KR20010023070A - 고품질의 연속적인 재료 처리, 조직 고정-탈수-지방제거-함침 방법 - Google Patents
고품질의 연속적인 재료 처리, 조직 고정-탈수-지방제거-함침 방법 Download PDFInfo
- Publication number
- KR20010023070A KR20010023070A KR1020007001688A KR20007001688A KR20010023070A KR 20010023070 A KR20010023070 A KR 20010023070A KR 1020007001688 A KR1020007001688 A KR 1020007001688A KR 20007001688 A KR20007001688 A KR 20007001688A KR 20010023070 A KR20010023070 A KR 20010023070A
- Authority
- KR
- South Korea
- Prior art keywords
- tissue
- tissue sample
- solution
- paraffin
- minutes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 title claims abstract description 90
- 238000005470 impregnation Methods 0.000 title claims abstract description 48
- 239000000243 solution Substances 0.000 claims abstract description 125
- 238000012545 processing Methods 0.000 claims abstract description 43
- 238000006297 dehydration reaction Methods 0.000 claims abstract description 24
- 230000018044 dehydration Effects 0.000 claims abstract description 22
- 239000012188 paraffin wax Substances 0.000 claims description 45
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 44
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 37
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 32
- 239000003153 chemical reaction reagent Substances 0.000 claims description 27
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 25
- 239000001993 wax Substances 0.000 claims description 22
- 239000008096 xylene Substances 0.000 claims description 22
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims description 20
- 239000000834 fixative Substances 0.000 claims description 12
- 239000002202 Polyethylene glycol Substances 0.000 claims description 10
- 239000002480 mineral oil Substances 0.000 claims description 10
- 235000010446 mineral oil Nutrition 0.000 claims description 10
- 239000012457 nonaqueous media Substances 0.000 claims description 10
- 229920001223 polyethylene glycol Polymers 0.000 claims description 10
- 238000005406 washing Methods 0.000 claims description 9
- 150000002576 ketones Chemical class 0.000 claims description 7
- 239000004094 surface-active agent Substances 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims 2
- 238000011282 treatment Methods 0.000 abstract description 33
- 239000000203 mixture Substances 0.000 abstract description 18
- 238000003756 stirring Methods 0.000 abstract description 12
- 230000007170 pathology Effects 0.000 abstract description 8
- 239000007864 aqueous solution Substances 0.000 abstract description 2
- 210000001519 tissue Anatomy 0.000 description 281
- 239000000523 sample Substances 0.000 description 75
- 230000008569 process Effects 0.000 description 28
- 208000005156 Dehydration Diseases 0.000 description 24
- 235000019441 ethanol Nutrition 0.000 description 23
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 21
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 20
- 239000000427 antigen Substances 0.000 description 18
- 108091007433 antigens Proteins 0.000 description 18
- 102000036639 antigens Human genes 0.000 description 18
- 238000005520 cutting process Methods 0.000 description 16
- 238000011534 incubation Methods 0.000 description 16
- 210000004027 cell Anatomy 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- 108020004414 DNA Proteins 0.000 description 12
- 238000010186 staining Methods 0.000 description 12
- 238000007796 conventional method Methods 0.000 description 10
- 235000011187 glycerol Nutrition 0.000 description 10
- 239000000463 material Substances 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 230000002829 reductive effect Effects 0.000 description 9
- 239000002904 solvent Substances 0.000 description 8
- RZSYLLSAWYUBPE-UHFFFAOYSA-L Fast green FCF Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC(O)=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 RZSYLLSAWYUBPE-UHFFFAOYSA-L 0.000 description 7
- 230000005587 bubbling Effects 0.000 description 7
- 238000003745 diagnosis Methods 0.000 description 7
- 102000039446 nucleic acids Human genes 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 7
