CN108541953A - 一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物 - Google Patents
一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物 Download PDFInfo
- Publication number
- CN108541953A CN108541953A CN201810364707.9A CN201810364707A CN108541953A CN 108541953 A CN108541953 A CN 108541953A CN 201810364707 A CN201810364707 A CN 201810364707A CN 108541953 A CN108541953 A CN 108541953A
- Authority
- CN
- China
- Prior art keywords
- kaman
- proliferated
- salmonella
- composition
- enteric microorganism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 35
- 244000005700 microbiome Species 0.000 title claims abstract description 24
- 241000607142 Salmonella Species 0.000 title claims abstract description 19
- 235000013406 prebiotics Nutrition 0.000 claims abstract description 25
- 229920001202 Inulin Polymers 0.000 claims abstract description 16
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims abstract description 16
- 229940029339 inulin Drugs 0.000 claims abstract description 16
- 229920001353 Dextrin Polymers 0.000 claims abstract description 15
- 239000004375 Dextrin Substances 0.000 claims abstract description 15
- 235000019425 dextrin Nutrition 0.000 claims abstract description 15
- 235000018102 proteins Nutrition 0.000 claims abstract description 12
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 12
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 12
- 229930003231 vitamin Natural products 0.000 claims abstract description 12
- 239000011782 vitamin Substances 0.000 claims abstract description 12
- 229940088594 vitamin Drugs 0.000 claims abstract description 12
- 235000013343 vitamin Nutrition 0.000 claims abstract description 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 10
- 239000006041 probiotic Substances 0.000 claims abstract description 9
- 235000018291 probiotics Nutrition 0.000 claims abstract description 9
- 108010035532 Collagen Proteins 0.000 claims abstract description 8
- 102000008186 Collagen Human genes 0.000 claims abstract description 8
- 229920001436 collagen Polymers 0.000 claims abstract description 8
- 150000001875 compounds Chemical class 0.000 claims abstract description 8
- 229920001542 oligosaccharide Polymers 0.000 claims abstract description 8
- 150000002482 oligosaccharides Chemical class 0.000 claims abstract description 8
- 229920001184 polypeptide Polymers 0.000 claims abstract description 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 8
- 229960004329 metformin hydrochloride Drugs 0.000 claims abstract description 7
- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 claims abstract description 7
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin hydrochloride Natural products CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000000843 powder Substances 0.000 claims abstract description 7
- 108010073771 Soybean Proteins Proteins 0.000 claims abstract description 6
- 229930003316 Vitamin D Natural products 0.000 claims abstract description 6
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 6
- 229930003448 Vitamin K Natural products 0.000 claims abstract description 6
