KR20090006153A - 비루관계에 대한 약물 전달 방법, 구조, 및 조성물 - Google Patents

비루관계에 대한 약물 전달 방법, 구조, 및 조성물 Download PDF

Info

Publication number
KR20090006153A
KR20090006153A KR1020087026781A KR20087026781A KR20090006153A KR 20090006153 A KR20090006153 A KR 20090006153A KR 1020087026781 A KR1020087026781 A KR 1020087026781A KR 20087026781 A KR20087026781 A KR 20087026781A KR 20090006153 A KR20090006153 A KR 20090006153A
Authority
KR
South Korea
Prior art keywords
therapeutic agent
drug
implant
core
matrix
Prior art date
Application number
KR1020087026781A
Other languages
English (en)
Korean (ko)
Inventor
주앙 쥬니어 유진 드
캐리 라이히
스티븐 보이드
핸슨 에스. 기포드
마크 딤
Original Assignee
큐엘티 플러그 딜리버리, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38564290&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20090006153(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 큐엘티 플러그 딜리버리, 인코포레이티드 filed Critical 큐엘티 플러그 딜리버리, 인코포레이티드
Publication of KR20090006153A publication Critical patent/KR20090006153A/ko

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/00772—Apparatus for restoration of tear ducts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008—Fixation appliances for connecting prostheses to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0085—Identification means; Administration of patients
    • A61F2250/0087—Identification means; Administration of patients colour-coded

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
KR1020087026781A 2006-03-31 2007-04-02 비루관계에 대한 약물 전달 방법, 구조, 및 조성물 KR20090006153A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78777506P 2006-03-31 2006-03-31
US60/787,775 2006-03-31
US87186406P 2006-12-26 2006-12-26
US60/871,864 2006-12-26

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020117003795A Division KR20110038144A (ko) 2006-03-31 2007-04-02 비루관계에 대한 약물 전달 방법, 구조, 및 조성물

Publications (1)

Publication Number Publication Date
KR20090006153A true KR20090006153A (ko) 2009-01-14

Family

ID=38564290

Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020087026758A KR101062796B1 (ko) 2006-03-31 2007-04-02 약물 요법을 위한 비루관 배출계 임플란트
KR1020127008750A KR101270113B1 (ko) 2006-03-31 2007-04-02 비루관계에 대한 약물 전달 방법, 구조, 및 조성물
KR1020087026781A KR20090006153A (ko) 2006-03-31 2007-04-02 비루관계에 대한 약물 전달 방법, 구조, 및 조성물
KR1020117003795A KR20110038144A (ko) 2006-03-31 2007-04-02 비루관계에 대한 약물 전달 방법, 구조, 및 조성물

Family Applications Before (2)

Application Number Title Priority Date Filing Date
KR1020087026758A KR101062796B1 (ko) 2006-03-31 2007-04-02 약물 요법을 위한 비루관 배출계 임플란트
KR1020127008750A KR101270113B1 (ko) 2006-03-31 2007-04-02 비루관계에 대한 약물 전달 방법, 구조, 및 조성물

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020117003795A KR20110038144A (ko) 2006-03-31 2007-04-02 비루관계에 대한 약물 전달 방법, 구조, 및 조성물

Country Status (19)

Country Link
US (17) US7998497B2 (fr)
EP (3) EP3449873A1 (fr)
JP (10) JP2009532132A (fr)
KR (4) KR101062796B1 (fr)
CN (2) CN103393483B (fr)
AU (2) AU2007234445B2 (fr)
BR (2) BRPI0709672B8 (fr)
CA (2) CA2648066C (fr)
DK (2) DK2004172T3 (fr)
ES (2) ES2717607T3 (fr)
HK (2) HK1190908A1 (fr)
IL (5) IL194515A (fr)
MX (2) MX2008012601A (fr)
NO (2) NO20084275L (fr)
NZ (4) NZ572193A (fr)
RU (4) RU2414199C2 (fr)
SG (2) SG170816A1 (fr)
WO (2) WO2007115259A2 (fr)
ZA (2) ZA200808401B (fr)