- 150000007523 nucleic acids Chemical class 0.000 description 7
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 6
- 230000002068 genetic effect Effects 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
- 229960000583 acetic acid Drugs 0.000 description 5
- 150000001298 alcohols Chemical class 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 238000001574 biopsy Methods 0.000 description 5
- 238000009792 diffusion process Methods 0.000 description 5
- 238000010790 dilution Methods 0.000 description 5
- 239000012895 dilution Substances 0.000 description 5
- 239000012634 fragment Substances 0.000 description 5
- 210000000056 organ Anatomy 0.000 description 5
- 239000005297 pyrex Substances 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 238000005273 aeration Methods 0.000 description 4
- 230000027455 binding Effects 0.000 description 4
- 239000003989 dielectric material Substances 0.000 description 4
- 238000012252 genetic analysis Methods 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 230000035772 mutation Effects 0.000 description 4
- 239000008188 pellet Substances 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- 208000019901 Anxiety disease Diseases 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 3
- 102000011782 Keratins Human genes 0.000 description 3
- 108010076876 Keratins Proteins 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000003321 amplification Effects 0.000 description 3
- 230000036506 anxiety Effects 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 239000012024 dehydrating agents Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000004043 dyeing Methods 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- -1 for example Substances 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 239000012362 glacial acetic acid Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 101150026046 iga gene Proteins 0.000 description 3
- 238000003364 immunohistochemistry Methods 0.000 description 3
- 239000002523 lectin Substances 0.000 description 3
- 210000000265 leukocyte Anatomy 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 210000002826 placenta Anatomy 0.000 description 3
- 238000003752 polymerase chain reaction Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 238000003260 vortexing Methods 0.000 description 3
- 102000007469 Actins Human genes 0.000 description 2
- 108010085238 Actins Proteins 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 2
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 2
- 102100022524 Alpha-1-antichymotrypsin Human genes 0.000 description 2
- 108010077544 Chromatin Proteins 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 102100028652 Gamma-enolase Human genes 0.000 description 2
- 108090001053 Gastrin releasing peptide Proteins 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 239000000020 Nitrocellulose Substances 0.000 description 2
- 108090000445 Parathyroid hormone Proteins 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 108010072866 Prostate-Specific Antigen Proteins 0.000 description 2
- 102100038358 Prostate-specific antigen Human genes 0.000 description 2
- 238000002123 RNA extraction Methods 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- AIYUHDOJVYHVIT-UHFFFAOYSA-M caesium chloride Chemical compound [Cl-].[Cs+] AIYUHDOJVYHVIT-UHFFFAOYSA-M 0.000 description 2
- QGJOPFRUJISHPQ-NJFSPNSNSA-N carbon disulfide-14c Chemical compound S=[14C]=S QGJOPFRUJISHPQ-NJFSPNSNSA-N 0.000 description 2
- 239000010627 cedar oil Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 210000003483 chromatin Anatomy 0.000 description 2
- KRVSOGSZCMJSLX-UHFFFAOYSA-L chromic acid Substances O[Cr](O)(=O)=O KRVSOGSZCMJSLX-UHFFFAOYSA-L 0.000 description 2
- 239000010634 clove oil Substances 0.000 description 2
- 239000006059 cover glass Substances 0.000 description 2
- 238000007872 degassing Methods 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 239000003822 epoxy resin Substances 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- AWJWCTOOIBYHON-UHFFFAOYSA-N furo[3,4-b]pyrazine-5,7-dione Chemical compound C1=CN=C2C(=O)OC(=O)C2=N1 AWJWCTOOIBYHON-UHFFFAOYSA-N 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 208000002672 hepatitis B Diseases 0.000 description 2