- 239000002131 composite material Substances 0.000 claims abstract description 6
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims abstract description 6
- 235000019710 soybean protein Nutrition 0.000 claims abstract description 6
- 235000019166 vitamin D Nutrition 0.000 claims abstract description 6
- 239000011710 vitamin D Substances 0.000 claims abstract description 6
- 150000003710 vitamin D derivatives Chemical class 0.000 claims abstract description 6
- 235000019168 vitamin K Nutrition 0.000 claims abstract description 6
- 239000011712 vitamin K Substances 0.000 claims abstract description 6
- 150000003721 vitamin K derivatives Chemical class 0.000 claims abstract description 6
- 229940046008 vitamin d Drugs 0.000 claims abstract description 6
- 229940046010 vitamin k Drugs 0.000 claims abstract description 6
- 229930014669 anthocyanidin Natural products 0.000 claims abstract description 4
- 150000001452 anthocyanidin derivatives Chemical class 0.000 claims abstract description 4
- 235000008758 anthocyanidins Nutrition 0.000 claims abstract description 4
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 4
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 4
- 244000269722 Thea sinensis Species 0.000 claims abstract description 3
- 102000007544 Whey Proteins Human genes 0.000 claims abstract description 3
- 108010046377 Whey Proteins Proteins 0.000 claims abstract description 3
- 239000012141 concentrate Substances 0.000 claims abstract description 3
- 235000021119 whey protein Nutrition 0.000 claims abstract description 3
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 claims description 4
- 240000000111 Saccharum officinarum Species 0.000 claims description 3
- 235000007201 Saccharum officinarum Nutrition 0.000 claims description 3
- 235000013399 edible fruits Nutrition 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- FLDFNEBHEXLZRX-DLQNOBSRSA-N Nystose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(O[C@@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 FLDFNEBHEXLZRX-DLQNOBSRSA-N 0.000 claims description 2
- 229920001100 Polydextrose Polymers 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 235000013325 dietary fiber Nutrition 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- FLDFNEBHEXLZRX-UHFFFAOYSA-N nystose Natural products OC1C(O)C(CO)OC1(CO)OCC1(OCC2(OC3C(C(O)C(O)C(CO)O3)O)C(C(O)C(CO)O2)O)C(O)C(O)C(CO)O1 FLDFNEBHEXLZRX-UHFFFAOYSA-N 0.000 claims description 2
- 235000013856 polydextrose Nutrition 0.000 claims description 2
- 239000001259 polydextrose Substances 0.000 claims description 2
- 229940035035 polydextrose Drugs 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 238000007670 refining Methods 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 208000007976 Ketosis Diseases 0.000 claims 1
- 125000003147 glycosyl group Chemical group 0.000 claims 1
- 150000002584 ketoses Chemical class 0.000 claims 1
- 241000192125 Firmicutes Species 0.000 abstract description 9
- 241000605059 Bacteroidetes Species 0.000 abstract description 7
- 230000035755 proliferation Effects 0.000 abstract description 6