Families Citing this family (170)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9808052D0 (en) 1998-04-17 1998-06-17 Secr Defence Implants for administering substances and methods of producing implants
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US20040225250A1 (en) 2003-05-05 2004-11-11 Michael Yablonski Internal shunt and method for treating glaucoma
US7291125B2 (en) 2003-11-14 2007-11-06 Transcend Medical, Inc. Ocular pressure regulation
US20050232972A1 (en) 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
AU2005269988B2 (en) 2004-07-02 2012-02-02 Mati Therapeutics Inc. Treatment medium delivery device and methods for delivery
WO2006078320A2 (fr) 2004-08-04 2006-07-27 Brookwood Pharmaceuticals, Inc. Procede de production de systemes d'administration, et systemes d'administration
EP1933810B1 (fr) 2005-08-11 2012-10-10 Massachusetts Institute of Technology Dispositif et procede d'administration de medicament par voie intravesicale
CA2621303A1 (fr) * 2005-09-01 2007-03-08 Bristol-Myers Squibb Company Marqueurs biologiques et procedes permettant de determiner la receptivite aux modulateurs du facteur de croissance endotheliale vasculaire 2 (vegfr-2)
US20070212397A1 (en) * 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
KR101377900B1 (ko) 2005-10-13 2014-03-27 신세스 게엠바하 약물-함침 용기
WO2007084582A2 (fr) 2006-01-17 2007-07-26 Forsight Labs, Llc Dispositif de traitement d’administration de medicament
PT2526910E (pt) 2006-01-17 2015-11-18 Transcend Medical Inc Dispositivo para tratamento de glaucoma
ATE497797T1 (de) 2006-03-14 2011-02-15 Univ Southern California Mems-vorrichtung zur wirkstofffreisetzung
NZ572193A (en) 2006-03-31 2011-10-28 Quadra Logic Tech Inc Nasolacrimal drainage system implants for drug therapy with non-fluid swellable retention structure around drug core
CN101505696B (zh) * 2006-06-21 2012-11-14 庄臣及庄臣视力保护公司 用于递送活性试剂的泪点塞
US9474645B2 (en) * 2006-06-21 2016-10-25 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
KR20140032505A (ko) 2006-11-09 2014-03-14 알콘 리서치, 리미티드 약물 전달용 수불용성 폴리머 매트릭스
JP5340161B2 (ja) * 2006-11-09 2013-11-13 アルコン リサーチ， リミテッド 水不溶性ポリマーマトリックスを含む涙点プラグ
UY30883A1 (es) * 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
US8672870B2 (en) 2007-07-17 2014-03-18 Transcend Medical, Inc. Ocular implant with hydrogel expansion capabilities
DK2865361T3 (da) 2007-09-07 2019-07-08 Mati Therapeutics Inc Tåreimplantater og tilhørende fremgangsmåder
NZ598483A (en) * 2007-09-07 2013-08-30 Quadra Logic Tech Inc Drug cores for sustained release of therapeutic agents
BRPI0817074A2 (pt) 2007-09-07 2015-03-24 Qlt Plug Delivery Inc Aparelho, método para tratar uma desordem ocular, dispositivo de detecção e sistema de detecção
EP2205192A2 (fr) * 2007-09-07 2010-07-14 QLT Plug Delivery, Inc. Outil d'insertion et d'extraction pour implants lacrymaux
JP5330401B2 (ja) 2007-11-08 2013-10-30 アリメラ・サイエンシーズ，インコーポレーテッド 眼のための埋め込み装置、及びその装置を備えるキット
DK2231254T3 (da) 2007-12-11 2014-07-21 Massachusetts Inst Technology Implanterbar lægemiddelafgivelsesindretning
WO2009079559A1 (fr) * 2007-12-17 2009-06-25 University Of Florida Research Foundation, Inc. Traitement du dessèchement des yeux au moyen de bouchons de punctum
US8728528B2 (en) 2007-12-20 2014-05-20 Evonik Corporation Process for preparing microparticles having a low residual solvent volume
EP2242464B2 (fr) 2007-12-20 2017-03-01 University Of Southern California Appareil pour distribuer des agents thérapeutiques
WO2009105178A2 (fr) * 2008-02-18 2009-08-27 Qlt Plug Delivery, Inc. Implants lacrymaux et procédés apparentés
CN102105137B (zh) * 2008-04-30 2015-01-07 Qlt股份有限公司 复合泪管植入物及相关方法
WO2009137780A2 (fr) 2008-05-08 2009-11-12 Replenish Pumps, Llc Pompes implantables et canules à cet effet
US9333297B2 (en) 2008-05-08 2016-05-10 Minipumps, Llc Drug-delivery pump with intelligent control
EP2323716B1 (fr) 2008-05-08 2015-03-04 MiniPumps, LLC Pompes d'administration de médicaments
BRPI0912182A2 (pt) * 2008-05-09 2015-10-06 Qlt Plug Delivery Inc distribuição de liberação prolongada de agentes ativos pára tratar glaucoma e hipertensão ocular
US20090318549A1 (en) * 2008-06-24 2009-12-24 Qlt Plug Delivery, Inc. Combination treatment of glaucoma
ES2640867T3 (es) 2008-06-25 2017-11-07 Novartis Ag Implante ocular con capacidad de cambio de forma
WO2010006053A1 (fr) * 2008-07-08 2010-01-14 Qlt Plug Delivery, Inc. Corps d'implant lacrymal comprenant un agent de confort
KR101794899B1 (ko) 2008-08-09 2017-11-07 메사츄세츠 인스티튜트 어브 테크놀로지 남성 비뇨생식기 및 주위 조직을 치료하는 방법 및 체내이식형 약물 전달 장치
US20100204335A1 (en) * 2008-12-01 2010-08-12 Allergan, Inc. Kit and composition for eyelash growth
JP2012512725A (ja) * 2008-12-19 2012-06-07 キュー エル ティー インク． 物質送達用涙点インプラントおよび物質送達方法
AU2010206610A1 (en) * 2009-01-23 2011-08-11 Qlt Inc. Sustained released delivery of one or more agents
EP2548538B1 (fr) 2009-01-28 2020-04-01 Alcon Inc. Systèmes d'implantation pour implants oculaires rigides
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
SG173167A1 (en) 2009-01-29 2011-08-29 Forsight Labs Llc Posterior segment drug delivery
US20100204325A1 (en) * 2009-02-11 2010-08-12 Allergan, Inc. Valproic acid drug delivery systems and intraocular therapeutic uses thereof
US8409606B2 (en) 2009-02-12 2013-04-02 Incept, Llc Drug delivery through hydrogel plugs
RU2011138947A (ru) * 2009-02-23 2013-03-27 Клт Инк. Лакримальные имплантаты и связанные с ними способы
US8911495B2 (en) * 2009-03-16 2014-12-16 Endoshape, Inc. Reliably retained shape memory ophthalmological implants
US9421127B2 (en) 2009-03-31 2016-08-23 Johnson & Johnson Vision Care, Inc. Punctal plugs
TWI495459B (zh) * 2009-03-31 2015-08-11 Johnson & Johnson Vision Care 淚管塞（二）
EP2427179A4 (fr) 2009-05-04 2013-09-11 Psivida Inc Particules de silicium poreux d'élution de médicament
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
JP5695035B2 (ja) * 2009-06-03 2015-04-01 フォーサイト・ビジョン５・インコーポレイテッドＦｏｒｓｉｇｈｔ Ｖｉｓｉｏｎ５，Ｉｎｃ． 前眼部薬物供給
US10543166B2 (en) 2009-06-26 2020-01-28 Taris Biomedical Llc Implantable drug delivery devices and methods of making the same
WO2011022484A1 (fr) 2009-08-18 2011-02-24 Replenish Pumps. Llc Pompe électrolytique d'administration de médicament avec commande adaptative
US8808257B2 (en) * 2009-08-31 2014-08-19 Johnson & Johnson Vision Care, Inc. Methods and apparatus for pulsatile release of medicaments from a punctal plug
