CN109259240A - 调节肠道菌群和防治肥胖的组合物及其应用 - Google Patents
调节肠道菌群和防治肥胖的组合物及其应用 Download PDFInfo
- Publication number
- CN109259240A CN109259240A CN201811188535.0A CN201811188535A CN109259240A CN 109259240 A CN109259240 A CN 109259240A CN 201811188535 A CN201811188535 A CN 201811188535A CN 109259240 A CN109259240 A CN 109259240A
- Authority
- CN
- China
- Prior art keywords
- composition
- prevention
- intestinal flora
- fat
- carnitine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 52
- 230000000968 intestinal effect Effects 0.000 title claims abstract description 32
- 208000008589 Obesity Diseases 0.000 title claims abstract description 19
- 235000020824 obesity Nutrition 0.000 title claims abstract description 19
- 230000002265 prevention Effects 0.000 title claims abstract description 19
- 239000000843 powder Substances 0.000 claims abstract description 22
- 235000001674 Agaricus brunnescens Nutrition 0.000 claims abstract description 12
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims abstract description 11
- 239000004375 Dextrin Substances 0.000 claims abstract description 11
- 229920001353 Dextrin Polymers 0.000 claims abstract description 11
- 235000019425 dextrin Nutrition 0.000 claims abstract description 11
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 11
- 235000021255 galacto-oligosaccharides Nutrition 0.000 claims abstract description 11
- 150000003271 galactooligosaccharides Chemical class 0.000 claims abstract description 11
- 235000020688 green tea extract Nutrition 0.000 claims abstract description 11
- 235000013311 vegetables Nutrition 0.000 claims abstract description 11
- 229940094952 green tea extract Drugs 0.000 claims abstract description 10
- 229940087603 grape seed extract Drugs 0.000 claims abstract description 9
- 235000002532 grape seed extract Nutrition 0.000 claims abstract description 9
- 239000001717 vitis vinifera seed extract Substances 0.000 claims abstract description 9
- 230000036541 health Effects 0.000 claims abstract description 7
- 235000013305 food Nutrition 0.000 claims abstract description 5
- 206010010774 Constipation Diseases 0.000 claims abstract description 4
- 239000003814 drug Substances 0.000 claims abstract description 4
- 229940079593 drug Drugs 0.000 claims abstract description 4
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 claims description 16
- 229920001202 Inulin Polymers 0.000 claims description 10
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 10
- 229940029339 inulin Drugs 0.000 claims description 10
- 229920001100 Polydextrose Polymers 0.000 claims description 8
- 235000013856 polydextrose Nutrition 0.000 claims description 8