- 241000252983 Caecum Species 0.000 abstract description 5
- 210000004534 cecum Anatomy 0.000 abstract description 5
- 210000003405 ileum Anatomy 0.000 abstract description 5
- 241000702462 Akkermansia muciniphila Species 0.000 description 11
- 102000015728 Mucins Human genes 0.000 description 11
- 108010063954 Mucins Proteins 0.000 description 11
- 241000699666 Mus <mouse, genus> Species 0.000 description 10
- 241000894006 Bacteria Species 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 230000000968 intestinal effect Effects 0.000 description 6
- 210000000936 intestine Anatomy 0.000 description 6
- 150000003722 vitamin derivatives Chemical class 0.000 description 5
- 208000008589 Obesity Diseases 0.000 description 4
- 201000001421 hyperglycemia Diseases 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 208000030159 metabolic disease Diseases 0.000 description 4
- 235000020824 obesity Nutrition 0.000 description 4
- 241000186000 Bifidobacterium Species 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000003651 drinking water Substances 0.000 description 3
- 235000020188 drinking water Nutrition 0.000 description 3
- 229930003935 flavonoid Natural products 0.000 description 3
- 150000002215 flavonoids Chemical class 0.000 description 3
- 235000017173 flavonoids Nutrition 0.000 description 3
- 210000001630 jejunum Anatomy 0.000 description 3
- 210000003097 mucus Anatomy 0.000 description 3
- 208000015380 nutritional deficiency disease Diseases 0.000 description 3
- 210000000813 small intestine Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 102000009027 Albumins Human genes 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000606125 Bacteroides Species 0.000 description 2
- 208000031226 Hyperlipidaemia Diseases 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- 241000186660 Lactobacillus Species 0.000 description 2
- 241000736262 Microbiota Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 208000016097 disease of metabolism Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 230000034659 glycolysis Effects 0.000 description 2
- 244000005709 gut microbiome Species 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 229940039696 lactobacillus Drugs 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000702460 Akkermansia Species 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical class OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 description 1
- 102400000322 Glucagon-like peptide 1 Human genes 0.000 description 1
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000004407 Lactalbumin Human genes 0.000 description 1
- 108090000942 Lactalbumin Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 101150036359 clpB gene Proteins 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 238000005138 cryopreservation Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 208000030172 endocrine system disease Diseases 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 210000003736 gastrointestinal content Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 210000005027 intestinal barrier Anatomy 0.000 description 1