US9017312B2 (en) 2009-09-10 2015-04-28 Taris Biomedical Llc Implantable device for controlled drug delivery
EP2503969A1 (fr) 2009-11-27 2012-10-03 QLT Inc. Implants lacrimaux contenant un noyau de médicament fendu et insérable
US8529492B2 (en) 2009-12-23 2013-09-10 Trascend Medical, Inc. Drug delivery devices and methods
US10166142B2 (en) 2010-01-29 2019-01-01 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
US9259351B2 (en) 2010-03-29 2016-02-16 Johnson & Johnson Vision Care, Inc. Punctal plugs
US9259352B2 (en) 2010-03-29 2016-02-16 Johnson & Johnson Vision Care, Inc. Punctal plugs
US20110251568A1 (en) * 2010-04-08 2011-10-13 Beeley Nathan R F Punctal plugs for controlled release of therapeutic agents
EP3711750B1 (fr) 2010-08-05 2023-09-06 TARIS Biomedical LLC Dispositifs implantables d'administration de médicaments pour des sites génito-urinaires
EP2600930B1 (fr) 2010-08-05 2021-02-17 ForSight Vision4, Inc. Appareil d'injection pour l'administration de médicaments
AU2011285548B2 (en) 2010-08-05 2014-02-06 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
JP5907966B2 (ja) * 2010-08-05 2016-04-26 フォーサイト・ビジョン フォー・インコーポレーテッド 埋め込み型治療デバイス
US8821457B2 (en) * 2010-09-08 2014-09-02 Johnson & Johnson Vision Care, Inc. Punctal plug containing drug formulation
US8591484B2 (en) 2010-09-15 2013-11-26 AlphaMed, Inc. Lacrimal punctum measurement and occlusion
US9022967B2 (en) 2010-10-08 2015-05-05 Sinopsys Surgical, Inc. Implant device, tool, and methods relating to treatment of paranasal sinuses
IN2013MN00758A (fr) 2010-11-01 2015-06-12 Psivida Inc
WO2012068549A2 (fr) 2010-11-19 2012-05-24 Forsight Vision4, Inc. Formulations d'agents thérapeutiques pour des dispositifs implantés
CN103429266A (zh) * 2010-11-26 2013-12-04 约翰内斯堡金山大学 药物递送装置
US20120157938A1 (en) * 2010-12-16 2012-06-21 Tokarski Jason M Punctal plug with drug core retention features
EP2663300B1 (fr) 2011-01-10 2023-03-08 TARIS Biomedical LLC Régime posologique de lidocaine pour un traitement prolongé des douleurs vésicales et des mictions douloureuses
AU2012211960B2 (en) 2011-02-04 2016-12-01 Taris Biomedical Llc Implantable device for controlled release of low solubility drug
RU2456005C1 (ru) * 2011-04-20 2012-07-20 Общество с ограниченной ответственностью фирма "Биокор" Способ приготовления биологически активного препарата
WO2012149287A1 (fr) 2011-04-29 2012-11-01 Allergan, Inc. Implant à base de latanoprost à libération soutenue, sous forme d'un film de coulée en solvant
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
EP4249059A3 (fr) 2011-06-28 2023-11-29 ForSight Vision4, Inc. Un appareil pour collecter un échantillon de fluide à partir d'une chambre réservoir d'un dispositif thérapeutique pour l'oeil
CN103889401B (zh) 2011-08-29 2017-10-13 Qlt公司 持续释放递送活性剂以治疗青光眼和高眼压
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
AU2012308317B2 (en) 2011-09-14 2017-01-05 Forsight Vision5, Inc. Ocular insert apparatus and methods
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
CA2848385C (fr) 2011-09-16 2021-10-26 Forsight Vision4, Inc. Methodes et appareil d'echange d'un fluide d'un dispositif implantable
GB201120771D0 (en) * 2011-12-02 2012-01-11 Ljt Projects Ltd tear duct resistance measuring system
US8765210B2 (en) 2011-12-08 2014-07-01 Aquesys, Inc. Systems and methods for making gelatin shunts
TWI590843B (zh) 2011-12-28 2017-07-11 信迪思有限公司 膜及其製造方法
US10010448B2 (en) 2012-02-03 2018-07-03 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
US10342700B2 (en) * 2012-02-22 2019-07-09 Ira H. Schachar Device and method for treatment of retinal detachment and other maladies of the eye
IL224961A (en) * 2012-02-29 2017-06-29 Johnson & Johnson Vision Care Perforated cork with energy source restriction array
US9572964B2 (en) 2012-04-11 2017-02-21 Sinapsys Surgical, Inc. Implantation tools, tool assemblies, kits and methods
US10085633B2 (en) 2012-04-19 2018-10-02 Novartis Ag Direct visualization system for glaucoma treatment
US9241832B2 (en) 2012-04-24 2016-01-26 Transcend Medical, Inc. Delivery system for ocular implant
WO2013164671A1 (fr) 2012-05-03 2013-11-07 Qlt Inc. Système d'administration de médicament et procédés de traitement d'un glaucome à angle ouvert et de l'hypertension oculaire
KR101969594B1 (ko) * 2012-05-11 2019-04-16 서강대학교산학협력단 안내 약물 전달 임플란트
WO2014043698A2 (fr) 2012-09-17 2014-03-20 Transcend Medical, Inc. Dispositifs d'implant oculaire expansible et procédés associés
HUE046128T2 (hu) * 2012-10-26 2020-02-28 Forsight Vision5 Inc Szemészeti rendszer gyógyszer szembe való késleltetett kibocsátására
US9763829B2 (en) 2012-11-14 2017-09-19 Novartis Ag Flow promoting ocular implant
EP3281612B1 (fr) 2013-01-25 2020-04-22 Sinopsys Surgical, Inc. Dispositifs d'implant d'accès aux sinus paranasaux et kits
US10159600B2 (en) 2013-02-19 2018-12-25 Aquesys, Inc. Adjustable intraocular flow regulation
US9125723B2 (en) 2013-02-19 2015-09-08 Aquesys, Inc. Adjustable glaucoma implant
US9968603B2 (en) 2013-03-14 2018-05-15 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
KR102398262B1 (ko) 2013-03-15 2022-05-13 타리스 바이오메디컬 엘엘씨 약물-투과성 구성요소를 가지는 약물 전달 장치 및 방법
JP2016512839A (ja) 2013-03-15 2016-05-09 シヴィダ・ユーエス・インコーポレイテッドＰｓｉｖｉｄａ Ｕｓ， Ｉｎｃ． 治療物質の送達のための生体内分解性ケイ素系組成物
EP4302736A3 (fr) 2013-03-28 2024-04-03 ForSight Vision4, Inc. Implant ophtalmique pour l'administration de substances thérapeutiques
US9987163B2 (en) 2013-04-16 2018-06-05 Novartis Ag Device for dispensing intraocular substances
CN105555328B (zh) 2013-06-21 2019-01-11 德普伊新特斯产品公司 膜及制造方法
JP6486359B2 (ja) 2013-08-19 2019-03-20 タリス バイオメディカル エルエルシー 多ユニット薬物送達デバイス及び方法
WO2015069433A1 (fr) 2013-10-16 2015-05-14 Sinopsys Surgical, Inc. Appareils, outils et kits associés à des traitements de sinus paranasaux par manipulation de fluides
BR122020011777B1 (pt) 2013-11-14 2022-01-25 AqueSys, Inc Dispositivo de inserção para o tratamento de glaucoma
HU231309B1 (hu) 2014-02-25 2022-11-28 Darholding Kft. Nanostrukturált Indomethacint, gyógyszerészetileg elfogadott sóit és kokristályait tartalmazó készítmény és eljárás előállításukra
JP6655610B2 (ja) 2014-05-29 2020-02-26 グローコス コーポレーション 制御された薬物送達機能を備えるインプラント及びそれを使用する方法
KR102416726B1 (ko) 2014-07-15 2022-07-05 포사이트 비젼4, 인크. 안구 이식물 전달 디바이스 및 방법
US10898375B2 (en) 2014-07-24 2021-01-26 Sinopsys Surgical, Inc. Paranasal sinus access implant devices and related products and methods
