DK3185876T3 - Sammensætninger og fremgangsmåder til behandling af neurologiske lidelser - Google Patents

Sammensætninger og fremgangsmåder til behandling af neurologiske lidelser Download PDF

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Publication number
DK3185876T3
DK3185876T3 DK15835807.7T DK15835807T DK3185876T3 DK 3185876 T3 DK3185876 T3 DK 3185876T3 DK 15835807 T DK15835807 T DK 15835807T DK 3185876 T3 DK3185876 T3 DK 3185876T3
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Prior art keywords
compositions
treatment
methods
neurological disorders
neurological
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DK15835807.7T
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English (en)
Inventor
Richard Rox Anderson
William A Farinelli
Emilia Javorsky
Lilit Garibyan
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Massachusetts Gen Hospital
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245Amino benzoic acid types, e.g. procaine, novocaine
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
DK15835807.7T 2014-08-28 2015-08-27 Sammensætninger og fremgangsmåder til behandling af neurologiske lidelser DK3185876T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462042979P 2014-08-28 2014-08-28
US201562121329P 2015-02-26 2015-02-26
US201562121472P 2015-02-26 2015-02-26
PCT/US2015/047292 WO2016033380A1 (en) 2014-08-28 2015-08-27 Compositions and methods for treatment of neurological disorders

Publications (1)

Publication Number Publication Date
DK3185876T3 true DK3185876T3 (da) 2022-10-31

Family

ID=55400611

Family Applications (2)

Application Number Title Priority Date Filing Date
DK15835807.7T DK3185876T3 (da) 2014-08-28 2015-08-27 Sammensætninger og fremgangsmåder til behandling af neurologiske lidelser
DK15836780.5T DK3185854T3 (da) 2014-08-28 2015-08-27 Injicerbare opslæmninger og fremgangsmåder til fremstilling og anvendelse af disse

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK15836780.5T DK3185854T3 (da) 2014-08-28 2015-08-27 Injicerbare opslæmninger og fremgangsmåder til fremstilling og anvendelse af disse

Country Status (16)