- 230000001744 histochemical effect Effects 0.000 description 2
- 229940084986 human chorionic gonadotropin Drugs 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 229940087305 limonene Drugs 0.000 description 2
- 235000001510 limonene Nutrition 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000000386 microscopy Methods 0.000 description 2
- 229920001220 nitrocellulos Polymers 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 238000010827 pathological analysis Methods 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 229920001515 polyalkylene glycol Polymers 0.000 description 2
- 229920000647 polyepoxide Polymers 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 102000003998 progesterone receptors Human genes 0.000 description 2
- 108090000468 progesterone receptors Proteins 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
- 210000002460 smooth muscle Anatomy 0.000 description 2
- 238000007447 staining method Methods 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 239000008399 tap water Substances 0.000 description 2
- 235000020679 tap water Nutrition 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 230000035897 transcription Effects 0.000 description 2
- 238000013518 transcription Methods 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- 150000003738 xylenes Chemical class 0.000 description 2
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 2
- PVPBBTJXIKFICP-UHFFFAOYSA-N (7-aminophenothiazin-3-ylidene)azanium;chloride Chemical compound [Cl-].C1=CC(=[NH2+])C=C2SC3=CC(N)=CC=C3N=C21 PVPBBTJXIKFICP-UHFFFAOYSA-N 0.000 description 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- TZYRSLHNPKPEFV-UHFFFAOYSA-N 2-ethyl-1-butanol Chemical compound CCC(CC)CO TZYRSLHNPKPEFV-UHFFFAOYSA-N 0.000 description 1
- OFNXOACBUMGOPC-HZYVHMACSA-N 5'-hydroxystreptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](CO)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O OFNXOACBUMGOPC-HZYVHMACSA-N 0.000 description 1
- HFDKKNHCYWNNNQ-YOGANYHLSA-N 75976-10-2 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C1=CC=C(O)C=C1 HFDKKNHCYWNNNQ-YOGANYHLSA-N 0.000 description 1
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 1
- 101710197633 Actin-1 Proteins 0.000 description 1
- 102100022712 Alpha-1-antitrypsin Human genes 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 101710145634 Antigen 1 Proteins 0.000 description 1
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- 208000035404 Autolysis Diseases 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 101100165186 Caenorhabditis elegans bath-34 gene Proteins 0.000 description 1
- 102000003908 Cathepsin D Human genes 0.000 description 1
- 108090000258 Cathepsin D Proteins 0.000 description 1
- 206010057248 Cell death Diseases 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 102000011022 Chorionic Gonadotropin Human genes 0.000 description 1
- 108010062540 Chorionic Gonadotropin Proteins 0.000 description 1
- 102000007345 Chromogranins Human genes 0.000 description 1
- 108010007718 Chromogranins Proteins 0.000 description 1
- 102100026735 Coagulation factor VIII Human genes 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 description 1
- 108050006400 Cyclin Proteins 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- 102100027819 Cytosolic beta-glucosidase Human genes 0.000 description 1
- 238000007400 DNA extraction Methods 0.000 description 1
- 230000009946 DNA mutation Effects 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 108010067770 Endopeptidase K Proteins 0.000 description 1
- 102100031940 Epithelial cell adhesion molecule Human genes 0.000 description 1
- 108010007005 Estrogen Receptor alpha Proteins 0.000 description 1
- 102100038595 Estrogen receptor Human genes 0.000 description 1
- 108010054218 Factor VIII Proteins 0.000 description 1
- 102000001690 Factor VIII Human genes 0.000 description 1
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 1
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 1