JP2017524034A (ja) 2014-08-08 2017-08-24 フォーサイト・ビジョン フォー・インコーポレーテッドＦｏｒｓｉｇｈｔ Ｖｉｓｉｏｎ４， Ｉｎｃ． 受容体型チロシンキナーゼ阻害剤の安定で可溶な製剤およびその調製の方法
CN111214701A (zh) 2014-08-19 2020-06-02 加利福尼亚大学董事会 用于局部药物递送的植入物及其使用方法
RU2562515C1 (ru) * 2014-08-19 2015-09-10 федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Интубационный набор для биканаликулярного дренирования слезоотводящих путей
US10507101B2 (en) 2014-10-13 2019-12-17 W. L. Gore & Associates, Inc. Valved conduit
AU2015346450B2 (en) 2014-11-10 2020-01-30 Forsight Vision4, Inc. Expandable drug delivery devices and method of use
WO2016083891A1 (fr) * 2014-11-25 2016-06-02 Eyal Sheetrit Compositions et procédés d'administration d'un agent bio-actif ou d'agents bio-actifs
WO2016099946A1 (fr) * 2014-12-17 2016-06-23 Paul Gavaris Bouchon canaliculaire, procédé et kit pour traiter la sécheresse oculaire
RU2581823C1 (ru) * 2015-03-17 2016-04-20 федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Дренаж для хирургического лечения глаукомы
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
CN107529985B (zh) 2015-03-31 2020-03-31 加州理工学院 用于长期可植入传感器和电子装置的生物相容性封装
US20160296532A1 (en) 2015-04-13 2016-10-13 Forsight Vision5, Inc. Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
JP7425534B2 (ja) 2015-04-23 2024-01-31 タリス バイオメディカル エルエルシー 薬物透過性構成要素を有する薬物送達デバイス及び方法
WO2016187355A1 (fr) * 2015-05-20 2016-11-24 Glaukos Corporation Compositions médicamenteuses thérapeutiques et implants d'administration associés
JP2018517517A (ja) * 2015-06-16 2018-07-05 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ 涙産生刺激用の鼻涙インプラント及び関連方法
EP3319567A4 (fr) * 2015-07-06 2019-02-27 The Regents of The University of Colorado, A Body Corporate Implant de diagnostic de système de drainage lacrymal
CA2993182A1 (fr) 2015-07-22 2017-01-26 Incept, Llc Bouchon meatique revetu
WO2017040853A1 (fr) 2015-09-02 2017-03-09 Glaukos Corporation Implants d'administration de médicament présentant capacité d'administration bidirectionnelle
WO2017053885A1 (fr) * 2015-09-25 2017-03-30 Glaukos Corporation Implants lacrymaux à caractéristiques d'administration de médicament régulée et leurs procédés d'utilisation
WO2017062770A1 (fr) 2015-10-08 2017-04-13 Silverberg Noah Bouchon méatique et bioadhésifs
CA3005238A1 (fr) 2015-11-20 2017-05-26 Forsight Vision4, Inc. Structures poreuses pour dispositifs d'administration de medicament a liberation prolongee
RU2613435C1 (ru) * 2015-12-17 2017-03-16 Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Дренаж для хирургического лечения глаукомы
RU2620249C1 (ru) * 2015-12-17 2017-05-23 Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Многослойный биодеградируемый глазной имплантат с дозированным высвобождением лекарственного вещества и способ его изготовления
JP6936801B2 (ja) * 2015-12-21 2021-09-22 バイエル・オーイュー 薬剤送達装置の製造方法およびその方法に従って製造された薬剤送達装置
BR112018070383A2 (pt) 2016-04-05 2019-02-05 Forsight Vision4 Inc dispositivos para aplicação de fármaco oculares implantáveis
AU2017252294B2 (en) 2016-04-20 2021-12-02 Dose Medical Corporation Bioresorbable ocular drug delivery device
AU2017268379A1 (en) * 2016-05-20 2018-12-06 The Regents Of The University Of Colorado, A Body Corporate Lacrimal drug delivery device
GB2555373A (en) * 2016-08-23 2018-05-02 Reproductive Medicine And Gynaecology Associates Ltd Implant
CA3038115A1 (fr) 2016-09-30 2018-04-05 Mati Therapeutics Inc. Formulation ophtalmique a liberation pharmacologique prolongee et ses utilisations
US10722335B1 (en) * 2016-11-15 2020-07-28 Proximate Concepts Llc Device for the delivery of a prosthetic implant and method of use thereof
US9925028B1 (en) * 2016-11-15 2018-03-27 Proximate Concepts Llc Device for the delivery of a prosthetic implant and method of use thereof
US11523940B2 (en) 2017-03-17 2022-12-13 W. L. Gore & Associates, Inc. Delivery aids for glaucoma shunts
US11122975B2 (en) * 2017-05-12 2021-09-21 California Institute Of Technology Implantable extracompartmental pressure sensor
US20200147055A1 (en) * 2017-05-30 2020-05-14 Eximore Ltd. Compositions and methods for treating dry eye syndrome delivering antibiotic macrolide
TWI797136B (zh) 2017-06-16 2023-04-01 美商亞斯庫拉科技公司 熱感應聚合物及其用途
WO2019026903A1 (fr) 2017-07-31 2019-02-07 学校法人慶應義塾 Système de criblage de tumorigénicité rapide
CN111356422B (zh) 2017-09-20 2022-08-09 西诺普西斯外科股份有限公司 鼻旁窦流体进入植入工具、组件、套件及方法
JP2020536955A (ja) 2017-10-06 2020-12-17 ファウンドリー セラピューティクス， インコーポレイテッド 治療剤の制御放出のための埋込み可能なデポー
CA3082891A1 (fr) 2017-11-21 2019-05-31 Forsight Vision4, Inc. Appareil d'echange de fluide pour systeme d'administration a port extensible et methodes d'utilisation
UY38150A (es) 2018-03-22 2019-10-01 Alphamed Inc Aplicador de tapón de punto lagrimal soluble intracanalicular
WO2020050968A1 (fr) 2018-09-04 2020-03-12 University Hospitals Health System, Inc. Dispositif oculaire destiné au traitement du glaucome et procédé de chirurgie minimalement invasive associé du glaucome
US11678983B2 (en) 2018-12-12 2023-06-20 W. L. Gore & Associates, Inc. Implantable component with socket
US11850135B2 (en) 2019-08-01 2023-12-26 Paul H. Rosenberg Family Trust Prosthetic implant delivery device utilizing surface active agents
US11207267B2 (en) 2019-10-02 2021-12-28 Segal Innovations LLC Bio-adhesive dissolving compounds and device
US11701504B2 (en) 2020-01-17 2023-07-18 California Institute Of Technology Implantable intracranial pressure sensor
DK3861985T3 (da) 2020-02-06 2023-07-24 Ocular Therapeutix Inc Sammensætninger og fremgangsmåder til behandling af øjensygdomme
US11173291B2 (en) 2020-03-20 2021-11-16 The Regents Of The University Of California Implantable drug delivery devices for localized drug delivery
US11344526B2 (en) 2020-03-20 2022-05-31 The Regents Of The University Of California Implantable drug delivery devices for localized drug delivery
US11338119B2 (en) 2020-03-20 2022-05-24 The Regents Of The University Of California Implantable drug delivery devices for localized drug delivery
CA3171563A1 (fr) 2020-03-25 2021-09-30 Charles D. Blizzard Implant oculaire contenant un inhibiteur de tyrosine kinase
US20210338481A1 (en) * 2020-04-20 2021-11-04 Bruce B. Becker Lacrimal gland implant for drug delivery and method
TW202228761A (zh) 2020-09-24 2022-08-01 美商歐克萊製藥公司 包含水凝膠及環孢菌素之持續釋放可生物降解淚小管內插入物
JP2024508811A (ja) 2021-02-24 2024-02-28 オキュラ セラピューティクス，インコーポレイテッド 小管内デポーインサータ装置
USD1033637S1 (en) 2022-01-24 2024-07-02 Forsight Vision4, Inc. Fluid exchange device