- 230000007358 intestinal barrier function Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000037353 metabolic pathway Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 229940051875 mucins Drugs 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 150000004043 trisaccharides Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/185—Vegetable proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
本发明涉及一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物,该组合物包括复合蛋白质粉、低聚糖益生元、功能性益生元和复合脂溶性维生素,所述的低聚糖益生元包括短链菊粉、低聚果糖和抗性糊精;所述的复合蛋白质粉包括浓缩乳清蛋白、大豆分离蛋白和胶原多肽;所述的功能性益生元由盐酸二甲双胍、茶多酚、花青素和原花青素中的一种或几种组成;所述复合脂溶性维生素包括维生素A、维生素E、维生素D和维生素K。本发明通过多种益生元的特殊配比,达到定向增殖盲肠和回肠中嗜黏蛋白阿卡曼氏菌,并对肠道内的拟杆菌门/厚壁菌门比例进行调节。
Description
技术领域
本发明涉及一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物,属于调节肠道微生物技术领域。
背景技术
人体内寄宿着数万亿的微生物,其数量是人体细胞的10倍以上。这些细菌大部分寄宿在人体的肠道内,通过这些寄宿的各种微生物结构形成了一个相对稳定的肠道微生态环境。研究表明人体的肠道菌群是人体最大的免疫器官,在人体免疫调节中扮演着非常重要的角色,并且对人体的神经系统、内分泌系统有种重要的调节作用。各种疾病都伴随着肠道微生态结构的失衡,通过调整肠道微生态结构,能很好的预防和治疗多种疾病。并且大量研究表明肠道微生态结构的失衡是产生高血糖、高血脂、高血压等内分泌-代谢疾病以及人体肥胖的重要内在因素,肠道微生物介导了多种内分泌疾病的代谢途径。
厚壁菌-拟杆菌-放线菌门为主微生物组合构成了的成年人型菌群结构。人体的肠道微菌群结构直接影响了人体的内分泌系统,微生物结构的异常往往引起人体的代谢疾病,其中尤其与拟杆菌门和厚壁菌门二者间适合的比例有关,同时拟杆菌/厚壁菌门比例也对肠道的消化吸收有影响,通过改善拟杆菌/厚壁菌门比例能调节血糖、血脂与体重。
嗜黏蛋白阿卡曼氏菌Akkermansia muciniphila是人体肠道中一种可降解黏蛋白的细菌,研究表明它与肥胖、糖尿病、炎症和代谢紊乱呈负相关;它发挥益生作用的机制可能是可以调节肠道内黏液厚度和维持肠道屏障完整性,以及其他对内分泌的调节作用;尤其对高血糖、肥胖有很好的调节作用;高血糖、肥胖人群的肠道中Akkermansiamuciniphila的含量不到普通人群的1/100。
目前通过益生元调节肠道菌群结构是主要的改善肠道微生态结构的方法。然而由于多数的肠道益生菌对常见益生元的亲和性相近,因此一种益生元的使用会使大量菌群的数量改变,无法靶向增殖某一种或某一类的益生菌。而且如菊粉、水苏糖、中药提取物等常见益生元能大量增殖乳酸菌,而乳酸菌属于厚壁菌门,常见益生元的使用会使拟杆菌门/厚壁菌门降低,引起快速肥胖,长期使用有引起高血糖、高血脂、高血压等内分泌-代谢疾病的风险。对于嗜黏蛋白阿卡曼氏菌Akkermansia muciniphila,目前处于研究阶段,仅发现部分物质能增殖Akkermansia muciniphila且往往会同时增殖双歧杆菌与乳杆菌,靶向性差。目前多种益生元配合药物成分构成的组合物是定向调节肠道微生态结构是学界的研究热点。
发明内容
本发明的目的在于:针对现有技术的缺陷,提出了一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物,通过多种益生元的特殊配比,达到定向增殖盲肠和回肠中嗜黏蛋白阿卡曼氏菌,并对肠道内的拟杆菌门/厚壁菌门比例进行调节。
本发明所采用的技术方案是:一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物,该组合物包括复合蛋白质粉、低聚糖益生元、功能性益生元和复合脂溶性维生素;所述的低聚糖益生元包括短链菊粉、低聚果糖和抗性糊精,其中所述短链菊粉、低聚果糖、抗性糊精三者质量比例为1:1:1.43。菊粉包括长链菊粉与短链菊粉两种,其中长链菊粉主要作用在增殖乳酸菌等益生菌,但对Akkermansia muciniphila没有明显的增殖作用,短链菊粉对益生菌没有明显的增殖功能,但能促进肠道粘液的生成,增加肠道粘液的量。
低聚果糖是由1~3个果糖基通过β(2—1)糖苷键与蔗糖中的果糖基结合生成的蔗果三糖、蔗果四糖和蔗果五糖的混合物;是一种人体无法消化吸收,但能被肠道内微生物利用的低聚糖,并且具有降低血脂的功能;低聚果糖能促进双歧杆菌生长繁殖,与其他益生元配比能增加Akkermansia muciniphila的丰度。
抗性糊精由淀粉加工而成,是将焙烤糊精的难消化成分用工业技术提取处理并精炼而成的一种低热量葡聚糖,属于低分子水溶性膳食纤维。抗性糊精能为被肠道内微生物分解利用,提供微生物生长所需的物质。抗性糊精黏度较低,能缓和短链菊粉与抗性糊精较高的粘性,避免益生元粘性过大而产生便秘。短链菊粉和抗性糊精通过特殊配比能诱导人体大肠杆菌K12增殖,从而产生ClpB等特殊蛋白,促进肠道细胞分泌多肽YY和GLP-1,降低人体食欲,而且对人体乳杆菌没有较强的促进作用。
在本发明中,所述复合蛋白质粉包括浓缩乳清蛋白、大豆分离蛋白、胶原多肽,且三者的质量比例为5:12:1。
通过控制蛋白质的含量和比例能确保部分蛋白质不在小肠内吸收,而进入肠道被肠道微生物分解吸收,而成为微生物发酵底物而产生醋酸盐。而剩余两种蛋白质能吸收膨胀,而短链菊粉和低聚果糖黏度大能延缓蛋白质的分解。胶原多肽是胶原蛋白水解后的短肽复合物,小肠能快速吸收短肽,使胶原多肽快速吸收。乳清蛋白吸收速率最快,30-40min内即可吸收完毕,大豆蛋白吸收速度适中,在1小时候才能被吸收,通过一个较长的吸收过程,使一定数量的蛋白质能进入肠道被肠道菌群分解,产生益生元的功效。
在本发明中,所述的功能性益生元由盐酸二甲双胍、茶多酚、花青素、原花青素中一种或几种组成。
盐酸二甲双胍是一种白色粉末,是目前常用的口服降血糖药物。降糖作用主要是增加周围组织糖的无氧酵解,增加糖的利用,这一作用的主要部位在小肠,动物试验证实本品可增加小肠的无氧酵解,使空肠对糖的利用增加20%。盐酸二甲双胍对部分肠道微生物有促进作用,并且其与低聚果糖等益生元配合能增殖Akkermansia muciniphila。
植物类黄酮是一种从植物中提取的黄酮类物质,为三元环化合物。包含各种植物色素,具有一定的抗氧化作用,和保护心血管的作用。类黄酮具有调节肠道菌群结构的作用,并且对Akkermansia muciniphila有一定的促进作用。
