DK3347030T3 - Brug af pasteuriseret akkermansia til behandling af stofskiftesygdomme - Google Patents

Brug af pasteuriseret akkermansia til behandling af stofskiftesygdomme Download PDF

Info

Publication number
DK3347030T3
DK3347030T3 DK16763806.3T DK16763806T DK3347030T3 DK 3347030 T3 DK3347030 T3 DK 3347030T3 DK 16763806 T DK16763806 T DK 16763806T DK 3347030 T3 DK3347030 T3 DK 3347030T3
Authority
DK
Denmark
Prior art keywords
metable
diseases
treatment
pasteurized akkermansia
akkermansia
Prior art date
Application number
DK16763806.3T
Other languages
English (en)
Inventor
Clara Belzer
Vos Willem De
Patrice Cani
Amandine Everard
Hubert Plovier
Céline Druart
Original Assignee
Univ Catholique Louvain
Univ Wageningen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54145609&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3347030(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Catholique Louvain, Univ Wageningen filed Critical Univ Catholique Louvain
Application granted granted Critical
Publication of DK3347030T3 publication Critical patent/DK3347030T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/06—Preparations for care of the skin for countering cellulitis
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/308—Foods, ingredients or supplements having a functional effect on health having an effect on cancer prevention
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/332—Promoters of weight control and weight loss
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/92—Oral administration
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
DK16763806.3T 2015-09-10 2016-09-09 Brug af pasteuriseret akkermansia til behandling af stofskiftesygdomme DK3347030T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15184758 2015-09-10
PCT/EP2016/071327 WO2017042347A1 (en) 2015-09-10 2016-09-09 Use of pasteurized akkermansia for treating metabolic disorders

Publications (1)

Publication Number Publication Date
DK3347030T3 true DK3347030T3 (da) 2021-08-09

Family

ID=54145609

Family Applications (2)

Application Number Title Priority Date Filing Date
DK16763806.3T DK3347030T3 (da) 2015-09-10 2016-09-09 Brug af pasteuriseret akkermansia til behandling af stofskiftesygdomme
DK19201220.1T DK3626081T3 (da) 2015-09-10 2016-09-09 Pasteuriseret akkermansia til fremme af vægttab

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK19201220.1T DK3626081T3 (da) 2015-09-10 2016-09-09 Pasteuriseret akkermansia til fremme af vægttab

Country Status (17)