- 102400000921 Gastrin Human genes 0.000 description 1
- 102100021022 Gastrin Human genes 0.000 description 1
- 102000004862 Gastrin releasing peptide Human genes 0.000 description 1
- 102100036519 Gastrin-releasing peptide Human genes 0.000 description 1
- 108010052343 Gastrins Proteins 0.000 description 1
- 102100039289 Glial fibrillary acidic protein Human genes 0.000 description 1
- 101710193519 Glial fibrillary acidic protein Proteins 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 108010000487 High-Molecular-Weight Kininogen Proteins 0.000 description 1
- 241000228402 Histoplasma Species 0.000 description 1
- 101000678026 Homo sapiens Alpha-1-antichymotrypsin Proteins 0.000 description 1
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 description 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
- 101000859692 Homo sapiens Cytosolic beta-glucosidase Proteins 0.000 description 1
- 101000920667 Homo sapiens Epithelial cell adhesion molecule Proteins 0.000 description 1
- 101000997662 Homo sapiens Lysosomal acid glucosylceramidase Proteins 0.000 description 1
- 101000945496 Homo sapiens Proliferation marker protein Ki-67 Proteins 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 102000004157 Hydrolases Human genes 0.000 description 1
- 108090000604 Hydrolases Proteins 0.000 description 1
- 102100023915 Insulin Human genes 0.000 description 1
- 101710186630 Insulin-1 Proteins 0.000 description 1
- 102100022905 Keratin, type II cytoskeletal 1 Human genes 0.000 description 1
- 102100023974 Keratin, type II cytoskeletal 7 Human genes 0.000 description 1
- 108010070514 Keratin-1 Proteins 0.000 description 1
- 108010070507 Keratin-7 Proteins 0.000 description 1
- 108010044023 Ki-1 Antigen Proteins 0.000 description 1
- 102100035792 Kininogen-1 Human genes 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 102000009151 Luteinizing Hormone Human genes 0.000 description 1
- 108010073521 Luteinizing Hormone Proteins 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 206010027406 Mesothelioma Diseases 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 101000934342 Mus musculus T-cell surface glycoprotein CD5 Proteins 0.000 description 1
- 102000006386 Myelin Proteins Human genes 0.000 description 1
- 108010083674 Myelin Proteins Proteins 0.000 description 1
- 102000003896 Myeloperoxidases Human genes 0.000 description 1
- 108090000235 Myeloperoxidases Proteins 0.000 description 1
- 102000004364 Myogenin Human genes 0.000 description 1
- 108010056785 Myogenin Proteins 0.000 description 1
- 102100030856 Myoglobin Human genes 0.000 description 1
- 108010062374 Myoglobin Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- BACYUWVYYTXETD-UHFFFAOYSA-N N-Lauroylsarcosine Chemical compound CCCCCCCCCCCC(=O)N(C)CC(O)=O BACYUWVYYTXETD-UHFFFAOYSA-N 0.000 description 1
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 1
- 238000011887 Necropsy Methods 0.000 description 1
- 206010061309 Neoplasm progression Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 206010029260 Neuroblastoma Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 108010051791 Nuclear Antigens Proteins 0.000 description 1
- 102000019040 Nuclear Antigens Human genes 0.000 description 1
- 108700020796 Oncogene Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 102000018886 Pancreatic Polypeptide Human genes 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 102000003982 Parathyroid hormone Human genes 0.000 description 1
- 102100036893 Parathyroid hormone Human genes 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 102000037602 Platelet Endothelial Cell Adhesion Molecule-1 Human genes 0.000 description 1
- 108010069381 Platelet Endothelial Cell Adhesion Molecule-1 Proteins 0.000 description 1
- 208000002151 Pleural effusion Diseases 0.000 description 1
- 241000233870 Pneumocystis Species 0.000 description 1
- 241000183024 Populus tremula Species 0.000 description 1
- 102000009339 Proliferating Cell Nuclear Antigen Human genes 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 241001510071 Pyrrhocoridae Species 0.000 description 1
- 239000013614 RNA sample Substances 0.000 description 1
