RU2010149861A - Имплантаты назолакримальной дренажной системы для медикаментозной терапии - Google Patents

Имплантаты назолакримальной дренажной системы для медикаментозной терапии Download PDF

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RU2010149861A
RU2010149861A RU2010149861/14A RU2010149861A RU2010149861A RU 2010149861 A RU2010149861 A RU 2010149861A RU 2010149861/14 A RU2010149861/14 A RU 2010149861/14A RU 2010149861 A RU2010149861 A RU 2010149861A RU 2010149861 A RU2010149861 A RU 2010149861A
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opening
drug core
implant
lacrimal
eye
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ДЖУАН Мл. Юджин ДЕ (US)
ДЖУАН Мл. Юджин ДЕ
Стивен БОЙД (US)
Стивен БОЙД
Кэри Дж. РЕЙЧ (US)
Кэри Дж. РЕЙЧ
Алан Р. РАПАКИ (US)
Алан Р. РАПАКИ
Хэнсон С. ДЖИФФОРД (US)
Хэнсон С. ДЖИФФОРД
Марк ДИМ (US)
Марк Дим
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Клт Плаг Диливери, Инк. (Us)
Клт Плаг Диливери, Инк.
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Abstract

1. Имплантат для вставления в отверстие слезного канала пациента, включающий: ! лекарственную сердцевину, имеющую дистальный конец и проксимальный конец, причем дистальный конец лекарственной сердцевины имеет перечное сечение, пригодное для вставления в отверстие слезного канала, причем лекарственная сердцевина включает лечебный агент, доставляемый в глаз; и ! оболочку, расположенную поверх части лекарственной сердцевины для задания, по крайней мере, одной экспонированной поверхности лекарственной сердцевины, где, по крайней мере, одна экспонированная поверхность лекарственной сердцевины расположена рядом с проксимальным концом для контакта со слезой или жидкостью слезной пленки и высвобождения лечебного агента на лечебных уровнях на протяжении пролонгированного периода, когда имплантат вставлен для использования. ! 2. Имплантат по п.1, дополнительно включающий удерживающую структуру, присоединенную к лекарственной сердцевине для удержания лекарственной сердцевины рядом с отверстием слезного канала и/или в нем. ! 3. Имплантат по п.2. где удерживающая структура включает гидрогель, приспособленный для расширения, когда удерживающая структура помещена в отверстие слезного канала. ! 4. Имплантат по п.3, где удерживающая структура включает прикрепляющий элемент, имеющий аксиально ориентированную поверхность, а гидрогель способен расширяться, побуждая аксиально ориентированную поверхность удерживать гидрогель, когда гидрогель гидратирован. ! 5. Имплантат по п.4, где прикрепляющий элемент включает, по крайней мере, одно из: выступа, кромки, ободка, или отверстия сквозь часть удерживающей структуры. ! 6. Имп�

Claims (23)