Country Link
US (5) US20170274011A1 (da)
EP (4) EP3185876B1 (da)
JP (6) JP6707525B2 (da)
KR (2) KR20170044199A (da)
CN (4) CN113813222A (da)
AU (4) AU2015308794A1 (da)
BR (2) BR112017003111B1 (da)
CA (2) CA2958769A1 (da)
DK (2) DK3185876T3 (da)
ES (1) ES2898097T3 (da)
MX (3) MX2017002274A (da)
PL (1) PL3185854T3 (da)
PT (1) PT3185854T (da)
SG (4) SG11201701504WA (da)
WO (2) WO2016033380A1 (da)
ZA (3) ZA201701048B (da)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9980765B2 (en) 2010-02-15 2018-05-29 The General Hospital Corporation Methods and devices for selective disruption of visceral fat by controlled cooling
CA2817552C (en) 2010-11-16 2020-03-24 Tva Medical, Inc. Devices and methods for forming a fistula
AU2012362524B2 (en) 2011-12-30 2018-12-13 Relievant Medsystems, Inc. Systems and methods for treating back pain
US10588691B2 (en) 2012-09-12 2020-03-17 Relievant Medsystems, Inc. Radiofrequency ablation of tissue within a vertebral body
CA2887557C (en) 2012-10-11 2022-05-17 Tva Medical, Inc. Devices and methods for fistula formation
WO2014071161A1 (en) 2012-11-05 2014-05-08 Relievant Medsystems, Inc. System and methods for creating curved paths through bone and modulating nerves within the bone
EP2968852B1 (en) 2013-03-14 2019-07-31 TVA Medical, Inc. Fistula formation devices
US9724151B2 (en) 2013-08-08 2017-08-08 Relievant Medsystems, Inc. Modulating nerves within bone using bone fasteners
US10849678B2 (en) 2013-12-05 2020-12-01 Immunsys, Inc. Cancer immunotherapy by radiofrequency electrical membrane breakdown (RF-EMB)
WO2015138998A1 (en) 2014-03-14 2015-09-17 Tva Medical, Inc. Fistula formation devices and methods therefor
US10646666B2 (en) 2014-08-27 2020-05-12 Tva Medical, Inc. Cryolipolysis devices and methods therefor
EP3185876B1 (en) 2014-08-28 2022-08-10 The General Hospital Corporation Compositions and methods for treatment of neurological disorders
US11504322B2 (en) 2014-08-28 2022-11-22 The General Hospital Corporation Injectable slurries and methods of manufacturing the same
US11471401B2 (en) 2014-08-28 2022-10-18 The General Hospital Corporation Injectable slurries and methods of manufacturing the same
WO2016053741A1 (en) 2014-10-01 2016-04-07 Cryosa, Llc Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
US10603040B1 (en) 2015-02-09 2020-03-31 Tva Medical, Inc. Methods for treating hypertension and reducing blood pressure with formation of fistula
US11161156B2 (en) * 2015-10-27 2021-11-02 Hamilton Sundstrand Corporation Powder monitoring
US11612426B2 (en) * 2016-01-15 2023-03-28 Immunsys, Inc. Immunologic treatment of cancer
CN108883251B (zh) 2016-01-15 2021-12-07 Tva医疗公司 用于推进金属丝的装置和方法
US10874422B2 (en) 2016-01-15 2020-12-29 Tva Medical, Inc. Systems and methods for increasing blood flow
AU2017208069B2 (en) 2016-01-15 2021-11-25 Tva Medical, Inc. Devices and methods for forming a fistula
SG11201807138XA (en) 2016-02-26 2018-09-27 Massachusetts Gen Hospital Medical ice slurry production and delivery systems and methods
CA3037525A1 (en) 2016-09-25 2018-03-29 Tva Medical, Inc. Vascular stent devices and methods
CN113828180A (zh) 2016-11-02 2021-12-24 米拉基创新智库有限公司 用于生产输送到患者体内组织的冷料浆的设备及方法
US11324673B2 (en) * 2016-11-18 2022-05-10 Miraki Innovation Think Tank Llc Cosmetic appearance of skin
BR112019018191A2 (pt) * 2017-03-01 2020-06-23 Miraki Innovation Think Tank Llc Crioterapias
