KR20160099092A - Ox40 결합 효능제 및 pd-1 축 결합 길항제를 포함하는 조합 요법 - Google Patents

Ox40 결합 효능제 및 pd-1 축 결합 길항제를 포함하는 조합 요법 Download PDF

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KR20160099092A
KR20160099092A KR1020167018833A KR20167018833A KR20160099092A KR 20160099092 A KR20160099092 A KR 20160099092A KR 1020167018833 A KR1020167018833 A KR 1020167018833A KR 20167018833 A KR20167018833 A KR 20167018833A KR 20160099092 A KR20160099092 A KR 20160099092A
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antibody
binding
binding antagonist
cancer
agonist
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지앤 청
정 킴
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제넨테크, 인크.
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Chemical Kinetics & Catalysis (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020167018833A 2013-12-17 2014-12-17 Ox40 결합 효능제 및 pd-1 축 결합 길항제를 포함하는 조합 요법 Withdrawn KR20160099092A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361917264P 2013-12-17 2013-12-17
US61/917,264 2013-12-17
US201462080991P 2014-11-17 2014-11-17
US62/080,991 2014-11-17
PCT/US2014/070998 WO2015095423A2 (en) 2013-12-17 2014-12-17 Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists

Publications (1)

Publication Number Publication Date
KR20160099092A true KR20160099092A (ko) 2016-08-19

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KR1020167018833A Withdrawn KR20160099092A (ko) 2013-12-17 2014-12-17 Ox40 결합 효능제 및 pd-1 축 결합 길항제를 포함하는 조합 요법

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US (2) US20150190506A1 (https=)
EP (2) EP3083687A2 (https=)
JP (1) JP2017501167A (https=)
KR (1) KR20160099092A (https=)
CN (1) CN106102774A (https=)
AU (1) AU2014364606A1 (https=)
BR (1) BR112016013963A2 (https=)
CA (1) CA2934028A1 (https=)
IL (1) IL246251A0 (https=)
MX (1) MX2016007965A (https=)
SG (1) SG11201604979WA (https=)
WO (1) WO2015095423A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
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KR20180009754A (ko) * 2015-05-21 2018-01-29 엘리게이터 바이오사이언스 에이비 신규한 폴리펩타이드

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