在本发明中,所述复合脂溶性维生素包括维生素A、维生素E、维生素D、维生素K 。
脂溶性维生素是人体的必须从外界摄取的营养物质,对人体有多种生理功能,缺乏维生素会导致人体产生相应的缺素症,对人体产生较大的危害。由于本组合物含有较多的益生元类物质,尤其是低聚糖类,能显著降低血脂,从而导致血液中的脂溶性维生素浓度降低,吸收量减少,容易产生缺素症。额外添加维生素A、维生素E、维生素D、维生素K的量,能有助维持血液中脂溶性维生素的浓度,避免缺素症的产生。
采用上述技术方案后,本发明的有益效果为:本发明通过多种益生元的特殊配比,达到定向增殖盲肠和回肠中嗜黏蛋白阿卡曼氏菌(Akkermansia muciniphila),并对肠道内的拟杆菌门/厚壁菌门比例进行调节。
附图说明
图1是本发明中实施例1和2的实验结果对比示意图;
图2是本发明中实施例1和2的另一实验结果对比示意图。
具体实施方式
下面将结合实施例对本发明作进一步的说明。
实施例1
一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物,该组合物包括乳清蛋白1g、大豆分离蛋白2.5g、胶原多肽0.2g、盐酸二甲双胍0.07g、短链菊粉1.1g、低聚果糖1.1g、抗性糊精1.57g、复合脂溶性维生素(含维生素A、维生素E、维生素D、维生素K)0.01g。
实施例2
一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物,该组合物包括乳清蛋白1g、大豆分离蛋白2.5g、胶原多肽0.2g、原花青素0.1g、花青素0.08g、短链菊粉1.2g、低聚果糖1.2g、抗性糊精1.72g、复合脂溶性维生素(含维生素A、维生素E、维生素D、维生素K)0.01g。
实验一:对拟杆菌门/厚壁菌门的影响
实验动物:4周龄体重 18~22g的雄性小鼠。
实验方法:将小鼠放于温度 23~25℃,湿度40%的环境中饲养,每天光照12小时,自由进食及饮水(实验中小鼠饮水为开水),垫料3天更换一次。每只小鼠每天给药量为20mg,将组合物A(植物性多酚益生元组合物)及组合物B(盐酸二甲双胍益生元组合物)添加于饮水中喂养小鼠。每两周收集一次小鼠粪便,保存于灭菌2 ml EP管中,-20℃储存。荧光定量检测粪便中拟杆菌门、厚壁菌门、双歧杆菌及乳酸杆菌的含量。
实验结果:
如图1所示,益生元组合物喂食二周后粪便菌群:
如图2所示,益生元组合物喂食四周后粪便菌群。
实验二:对肠道 Akkermansia muciniphila 的影响
实验方法:取8周龄小鼠,小鼠自由饮水与采食,以适应环境7d后,进行灌胃试验,在灌胃结束后的第1d处死小鼠,每次每组处死3只,快速收集小鼠的空肠、回肠、盲肠、结肠,放在2mL的冻存管,置于液氮中保存对小鼠各肠道内容物进行提取基因组试验,后实时荧光定量PCR检查样品中Akkermansia muciniphila的分布情况。
实验结果:
表1:小鼠肠道中Akkermansia muciniphila的分布情况
分组 | 盲肠 | 结肠 | 空肠 | 回肠 |
control | - | - | - | - |
MIX A | 30.253±0.545 | 32.461±0.749 | - | - |
MIX B | 29.264±0.527 | 32.331±0.422 | - | - |
对于本领域的技术人员而言,任何对本技术方案的同等修改和替代都是在本发明的范围之中。因此,在不脱离本发明的精神和范围下所作的均等变换和修改,都应涵盖在本发明的范围。
Claims (7)
1.一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物,其特征在于:该组合物包括复合蛋白质粉、低聚糖益生元、功能性益生元和复合脂溶性维生素。
2.根据权利要求1所述的一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物,其特征在于:所述的低聚糖益生元包括短链菊粉、低聚果糖和抗性糊精,其中所述短链菊粉、低聚果糖、抗性糊精三者质量比例为1:1:1.43。
3.根据权利要求2所述的一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物,其特征在于:所述的低聚果糖是由1~3个果糖基通过β(2—1)糖苷键与蔗糖中的果糖基结合生成的蔗果三糖、蔗果四糖和蔗果五糖的混合物。
4.根据权利要求2所述的一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物,其特征在于:所述的抗性糊精由淀粉加工而成,是将焙烤糊精的难消化成分用工业技术提取处理并精炼而成的一种低热量葡聚糖,属于低分子水溶性膳食纤维。
5.根据权利要求1所述的一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物,其特征在于:所述的复合蛋白质粉包括浓缩乳清蛋白、大豆分离蛋白和胶原多肽,且三者质量比例为5:12:1。
6.根据权利要求1所述的一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物,其特征在于:所述的功能性益生元由盐酸二甲双胍、茶多酚、花青素和原花青素中的一种或几种组成。
7.根据权利要求1所述的一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物,其特征在于:所述复合脂溶性维生素包括维生素A、维生素E、维生素D和维生素K。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810364707.9A CN108541953A (zh) | 2018-04-23 | 2018-04-23 | 一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810364707.9A CN108541953A (zh) | 2018-04-23 | 2018-04-23 | 一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN108541953A true CN108541953A (zh) | 2018-09-18 |
Family
ID=63512149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810364707.9A Pending CN108541953A (zh) | 2018-04-23 | 2018-04-23 | 一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108541953A (zh) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109259240A (zh) * | 2018-10-12 | 2019-01-25 | 人和未来生物科技(长沙)有限公司 | 调节肠道菌群和防治肥胖的组合物及其应用 |
CN111700902A (zh) * | 2020-07-16 | 2020-09-25 | 河北农业大学 | 一种山楂原花青素-枣多糖组合物及其制备方法 |