CN110913781A (zh) 2017-04-05 2020-03-24 米拉基创新智库有限责任公司 冷浆容纳物
WO2018187573A1 (en) * 2017-04-05 2018-10-11 Arctic Fox Biomedical, Inc. Point of delivery cold slurry generation
US10500342B2 (en) * 2017-08-21 2019-12-10 Miraki Innovation Think Tank Llc Cold slurry syringe
WO2019113635A1 (en) * 2017-12-11 2019-06-20 Saban Ventures Pty Limited Suspension cleaning
WO2020072983A1 (en) * 2018-10-04 2020-04-09 Miraki Innovation Think Tank Llc Methods of treating subcutaneous fat layers
EP3860568A4 (en) * 2018-10-04 2022-07-06 Miraki Innovation Think Tank, LLC COMPOSITIONS IN SUSPENSION AND IN SOLUTION
WO2020077089A1 (en) * 2018-10-10 2020-04-16 Miraki Innovation Think Tank Llc Systems and methods for generating slurry
WO2020077090A1 (en) * 2018-10-10 2020-04-16 Miraki Innovation Think Tank Llc Systems and methods of generating slurry for injection
WO2020077072A1 (en) * 2018-10-12 2020-04-16 Miraki Innovation Think Tank Llc Cold solution for fat reduction
CN109800472B (zh) * 2018-12-26 2022-09-27 哈尔滨工程大学 一种冰桨接触过程中桨叶表面瞬时冰载压力分布计算方法
US11576812B2 (en) 2019-04-25 2023-02-14 Carlos Wambier Methods for reducing body fat in a subject
JP2022542571A (ja) 2019-07-24 2022-10-05 ザ ジェネラル ホスピタル コーポレイション カプセル化により異なる凝固点を有する物質を作製する方法
AU2020346827A1 (en) 2019-09-12 2022-03-31 Relievant Medsystems, Inc. Systems and methods for tissue modulation
CA3156012A1 (en) 2019-09-26 2021-04-01 Miraki Innovation Think Tank Llc CONTROLLABLE MINIATURIZED INTRABODY MEDICAL DEVICE
EP4081746A4 (en) * 2019-12-24 2024-01-17 Miraki Innovation Think Tank LLC SUBSTANTIALLY SOLID SOLUTION, SYSTEMS AND METHODS FOR PRODUCING A SUBSTANTIALLY SOLID SOLUTION AND METHODS FOR ADMINISTRATION THEREOF
WO2021133720A1 (en) * 2019-12-26 2021-07-01 Miraki Innovative Think Tank Llc Treatment of obstructive sleep apnea
WO2021138252A1 (en) * 2019-12-31 2021-07-08 Miraki Innovative Think Tank Llc Cold solution for inducing therapeutic hypothermia
WO2021151019A1 (en) 2020-01-23 2021-07-29 The General Hospital Corporation Novel method of enhanced drug delivery to the nervous system
CN115884791A (zh) * 2020-03-27 2023-03-31 视酷医疗有限公司 使用医用冰浆来减轻眼表不适的症状的方法
AU2021305336A1 (en) 2020-07-10 2023-03-02 C° Change Surgical Llc Injectable slush feed supply
US20230285350A1 (en) * 2020-07-15 2023-09-14 Lyotip, Inc. Formulations for tetracaine and lidocaine
US20220071900A1 (en) * 2020-09-08 2022-03-10 Brixton Biosciences, Inc. Systems and methods for preparing and transporting an injectable slurry
US20220087250A1 (en) * 2020-09-24 2022-03-24 Everest Medical Innovation GmbH Cryoprotective Compositions and Methods for Protection of a Surgical Site During Cryosurgery
US12082876B1 (en) 2020-09-28 2024-09-10 Relievant Medsystems, Inc. Introducer drill
JP2024505335A (ja) 2020-12-22 2024-02-06 リリーバント メドシステムズ、インコーポレイテッド 脊椎神経調節の候補の予測
US11241330B1 (en) 2021-04-02 2022-02-08 Brixton Biosciences, Inc. Apparatus for creation of injectable slurry
US11490925B1 (en) 2021-06-09 2022-11-08 Mohammed A. Alsufyani Combination ultrasound transducer and fat injecting cannula
JP2024522208A (ja) * 2021-06-11 2024-06-11 ブリクストン バイオサイエンシズ インコーポレイテッド リポソームエマルジョンを使用してスラリーを作製する方法
WO2023064528A1 (en) * 2021-10-14 2023-04-20 The General Hospital Corporation Compositions and methods for treatment of obstructive sleep apnea
AU2023214491A1 (en) * 2022-02-07 2024-08-22 Martin J. MOSKOVITZ Cryo-surgical device and materials and method of use thereof