- 239000001259 polydextrose Substances 0.000 claims description 8
- 229940035035 polydextrose Drugs 0.000 claims description 8
- 235000013336 milk Nutrition 0.000 claims description 3
- 239000008267 milk Substances 0.000 claims description 3
- 210000004080 milk Anatomy 0.000 claims description 3
- 235000013618 yogurt Nutrition 0.000 claims description 3
- 241000219095 Vitis Species 0.000 claims description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 claims description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 claims description 2
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 10
- 241000894006 Bacteria Species 0.000 description 19
- 241000193830 Bacillus <bacterium> Species 0.000 description 9
- 241000186000 Bifidobacterium Species 0.000 description 6
- 230000009286 beneficial effect Effects 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 210000000936 intestine Anatomy 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000008855 peristalsis Effects 0.000 description 3
- 239000006041 probiotic Substances 0.000 description 3
- 235000018291 probiotics Nutrition 0.000 description 3
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 235000019577 caloric intake Nutrition 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000002485 combustion reaction Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003337 fertilizer Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 2
- 208000016261 weight loss Diseases 0.000 description 2
- 230000004580 weight loss Effects 0.000 description 2
- 102000011690 Adiponectin Human genes 0.000 description 1
- 108010076365 Adiponectin Proteins 0.000 description 1
- 241000304886 Bacilli Species 0.000 description 1
- 241000606125 Bacteroides Species 0.000 description 1
- 241000605059 Bacteroidetes Species 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 241000305071 Enterobacterales Species 0.000 description 1
- 241000194033 Enterococcus Species 0.000 description 1
- 241000186394 Eubacterium Species 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241000605909 Fusobacterium Species 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 102000016267 Leptin Human genes 0.000 description 1
- 108010092277 Leptin Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000191992 Peptostreptococcus Species 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 241000863032 Trieres Species 0.000 description 1
- 230000003579 anti-obesity Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 229960004203 carnitine Drugs 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000007366 host health Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 229940039781 leptin Drugs 0.000 description 1