Country Link
US (2) US10736924B2 (da)
EP (3) EP3626081B1 (da)
JP (2) JP6954563B2 (da)
KR (4) KR102581908B1 (da)
CN (2) CN108289918B (da)
AU (2) AU2016319221B2 (da)
BR (1) BR112018004532B1 (da)
CA (1) CA2998039A1 (da)
DK (2) DK3347030T3 (da)
EA (1) EA201800199A1 (da)
ES (2) ES2908310T3 (da)
HK (1) HK1257222A1 (da)
IL (1) IL257978B (da)
MX (1) MX2018002990A (da)
PL (2) PL3347030T3 (da)
PT (2) PT3626081T (da)
WO (1) WO2017042347A1 (da)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3212001A4 (en) 2014-10-31 2018-04-25 Whole Biome Inc. Methods and compositions relating to microbial treatment and diagnosis of disorders
EP3563684A1 (en) 2015-05-06 2019-11-06 Snipr Technologies Limited Altering microbial populations & modifying microbiota
DK3292135T3 (da) 2015-05-06 2022-10-31 Univ Wageningen Anvendelse af et polypeptid til at fremkalde immunsignalering og/eller påvirke tarmbarrierefunktion og/eller modulere metabolsk status
PT3626081T (pt) * 2015-09-10 2022-02-25 Univ Catholique Louvain Akkermansia pasteurizada para promover a perda de peso
MX2018012408A (es) * 2016-04-11 2019-06-17 Univ Wageningen Nuevas especies bacterianas.
GB201609811D0 (en) 2016-06-05 2016-07-20 Snipr Technologies Ltd Methods, cells, systems, arrays, RNA and kits
CA3058943C (en) 2017-04-03 2023-10-17 Gusto Global, Llc Rational design of microbial-based biotherapeutics
TWI636788B (zh) * 2017-08-28 2018-10-01 長庚生物科技股份有限公司 戈氏副擬桿菌用於抑制脂肪肝疾病之用途
EP3675882A4 (en) 2017-08-30 2021-07-28 Pendulum Therapeutics, Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF MICROBIOMA ASSOCIATED DISORDERS
US11510948B2 (en) 2017-09-28 2022-11-29 Kobiolabs, Inc. Composition for diagnosis and treatment of alcoholic liver disease, using change in short-chain fatty acid producing gut bacterial community
US10760075B2 (en) 2018-04-30 2020-09-01 Snipr Biome Aps Treating and preventing microbial infections
WO2019199895A1 (en) 2018-04-10 2019-10-17 Siolta Therapeutics, Inc. Microbial consortia
KR102377407B1 (ko) * 2018-10-01 2022-03-22 한국생명공학연구원 아커만시아 뮤시니필라 균주 또는 이의 배양물을 유효성분으로 함유하는 노화방지용 조성물
KR102197180B1 (ko) * 2018-10-11 2020-12-31 주식회사 고바이오랩 아커만시아 뮤시니필라 균주 및 이를 포함하는 식욕 억제 및 대사성 질환 예방, 개선, 완화 및 치료용 조성물
CN109259240A (zh) * 2018-10-12 2019-01-25 人和未来生物科技（长沙）有限公司 调节肠道菌群和防治肥胖的组合物及其应用
US11851663B2 (en) 2018-10-14 2023-12-26 Snipr Biome Aps Single-vector type I vectors
FR3099054A1 (fr) * 2019-07-24 2021-01-29 Institut National De La Recherche Agronomique (Inra) Souche de Christensenella pour son utilisation dans le traitement et la prévention d’une inflammation gastro-intestinale
WO2020226438A1 (ko) * 2019-05-07 2020-11-12 한국생명공학연구원 염증성 장질환의 예방 또는 치료용 펩타이드
KR102128289B1 (ko) * 2019-08-23 2020-06-30 주식회사 엔테로바이옴 아커만시아 뮤시니필라 eb-amdk27 균주 및 그의 용도
KR102128287B1 (ko) * 2019-08-23 2020-06-30 주식회사 엔테로바이옴 아커만시아 뮤시니필라 eb-amdk19 균주 및 그의 용도
CN110679949A (zh) * 2019-09-30 2020-01-14 山东晶辉生物技术有限公司 一种减肥组合物及其制备方法
KR102397916B1 (ko) * 2019-10-01 2022-05-17 (주)헬스바이옴 건강한 임산부 모유 유래 혐기성 인체 균주 및 이를 이용한 대사성 질환의 예방 또는 치료방법
KR20220108765A (ko) 2019-10-07 2022-08-03 시올타 테라퓨틱스, 인크. 치료용 약학 조성물
CN110786376A (zh) * 2019-11-07 2020-02-14 中南大学湘雅医院 嗜黏蛋白艾克曼氏灭活菌在制备酸奶中的应用及酸奶的制备方法和应用
CA3162695A1 (en) * 2019-12-23 2021-07-01 Nicholas B. Justice Compositions comprising microbes and methods of use and making thereof
EP4125441A2 (en) * 2020-04-03 2023-02-08 DuPont Nutrition Biosciences ApS Composition comprising bacterial strains for improving metabolic health
KR20210131895A (ko) 2020-04-24 2021-11-03 주식회사 고바이오랩 Glp-1 유도 활성을 갖는 단백질 변이체 및 이의 용도
KR102309911B1 (ko) * 2020-05-11 2021-10-07 재단법인 아산사회복지재단 신규한 아커만시아 뮤시니필라 ak32 균주의 발견 및 장 손상의 예방 또는 치료를 위한 응용
KR102185827B1 (ko) * 2020-08-26 2020-12-03 주식회사 엔테로바이옴 아커만시아 뮤시니필라 균주를 포함하는 아토피성 질환 예방 또는 치료용 약학적 조성물
BE1028330B1 (fr) * 2020-11-09 2021-12-17 A Mansia Biotech Composition comprenant de l'Akkermansia muciniphila et de l'extrait de camu camu
BE1028339B1 (fr) 2020-11-09 2021-12-21 A Mansia Biotech Composition comprenant de l'Akkermansia muciniphila et de l'extrait de thé vert
CN113041214A (zh) * 2021-03-16 2021-06-29 中南大学湘雅医院 一种负载嗜粘蛋白-艾克曼菌的改性透明质酸水凝胶及其制备方法和应用
CN113116936A (zh) * 2021-04-02 2021-07-16 上海市第六人民医院 嗜黏蛋白艾克曼氏菌在制备β-鹅脱氧胆酸抑制剂中的应用
CN113265359A (zh) * 2021-05-26 2021-08-17 广西壮族自治区兽医研究所 一种改良的嗜黏蛋白阿克曼氏菌液体培养方法