Family Cites Families (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1256372A (en) 1985-04-11 1989-06-27 Koichiro Miyazima Process for producing liposome composition
US5143063A (en) 1988-02-09 1992-09-01 Fellner Donald G Method of removing adipose tissue from the body
JP2512095B2 (ja) * 1988-08-12 1996-07-03 株式会社日立製作所 冷熱発生方法
EP0437479B1 (en) 1988-10-05 1994-06-22 Vestar, Inc. Method of making liposomes with improved stability during drying
US5005364A (en) 1990-02-07 1991-04-09 Nelson William R Apparatus for and method of making and delivering slush ice
CA2112109A1 (en) * 1991-07-05 1993-01-21 Arne Berg Improvements in or relating to contrast agents
US5507790A (en) 1994-03-21 1996-04-16 Weiss; William V. Method of non-invasive reduction of human site-specific subcutaneous fat tissue deposits by accelerated lipolysis metabolism
US5769879A (en) 1995-06-07 1998-06-23 Medical Contouring Corporation Microwave applicator and method of operation
US6126657A (en) 1996-02-23 2000-10-03 Somnus Medical Technologies, Inc. Apparatus for treatment of air way obstructions
US6464697B1 (en) 1998-02-19 2002-10-15 Curon Medical, Inc. Stomach and adjoining tissue regions in the esophagus
US6467953B1 (en) 1999-03-30 2002-10-22 Medical Solutions, Inc. Method and apparatus for monitoring temperature of intravenously delivered fluids and other medical items
US7892229B2 (en) 2003-01-18 2011-02-22 Tsunami Medtech, Llc Medical instruments and techniques for treating pulmonary disorders
US6126684A (en) 1998-04-21 2000-10-03 The Regents Of The University Of California Indwelling heat exchange catheter and method of using same
US6546932B1 (en) 1999-04-05 2003-04-15 Cryocath Technologies Inc. Cryogenic method and apparatus for promoting angiogenesis
JP3111219B1 (ja) * 1999-05-25 2000-11-20 工業技術院長 ポリビニルアルコールを利用した冷熱輸送方法及び装置
AU775038B2 (en) 1999-07-16 2004-07-15 Alza Corporation A liposome composition having resistance to freeze/thaw damage
US6596333B1 (en) 1999-07-21 2003-07-22 Nestec S.A. Process for producing aerated frozen products
US6962601B2 (en) 1999-08-02 2005-11-08 University Of Chicago Office Of Technology Transfer Method for inducing hypothermia
US6244052B1 (en) * 1999-08-02 2001-06-12 The University Of Chicago Method and apparatus for producing phase change ice particulate perfluorocarbon slurries
US6413444B1 (en) 1999-08-02 2002-07-02 The University Of Chicago Methods and apparatus for producing phase change ice particulate saline slurries
US7422601B2 (en) * 1999-08-02 2008-09-09 University Of Chicago Office Of Technology Transfer Method for inducing hypothermia
US6495164B1 (en) * 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
US7306591B2 (en) 2000-10-02 2007-12-11 Novasys Medical, Inc. Apparatus and methods for treating female urinary incontinence
US7255865B2 (en) * 2000-12-05 2007-08-14 Allergan, Inc. Methods of administering botulinum toxin
US7897141B2 (en) 2002-04-01 2011-03-01 Drexel University Echogenic polymer microcapsules and nanocapsules and methods for production and use thereof
US20030032996A1 (en) * 2001-08-08 2003-02-13 Hallman Arlan Jay Cryogenic massage tube and compress
US6709431B2 (en) 2001-12-18 2004-03-23 Scimed Life Systems, Inc. Cryo-temperature monitoring
IL163689A0 (en) * 2002-02-26 2005-12-18 Astrazeneca Ab Novel crystalline forms of the anti-cancer compound zd1839
US8840608B2 (en) 2002-03-15 2014-09-23 The General Hospital Corporation Methods and devices for selective disruption of fatty tissue by controlled cooling
SI2241295T1 (sl) 2002-03-15 2012-11-30 Gen Hospital Corp Naprave za selektivno razbitje maščobnega tkivaz nadzorovanim hlajenjem
US6858025B2 (en) 2002-08-06 2005-02-22 Medically Advanced Designs, Llc Cryo-surgical apparatus and method of use
US7211104B2 (en) 2002-10-08 2007-05-01 Vital Wear, Inc. Contrast therapy system and method
US7083612B2 (en) 2003-01-15 2006-08-01 Cryodynamics, Llc Cryotherapy system