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 description 1
- 208000020442 loss of weight Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000036186 satiety Effects 0.000 description 1
- 235000019627 satiety Nutrition 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
- A23L7/10—Cereal-derived products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
本发明公开了一种调节肠道菌群和防治肥胖的组合物及其应用，组合物包括低聚半乳糖、抗性糊精、绿茶提取物、葡萄籽提取物、左旋肉碱、果蔬粉、蘑菇粉和燕麦。本发明的组合物热量低、适用于各种人群长期服用的能调节肠道菌群和防治肥胖的组合物，具有显著的减肥效果，且能有效强化肠道功能，并具有一定的保健作用。本发明的组合物可用于防治便秘和肥胖的保健品、药物或食品。
Description
技术领域
本发明涉及保健品领域，尤其涉及一种调节肠道菌群和防治肥胖的组合物及其应用。
背景技术
随着现代的生活节奏逐渐加快，压力增大以及物质条件的丰富，肥胖正越来越成为困扰现代人的重要健康问题，肥胖越来越呈现年轻化的趋势。肥胖是二型糖尿病、心血管疾病等的重要风险因素之一，同时肥胖也会严重影响个人形象，造成相应的社会、心理方面的问题，然而目前对于肥胖的机制认识依然不够清晰，除了遗传因素与社会环境因素之外，目前的研究表明，肠道菌群与肥胖之间存在着密切的关系。
人体肠道内大约存在着1014个微生物，每个人的菌群构成均有所不同，其构成与生活习惯，饮食和宿主的基因密切相关。厌氧菌如拟杆菌属、真杆菌属、双歧杆菌属、梭菌属、消化链球菌属和奇异菌属占了消化道菌群的主要部分，而兼性厌氧菌如乳酸杆菌，肠球菌，链球菌，肠杆菌等只占了很小的一部分。肠道菌群与宿主构成微生态系统，参与营养物质吸收、免疫调节、能量代谢等生命活动，构成肠道黏膜的保护屏障，而肠道菌群的失调与肥胖、免疫低下、炎性肠病、2型糖尿病、肿瘤、抑郁症的发生发展有着密切联系，随着检测技术的发展，肠道微生物与宿主健康和疾病的关系成为研究的热点。
目前的研究结果表明，肥胖人群的肠道菌群厚壁菌门与拟杆菌门的比值升高，而某些有益菌如Akk菌，普氏栖粪杆菌、乳酸杆菌、双歧杆菌等丰度下降，同时肠道菌群与肥胖相关的激素如脂联素、瘦素以及血清代谢物存在着相关性。将诱导肥胖小鼠的菌群移植到正常小鼠体内可诱导正常小鼠肥胖，将肥胖人群的菌群移植到正常小鼠体内可诱导正常小鼠肥胖。因此通过开发产品用于调控肠道菌群结合其他调控成分共同抑制肥是非常有必要和有前景的。
发明内容
本发明要解决的技术问题是克服现有技术的不足，提供一种热量低、适用于各种人群长期服用、对人体无害的能调节肠道菌群和防治肥胖的组合物，该组合物具有显著的减肥效果，且能有效强化肠道功能，并具有一定的保健作用。
为解决上述技术问题，本发明采用以下技术方案：
调节肠道菌群和防治肥胖的组合物，所述组合物包括低聚半乳糖、抗性糊精、绿茶提取物、葡萄籽提取物、左旋肉碱、果蔬粉、蘑菇粉和燕麦、菊粉和聚葡萄糖。
上述的调节肠道菌群和防治肥胖的组合物，优选地，所述组合物中，按质量比计，低聚半乳糖∶抗性糊精∶绿茶提取物∶葡萄籽提取物∶左旋肉碱∶果蔬粉∶蘑菇粉∶燕麦：菊粉：多聚葡萄糖为1.5～5∶2～4∶0.04～0.1∶0.04～0.1∶0.02～0.04∶1～3∶1～3∶5～7∶1.2～2.4∶1.4～2.8。
上述的调节肠道菌群和防治肥胖的组合物，优选地，按质量百分含量计，所述组合物中包括低聚半乳糖7.5～25％、抗性糊精10～20％、绿茶提取物0.2～0.5％，葡萄籽提取物0.2～0.5％、左旋肉碱0.1～0.2％、果蔬粉5～15％、蘑菇粉5～15％、燕麦25～35％、菊粉6～12％和聚葡萄糖7～14％。
上述的调节肠道菌群和防治肥胖的组合物，优选地，按质量百分含量计，所述组合物中包括低聚半乳糖15％、抗性糊精15％、绿茶提取物0.25％、葡萄籽提取物0.25％、左旋肉碱0.15％、果蔬粉10％、蘑菇粉10％、燕麦30％、菊粉8％和聚葡萄糖11.35％。
上述的调节肠道菌群和防治肥胖的组合物，优选地，所述组合物中还含有保健品或药物可接受的添加剂。
上述的调节肠道菌群和防治肥胖的组合物，优选地，所述组合物为片剂、丸剂、胶囊、颗粒剂或粉剂。
作为一个总的发明构思，本发明还公开了前述的组合物在防治便秘和肥胖的保健品、药物或食品中的应用。
上述的应用，优选地，所述食品为牛奶、酸奶或茶叶。
与现有技术相比，本发明的优点在于：
本发明经过大量研究，得到一种合适的成分和配比的有效调节肠道菌群和防治肥胖的组合物，组合物受试者在连续服用该组合物2个月后，肠道内的乳酸杆菌、双歧杆菌、普氏栖粪杆菌和阿克曼菌丰度显著增高，服用4个月后，肠道内的这几种细菌丰度仍维持相对稳定；普氏栖粪杆菌可以调节肠道免疫系统、氧化应激和结肠上皮细胞的代谢，还可以发酵产生丁酸，使肠道的酸碱度降低，有效地促进肠道内正常菌群(如双歧杆菌等)生长，阿克曼菌誉为减肥菌。组合物中的各成分有机配合，同时实现了提高肠道中乳酸杆菌、双歧杆菌、普氏栖粪杆菌和阿克曼菌这4种菌中多种菌的丰度、促进肠道蠕动、促进脂肪燃烧、减少热量摄入，多重作用多管齐下，具有显著的减肥作用，并且还能强化肠道功能，还具有一定的抗氧化和其他保健效果，肥胖试用者在连续服用组合物2月后体重降低了4～7.5kg，连续服用4月后体重降低6～12kg，减肥效果显著，该组合物热量含量低，对身体无害，适合长期服用。
附图说明
图1为本发明实施例的23名肥胖人员在服用组合前、服用组合物2月和4月之后，体重和BMI变化图。
具体实施方式
以下将结合说明书附图和具体实施例对本发明做进一步详细说明。
实施例
