DK3430143T3 - Inhibitorer af SRSF1 til behandlingen af neurodegenerative sygdomme - Google Patents

Inhibitorer af SRSF1 til behandlingen af neurodegenerative sygdomme Download PDF

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Publication number
DK3430143T3
DK3430143T3 DK17730896.2T DK17730896T DK3430143T3 DK 3430143 T3 DK3430143 T3 DK 3430143T3 DK 17730896 T DK17730896 T DK 17730896T DK 3430143 T3 DK3430143 T3 DK 3430143T3
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DK
Denmark
Prior art keywords
srsf1
inhibitors
treatment
neurodegenerative diseases
neurodegenerative
Prior art date
Application number
DK17730896.2T
Other languages
English (en)
Inventor
Guillaume Hautbergue
Mimoun Azzouz
Alexander Whitworth
Pamela Shaw
Original Assignee
Univ Sheffield
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Publication date
Application filed by Univ Sheffield filed Critical Univ Sheffield
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Publication of DK3430143T3 publication Critical patent/DK3430143T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11001—Non-specific serine/threonine protein kinase (2.7.11.1), i.e. casein kinase or checkpoint kinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
DK17730896.2T 2016-06-01 2017-05-30 Inhibitorer af SRSF1 til behandlingen af neurodegenerative sygdomme DK3430143T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1609597.8A GB201609597D0 (en) 2016-06-01 2016-06-01 Therapy
PCT/GB2017/051539 WO2017207979A1 (en) 2016-06-01 2017-05-30 Inhibitors of srsf1 to treat neurodegenerative disorders

Publications (1)

Publication Number Publication Date
DK3430143T3 true DK3430143T3 (da) 2021-03-29

Family

ID=56410846

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17730896.2T DK3430143T3 (da) 2016-06-01 2017-05-30 Inhibitorer af SRSF1 til behandlingen af neurodegenerative sygdomme

Country Status (6)

Country Link
US (1) US10801027B2 (da)
EP (1) EP3430143B1 (da)
DK (1) DK3430143T3 (da)
ES (1) ES2883998T3 (da)
GB (1) GB201609597D0 (da)
WO (1) WO2017207979A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107058315B (zh) * 2016-12-08 2019-11-08 上海优卡迪生物医药科技有限公司 敲减人PD-1的siRNA、重组表达CAR-T载体及其构建方法和应用
KR20210063348A (ko) * 2018-08-28 2021-06-01 이뮤노테크 바이오팜 씨오., 엘티디. 개선된 치료용 t 세포
JP7386848B2 (ja) * 2018-08-28 2023-11-27 法▲羅▼斯疫苗株式会社 改良されたレンチウイルスベクター
WO2020196737A1 (ja) * 2019-03-26 2020-10-01 富士フイルム株式会社 Ｂ型肝炎ウイルスタンパク質の産生を阻害する医薬組成物およびスクリーニング方法
DK3959235T3 (da) 2019-04-26 2023-10-16 Allogene Therapeutics Inc Rituximab-resistente kimære antigenreceptorer og anvendelser deraf
JP2022541915A (ja) * 2019-07-23 2022-09-28 ヤンセン バイオテツク，インコーポレーテツド 生物製造のための合成遺伝子要素
WO2024033329A2 (en) 2022-08-09 2024-02-15 University Of Sheffield Viral vector

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7217807B2 (en) 2002-11-26 2007-05-15 Rosetta Genomics Ltd Bioinformatically detectable group of novel HIV regulatory genes and uses thereof
WO2013106934A1 (en) 2012-01-17 2013-07-25 Université de Montréal Novel regulators of innate immunity and uses thereof
CN102747083B (zh) 2012-07-03 2014-04-02 首都医科大学附属北京儿童医院 剪切因子癌蛋白sf2/asf在制备白血病治疗药物中的应用
US10731161B2 (en) * 2013-03-11 2020-08-04 The Johns Hopkins University Influenza-activated constructs and methods of use thereof
WO2016040167A1 (en) 2014-09-08 2016-03-17 Brandon Higgs Compositions and methods for detecting and treating small cell lung cancer
EP3218484A4 (en) 2014-11-14 2018-05-30 Voyager Therapeutics, Inc. Compositions and methods of treating amyotrophic lateral sclerosis (als)

Also Published As

Publication number Publication date
EP3430143A1 (en) 2019-01-23
US10801027B2 (en) 2020-10-13
WO2017207979A1 (en) 2017-12-07
ES2883998T3 (es) 2021-12-09
EP3430143B1 (en) 2021-03-03
US20190194660A1 (en) 2019-06-27
GB201609597D0 (en) 2016-07-13

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