US20040258760A1 (en) 2003-03-20 2004-12-23 Wheatley Margaret A. Isolated nanocapsule populations and surfactant-stabilized microcapsules and nanocapsules for diagnostic imaging and drug delivery and methods for their production
EP1608225A4 (en) 2003-03-26 2007-07-04 Univ Minnesota HEAT METHOD AND COMPOSITIONS
US20060161232A1 (en) 2005-01-18 2006-07-20 Kasza, Oras and Son to The University of Chicago Phase-change particulate ice slurry coolant medical delivery tubing and insertion devices
US7850683B2 (en) 2005-05-20 2010-12-14 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US7713266B2 (en) 2005-05-20 2010-05-11 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
WO2006127897A2 (en) 2005-05-24 2006-11-30 Uab Research Foundation Surgical delivery devices and methods
US7389653B2 (en) * 2005-09-15 2008-06-24 The University Of Chicago Medical ice slurry production device
US20070093697A1 (en) 2005-10-21 2007-04-26 Theranova, Llc Method and apparatus for detection of right to left shunting in the cardiopulmonary vasculature
US7854754B2 (en) 2006-02-22 2010-12-21 Zeltiq Aesthetics, Inc. Cooling device for removing heat from subcutaneous lipid-rich cells
GB0615287D0 (en) 2006-08-01 2006-09-06 Ares Trading Sa Integral membrane protein
US8192474B2 (en) 2006-09-26 2012-06-05 Zeltiq Aesthetics, Inc. Tissue treatment methods
CA2667964A1 (en) 2006-10-31 2008-05-08 Zeltiq Aesthetics, Inc. Method and apparatus for cooling subcutaneous lipid-rich cells or tissue
US9254162B2 (en) 2006-12-21 2016-02-09 Myoscience, Inc. Dermal and transdermal cryogenic microprobe systems
US20080247957A1 (en) 2007-02-16 2008-10-09 Drexel University Advanced drug delivery strategy and platform for minimally-invasive treatment of liver cancer
EP2195070A4 (en) 2007-05-30 2011-10-26 Critical Care Innovations Inc METHOD AND DEVICE FOR SELECTIVELY TREATING INTERSTITIAL TISSUE
US20090028797A1 (en) 2007-06-14 2009-01-29 Drexel University Novel polymeric ultrasound contrast agent and methods of making thereof
WO2009009540A1 (en) 2007-07-09 2009-01-15 Velomedix, Inc. Hypothermia devices and methods
US8523927B2 (en) 2007-07-13 2013-09-03 Zeltiq Aesthetics, Inc. System for treating lipid-rich regions
JP2011501662A (ja) 2007-10-12 2011-01-13 ザ・プロウボウスト・フェロウズ・アンド・スカラーズ・オブ・ザ・カレッジ・オブ・ザ・ホリー・アンド・アンデバイデッド・トリニティ・オブ・クイーン・エリザベス・ニア・ダブリン タイト結合を開放するための方法
US8298216B2 (en) 2007-11-14 2012-10-30 Myoscience, Inc. Pain management using cryogenic remodeling
WO2009102367A2 (en) 2007-11-19 2009-08-20 The Regents Of The University Of Colorado Tight junction protein modulators and uses thereof
US20090234325A1 (en) 2008-03-17 2009-09-17 Allan Rozenberg Methods and devices for non-invasive cerebral and systemic cooling
US20110224761A1 (en) 2008-04-01 2011-09-15 The General Hospital Corporation Method and apparatus for cooling biological tissue
US8505315B2 (en) * 2008-04-15 2013-08-13 Uchicago Argonne, Llc Enhanced integrated operation blender based sterile medical ice slurry production device
US7874167B2 (en) 2008-06-06 2011-01-25 C Change Surgical Llc Method and apparatus for producing slush for surgical use
US20100036295A1 (en) 2008-08-08 2010-02-11 Palomar Medical Technologies, Inc. Method and apparatus for fractional deformation and treatment of cutaneous and subcutaneous tissue
US8518031B2 (en) * 2008-10-31 2013-08-27 The Invention Science Fund I, Llc Systems, devices and methods for making or administering frozen particles
US9060931B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for delivery of frozen particle adhesives
US8603073B2 (en) 2008-12-17 2013-12-10 Zeltiq Aesthetics, Inc. Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells
US8480664B2 (en) 2009-01-15 2013-07-09 Boston Scientific Scimed, Inc. Controlling depth of cryoablation
US8608696B1 (en) 2009-02-24 2013-12-17 North Carolina State University Rapid fluid cooling devices and methods for cooling fluids
US20110009748A1 (en) 2009-06-11 2011-01-13 Galil Medical Ltd. Transperineal prostate biopsy system and methods
US20130011332A1 (en) 2009-09-15 2013-01-10 Searete Llc, Frozen Compositions and Methods for Piercing a Substrate
