905A KR20187010905A KR20180044433A KR 20180044433 A KR20180044433 A KR 20180044433A KR 1020187010905 A KR1020187010905 A KR 1020187010905A KR 20187010905 A KR20187010905 A KR 20187010905A KR 20180044433 A KR20180044433 A KR 20180044433A
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- South Korea
- Prior art keywords
- certain embodiments
- modified
- rxrna
- molecule
- nucleotides
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- 0 CCCCCCCCCCCCCCCCCCC[C@@](C)[C@@](CC1)([C@@](C)(CC2)[C@]1C1[C@]2[C@@](C)(CC[C@@](*)C2)C2=CC1)N=C Chemical compound CCCCCCCCCCCCCCCCCCC[C@@](C)[C@@](CC1)([C@@](C)(CC2)[C@]1C1[C@]2[C@@](C)(CC[C@@](*)C2)C2=CC1)N=C 0.000 description 3
- RQVUAATVZIRUBZ-UHFFFAOYSA-N OCCC1OCCC1CN=O Chemical compound OCCC1OCCC1CN=O RQVUAATVZIRUBZ-UHFFFAOYSA-N 0.000 description 1
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- C12N2310/3521—Methyl
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- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/52—Methods for regulating/modulating their activity modulating the physical stability, e.g. GC-content
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020217003374A KR102453078B1 (ko) | 2010-03-24 | 2011-03-24 | 진피 및 섬유증성 적응증에서의 rna 간섭 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31725210P | 2010-03-24 | 2010-03-24 | |
| US61/317,252 | 2010-03-24 | ||
| US31763310P | 2010-03-25 | 2010-03-25 | |
| US61/317,633 | 2010-03-25 | ||
| PCT/US2011/029867 WO2011119887A1 (en) | 2010-03-24 | 2011-03-24 | Rna interference in dermal and fibrotic indications |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127027579A Division KR101852210B1 (ko) | 2010-03-24 | 2011-03-24 | 진피 및 섬유증성 적응증에서의 rna 간섭 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217003374A Division KR102453078B1 (ko) | 2010-03-24 | 2011-03-24 | 진피 및 섬유증성 적응증에서의 rna 간섭 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20180044433A true KR20180044433A (ko) | 2018-05-02 |
Family
ID=44673640
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187010905A Ceased KR20180044433A (ko) | 2010-03-24 | 2011-03-24 | 진피 및 섬유증성 적응증에서의 rna 간섭 |
| KR1020127027579A Expired - Fee Related KR101852210B1 (ko) | 2010-03-24 | 2011-03-24 | 진피 및 섬유증성 적응증에서의 rna 간섭 |
| KR1020217003374A Active KR102453078B1 (ko) | 2010-03-24 | 2011-03-24 | 진피 및 섬유증성 적응증에서의 rna 간섭 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127027579A Expired - Fee Related KR101852210B1 (ko) | 2010-03-24 | 2011-03-24 | 진피 및 섬유증성 적응증에서의 rna 간섭 |
| KR1020217003374A Active KR102453078B1 (ko) | 2010-03-24 | 2011-03-24 | 진피 및 섬유증성 적응증에서의 rna 간섭 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US9340786B2 (enExample) |
| EP (2) | EP3560503B1 (enExample) |
| JP (4) | JP6060071B2 (enExample) |
| KR (3) | KR20180044433A (enExample) |
| CN (3) | CN110042099A (enExample) |
| AU (3) | AU2011232365A1 (enExample) |
| BR (1) | BR112012024049A2 (enExample) |
| CA (1) | CA2794189C (enExample) |
| IL (1) | IL265674B2 (enExample) |
| WO (1) | WO2011119887A1 (enExample) |
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|---|---|---|---|---|
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| WO2010059226A2 (en) | 2008-11-19 | 2010-05-27 | Rxi Pharmaceuticals Corporation | Inhibition of map4k4 through rnai |