- 108010081750 Reticulin Proteins 0.000 description 1
- 102000006382 Ribonucleases Human genes 0.000 description 1
- 108010083644 Ribonucleases Proteins 0.000 description 1
- 102100038803 Somatotropin Human genes 0.000 description 1
- 238000002105 Southern blotting Methods 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- 101000983124 Sus scrofa Pancreatic prohormone precursor Proteins 0.000 description 1
- 102000004874 Synaptophysin Human genes 0.000 description 1
- 108090001076 Synaptophysin Proteins 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 108010076830 Thionins Proteins 0.000 description 1
- 102000012607 Thrombomodulin Human genes 0.000 description 1
- 108010079274 Thrombomodulin Proteins 0.000 description 1
- 102000011923 Thyrotropin Human genes 0.000 description 1
- 108010061174 Thyrotropin Proteins 0.000 description 1
- 241000223996 Toxoplasma Species 0.000 description 1
- 241000589886 Treponema Species 0.000 description 1
- 229920004890 Triton X-100 Polymers 0.000 description 1
- 239000013504 Triton X-100 Substances 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 102000015098 Tumor Suppressor Protein p53 Human genes 0.000 description 1
- 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 description 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 description 1
- 102000044159 Ubiquitin Human genes 0.000 description 1
- 108090000848 Ubiquitin Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- GPKUGWDQUVWHIC-UHFFFAOYSA-N [4-(4-hydrazinylphenyl)phenyl]hydrazine tetrahydrochloride Chemical compound Cl.Cl.Cl.Cl.NNC1=CC=C(C=C1)C1=CC=C(NN)C=C1 GPKUGWDQUVWHIC-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001919 adrenal effect Effects 0.000 description 1
- 238000000246 agarose gel electrophoresis Methods 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 108010091628 alpha 1-Antichymotrypsin Proteins 0.000 description 1
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 description 1
- 229940024142 alpha 1-antitrypsin Drugs 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- VQYOKDLEFVOVEV-UHFFFAOYSA-L bis(2,6-diphenylphenoxy)-methylalumane Chemical compound [Al+2]C.[O-]C1=C(C=2C=CC=CC=2)C=CC=C1C1=CC=CC=C1.[O-]C1=C(C=2C=CC=CC=2)C=CC=C1C1=CC=CC=C1 VQYOKDLEFVOVEV-UHFFFAOYSA-L 0.000 description 1
- 208000029162 bladder disease Diseases 0.000 description 1
- 239000003114 blood coagulation factor Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 210000003855 cell nucleus Anatomy 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 229940001468 citrate Drugs 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000005112 continuous flow technique Methods 0.000 description 1
- 239000000109 continuous material Substances 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 1
- 229960000258 corticotropin Drugs 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 208000016097 disease of metabolism Diseases 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- KFMQPIHLHGRTFB-UHFFFAOYSA-L disodium;2,2-dimethyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].[O-]C(=O)C(C)(C)C(C([O-])=O)S(O)(=O)=O KFMQPIHLHGRTFB-UHFFFAOYSA-L 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000001839 endoscopy Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229960000301 factor viii Drugs 0.000 description 1
- 229940028334 follicle stimulating hormone Drugs 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 238000012239 gene modification Methods 0.000 description 1
- 230000005017 genetic modification Effects 0.000 description 1
- 235000013617 genetically modified food Nutrition 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 210000005046 glial fibrillary acidic protein Anatomy 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 239000003966 growth inhibitor Substances 0.000 description 1
- ZJYYHGLJYGJLLN-UHFFFAOYSA-N guanidinium thiocyanate Chemical compound SC#N.NC(N)=N ZJYYHGLJYGJLLN-UHFFFAOYSA-N 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- OFNXOACBUMGOPC-UHFFFAOYSA-N hydroxystreptomycin Natural products CNC1C(O)C(O)C(CO)OC1OC1C(C=O)(O)C(CO)OC1OC1C(N=C(N)N)C(O)C(N=C(N)N)C(O)C1O OFNXOACBUMGOPC-UHFFFAOYSA-N 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 229940127121 immunoconjugate Drugs 0.000 description 1