本实施例中，选取23名肥胖人群，编号为1-23，按照30g/天的服用量连续服用组合物4个月，要求餐前服用，组合物的成分如下：按质量百分含量计，含低聚半乳糖(15％)、抗性糊精(15％)、绿茶提取物(0.25％)、葡萄籽提取物(0.25％)、左旋肉碱(0.15％)、果蔬粉(10％)、蘑菇粉(10％)和燕麦(30％)，菊粉8％，聚葡萄糖11.35％。
低聚半乳糖，抗性糊精，菊粉：具有降脂和促进肠道有益菌增殖的作用；绿茶提取物：富含绿茶多酚，抗氧化，促进脂肪燃烧；葡萄籽提取物：富含葡萄多酚，抗氧化，促进Akk菌的生长；左旋肉碱：促进脂肪的燃烧，促进减肥；果蔬粉、燕麦：富含膳食纤维及维生素，促进肠道蠕动，减少热量摄入，促进益生菌的生长；蘑菇粉：富含壳聚糖，促进益生菌生长，减少热量摄入，聚葡萄糖：为大分子聚合糖，促进肠道蠕动及有益菌增殖。
在未服用组合物前采取1次粪便，服用过程中，每服用2个月采取一次粪便，采用16S高通量测序检测肠道菌群的变化，同时测量其体重与计算BMI，得到的数据如下表1-4所示。
组合物干预效果验证：
本组合物服用后有饱腹感，会降低食欲，图1为肥胖人员在服用组合前，服用组合物2月和4月之后，对应的体重和BMI值变化，可见在服用组合物之后，肥胖人员的体重和BMI值均明显降低，表明在持续服用组合物具有较显著的减肥效果。
表1为23名便秘人员在未服用组合前，服用2个月和4个月后，所取粪便中测得的乳酸杆菌、双歧杆菌、普氏栖粪杆菌和阿克曼菌丰度，从表1中可看出，服用组合物2个月之后，所取粪便中的四种细菌中的多种丰度显著增高，证实产品对肠道菌群有显著的有益调节作用，在服用4个月之后，与第2个月相比，这几种益生菌的丰度依然维持在一个较高的水平。
表1：
表2为对表1中的数据进行整理得到，通过对干预前、干预2个月和干预4个月对应四种有益菌的丰度进行对比，通过秩和检验检验它们之间的差异是否具有统计学意义，一般认为P值小于或等于0.05，则对比的两组差异是显著的，可见干预2个月、干预4个月与干预前相比，这4种菌的丰度均呈增加趋势。平均值为每种菌丰度的平均值统计数据，从表2可得出在干预2个月和4个月后有益菌的丰度与干预前相比，显著增加，干预2个月和4个月相比，各细菌丰度维持在相对稳定的状态。
表2：
表3为31名肥胖人员在服用组合物前、服用2个月和4个月后测得的体重及BMI值，从表3中可看出，服用2个月之后，受试者的体重和BMI显著降低，服用4月后受试者体重和BMI进一步降低，表明该组合物的效果是持续起作用的。
表3：
表4为对表3的数据进行进一步整理得到，通过对23名肥胖人员干预前、干预2个月、干预4个月的体重进行对比，通过秩和检验检验它们之间的差异是否具有统计学意义，一般认为P值小于或等于0.05，则对比的两组差异是显著的，可见干预2个月、干预4个月与干预前相比，所有受试人员的体重和BMI均降低。平均值为体重与BMI的平均值统计数据，从表4中可得出，干预2个月和4个月体重与BMI干预前相比，显著降低，2个月和4个月相比，体重进一步降低，表明其作用是持续的。
表4：
本组合物热量含量低，适合各个人群的长期服用，本品可与加入牛奶、酸奶或茶叶等中作为食品添加剂使用，也可用于保健品或药品。
虽然本发明已以较佳实施例揭示如上，然而并非用以限定本发明。任何熟悉本领域的技术人员，在不脱离本发明技术方案范围的情况下，都可利用上述揭示的技术内容对本发明技术方案做出许多可能的变动和修饰，或修改为等同变化的等效实施例。因此，凡是未脱离本发明技术方案的内容，依据本发明技术实质对以上实施例所做的任何简单修改、等同变化及修饰，均应落在本发明技术方案保护的范围内。
Claims (8)
1.调节肠道菌群和防治肥胖的组合物，其特征在于，所述组合物包括低聚半乳糖、抗性糊精、绿茶提取物、葡萄籽提取物、左旋肉碱、果蔬粉、蘑菇粉和燕麦、菊粉和聚葡萄糖。
2.根据权利要求1所述的调节肠道菌群和防治肥胖的组合物，其特征在于，所述组合物中，按质量比计，低聚半乳糖∶抗性糊精∶绿茶提取物∶葡萄籽提取物∶左旋肉碱∶果蔬粉∶蘑菇粉∶燕麦：菊粉：多聚葡萄糖为1.5～5∶2～4∶0.04～0.1∶0.04～0.1∶0.02～0.04∶1～3∶1～3∶5～7∶1.2～2.4∶1.4～2.8。
3.根据权利要求2所述的调节肠道菌群和防治肥胖的组合物，其特征在于，按质量百分含量计，所述组合物中包括低聚半乳糖7.5～25％、抗性糊精10～20％、绿茶提取物0.2～0.5％，葡萄籽提取物0.2～0.5％、左旋肉碱0.1～0.2％、果蔬粉5～15％、蘑菇粉5～15％、燕麦25～35％、菊粉6～12％和聚葡萄糖7～14％。
4.根据权利要求2所述的调节肠道菌群和防治肥胖的组合物，其特征在于，按质量百分含量计，所述组合物中包括低聚半乳糖15％、抗性糊精15％、绿茶提取物0.25％、葡萄籽提取物0.25％、左旋肉碱0.15％、果蔬粉10％、蘑菇粉10％、燕麦30％、菊粉8％和聚葡萄糖11.35％。
5.根据权利要求1～4任意一项所述的调节肠道菌群和防治肥胖的组合物，其特征在于，所述组合物中还含有保健品或药物可接受的添加剂。
6.根据权利要求1～4任意一项所述的调节肠道菌群和防治肥胖的组合物，其特征在于，所述组合物为片剂、丸剂、胶囊、颗粒剂或粉剂。
7.根据权利要求1～6任意一项所述的组合物在防治便秘和肥胖的保健品、药物或食品中的应用。
8.根据权利要求7所述的应用，所述食品为牛奶、酸奶或茶叶。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811188535.0A CN109259240A (zh) | 2018-10-12 | 2018-10-12 | 调节肠道菌群和防治肥胖的组合物及其应用 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811188535.0A CN109259240A (zh) | 2018-10-12 | 2018-10-12 | 调节肠道菌群和防治肥胖的组合物及其应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109259240A true CN109259240A (zh) | 2019-01-25 |
Family