Family Cites Families (244)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3880991A (en) * 1969-03-24 1975-04-29 Brook David E Polymeric article for dispensing drugs
US3865108A (en) 1971-05-17 1975-02-11 Ortho Pharma Corp Expandable drug delivery device
US3828777A (en) 1971-11-08 1974-08-13 Alza Corp Microporous ocular device
US3949750A (en) 1974-10-07 1976-04-13 Freeman Jerre M Punctum plug and method for treating keratoconjunctivitis sicca (dry eye) and other ophthalmic aliments using same
US4014335A (en) 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4281654A (en) * 1980-04-07 1981-08-04 Alza Corporation Drug delivery system for controlled ocular therapy
US4304765A (en) * 1980-10-14 1981-12-08 Alza Corporation Ocular insert housing steroid in two different therapeutic forms
NZ200429A (en) * 1981-04-30 1984-10-19 Smith & Nephew Ass Applicator for placing pharmaceutically active agent in contact with moist surface,e.g.,eye
US5053030A (en) 1984-11-07 1991-10-01 Herrick Robert S Intracanalicular implant for horizontal canalicular blockade treatment of the eye
US4660546A (en) 1984-11-07 1987-04-28 Robert S. Herrick Method for treating for deficiency of tears
US5049142A (en) 1984-11-07 1991-09-17 Herrick Robert S Intracanalicular implant for horizontal canalicular blockade treatment of the eye
US5229128A (en) 1986-06-11 1993-07-20 Haddad Heskel M Drug delivery ophthalmic insert and method of preparing same
US5322691A (en) 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US4747404A (en) 1986-11-10 1988-05-31 Kresge Eye Institute Of Wayne State University Foldable intraocular lens inserter
US4886488A (en) 1987-08-06 1989-12-12 White Thomas C Glaucoma drainage the lacrimal system and method
GB8806367D0 (en) * 1988-03-17 1988-04-13 Erba Carlo Spa Siloxane matrices with internal non-uniform drug distribution
US4915684A (en) 1988-06-21 1990-04-10 Mackeen Donald L Method and apparatus for modulating the flow of lacrimal fluid through a punctum and associated canaliculus
US4915664A (en) 1988-12-22 1990-04-10 Erik Bakker Toy glider with wing converging mechanism
US5133159A (en) 1989-01-13 1992-07-28 Nestle S.A. Method for polishing silicone products
US4959048A (en) 1989-01-17 1990-09-25 Helix Medical, Inc. Lacrimal duct occluder
US5098443A (en) 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
US5128058A (en) 1989-05-31 1992-07-07 Hoya Corporation Contact lens cleaner containing a microcapsular polishing agent
IE910450A1 (en) 1990-02-15 1991-08-28 Bausch & Lomb Soft contact lens processing aid
US5163959A (en) 1990-03-29 1992-11-17 Herrick Robert S Method for treating an eye with a canalicular implant having a collapsible flared section
US5171270A (en) 1990-03-29 1992-12-15 Herrick Robert S Canalicular implant having a collapsible flared section and method
US5041081A (en) 1990-05-18 1991-08-20 Odrich Ronald B Ocular implant for controlling glaucoma
US5116371A (en) 1990-07-06 1992-05-26 Christensen James M Prosthesis with improved biocompatibility
US5143724A (en) * 1990-07-09 1992-09-01 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use
US5077033A (en) * 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
KR100281609B1 (ko) 1991-12-27 2001-02-15 폴락 돈나 엘. 유효 제제를 포함하는 분산액의 동일 반응계내 생성 및 방출을 조절하는 약물 전달 장치
US5283063A (en) * 1992-01-31 1994-02-01 Eagle Vision Punctum plug method and apparatus
US5334137A (en) 1992-02-21 1994-08-02 Eagle Vision, Inc. Lacrimal fluid control device
US5254089A (en) * 1992-04-02 1993-10-19 Boston Scientific Corp. Medication dispensing balloon catheter
US5178635A (en) 1992-05-04 1993-01-12 Allergan, Inc. Method for determining amount of medication in an implantable device
US5514379A (en) * 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
US5469867A (en) 1992-09-02 1995-11-28 Landec Corporation Cast-in place thermoplastic channel occluder
US5318513A (en) 1992-09-24 1994-06-07 Leib Martin L Canalicular balloon fixation stent
FR2700265B1 (fr) * 1993-01-08 1995-03-31 France Chirurgie Instr Bouchon méatique pour pathologie lacrymale.
US5707643A (en) 1993-02-26 1998-01-13 Santen Pharmaceutical Co., Ltd. Biodegradable scleral plug
US6117907A (en) * 1993-04-14 2000-09-12 Sher; Neal A. Topical treatment of ocular pain after corneal surgery
US5824048A (en) 1993-04-26 1998-10-20 Medtronic, Inc. Method for delivering a therapeutic substance to a body lumen
US5417651A (en) 1993-07-01 1995-05-23 Guena; Nicolas Punctum plug and monocanalicular probe for lacrimal pathology
WO1995003807A1 (fr) 1993-07-27 1995-02-09 The University Of Sydney Traitement de la degenerescence maculaire due au vieillissement
US5423777A (en) 1993-10-27 1995-06-13 Tajiri; Akira Punctum plug
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US6350781B1 (en) * 1994-01-14 2002-02-26 Lee Shahinia, Jr. Method and analgesic preparations for sustained and extended corneal analgesia with subanesthetic concentrations of lidocaine
US5466233A (en) 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
JP3486758B2 (ja) 1994-06-24 2004-01-13 株式会社高研 注入可能な涙小管閉鎖剤
JPH0878130A (ja) 1994-09-08 1996-03-22 Wako:Kk 接地極の埋設方法
US6416760B2 (en) 1995-01-26 2002-07-09 Societe L'oreal Therapeutic/cosmetic compositions comprising CGRP antagonists for treating sensitive human skin
DE69633074T2 (de) * 1995-05-14 2004-12-30 Optonol Ltd. Intraokulares implantat, einführgerät sowie implantierungsverfahren
WO1996040005A1 (fr) * 1995-06-07 1996-12-19 Keravision, Inc. Implant radial destine a etre insere dans le stroma de la cornee et son procede d'insertion
US6149684A (en) 1995-06-07 2000-11-21 Herrick; Robert S. Punctum plug having a thin elongated lip and a distal starting tip and method of using
US5723005A (en) 1995-06-07 1998-03-03 Herrick Family Limited Partnership Punctum plug having a collapsible flared section and method
US5766243A (en) 1995-08-21 1998-06-16 Oasis Medical, Inc. Abrasive polished canalicular implant
US5773019A (en) 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US5741292A (en) 1995-10-26 1998-04-21 Eagle Vision Punctum dilating and plug inserting instrument with push-button plug release
US6441047B2 (en) 1995-11-17 2002-08-27 Alcon Manufacturing Ltd.. Combination therapy for treating glaucoma
WO1997020578A1 (fr) * 1995-12-04 1997-06-12 University Of Miami Corticosteroide sans conservateur pour application locale, destine au traitement du syndrome de l'oeil sec, de la keratite filamenteuse, et du retard de clairance lacrymale
US5824073A (en) 1996-03-18 1998-10-20 Peyman; Gholam A. Macular indentor for use in the treatment of subretinal neovascular membranes
FR2747033B1 (fr) * 1996-04-03 1998-05-22 Parrat Michel Jesus Hubert Obturateur meatique dynamique pour canalicules lacrymaux
JP3675035B2 (ja) 1996-06-10 2005-07-27 トヨタ自動車株式会社 内燃機関の燃料噴射量制御装置
JPH1033584A (ja) 1996-07-26 1998-02-10 M L C:Kk 涙道挿管器具
US5928662A (en) * 1996-07-31 1999-07-27 Phillips; Andrew F. Ocular drug delivery device
JP3345428B2 (ja) 1996-08-20 2002-11-18 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 合成甲状腺ホルマン組成物を使用した眼の処置
US5993407A (en) 1996-10-25 1999-11-30 Moazed; Kambiz Thomas Transnasal lacrimal insert
DE69712905T2 (de) 1996-11-01 2002-11-21 Alcon Lab Inc Polierverfahren für weiche acrylgegenstände
AU1727697A (en) 1997-02-04 1998-08-25 Alain Fouere Meatus plug for lachrymal canal capable of being screwed
US6041785A (en) 1997-03-27 2000-03-28 Eaglevision, Inc. Punctum plug
US6082362A (en) 1997-03-27 2000-07-04 Eagle Vision, Inc. Punctum plug
US6016806A (en) 1997-03-27 2000-01-25 Eaglevision, Inc Punctum plug
US6027470A (en) 1998-06-10 2000-02-22 Eagle Vision, Inc. Punctum plug and method for inserting the same into the punctual opening
AU741482B2 (en) * 1997-05-07 2001-11-29 Allergan Pharmaceuticals International Limited Intravaginal drug delivery devices for the administration of testosterone and testosterone precursors
US5961370A (en) 1997-05-08 1999-10-05 Chiron Vision Corporation Intraocular lens tumbling process using coated beads
MY125870A (en) 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
US6306426B1 (en) 1997-08-11 2001-10-23 Allergan Sales, Inc. Implant device with a retinoid for improved biocompatibility
US5830171A (en) 1997-08-12 1998-11-03 Odyssey Medical, Inc. Punctal occluder
US5902598A (en) * 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6060439A (en) 1997-09-29 2000-05-09 Kyzen Corporation Cleaning compositions and methods for cleaning resin and polymeric materials used in manufacture
US6645963B2 (en) 1997-11-05 2003-11-11 Senju Pharmaceutical Co., Ltd. Prolonged-action eye drop
US5947974A (en) 1997-12-09 1999-09-07 Allergan Folding device and method for an intraocular lens
US6646001B2 (en) 1997-12-19 2003-11-11 Alcon Manufacturing, Ltd. Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension
NL1008090C2 (nl) 1998-01-22 1999-07-26 Lubberman Bernardus H M Plug voor het afsluiten van een traanbuis.
US6290684B1 (en) 1998-03-02 2001-09-18 Herrick Family Limited Partnership Punctum plug having a collapsible expanded section and distal tip extending substantially perpendicular thereto and method of inserting same