BE1029502B1 (fr) 2021-08-19 2023-01-17 The Akkermansia Company Composition comprenant de l'Akkermansia muciniphila pasteurisée pour le traitement ou la prévention de l'anxiété liée au syndrome du côlon irritable
BE1029496B1 (fr) 2021-08-19 2023-01-16 The Akkermansia Company Composition comprenant de l'Akkermansia muciniphila pasteurisée pour le traitement ou la prévention des troubles de la contractilité intestinale, en particulier des troubles de l'amplitude de la contractilité duodénale
FR3129831A1 (fr) 2021-12-07 2023-06-09 Activ'inside Utilisation d’une composition à base de Crocus sativus comme prébiotique
CN114949002B (zh) * 2022-06-08 2024-03-19 广州知易生物科技有限公司 嗜粘蛋白阿克曼菌在制备防治动脉粥样硬化的组合物中的应用
CN114949003B (zh) * 2022-06-08 2024-03-19 广州知易生物科技有限公司 嗜粘蛋白阿克曼菌及其应用和培养方法
CN115612635A (zh) * 2022-06-23 2023-01-17 济南大学 一种嗜黏蛋白艾克曼菌ww001及其组合物、复合菌剂与应用
CN116925975B (zh) * 2023-08-18 2024-01-23 善恩康生物科技（苏州）有限公司 一种Akkermansia muciniphila及其产品和应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003303894A1 (en) * 2003-01-30 2004-08-30 The Regents Of The University Of California Inactivated probiotic bacteria and methods of use thereof
ES2561584T3 (es) * 2005-09-28 2016-02-29 Nordisk Rebalance A/S Tratamiento del SII usando como efectores de tratamiento tanto bacterias probióticas como cereales fermentados
US20100172874A1 (en) 2006-12-18 2010-07-08 The Washington University Gut microbiome as a biomarker and therapeutic target for treating obesity or an obesity related disorder
EP2030623A1 (en) 2007-08-17 2009-03-04 Nestec S.A. Preventing and/or treating metabolic disorders by modulating the amount of enterobacteria
FR2944524B1 (fr) 2009-04-17 2012-11-30 Ipsen Pharma Sas Derives d'imidazolidine-2,4-dione et leur utilisation comme medicament
MY159273A (en) * 2009-05-11 2016-12-30 Nestec Sa Bifidobacterium longum ncc2705 (cncm i-2618) and immune disorders
US9150889B2 (en) * 2010-01-15 2015-10-06 The Regents Of The University Of California Electro-autotrophic synthesis of higher alcohols
ES2565407T3 (es) * 2010-11-05 2016-04-04 Nestec S.A. Procedimiento para la preparación de un producto alimenticio para animales de compañía, el cual contiene microorganismos probióticos
EP2449891A1 (en) * 2010-11-05 2012-05-09 Nestec S.A. Drinking yoghurt preparations containing non-replicating probiotic micro-organisms
EP2637510A1 (en) * 2010-11-11 2013-09-18 Nestec S.A. Spoonable yogurt preparations containing non-replicating probiotic micro-organisms
JP5813976B2 (ja) * 2011-03-29 2015-11-17 ユニ・チャーム株式会社 ペット用おむつ
WO2012170478A2 (en) * 2011-06-06 2012-12-13 The University Of North Carolina At Chapel Hill Methods and kits for detecting adenomas, colorectal cancer, and uses thereof
US9173910B2 (en) * 2012-02-29 2015-11-03 The General Hospital Corporation Compositions of microbiota and methods related thereto
WO2014007606A1 (en) * 2012-07-05 2014-01-09 N.V. Nutricia Product for use in the prophylactic or therapeutic treatment of a negative emotion or introvert behaviour
CN104540962B (zh) * 2012-08-01 2017-09-19 深圳华大基因研究院 糖尿病生物标志物及其应用
WO2014075745A1 (en) * 2012-11-19 2014-05-22 Université Catholique de Louvain Use of akkermansia for treating metabolic disorders
WO2014201037A2 (en) * 2013-06-10 2014-12-18 New York University Methods for manipulating immune responses by altering microbiota
WO2016172657A2 (en) * 2015-04-23 2016-10-27 Kaleido Biosciences, Inc. Glycan therapeutics and methods of treatment
DK3292135T3 (da) * 2015-05-06 2022-10-31 Univ Wageningen Anvendelse af et polypeptid til at fremkalde immunsignalering og/eller påvirke tarmbarrierefunktion og/eller modulere metabolsk status
PT3626081T (pt) * 2015-09-10 2022-02-25 Univ Catholique Louvain Akkermansia pasteurizada para promover a perda de peso
US10537597B2 (en) * 2015-10-05 2020-01-21 Schweizerisches Forschungsinstitut Fur Hochgebrigsklima Und Medizin In Davos Use of Akkermansia muciniphila for treating inflammatory conditions
US20230265131A1 (en) * 2020-07-01 2023-08-24 Wageningen Universiteit Amuc-1100 polypeptide variants for effecting immune signalling and/or affecting intestinal barrier function and/or modulating metabolic status
CN113862193B (zh) * 2021-10-28 2023-12-22 江西普瑞森基因科技有限公司 一株嗜黏蛋白阿克曼氏菌及其在制备抗肿瘤药物中的应用