CN111938158A (zh) * | 2020-08-18 | 2020-11-17 | 王意 | 一种防止肠道Akkermansia muciniphila菌丰度降低的组合物 |
US11065295B1 (en) | 2020-02-05 | 2021-07-20 | DailyColors Health Inc. | Compositions and methods for nutritional supplements |
WO2022096501A1 (en) | 2020-11-09 | 2022-05-12 | A-Mansia Biotech | Composition comprising akkermansia muciniphila and green tea extract |
US11503851B1 (en) | 2021-06-28 | 2022-11-22 | DailyColors Health, Inc. | Compositions and methods to counteract processes associated with inflammation and senescence and to support cellular energy and/or metabolism |
-
2018
- 2018-04-23 CN CN201810364707.9A patent/CN108541953A/zh active Pending
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109259240A (zh) * | 2018-10-12 | 2019-01-25 | 人和未来生物科技(长沙)有限公司 | 调节肠道菌群和防治肥胖的组合物及其应用 |
US11065295B1 (en) | 2020-02-05 | 2021-07-20 | DailyColors Health Inc. | Compositions and methods for nutritional supplements |
US11202816B1 (en) | 2020-02-05 | 2021-12-21 | DailyColors Health Inc. | Compositions and methods for nutritional supplements |
US11752188B2 (en) | 2020-02-05 | 2023-09-12 | Daily Colors Health Inc. | Compositions and methods for nutritional supplements |
CN111700902A (zh) * | 2020-07-16 | 2020-09-25 | 河北农业大学 | 一种山楂原花青素-枣多糖组合物及其制备方法 |
CN111700902B (zh) * | 2020-07-16 | 2022-02-22 | 河北农业大学 | 一种山楂原花青素-枣多糖组合物及其制备方法 |
CN111938158A (zh) * | 2020-08-18 | 2020-11-17 | 王意 | 一种防止肠道Akkermansia muciniphila菌丰度降低的组合物 |
WO2022096501A1 (en) | 2020-11-09 | 2022-05-12 | A-Mansia Biotech | Composition comprising akkermansia muciniphila and green tea extract |
US11503851B1 (en) | 2021-06-28 | 2022-11-22 | DailyColors Health, Inc. | Compositions and methods to counteract processes associated with inflammation and senescence and to support cellular energy and/or metabolism |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN108541953A (zh) | 一种具有调节肠道微生物结构并增殖嗜黏蛋白阿卡曼氏菌的组合物 | |
Li et al. | Synergy of Astragalus polysaccharides and probiotics (Lactobacillus and Bacillus cereus) on immunity and intestinal microbiota in chicks | |
CN104758318B (zh) | 一种降低断奶仔猪腹泻率的复合制剂及其制备方法 | |
CN109430666A (zh) | 一种益生菌冻干粉固体饮料 | |
CN104642870B (zh) | 一种益生元组合物 | |
CN106619743A (zh) | 一种具有降血糖作用的益生菌固体饮料及其制备方法 | |
JP2016166176A (ja) | 腸内微生物叢バランス及び健康を促進するための栄養組成物 | |
CN107594279A (zh) | 一种益生菌粉固体饮料及其制备方法 | |
CN106174585A (zh) | 降血糖的组合物及降血糖的复合益生菌特膳食品 | |
CN105535030A (zh) | 鼠李糖乳杆菌和体重控制 | |
CN105722409A (zh) | 用于预防或治疗婴儿和幼儿的坏死性小肠结肠炎的组合物 | |
CN105744938A (zh) | 用于预防或治疗婴儿和幼儿的坏死性小肠结肠炎的组合物 | |
JP2021504420A (ja) | 微生物叢調節のためのヒトミルクオリゴ糖およびその合成組成物 | |
CN105722515A (zh) | 用于预防或治疗有风险婴儿或幼儿的urt感染的组合物 | |
CN107405354A (zh) | 治疗急性呼吸道感染的组合物和方法 | |
CN102665737A (zh) | 长双歧杆菌atcc baa-999(bl999)和体重控制 | |
CN110650635A (zh) | 出于健康目的而用于婴儿或幼儿的hmo共混物 | |
CN109287920A (zh) | 一种多元维生素与多联益生菌的固体饮料及其制作方法 | |
CN111227261A (zh) | 一种益生元组合物及其应用 | |
CN105982009A (zh) | 用于调节人体肠道微生态的组合物 | |
CN109315769A (zh) | 一种用于改善人体肠内环境的组合物及其制备方法 | |
CN115500515A (zh) | 一种植物乳杆菌在调节肠道菌群中的应用 | |
CN107889997A (zh) | 一种益生菌冻干粉固体饮料 | |
CN108669563A (zh) | 一种组合物、其应用和增强免疫力、改善过敏的产品 | |
CN107647410A (zh) | 一种复合配比的益生菌粉及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180918 |