US20140200511A1 (en) * 2009-10-30 2014-07-17 Searete Llc Systems, devices, and methods for making or administering frozen particles
US9980765B2 (en) 2010-02-15 2018-05-29 The General Hospital Corporation Methods and devices for selective disruption of visceral fat by controlled cooling
WO2012027641A2 (en) 2010-08-26 2012-03-01 Cryomedix, Llc Cryoablation balloon catheter and related method
US9095320B2 (en) 2010-09-27 2015-08-04 CyroMedix, LLC Cryo-induced renal neuromodulation devices and methods
US20120143294A1 (en) 2010-10-26 2012-06-07 Medtronic Adrian Luxembourg S.a.r.l. Neuromodulation cryotherapeutic devices and associated systems and methods
US9060754B2 (en) 2010-10-26 2015-06-23 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US9039688B2 (en) 2010-12-13 2015-05-26 Myoscience, Inc. Method for reducing hyperdynamic facial wrinkles
GB2485864B (en) 2011-07-14 2013-05-29 Ide Technologies Ltd Vacuum ice maker (vim) with an integrated water vapor depostion process
MX341823B (es) 2011-02-01 2016-09-05 Channel Medsystems Inc Metodo y aparato para tratamiento criogenico de una cavidad o lumen corporal.
SG10201607576PA (en) 2011-06-14 2016-11-29 Aerin Medical Inc Devices for treating nasal airways
EP2561886A1 (en) 2011-08-23 2013-02-27 Forschungsverbund Berlin e.V. Peptide adjuvant for improved peripheral analgesia
HUE045978T2 (hu) 2011-10-21 2020-01-28 Jazz Pharmaceuticals Res Llc Liofilizált liposzómák
JP6046158B2 (ja) 2011-11-16 2016-12-14 ザ ジェネラル ホスピタル コーポレイション 皮膚組織の低温処置のための方法及び装置
CN104159534B (zh) 2012-01-13 2017-02-22 肌肉科技股份有限公司 用于美容和其他处理的皮下低温重塑的皮肤保护
WO2013181667A1 (en) 2012-06-01 2013-12-05 Cibiem, Inc. Percutaneous methods and devices for carotid body ablation
JP6168644B2 (ja) 2012-07-12 2017-07-26 国立大学法人弘前大学 氷スラリー製造装置および氷スラリー製造方法
US9844460B2 (en) 2013-03-14 2017-12-19 Zeltiq Aesthetics, Inc. Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same
US9023022B2 (en) 2013-03-15 2015-05-05 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device having release instrument
US9131975B2 (en) 2013-03-15 2015-09-15 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device
US9023023B2 (en) 2013-03-15 2015-05-05 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device
US9610112B2 (en) 2013-03-15 2017-04-04 Myoscience, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
US9033966B2 (en) 2013-03-15 2015-05-19 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device
EP2967706B1 (en) 2013-03-15 2021-09-08 Pacira CryoTech, Inc. Cryogenic blunt dissection devices
US9295512B2 (en) 2013-03-15 2016-03-29 Myoscience, Inc. Methods and devices for pain management
EP3030305B1 (en) 2013-08-05 2020-07-01 Yue Wu System for producing and delivering airless medical ice slurry to induce hypothermia
WO2015048806A2 (en) 2013-09-30 2015-04-02 Nidus Medical, Llc Apparatus and methods for treating rhinitis
US10660688B2 (en) 2014-05-12 2020-05-26 Gary Kalser Cryotherapy device with cryoprotection and methods for performing cryotherapy with cryoprotection
US9763743B2 (en) 2014-07-25 2017-09-19 Arrinex, Inc. Apparatus and method for treating rhinitis
US10646666B2 (en) 2014-08-27 2020-05-12 Tva Medical, Inc. Cryolipolysis devices and methods therefor
EP3185876B1 (en) 2014-08-28 2022-08-10 The General Hospital Corporation Compositions and methods for treatment of neurological disorders
US11504322B2 (en) 2014-08-28 2022-11-22 The General Hospital Corporation Injectable slurries and methods of manufacturing the same
US11471401B2 (en) 2014-08-28 2022-10-18 The General Hospital Corporation Injectable slurries and methods of manufacturing the same
US9549843B2 (en) 2014-11-30 2017-01-24 C° Change Surgical Llc Production of well-mixed surgical slush
CN204468406U (zh) 2015-02-05 2015-07-15 张淑华 一种新型便携式冷敷装置
US10470813B2 (en) 2015-03-12 2019-11-12 Pacira Cryotech, Inc. Methods and systems for preventing neuroma formations
US20160317346A1 (en) 2015-04-28 2016-11-03 Zeltiq Aesthetics, Inc. Systems and methods for monitoring cooling of skin and tissue to identify freeze events