ID=65197119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811188535.0A Pending CN109259240A (zh) | 2018-10-12 | 2018-10-12 | 调节肠道菌群和防治肥胖的组合物及其应用 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109259240A (zh) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110679949A (zh) * | 2019-09-30 | 2020-01-14 | 山东晶辉生物技术有限公司 | 一种减肥组合物及其制备方法 |
| CN112841626A (zh) * | 2021-01-18 | 2021-05-28 | 优杨格股份有限公司 | 一种辣木叶益生菌粉 |
| CN113750172A (zh) * | 2021-09-01 | 2021-12-07 | 西安诺众康健生物科技有限责任公司 | 一种减重组合物及其在制备减肥产品中的应用 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105795468A (zh) * | 2016-01-08 | 2016-07-27 | 天津天狮生物发展有限公司 | 一种具有减肥功效的组合物 |
| CN105982009A (zh) * | 2015-02-05 | 2016-10-05 | 骆奇 | 用于调节人体肠道微生态的组合物 |
| CN106974262A (zh) * | 2016-01-15 | 2017-07-25 | 深圳华大基因研究院 | 肠道益生杆菌在治疗和预防肥胖及其相关疾病中的应用 |
| CN107198250A (zh) * | 2017-05-23 | 2017-09-26 | 北京瑞千景科技发展有限公司 | 改善肠道微生态预防慢性病组合物和均衡营养食品及应用 |
| CN108289918A (zh) * | 2015-09-10 | 2018-07-17 | 卢万天主教大学 | 经巴氏灭菌的艾克曼菌用于治疗代谢病症的用途 |
| CN108541953A (zh) * | 2018-04-23 | 2018-09-18 | 张清禹 | 一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物 |
-
2018
- 2018-10-12 CN CN201811188535.0A patent/CN109259240A/zh active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105982009A (zh) * | 2015-02-05 | 2016-10-05 | 骆奇 | 用于调节人体肠道微生态的组合物 |
| CN108289918A (zh) * | 2015-09-10 | 2018-07-17 | 卢万天主教大学 | 经巴氏灭菌的艾克曼菌用于治疗代谢病症的用途 |
| CN105795468A (zh) * | 2016-01-08 | 2016-07-27 | 天津天狮生物发展有限公司 | 一种具有减肥功效的组合物 |
| CN106974262A (zh) * | 2016-01-15 | 2017-07-25 | 深圳华大基因研究院 | 肠道益生杆菌在治疗和预防肥胖及其相关疾病中的应用 |
| CN107198250A (zh) * | 2017-05-23 | 2017-09-26 | 北京瑞千景科技发展有限公司 | 改善肠道微生态预防慢性病组合物和均衡营养食品及应用 |
| CN108541953A (zh) * | 2018-04-23 | 2018-09-18 | 张清禹 | 一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物 |
Non-Patent Citations (3)
| Title |
|---|
| CARLETT RAMIREZ-FARIAS 等: "Effect of inulin on the human gut microbiota: stimulation of Bifidobacterium adolescentis and Faecalibacterium prausnitzii", 《BRITISH JOURNAL OF NUTRITION》 * |
| DIANA E ROOPCHAND 等: "Dietary Polyphenols Promote Growth of the Gut Bacterium Akkermansia muciniphila and Attenuate High-Fat Diet-Induced Metabolic Syndrome", 《DIABETES》 * |
| 乌日拉嘎 等: "Faecalibacterium prausnitzii与人类疾病关系的研究进展", 《中国微生态学杂质》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110679949A (zh) * | 2019-09-30 | 2020-01-14 | 山东晶辉生物技术有限公司 | 一种减肥组合物及其制备方法 |
| CN112841626A (zh) * | 2021-01-18 | 2021-05-28 | 优杨格股份有限公司 | 一种辣木叶益生菌粉 |
| CN113750172A (zh) * | 2021-09-01 | 2021-12-07 | 西安诺众康健生物科技有限责任公司 | 一种减重组合物及其在制备减肥产品中的应用 |
| CN113750172B (zh) * | 2021-09-01 | 2022-06-28 | 西安诺众康健生物科技有限责任公司 | 一种减重组合物及其在制备减肥产品中的应用 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Franco et al. | Psyllium (Plantago ovata Forsk): From evidence of health benefits to its food application | |