1. Имплантат для вставления в отверстие слезного канала пациента, включающий:
лекарственную сердцевину, имеющую дистальный конец и проксимальный конец, причем дистальный конец лекарственной сердцевины имеет перечное сечение, пригодное для вставления в отверстие слезного канала, причем лекарственная сердцевина включает лечебный агент, доставляемый в глаз; и
оболочку, расположенную поверх части лекарственной сердцевины для задания, по крайней мере, одной экспонированной поверхности лекарственной сердцевины, где, по крайней мере, одна экспонированная поверхность лекарственной сердцевины расположена рядом с проксимальным концом для контакта со слезой или жидкостью слезной пленки и высвобождения лечебного агента на лечебных уровнях на протяжении пролонгированного периода, когда имплантат вставлен для использования.
2. Имплантат по п.1, дополнительно включающий удерживающую структуру, присоединенную к лекарственной сердцевине для удержания лекарственной сердцевины рядом с отверстием слезного канала и/или в нем.
3. Имплантат по п.2. где удерживающая структура включает гидрогель, приспособленный для расширения, когда удерживающая структура помещена в отверстие слезного канала.
4. Имплантат по п.3, где удерживающая структура включает прикрепляющий элемент, имеющий аксиально ориентированную поверхность, а гидрогель способен расширяться, побуждая аксиально ориентированную поверхность удерживать гидрогель, когда гидрогель гидратирован.
5. Имплантат по п.4, где прикрепляющий элемент включает, по крайней мере, одно из: выступа, кромки, ободка, или отверстия сквозь часть удерживающей структуры.
6. Имплантат по п.2, где удерживающая структура способна к расширению между конфигурацией с малым сечением, пригодной для вставления, и конфигурацией с большим сечением для закрепления удерживающей структуры в просвете канальца.
7. Имплантат по п.2, где удерживающая структура расположена, по крайней мере, частично поверх лекарственной сердцевины.
8. Имплантат по п.1, где оболочка включает слой, расположенный поверх лекарственной сердцевины, для ингибирования высвобождения лечебного агента через слой.
9. Имплантат по п.8, где лекарственная сердцевина высвобождает лечебный агент через экспонированную поверхность.
10. Имплантат по п.1, где лекарственная сердцевина высвобождает лечебный агент на лечебных уровнях на протяжении периода времени, по крайней мере, одной недели, когда имплантат вставлен с поверхностью, экспонированной в слезу или жидкость слезной пленки.
11. Имплантат по п.1, где лекарственная сердцевина включает включения агента, и агент растворим в лекарственной сердцевине для обеспечения по существу однородной скорости высвобождения, когда лекарственная сердцевина имплантирована.
12. Имплантат по п.1, дополнительно включающий окклюзионный элемент для ингибирования тока слезной жидкости через просвет канальца.
13. Способ лечения глаза лечебным агентом, включающий;
вставление удерживающей структуры и дистального конца лекарственной сердцевины имплантата в отверстие слезного канала;
доставку лечебного агента из лекарственной сердцевины к глазу;
ограничение экспонированной поверхности лекарственной сердцевины рядом с проксимальным концом лекарственной сердцевины при помощи оболочки, где экспонированная поверхность контактирует со слезой или жидкостью слезной пленки, а лечебный агент мигрирует из экспонированной поверхности к глазу на протяжении пролонгированного периода, в то время как лекарственная сердцевина удерживается рядом с отверстием слезного канала посредством удерживающей структуры.
14. Способ лечения глаза, включающий:
вставление дистального конца имплантата в отверстие слезного канала;
расширение удерживающей структуры имплантата так, чтобы ингибировать выталкивание имплантата, причем расширение имплантата помогает закрыть поток слезной жидкости через отверстие слезного канала;
доставку лечебного агента от проксимального конца имплантата к слезной жидкости, касающейся глаза; и
ингибирование доставки лечебного агента дистально от проксимального конца.
15. Способ по п.14, где доставку лечебного агента к слезе ингибируют при помощи оболочки, имеющей часть, экспонированную в слезную жидкость.
16. Способ по п.14, где удерживающая структура включает гидрогель и распространяется дистально от лекарственной сердцевины.
17. Имплантат для лечения глаза, где глаз имеет слезную жидкость и отверстие слезного канала, включающий:
лекарственную сердцевину, имеющую проксимальный конец, дистальный конец и поперечное сечение, пригодное для вставления в отверстие слезного канала;
манжету, расположенную поверх лекарственной сердцевины, по крайней мере, дистально от проксимального конца; и
способный к набуханию материал, расположенный дистально от проксимального конца и, по крайней мере, частично покрытый манжетой, где способный к набуханию материал приспособлен набухать после вставления в отверстие слезного канала для удержания лекарственной сердцевины и препятствия слезе, находящейся в жидкостном контакте с лекарственной сердцевиной.
18. Имплантат по п.17, где манжета включает лепестки для удержания пробки для отверстия слезного канала при расширении способного к набуханию материала.
19. Пробка для отверстия слезного канала для лечения глаза, где глаз имеет слезную жидкость и отверстие слезного канала, включающая:
корпус пробки; и
лекарственную сердцевину внутри корпуса пробки, где лекарственная сердцевина включает смесь лечебного агента и матрикса, где поверхность сердцевины экспонирована в слезную жидкость для лечения глаза.
20. Пробка для отверстия слезного канала по п.19, где лекарственная сердцевина способна к эластичному расширению для того, чтобы вмещать иглу, вставляемую в нее, когда пробка вставлена в отверстие слезного канала газа.
21. Пробка для отверстия слезного канала для лечения глаза, где глаз имеет слезную жидкость и отверстие слезного канала, включающая:
способный к расширению удерживающий элемент для расширения и вхождения в зацепление с отверстием слезного канала при размещении в отверстии слезного канала; и
корпус, соединенный со способным к расширению удерживающим элементом, где корпус включает выступ для удаления удерживающего элемента из отверстия слезного канала.
22. Пробка для отверстия слезного канала по п.21, где способный к расширению удерживающий элемент включает способный к набуханию материал, а корпус приспособлен для удерживания способного к набуханию материала при удалении корпуса.
23. Пробка для отверстия слезного канала по п.22, где способный к набуханию материал включает гидрогель.
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