AU2017206118B2 (en) 2016-01-07 2021-09-30 Zeltiq Aesthetics, Inc. Temperature-dependent adhesion between applicator and skin during cooling of tissue
SG11201807138XA (en) 2016-02-26 2018-09-27 Massachusetts Gen Hospital Medical ice slurry production and delivery systems and methods
CN105640642B (zh) 2016-04-07 2018-01-12 上海导向医疗系统有限公司 带扩张球囊的内冷却微波消融针
US11382790B2 (en) 2016-05-10 2022-07-12 Zeltiq Aesthetics, Inc. Skin freezing systems for treating acne and skin conditions
DE102016115387B3 (de) 2016-08-18 2018-02-01 Cardiolectra GmbH Medizinisches Gerät zur Denervierung renaler perivaskulärer Nerven
EP3506846A4 (en) 2016-08-30 2021-01-06 The General Hospital Corporation CRYOTHERAPY AND CRYOABLATION SYSTEMS AND METHODS OF TISSUE TREATMENT
CN113828180A (zh) 2016-11-02 2021-12-24 米拉基创新智库有限公司 用于生产输送到患者体内组织的冷料浆的设备及方法
KR101905830B1 (ko) 2016-11-15 2018-10-08 울산과학기술원 국부 냉각 마취 장치, 국부 냉각 마취 장치의 제어 방법 및 국부 냉각 마취 장치의 냉각 온도 조절기
US11324673B2 (en) 2016-11-18 2022-05-10 Miraki Innovation Think Tank Llc Cosmetic appearance of skin
JP7177072B2 (ja) 2017-02-04 2022-11-22 ヴェッシー メディカル リミテッド 凍結療法デバイスの流れ制御
US9980076B1 (en) 2017-02-21 2018-05-22 At&T Intellectual Property I, L.P. Audio adjustment and profile system
BR112019018191A2 (pt) 2017-03-01 2020-06-23 Miraki Innovation Think Tank Llc Crioterapias
US20180271767A1 (en) 2017-03-21 2018-09-27 Zeltiq Aesthetics, Inc. Use of saccharides for cryoprotection and related technology
WO2018187573A1 (en) 2017-04-05 2018-10-11 Arctic Fox Biomedical, Inc. Point of delivery cold slurry generation
CN110913781A (zh) 2017-04-05 2020-03-24 米拉基创新智库有限责任公司 冷浆容纳物
US10500342B2 (en) 2017-08-21 2019-12-10 Miraki Innovation Think Tank Llc Cold slurry syringe
US11523855B2 (en) 2018-09-28 2022-12-13 Team Neuro LLC Spinal pain management system and method
WO2020072983A1 (en) 2018-10-04 2020-04-09 Miraki Innovation Think Tank Llc Methods of treating subcutaneous fat layers
EP3860568A4 (en) 2018-10-04 2022-07-06 Miraki Innovation Think Tank, LLC COMPOSITIONS IN SUSPENSION AND IN SOLUTION
WO2020077089A1 (en) 2018-10-10 2020-04-16 Miraki Innovation Think Tank Llc Systems and methods for generating slurry
WO2020077090A1 (en) 2018-10-10 2020-04-16 Miraki Innovation Think Tank Llc Systems and methods of generating slurry for injection
WO2020077072A1 (en) 2018-10-12 2020-04-16 Miraki Innovation Think Tank Llc Cold solution for fat reduction
JP2022542571A (ja) 2019-07-24 2022-10-05 ザ ジェネラル ホスピタル コーポレイション カプセル化により異なる凝固点を有する物質を作製する方法
EP4031042A1 (en) 2019-09-17 2022-07-27 Arrinex, Inc. Apparatus and methods for improved nasal cavity treatments
EP4081746A4 (en) 2019-12-24 2024-01-17 Miraki Innovation Think Tank LLC SUBSTANTIALLY SOLID SOLUTION, SYSTEMS AND METHODS FOR PRODUCING A SUBSTANTIALLY SOLID SOLUTION AND METHODS FOR ADMINISTRATION THEREOF
WO2021133720A1 (en) 2019-12-26 2021-07-01 Miraki Innovative Think Tank Llc Treatment of obstructive sleep apnea
WO2021151019A1 (en) 2020-01-23 2021-07-29 The General Hospital Corporation Novel method of enhanced drug delivery to the nervous system
CN115135263A (zh) 2020-02-19 2022-09-30 科瑞奥萨公司 用于治疗阻塞性睡眠呼吸暂停的系统和方法
CN115884791A (zh) 2020-03-27 2023-03-31 视酷医疗有限公司 使用医用冰浆来减轻眼表不适的症状的方法
US20210330927A1 (en) 2020-04-27 2021-10-28 Black Cat Medical Llc Method of performing cryoneurolysis
US20220071900A1 (en) 2020-09-08 2022-03-10 Brixton Biosciences, Inc. Systems and methods for preparing and transporting an injectable slurry
US20220087250A1 (en) 2020-09-24 2022-03-24 Everest Medical Innovation GmbH Cryoprotective Compositions and Methods for Protection of a Surgical Site During Cryosurgery
US20220211923A1 (en) 2020-09-24 2022-07-07 Everest Medical Innovation GmbH Cryoprotective Compositions, Surgical Kits, and Methods for Protection of a Surgical Site During Cryosurgery
US20220409428A1 (en) 2021-06-23 2022-12-29 Black Cat Medical Llc Method of performing cryoneurolysis

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