WO1999044553A1 (fr) 1998-03-02 1999-09-10 Herrick Family Limited Partnership Obturateur du punctum lacrimale pourvu d'une section en forme de tromblon et susceptible de s'aplatir
US6512747B1 (en) 1998-03-05 2003-01-28 Nippon Telegraph And Telephone Corporation ATM transmission system
US6196993B1 (en) 1998-04-20 2001-03-06 Eyelab Group, Llc Ophthalmic insert and method for sustained release of medication to the eye
US6015433A (en) * 1998-05-29 2000-01-18 Micro Therapeutics, Inc. Rolled stent with waveform perforation pattern
US6224630B1 (en) * 1998-05-29 2001-05-01 Advanced Bio Surfaces, Inc. Implantable tissue repair device
US6306114B1 (en) 1998-06-16 2001-10-23 Eagle Vision, Inc. Valved canalicular plug for lacrimal duct occlusion
US6117441A (en) * 1998-07-02 2000-09-12 The Population Council, Inc. Silicone core long term androgen delivery implant
AU742237B2 (en) 1998-07-14 2001-12-20 Alcon Manufacturing Limited Use of 11-(3-dimenthylaminopropylidene)-6,11-dihydrodibenz (B,E)oxepin-2-acetic acid for the manufacture of medicament for treating non-allergic opthalmic inflammatory disorders and for the prevention of ocular neovascularization
US6225348B1 (en) * 1998-08-20 2001-05-01 Alfred W. Paulsen Method of treating macular degeneration with a prostaglandin derivative
JP2000070296A (ja) 1998-08-27 2000-03-07 M L C:Kk 涙道内挿管器具
US6095901A (en) 1998-12-09 2000-08-01 Alcon Laboratories, Inc. Polishing method for soft acrylic articles
US20040121014A1 (en) 1999-03-22 2004-06-24 Control Delivery Systems, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6234175B1 (en) 1999-03-23 2001-05-22 Medennium, Inc. Smart ocular plug design and method of insertion for punctal and intracanalicular implants
US6383192B1 (en) 1999-04-28 2002-05-07 Mlc Limited Company Apparatus for intubation of lacrimal duct
US6428502B1 (en) 1999-06-25 2002-08-06 Alcon Manufacturing, Ltd. Punctal cannula
US6706275B1 (en) 1999-09-08 2004-03-16 Matthew W. Camp Scleral plug system
KR100732262B1 (ko) * 1999-10-21 2007-06-25 알콘, 인코퍼레이티드 약물 전달 장치
US6331313B1 (en) * 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US6264971B1 (en) 1999-11-04 2001-07-24 Btg International Limited Ocular insert
US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
US20050119737A1 (en) * 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
US6344047B1 (en) 2000-02-02 2002-02-05 Eagle Vision Instrument for inserting a punctum plug and method for manufacturing the instrument
US7867186B2 (en) 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
US6638239B1 (en) 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US20040175410A1 (en) 2000-04-26 2004-09-09 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors
US20040208910A1 (en) * 2000-04-26 2004-10-21 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of adrenergic agents
US6375972B1 (en) * 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US6371122B1 (en) 2000-06-20 2002-04-16 Robert M. Mandelkorn Gauge/dilator apparatus
US6629533B1 (en) 2000-06-30 2003-10-07 Eagle Vision, Inc. Punctum plug with at least one anchoring arm
EP1305061B1 (fr) * 2000-08-04 2004-11-03 Medennium, Inc. Obturateur oculaire pour implants d'orifices lacrymaux et intracanaliculaires
US6534693B2 (en) 2000-11-06 2003-03-18 Afmedica, Inc. Surgically implanted devices having reduced scar tissue formation
CA2434156A1 (fr) 2000-12-29 2002-07-25 Bausch & Lomb Incorporated Dispositif d'apport de medicaments en continu
US7041868B2 (en) * 2000-12-29 2006-05-09 Kimberly-Clark Worldwide, Inc. Bioabsorbable wound dressing
WO2002053129A1 (fr) 2001-01-03 2002-07-11 Bausch & Lomb Incorporated Dispositifs d'administration de medicament a liberation prolongee a tampons permeables prefabriques
CA2433528A1 (fr) 2001-01-26 2002-08-01 Bausch & Lomb Incorporated Procede ameliore de fabrication de dispositifs d'administration de medicaments a liberation modifiee
US20020193441A1 (en) 2001-02-21 2002-12-19 Robertson Stella M. Prostanoid therapies for the treatment of glaucoma
US6713081B2 (en) 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US6981958B1 (en) 2001-05-02 2006-01-03 Glaukos Corporation Implant with pressure sensor for glaucoma treatment
EP1977724A1 (fr) 2001-04-07 2008-10-08 Glaukos Corporation Système de traitement de troubles oculaires
US6605108B2 (en) 2001-04-13 2003-08-12 Eagle Vision, Inc. Monocanalicular stent
US6982090B2 (en) 2001-05-10 2006-01-03 Gillespie Donald E More easily visualized punctum plug configurations
US7404825B2 (en) 2001-06-11 2008-07-29 Herrick Ii Robert S Implant capable of forming a differential image in an eye
US6743439B1 (en) * 2001-06-27 2004-06-01 Alcon, Inc. Ophthalmic compositions containing copolymers of sulfonated styrene and maleic anhydride
CN100349562C (zh) * 2001-07-23 2007-11-21 爱尔康公司 眼部药物输送装置
KR20040024873A (ko) * 2001-08-03 2004-03-22 글루코마 리서치 테크널러지스 인코포레이션 녹내장과 노안 치료를 위한 공막내 이식장치와 그 방법
FR2829019B3 (fr) 2001-08-31 2003-10-31 Alain Fouere Bouchons lacrymaux et methodes de mise en place de ces dispositifs
NZ530550A (en) 2001-09-11 2004-11-26 Smart Drug Systems Inc Preparation of sustained release pharmaceutical composition
US6996063B2 (en) 2001-11-16 2006-02-07 Asustek Computer Inc. Applicable PDU range test and calculation for window-based polling
FR2833175B1 (fr) 2001-12-06 2004-05-14 Sobem Dispositif de controle de debit, a usage medical
US7001615B1 (en) 2001-12-07 2006-02-21 Alcon, Inc. Sustained release ophthalmic, otic and nasal suspension
US6729939B2 (en) 2001-12-17 2004-05-04 Bausch & Lomb Incorporated Polishing method for intraocular lens
FR2834446B1 (fr) 2002-01-08 2004-02-13 Ioltechnologie Production Clou meatique a expansion
WO2003061625A2 (fr) * 2002-01-18 2003-07-31 Snyder Michael E Dispositif ophtalmologique a liberation prolongee et son procede de fabrication et d'utilisation
US20050255564A1 (en) 2002-01-18 2005-11-17 Takara Bio Inc Sulfated fucan
TW200305424A (en) * 2002-01-29 2003-11-01 Santen Pharmaceutical Co Ltd Glaucoma-treating agent comprising bunazosin and prostaglandin
US7204995B2 (en) 2002-01-31 2007-04-17 El-Sherif Dalia M Treatment and control of dry eye by use of biodegradable polymer capsules
US20040116524A1 (en) * 2002-02-04 2004-06-17 Cohen Ben Z. Method of administering opthalmic fluids
RU2322233C2 (ru) * 2002-03-11 2008-04-20 Алькон, Инк. Имплантируемая система для доставки лекарственных средств
US9301875B2 (en) 2002-04-08 2016-04-05 Glaukos Corporation Ocular disorder treatment implants with multiple opening
US20040147870A1 (en) 2002-04-08 2004-07-29 Burns Thomas W. Glaucoma treatment kit
AU2003234439A1 (en) * 2002-05-07 2003-11-11 Control Delivery Systems, Inc. Processes for forming a drug delivery device
US8871241B2 (en) * 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
US20040043067A1 (en) 2002-06-19 2004-03-04 Salamone Joseph C. Fluorosiloxane matrix controlled diffusion drug delivery systems
US6866563B2 (en) 2002-06-27 2005-03-15 Bausch & Lomb Incorporated Apparatus and method for target polishing intraocular lenses
FR2841770B1 (fr) * 2002-07-05 2004-10-01 Ioltechnologie Production Clou meatique d'obturation d'un meat lacrymal
FR2844182B1 (fr) 2002-09-11 2004-12-03 Humanoptics Ag Bouchon d'obturation d'un canalicule lacrymal
US7169163B2 (en) 2002-09-30 2007-01-30 Bruce Becker Transnasal method and catheter for lacrimal system
US7785578B2 (en) 2002-10-11 2010-08-31 Aciont, Inc. Non-invasive ocular drug delivery
DE60221669T2 (de) 2002-10-16 2008-05-21 Alcatel Lucent Paketvermittlung für Paketdatenübertragungssysteme in einer Multikanalfunkanordnung
US7354574B2 (en) * 2002-11-07 2008-04-08 Advanced Ocular Systems Limited Treatment of ocular disease
US7580394B2 (en) 2002-11-27 2009-08-25 Nokia Corporation System and method for collision-free transmission scheduling in a network
WO2004058289A1 (fr) * 2002-12-20 2004-07-15 Chakshu Research, Inc. Formulation ophtalmique pour la prevention et le traitement de pathologies oculaires
US20040144392A1 (en) * 2003-01-23 2004-07-29 Mueller Richard L. Breast nipple duct protective device
ATE440595T1 (de) * 2003-01-24 2009-09-15 Psivida Inc Vorrichtung mit verlängerter freisetzung und verfahren zur okularen verabreichung von adrenergen wirkstoffen
KR20050108345A (ko) * 2003-01-24 2005-11-16 컨트롤 딜리버리 시스템즈 인코포레이티드 탄산 탈수효소 저해제의 안구 전달을 위한 서방 장치와방법
US8149707B2 (en) 2003-02-12 2012-04-03 Rockstar Bidco, LP Minimization of radio resource usage in multi-hop networks with multiple routings
JP2006520217A (ja) 2003-02-26 2006-09-07 メディバス エルエルシー 生物活性ステントおよびその使用方法
WO2004078140A2 (fr) * 2003-03-05 2004-09-16 Halozyme, Inc. Glycoproteine hyaluronidase soluble (shasegp), procede de fabrication et compositions pharmaceutiques contenant ladite proteine
US20050283109A1 (en) 2003-03-07 2005-12-22 Peyman Gholam A Method and apparatus for lacrimal canal obstruction
US7065376B2 (en) 2003-03-20 2006-06-20 Microsoft Corporation Multi-radio unification protocol
US20040193095A1 (en) * 2003-03-29 2004-09-30 Shadduck John H. Implants for treating ocular hypertension, methods of use and methods of fabrication
