DK3277815T3 - Oligonukleotidforbindelser til behandling af præeklampsi og andre angiogene lidelser - Google Patents

Oligonukleotidforbindelser til behandling af præeklampsi og andre angiogene lidelser Download PDF

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Publication number
DK3277815T3
DK3277815T3 DK16716413.6T DK16716413T DK3277815T3 DK 3277815 T3 DK3277815 T3 DK 3277815T3 DK 16716413 T DK16716413 T DK 16716413T DK 3277815 T3 DK3277815 T3 DK 3277815T3
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clampsy
treatment
angiogenic disorders
oligonucleotide compounds
oligonucleotide
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DK16716413.6T
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English (en)
Inventor
Anastasia Khvorova
Melissa Moore
Anton A Turanov
Ananth Karumanchi
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Univ Massachusetts
Beth Israel Deaconess Medical Ct Inc
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK16716413.6T 2015-04-03 2016-04-01 Oligonukleotidforbindelser til behandling af præeklampsi og andre angiogene lidelser DK3277815T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562142745P 2015-04-03 2015-04-03
US201662291961P 2016-02-05 2016-02-05
US201662291678P 2016-02-05 2016-02-05
PCT/US2016/025731 WO2016161378A1 (en) 2015-04-03 2016-04-01 Oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders

Publications (1)

Publication Number Publication Date
DK3277815T3 true DK3277815T3 (da) 2021-12-13

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DK16716413.6T DK3277815T3 (da) 2015-04-03 2016-04-01 Oligonukleotidforbindelser til behandling af præeklampsi og andre angiogene lidelser

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US (4) US9862952B2 (da)
EP (2) EP3995581A3 (da)
CA (1) CA2980339A1 (da)
DK (1) DK3277815T3 (da)
ES (1) ES2901455T3 (da)
HU (1) HUE057431T2 (da)
PL (1) PL3277815T3 (da)
PT (1) PT3277815T (da)
RS (1) RS62672B1 (da)
SI (1) SI3277815T1 (da)
WO (1) WO2016161378A1 (da)

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Publication number Publication date
EP3995581A3 (en) 2022-10-26
US20160355826A1 (en) 2016-12-08
US10519451B2 (en) 2019-12-31
ES2901455T3 (es) 2022-03-22
PT3277815T (pt) 2021-11-11
CA2980339A1 (en) 2016-10-06
EP3277815A1 (en) 2018-02-07
SI3277815T1 (sl) 2022-01-31
WO2016161378A1 (en) 2016-10-06
US20180179546A1 (en) 2018-06-28
RS62672B1 (sr) 2021-12-31
US20220364100A1 (en) 2022-11-17
US9862952B2 (en) 2018-01-09
HUE057431T2 (hu) 2022-05-28
EP3995581A2 (en) 2022-05-11
EP3277815B1 (en) 2021-09-22
US11345917B2 (en) 2022-05-31
US20200165618A1 (en) 2020-05-28
PL3277815T3 (pl) 2022-03-21

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