Also Published As

Publication number Publication date
CA2998039A1 (en) 2017-03-16
PT3626081T (pt) 2022-02-25
AU2016319221A1 (en) 2018-03-29
CN108289918B (zh) 2022-01-18
WO2017042347A1 (en) 2017-03-16
US20180250347A1 (en) 2018-09-06
KR102581908B1 (ko) 2023-09-22
EP3347030B1 (en) 2021-07-14
EP3347030A1 (en) 2018-07-18
DK3626081T3 (da) 2022-02-28
KR20230070053A (ko) 2023-05-19
CN108289918A (zh) 2018-07-17
BR112018004532A2 (pt) 2018-12-11
US20210015876A1 (en) 2021-01-21
JP2019500004A (ja) 2019-01-10
KR102530852B1 (ko) 2023-05-12
HK1257222A1 (zh) 2019-10-18
EP3626081B1 (en) 2022-02-09
PT3347030T (pt) 2021-08-19
US10736924B2 (en) 2020-08-11
KR102569754B1 (ko) 2023-08-23
JP6954563B2 (ja) 2021-10-27
BR112018004532B1 (pt) 2022-03-15
EA201800199A1 (ru) 2018-12-28
ES2883231T3 (es) 2021-12-07
IL257978A (en) 2018-05-31
KR20220148941A (ko) 2022-11-07
AU2022203731A1 (en) 2022-06-23
JP2022000040A (ja) 2022-01-04
KR20180053336A (ko) 2018-05-21
IL257978B (en) 2021-12-01
MX2018002990A (es) 2018-06-08
KR20230125340A (ko) 2023-08-29
PL3626081T3 (pl) 2022-04-25
EP3943093A1 (en) 2022-01-26
CN114276960A (zh) 2022-04-05
PL3347030T3 (pl) 2021-11-22
EP3626081A1 (en) 2020-03-25
ES2908310T3 (es) 2022-04-28
AU2016319221B2 (en) 2022-06-30

Similar Documents

Publication Publication Date Title
DK3347030T3 (da) Brug af pasteuriseret akkermansia til behandling af stofskiftesygdomme
DK3173092T3 (da) Rna-holdig sammensætning til behandling af tumorsygdomme
DK3889145T3 (da) 8-cyano-5-piperidino-quinoliner som TLR7/8-antagonister og anvendelser deraf til behandling af immunsygdomme
DK3212233T3 (da) Kombinationsterapi til behandling af sygdom
IL253945A0 (en) kdm1a inhibitors to treat the disease
DK3728271T3 (da) Makrocykliske forbindelser til behandling af sygdomme
DK3439635T3 (da) Formuleringer til behandling af fast tumor
DK3240612T3 (da) Fremgangsmåder til behandling af nethindesygdomme
DK3362066T3 (da) Kombinationsterapi til behandling af maligniteter
DK3481846T3 (da) 11-substituerede 24-hydroxysteroler til anvendelse til behandling af nmda-relaterede tilstande
DK3474802T3 (da) Medicinsk forbinding
DK3390390T3 (da) Bipyrazolylderivater egnede til behandling af autoimmunsygdomme
MA39483A (fr) Agents thérapeutiques cibles
BR112016022976A2 (pt) Métodos para o tratamento de hcv
DK3265087T3 (da) Fremgangsmåde til behandling med tradipitant
ITUA20164542A1 (it) Mascherina chirurgica monouso
DK3307267T3 (da) Behandling af multipel sklerose
DK3166628T3 (da) Terapeutisk anvendelse af knoglemorfogenetiske proteiner
DK3430143T3 (da) Inhibitorer af SRSF1 til behandlingen af neurodegenerative sygdomme
DK3157522T3 (da) Muskarin-antagonister og kombinationer deraf til behandlingen af luftvejssygdomme i heste
DK3097085T3 (da) Benzoxazinonderivater til behandling af hudsygdomme
DK3578562T3 (da) L-valinatamidbenzoxaborolderivater til behandling af parasitiske sygdomme
DK3408265T3 (da) Terapeutiske forbindelser
DK3210973T3 (da) Heteroarylforbindelser til behandling af oftalmiske sygdomme
DK3122743T3 (da) Sammensætninger og fremgangsmåder til behandling af neurodegenerative sygdomme