US20050255144A1 (en) * 2003-04-09 2005-11-17 Directcontact Llc Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases
AU2004237774B2 (en) 2003-05-02 2009-09-10 Surmodics, Inc. Implantable controlled release bioactive agent delivery device
US7017580B2 (en) 2003-05-22 2006-03-28 Clarity Corporation Punctum plug system including a punctum plug and passive insertion tool therefor
US7204253B2 (en) 2003-05-22 2007-04-17 Clarity Corporation Punctum plug
US20040236343A1 (en) 2003-05-23 2004-11-25 Taylor Jon B. Insertion tool for ocular implant and method for using same
US20050054723A1 (en) * 2003-05-27 2005-03-10 Johan Stjernschantz Method for the treatment of glaucoma and ocular hypertension with prostaglandin analogues without melanogenic side effect
JP4104137B2 (ja) 2003-05-30 2008-06-18 有限会社エム・エル・シー 涙点プラグ
US7662864B2 (en) 2003-06-04 2010-02-16 Rutgers, The State University Of New Jersey Solution polymerization processes to prepare a polymer that degrades to release a physiologically active agent
JP4339635B2 (ja) 2003-06-12 2009-10-07 有限会社エム・エル・シー 涙点プラグ
US6994684B2 (en) 2003-06-16 2006-02-07 Alphamed Inc. Punctum plugs having fluid collecting recesses and methods of punctal occlusion
US20040265356A1 (en) 2003-06-30 2004-12-30 Bausch & Lomb Incorporated Drug delivery device
EP1646363B1 (fr) 2003-07-10 2013-10-16 Warner Chilcott (Ireland) Limited Dispositifs d'administration de medicaments par voie intravaginale
JP4280128B2 (ja) 2003-08-19 2009-06-17 有限会社エム・エル・シー 涙点プラグ
CN102144961A (zh) * 2003-09-18 2011-08-10 参天制药株式会社 经巩膜递送
JP2005110765A (ja) 2003-10-03 2005-04-28 M L C:Kk 涙点プラグセット
WO2005039619A1 (fr) * 2003-10-03 2005-05-06 Allergan, Inc. Compositions et methodes comprenant des composes du type prostaglandine et peptides de la famille du facteur en feuille de trefle utiles pour le traitement du glaucome avec hyperemie reduite
JP2005110930A (ja) 2003-10-07 2005-04-28 M L C:Kk 涙点プラグセット
US20050129731A1 (en) 2003-11-03 2005-06-16 Roland Horres Biocompatible, biostable coating of medical surfaces
US20050095269A1 (en) 2003-11-04 2005-05-05 Ainpour Parviz R. Gel plug for blockage of the canaliculus
EP2233112B3 (fr) 2003-11-13 2014-05-14 PSivida US Inc. Implant injectable à libération prolongée comprenant un noyau à matrice bioérodable et un revêtement bioérodable
US7291125B2 (en) 2003-11-14 2007-11-06 Transcend Medical, Inc. Ocular pressure regulation
ATE471642T1 (de) 2003-12-17 2010-07-15 Ericsson Telefon Ab L M Verfahren, system und endgerät und computerprogrammprodukt zur auswahl eines funkzugriffsystems in einem mehrfachzugriffsystem
EP1700414B1 (fr) 2003-12-29 2009-05-06 Electronics and Telecommunications Research Institute Procede pour creer des messages de retour pour arq dans un systeme de communication mobile
US20050197614A1 (en) 2004-03-04 2005-09-08 Wilson Pritchard Occlusive biomedical devices, punctum plugs, and methods of use thereof
US20050220882A1 (en) 2004-03-04 2005-10-06 Wilson Pritchard Materials for medical implants and occlusive devices
US20050232972A1 (en) 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
JP2004202276A (ja) 2004-04-16 2004-07-22 M L C:Kk 涙道再建用挿管器具
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
US8425929B2 (en) * 2004-04-30 2013-04-23 Allergan, Inc. Sustained release intraocular implants and methods for preventing retinal dysfunction
US7799336B2 (en) * 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
JP2005312835A (ja) 2004-04-30 2005-11-10 M L C:Kk 糸で補強した涙道ステント
US20050244461A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Controlled release drug delivery systems and methods for treatment of an eye
JP4644438B2 (ja) 2004-05-11 2011-03-02 有限会社エム・エル・シー ツバつき涙道ステント
JP4510511B2 (ja) 2004-05-18 2010-07-28 有限会社エム・エル・シー ツバを円盤で補強した涙道ステント及び涙道プラグ
AU2005269988B2 (en) 2004-07-02 2012-02-02 Mati Therapeutics Inc. Treatment medium delivery device and methods for delivery
US7117870B2 (en) * 2004-07-26 2006-10-10 Clarity Corporation Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same
EP1778198A1 (fr) 2004-07-26 2007-05-02 Clarity Corporation Dispositif implantable comprenant un reservoir a liberation commandee de medicament et procede de fabrication de celui-ci
US20060020253A1 (en) 2004-07-26 2006-01-26 Prescott Anthony D Implantable device having reservoir with controlled release of medication and method of manufacturing the same
US20080038317A1 (en) 2004-09-10 2008-02-14 Chin-Ming Chang Therapeutic Lacrimal Canalicular Inserts And Related Methods
US20060074370A1 (en) 2004-09-24 2006-04-06 Medennium, Inc. Ocular occluder and method of insertion
RU2007115853A (ru) * 2004-10-04 2008-11-10 КьюЭлТи ЮЭсЭй, ИНК. (US) Композиция, применимая в качестве имплантата с контролируемым высвобождением
MX2007006214A (es) 2004-11-24 2008-04-16 Therakine Ltd Un implante para suministro de farmaco intraocular.
CN1790976A (zh) 2004-12-17 2006-06-21 松下电器产业株式会社 用于多天线传输中的重传方法
US7986633B2 (en) 2004-12-27 2011-07-26 Lg Electronics Inc. Method of controlling data transmission for multimedia and broadcasting services in a broadband wireless access system
CN100394900C (zh) * 2005-02-02 2008-06-18 周星 螺旋弹簧型人工泪道
DE602005001441T2 (de) 2005-03-04 2007-10-31 Matsushita Electric Industrial Co., Ltd., Kadoma Verfahren und Vorrichtung zur Synchronisation der physikalischen Protokollschichten in heterogenen Mobilkommunikationsnetzwerken
US20060233858A1 (en) 2005-03-08 2006-10-19 Allergan, Inc. Systems and methods providing targeted intraocular drug delivery
WO2006122414A1 (fr) * 2005-05-17 2006-11-23 Matregen Corp. Sites tissulaires de stockage utilises pour l'apport prolonge et regule de methotrexate
US20060292099A1 (en) * 2005-05-25 2006-12-28 Michael Milburn Treatment of eye disorders with sirtuin modulators
EP1919365A2 (fr) * 2005-07-13 2008-05-14 Anthrogenesis Corporation Obturateur oculaire forme a partir dun tissu biologique a base de collagene derive du placenta
US7862532B2 (en) 2005-10-07 2011-01-04 Delta Life Sciences, Inc. Punctum plugs having insertion guides and strengthening beams
US20070088444A1 (en) * 2005-10-13 2007-04-19 Robert A Hodorek Method for repairing a bone defect using a formable implant which hardens in vivo
US20070132125A1 (en) 2005-12-08 2007-06-14 Bausch & Lomb Incorporated Use of a super-cooled fluid in lens processing
JP4078371B2 (ja) 2006-01-27 2008-04-23 章弘 小栗 涙点プラグ
NZ572193A (en) 2006-03-31 2011-10-28 Quadra Logic Tech Inc Nasolacrimal drainage system implants for drug therapy with non-fluid swellable retention structure around drug core
US9474645B2 (en) 2006-06-21 2016-10-25 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
US20080045911A1 (en) 2006-06-21 2008-02-21 Borgia Maureen J Punctal plugs for the delivery of active agents
US9173773B2 (en) 2006-06-21 2015-11-03 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
CA2657380A1 (fr) * 2006-07-20 2008-01-24 Neurosystec Corporation Dispositifs, systemes et procedes destines a administrer des medicaments ophtalmiques
FR2908042B1 (fr) 2006-11-08 2009-06-05 Bruno Fayet Ensemble d'intubation monocanaliculonasal et/ou monocanaliculaire,notamment pour l'imperforation lacrymonasale.
EP2097044A4 (fr) * 2006-12-26 2012-10-10 Quadra Logic Tech Inc Implants à libération de médicaments pour inhiber des défauts optiques
UY30883A1 (es) 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
US20080299176A1 (en) 2007-05-30 2008-12-04 Yu-Chin Lai Drug delivery device comprising crosslinked polyurethane-siloxane-containing copolymers
BRPI0817074A2 (pt) 2007-09-07 2015-03-24 Qlt Plug Delivery Inc Aparelho, método para tratar uma desordem ocular, dispositivo de detecção e sistema de detecção
WO2009035565A1 (fr) 2007-09-07 2009-03-19 Qlt Plug Delivery, Inc Analogues de prostaglandines pour des dispositifs d'implant et procédés
NZ598483A (en) 2007-09-07 2013-08-30 Quadra Logic Tech Inc Drug cores for sustained release of therapeutic agents
EP2205192A2 (fr) 2007-09-07 2010-07-14 QLT Plug Delivery, Inc. Outil d'insertion et d'extraction pour implants lacrymaux
DK2865361T3 (da) 2007-09-07 2019-07-08 Mati Therapeutics Inc Tåreimplantater og tilhørende fremgangsmåder
WO2009105178A2 (fr) 2008-02-18 2009-08-27 Qlt Plug Delivery, Inc. Implants lacrymaux et procédés apparentés
CN102105137B (zh) 2008-04-30 2015-01-07 Qlt股份有限公司 复合泪管植入物及相关方法
BRPI0912182A2 (pt) 2008-05-09 2015-10-06 Qlt Plug Delivery Inc distribuição de liberação prolongada de agentes ativos pára tratar glaucoma e hipertensão ocular
US8210902B2 (en) 2008-05-30 2012-07-03 Qlt Inc. Surface treated implantable articles and related methods
US20090318549A1 (en) 2008-06-24 2009-12-24 Qlt Plug Delivery, Inc. Combination treatment of glaucoma
WO2010006053A1 (fr) 2008-07-08 2010-01-14 Qlt Plug Delivery, Inc. Corps d'implant lacrymal comprenant un agent de confort
JP2012512725A (ja) 2008-12-19 2012-06-07 キュー エル ティー インク． 物質送達用涙点インプラントおよび物質送達方法
AU2010206610A1 (en) 2009-01-23 2011-08-11 Qlt Inc. Sustained released delivery of one or more agents
RU2011138947A (ru) 2009-02-23 2013-03-27 Клт Инк. Лакримальные имплантаты и связанные с ними способы