- 238000007901 in situ hybridization Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- OKPOKMCPHKVCPP-UHFFFAOYSA-N isoorientaline Natural products C1=C(O)C(OC)=CC(CC2C3=CC(OC)=C(O)C=C3CCN2C)=C1 OKPOKMCPHKVCPP-UHFFFAOYSA-N 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 229940046892 lead acetate Drugs 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 229960005375 lutein Drugs 0.000 description 1
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 description 1
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 description 1
- 235000012680 lutein Nutrition 0.000 description 1
- 239000001656 lutein Substances 0.000 description 1
- 229940040129 luteinizing hormone Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 238000010907 mechanical stirring Methods 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 206010027191 meningioma Diseases 0.000 description 1
- 150000002730 mercury Chemical class 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 1
- 229960000907 methylthioninium chloride Drugs 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229940051921 muramidase Drugs 0.000 description 1
- 210000005012 myelin Anatomy 0.000 description 1
- 238000013188 needle biopsy Methods 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 108091008819 oncoproteins Proteins 0.000 description 1
- 102000027450 oncoproteins Human genes 0.000 description 1
- 229910052762 osmium Inorganic materials 0.000 description 1
- SYQBFIAQOQZEGI-UHFFFAOYSA-N osmium atom Chemical compound [Os] SYQBFIAQOQZEGI-UHFFFAOYSA-N 0.000 description 1
- 239000012285 osmium tetroxide Substances 0.000 description 1
- 229910000489 osmium tetroxide Inorganic materials 0.000 description 1
- 210000002741 palatine tonsil Anatomy 0.000 description 1
- 239000000199 parathyroid hormone Substances 0.000 description 1
- 229960001319 parathyroid hormone Drugs 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 238000012335 pathological evaluation Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- BLFWHYXWBKKRHI-JYBILGDPSA-N plap Chemical compound N([C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H](N)CCC(O)=O BLFWHYXWBKKRHI-JYBILGDPSA-N 0.000 description 1
- 239000002984 plastic foam Substances 0.000 description 1
- 201000000317 pneumocystosis Diseases 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 201000007094 prostatitis Diseases 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- JTQHYPFKHZLTSH-UHFFFAOYSA-N reticulin Natural products COC1CC(OC2C(CO)OC(OC3C(O)CC(OC4C(C)OC(CC4OC)OC5CCC6(C)C7CCC8(C)C(CCC8(O)C7CC=C6C5)C(C)O)OC3C)C(O)C2OC)OC(C)C1O JTQHYPFKHZLTSH-UHFFFAOYSA-N 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 230000028043 self proteolysis Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 230000005751 tumor progression Effects 0.000 description 1
- 208000026533 urinary bladder disease Diseases 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 108010047303 von Willebrand Factor Proteins 0.000 description 1
- 102100036537 von Willebrand factor Human genes 0.000 description 1
- 229960001134 von willebrand factor Drugs 0.000 description 1
- 239000010887 waste solvent Substances 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/50—Clamping means, tongs
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
- G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N1/312—Apparatus therefor for samples mounted on planar substrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/36—Embedding or analogous mounting of samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N2001/305—Fixative compositions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N2001/315—Basket-type carriers for tissues
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- General Preparation And Processing Of Foods (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5610297P | 1997-08-20 | 1997-08-20 | |
| US60/056,102 | 1997-08-20 | ||