| Erdoğan et al. | Effects of dietary supplementation of synbiotics and phytobiotics on performance, caecal coliform population and some oxidant/antioxidant parameters of broilers | |
| Wong | Gut microbiota and cardiometabolic outcomes: influence of dietary patterns and their associated components | |
| EP2991659B1 (en) | Lachnospiraceae in the gut microbiota and association with body weight | |
| EP2422813A1 (en) | Agent for regulating composition ratio of intestinal bacterial flora | |
| CN109259240A (zh) | 调节肠道菌群和防治肥胖的组合物及其应用 | |
| AU2005294369A1 (en) | Synbiotics | |
| Ripoll et al. | Gastrointestinal tolerance to an inulin-rich soluble roasted chicory extract after consumption in healthy subjects | |
| Zhou et al. | Compound Fu brick tea modifies the intestinal microbiome composition in high‐fat diet‐induced obesity mice | |
| Yadav et al. | Hypocholesterolaemic and prebiotic effect of partially hydrolysed psyllium husk supplemented yoghurt | |
| Sudheer et al. | Shaping the gut microbiota by bioactive phytochemicals: An emerging approach for the prevention and treatment of human diseases | |
| CN112568324A (zh) | 一种复合益生菌发酵中药饲料添加剂及制备方法和应用 | |
| Kumar et al. | Potent health-promoting effects of a synbiotic formulation prepared from Lactobacillus acidophilus NCDC15 fermented milk and Cichorium intybus root powder in Labrador dogs | |
| McRorie Jr et al. | Psyllium: The gel-forming nonfermented isolated fiber that delivers multiple fiber-related health benefits | |
| Yu et al. | Inulin and isomalto-oligosaccharide alleviate constipation and improve reproductive performance by modulating motility-related hormones, short-chain fatty acids, and feces microflora in pregnant sows | |
| CN115671132B (zh) | 一种益生菌和益生元的组合物及其应用 | |
| Santos et al. | What is the role of phenolic compounds of yerba mate (Ilex paraguariensis) in gut microbiota? | |
| KR102000170B1 (ko) | 체지방 감소 및 장관면역활성 증진을 위한 건강보조식품 | |
| Li et al. | Beneficial effects of fermented jujube pulp in relieving loperamide hydrochloride-induced constipation in male ICR mice | |
| JP2010254594A (ja) | 腸内バクテロイデス増殖促進剤 | |
| CN109043555A (zh) | 一种高血糖患者食用的特殊食品及其制备方法 | |
| CN107950864A (zh) | 一种合生元谷蔬代餐粉及其制备方法和应用 | |
| KR20150137647A (ko) | 다시마 및 복합 유산균을 함유한 항비만용 신바이오틱스 조성물 | |
| Ahmed et al. | Effect of gum Arabic on the fecal bacterial mass in healthy human volunteers | |
| US20200069744A1 (en) | Combination probiotic compositions and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190125 |
|
| RJ01 | Rejection of invention patent application after publication |