| US9493774B2 (en) | 2009-01-05 | 2016-11-15 | Rxi Pharmaceuticals Corporation | Inhibition of PCSK9 through RNAi |
| WO2010090762A1 (en) | 2009-02-04 | 2010-08-12 | Rxi Pharmaceuticals Corporation | Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality |
| WO2011109248A1 (en) | 2010-03-02 | 2011-09-09 | Hapten Pharmaceuticals, Llc | Effective sensitizing dose of a gelled immunomodulating topical composition |
| US9095504B2 (en) | 2010-03-24 | 2015-08-04 | Rxi Pharmaceuticals Corporation | RNA interference in ocular indications |
| IL265674B2 (en) | 2010-03-24 | 2024-05-01 | Phio Pharm Corp | Rana disorder in cutaneous and fibrotic symptoms |
| RU2615143C2 (ru) | 2010-03-24 | 2017-04-04 | Адвирна | Самодоставляющие PHKi соединения уменьшенного размера |
| AR083445A1 (es) * | 2010-10-14 | 2013-02-27 | Univ Mie | siARN CONTRA LA FIBROSIS |
| AU2015261583C1 (en) * | 2010-10-14 | 2017-07-06 | Mie University | Preventative or therapeutic agent for fibrosis |
| US8802839B2 (en) * | 2011-07-15 | 2014-08-12 | Fibrogen, Inc. | Connective tissue growth factor antisense oligonucleotides |
| KR20140102759A (ko) * | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| WO2013177478A2 (en) * | 2012-05-24 | 2013-11-28 | Glaxosmithkline Intellectual Property (No.2) Limited | Treatment method |
| JP6346568B2 (ja) * | 2012-11-29 | 2018-06-20 | 国立大学法人岐阜大学 | Rna干渉剤、その製造方法及びその利用 |
| US10077446B2 (en) * | 2013-06-25 | 2018-09-18 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Glucan-encapsulated siRNA for treating type 2 diabetes mellitus |
| US20160122764A1 (en) * | 2013-07-05 | 2016-05-05 | Bioneer Corporation | Respiratory disease-related gene specific sirna, double-helical oligo rna structure containing sirna, compositon containing same for preventing or treating respiratory disease |
| CN106061488B (zh) | 2013-12-02 | 2021-04-09 | 菲奥医药公司 | 癌症的免疫治疗 |
| EP3077050B1 (en) | 2013-12-04 | 2020-10-21 | Phio Pharmaceuticals Corp. | Methods for treatment of wound healing utilizing chemically modified oligonucleotides |
| US10612020B2 (en) | 2013-12-26 | 2020-04-07 | Tokyo Medical University | Artificial mimic miRNA for controlling gene expression, and use of same |
| CA2935022A1 (en) | 2013-12-27 | 2015-07-02 | Bonac Corporation | Artificial match-type mirna for controlling gene expression and use therefor |
| CN103933579A (zh) * | 2014-04-03 | 2014-07-23 | 华侨大学 | 一种阳离子脂质体及其制备方法和应用 |
| CA2947270A1 (en) | 2014-04-28 | 2015-11-05 | Rxi Pharmaceuticals Corporation | Methods for treating cancer using nucleic acids targeting mdm2 or mycn |
| KR102506169B1 (ko) | 2014-09-05 | 2023-03-08 | 피오 파마슈티칼스 코프. | Tyr 또는 mmp1을 표적화하는 핵산을 사용한 노화 및 피부 장애의 치료 방법 |
| CA2969590A1 (en) * | 2014-12-03 | 2016-06-09 | Rxi Pharmaceuticals Corporation | Methods for the treatment of alopecia areata utilizing gene modulation approaches |
| JP6726105B2 (ja) * | 2014-12-15 | 2020-07-22 | 株式会社ボナック | TGF−β1発現抑制のための一本鎖核酸分子 |
| CA2968336C (en) | 2014-12-17 | 2021-11-23 | Proqr Therapeutics Ii B.V. | Construct for site directed editing of an adenosine nucleotide in target rna |
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| US11021707B2 (en) | 2015-10-19 | 2021-06-01 | Phio Pharmaceuticals Corp. | Reduced size self-delivering nucleic acid compounds targeting long non-coding RNA |
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