Also Published As

Publication number Publication date
RU2414199C2 (ru) 2011-03-20
WO2007115259A3 (fr) 2008-10-16
US20140236293A1 (en) 2014-08-21
BRPI0709672B1 (pt) 2019-07-02
NO20084275L (no) 2008-12-30
US20150224200A1 (en) 2015-08-13
US9168222B2 (en) 2015-10-27
US7998497B2 (en) 2011-08-16
CN103393496A (zh) 2013-11-20
US10300014B2 (en) 2019-05-28
BRPI0709663A2 (pt) 2011-07-26
ES2640458T3 (es) 2017-11-03
HK1190909A1 (zh) 2014-07-18
IL194515A0 (en) 2011-08-01
JP2017060789A (ja) 2017-03-30
EP2004172A4 (fr) 2013-01-02
IL194515A (en) 2013-09-30
JP5208916B2 (ja) 2013-06-12
HK1190908A1 (zh) 2014-07-18
JP2021176523A (ja) 2021-11-11
RU2008143223A (ru) 2010-05-10
JP2009532133A (ja) 2009-09-10
US8691265B2 (en) 2014-04-08
US20190054017A1 (en) 2019-02-21
IL225842B (en) 2018-01-31
US8747884B2 (en) 2014-06-10
KR20090014268A (ko) 2009-02-09
IL212114A0 (en) 2011-06-30
BRPI0709672A2 (pt) 2011-07-19
US10874606B2 (en) 2020-12-29
JP2009532132A (ja) 2009-09-10
US20130101658A1 (en) 2013-04-25
US20210212941A1 (en) 2021-07-15
IL194514A0 (en) 2011-08-01
US20070243230A1 (en) 2007-10-18
WO2007115261A3 (fr) 2009-01-22
JP7273891B2 (ja) 2023-05-15
KR20120041272A (ko) 2012-04-30
JP2018187396A (ja) 2018-11-29
IL212113A0 (en) 2011-06-30
US10383817B2 (en) 2019-08-20
EP2004172A2 (fr) 2008-12-24
EP2010096B1 (fr) 2017-07-19
WO2007115261A2 (fr) 2007-10-11
AU2007234445B2 (en) 2011-07-21
EP2004172B1 (fr) 2019-03-13
ES2717607T3 (es) 2019-06-24
US20140328894A1 (en) 2014-11-06
US9610194B2 (en) 2017-04-04
ZA200808401B (en) 2009-06-24
US20200000715A1 (en) 2020-01-02
AU2007234447B2 (en) 2011-07-14
JP2012228571A (ja) 2012-11-22
CA2648421A1 (fr) 2007-10-11
AU2007234445A1 (en) 2007-10-11
US20090092654A1 (en) 2009-04-09
NZ595623A (en) 2013-01-25
KR20110038144A (ko) 2011-04-13
NZ572193A (en) 2011-10-28
RU2010149066A (ru) 2012-06-10
DK2004172T3 (en) 2019-04-23
IL212113A (en) 2017-04-30
RU2413480C2 (ru) 2011-03-10
JP2014087650A (ja) 2014-05-15
CA2648066A1 (fr) 2007-10-11
US9849082B2 (en) 2017-12-26
RU2008143224A (ru) 2010-05-10
MX2008012603A (es) 2009-02-10
NO20084471L (no) 2008-12-29
MX2008012601A (es) 2009-02-10
CA2648421C (fr) 2016-01-12
JP6279421B2 (ja) 2018-02-14
US20180133150A1 (en) 2018-05-17
US20170128361A1 (en) 2017-05-11
NZ571758A (en) 2012-06-29
CN103393483A (zh) 2013-11-20
SG170816A1 (en) 2011-05-30
US8795711B2 (en) 2014-08-05
US20140161863A1 (en) 2014-06-12
CN103393483B (zh) 2016-08-24
IL212114A (en) 2017-02-28
IL225842A0 (en) 2013-06-27
US20070269487A1 (en) 2007-11-22
EP2010096A4 (fr) 2012-11-21
EP2010096A2 (fr) 2009-01-07
US11406592B2 (en) 2022-08-09
KR101270113B1 (ko) 2013-06-07
NZ595349A (en) 2013-01-25
US20230165791A1 (en) 2023-06-01
US9549852B2 (en) 2017-01-24
US20160008171A1 (en) 2016-01-14
JP2015037542A (ja) 2015-02-26
US20190054018A1 (en) 2019-02-21
EP3449873A1 (fr) 2019-03-06
JP2019213885A (ja) 2019-12-19
AU2007234447A1 (en) 2007-10-11
ZA200809003B (en) 2009-10-28
BRPI0709672B8 (pt) 2021-06-22
WO2007115259A2 (fr) 2007-10-11
DK2010096T3 (en) 2017-10-02
CN103393496B (zh) 2016-08-17
RU2010149861A (ru) 2012-06-10
US20110276131A1 (en) 2011-11-10
CA2648066C (fr) 2012-07-03
KR101062796B1 (ko) 2011-09-06
JP2017148605A (ja) 2017-08-31
SG170806A1 (en) 2011-05-30

Similar Documents

Publication Publication Date Title
KR101270113B1 (ko) 비루관계에 대한 약물 전달 방법, 구조, 및 조성물
TWI543776B (zh) 供治療劑之持續釋放之藥物核心
US9949942B2 (en) Sustained release delivery of active agents to treat glaucoma and ocular hypertension
WO2010008883A1 (fr) Traitement d'association du glaucome
AU2011235978A1 (en) Nasolacrimal drainage system implants for drug therapy
AU2011235979A1 (en) Drug delivery methods, structures, and compositions for nasolacrimal system

Legal Events

Date Code Title Description
A201 Request for examination
AMND Amendment
E902 Notification of reason for refusal
AMND Amendment
E601 Decision to refuse application
J201 Request for trial against refusal decision
A107 Divisional application of patent
AMND Amendment
B601 Maintenance of original decision after re-examination before a trial
N231 Notification of change of applicant
N231 Notification of change of applicant
J301 Trial decision

Free format text: TRIAL DECISION FOR APPEAL AGAINST DECISION TO DECLINE REFUSAL REQUESTED 20110121

Effective date: 20111221

Free format text: TRIAL NUMBER: 2011101000425; TRIAL DECISION FOR APPEAL AGAINST DECISION TO DECLINE REFUSAL REQUESTED 20110121

Effective date: 20111221