| PCT/US1998/016463 WO1999009390A1 (en) | 1997-08-20 | 1998-08-19 | A high quality, continuous throughput, tissue fixation-dehydration-fat removal-impregnation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20010023070A true KR20010023070A (ko) | 2001-03-26 |
Family
ID=22002161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020007001688A Ceased KR20010023070A (ko) | 1997-08-20 | 1998-08-19 | 고품질의 연속적인 재료 처리, 조직 고정-탈수-지방제거-함침 방법 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US6207408B1 (enExample) |
| EP (2) | EP1005633B1 (enExample) |
| JP (2) | JP4164232B2 (enExample) |
| KR (1) | KR20010023070A (enExample) |
| AT (1) | ATE407353T1 (enExample) |
| AU (1) | AU746497B2 (enExample) |
| CA (2) | CA2301924C (enExample) |
| DE (1) | DE69839963D1 (enExample) |
| DK (1) | DK1005633T3 (enExample) |
| ES (1) | ES2313752T3 (enExample) |
| TW (1) | TW571100B (enExample) |
| WO (1) | WO1999009390A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102015998B1 (ko) * | 2017-01-26 | 2019-08-29 | 에스씨엘 바이오테크 리미티드 | 일차 세포 분리 장치 및 방법 |
Families Citing this family (138)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6451551B1 (en) * | 1994-03-11 | 2002-09-17 | Biogenex Laboratories | Releasing embedding media from tissue specimens |
| US6793890B2 (en) | 1997-08-20 | 2004-09-21 | The University Of Miami | Rapid tissue processor |
| KR20010023070A (ko) | 1997-08-20 | 2001-03-26 | 더 유니버시티 오브 마이애미 | 고품질의 연속적인 재료 처리, 조직 고정-탈수-지방제거-함침 방법 |
| US7075640B2 (en) | 1997-10-01 | 2006-07-11 | Arcturus Bioscience, Inc. | Consumable for laser capture microdissection |
| WO2000000813A1 (en) * | 1998-06-30 | 2000-01-06 | Lamina, Inc. | Cytological and histological fixative composition and methods of use |
| EP1210577A2 (en) * | 1999-04-29 | 2002-06-05 | Arcturus Engineering, Inc. | Processing technology for lcm samples |
| US7897106B2 (en) * | 1999-07-08 | 2011-03-01 | Lee Angros | Situ heat induced antigen recovery and staining apparatus and method |
| EP1208378B9 (en) | 1999-07-08 | 2014-12-10 | Lee H. Angros | Antigen recovery and/or staining apparatus and method |
| US7951612B2 (en) * | 1999-07-08 | 2011-05-31 | Lee H. Angros | In situ heat induced antigen recovery and staining apparatus and method |
| US8298485B2 (en) * | 1999-07-08 | 2012-10-30 | Lee H. Angros | In situ heat induced antigen recovery and staining apparatus and method |
| US6916608B2 (en) * | 1999-09-10 | 2005-07-12 | Becton, Dickinson And Company | Composition for providing long term stability to cells for diagnostic testing |
| DE19945621A1 (de) * | 1999-09-23 | 2001-04-05 | Aurel Popa | Geräteanordnung zur Präparation und Analyse von Gewebe für mirkoskopische Untersuchungen |
| WO2001044783A1 (en) * | 1999-12-14 | 2001-06-21 | University Of Miami | Rapid tissue processor |
| DK1292818T3 (en) | 2000-06-09 | 2016-04-11 | Univ Miami | Pathology board for rough cut |
| CN1488002A (zh) * | 2000-12-01 | 2004-04-07 | ��˹��ŵ�� | 测定表皮生长因子受体和HER2-neu的基因表达及其水平与存活率之间相关性的方法 |
| US7049059B2 (en) * | 2000-12-01 | 2006-05-23 | Response Genetics, Inc. | Method of determining a chemotherapeutic regimen based on ERCC1 and TS expression |
| US6582919B2 (en) | 2001-06-11 | 2003-06-24 | Response Genetics, Inc. | Method of determining epidermal growth factor receptor and HER2-neu gene expression and correlation of levels thereof with survival rates |
| US6602670B2 (en) | 2000-12-01 | 2003-08-05 | Response Genetics, Inc. | Method of determining a chemotherapeutic regimen based on ERCC1 expression |
| US6518416B1 (en) | 2000-12-01 | 2003-02-11 | Response Genetics, Inc. | Method of determining a chemotherapeutic regimen based on ERCC1 expression |
| US6956111B2 (en) * | 2001-03-02 | 2005-10-18 | Response Genetics, Inc. | Method of determining dihydropyrimidine dehydrogenase gene expression |
| US6458598B1 (en) * | 2001-08-13 | 2002-10-01 | Dako A/S | Process for preparing and presenting a tissue sample for histological study |
| CN100359313C (zh) * | 2001-09-20 | 2008-01-02 | 王世峰 | 一种活体组织脱水盒 |
| JP2005504323A (ja) * | 2001-10-01 | 2005-02-10 | ヴィジョン バイオシステムズ リミテッド | 組織学的組織標本処理 |
| US11249095B2 (en) | 2002-04-15 | 2022-02-15 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
| US7468161B2 (en) | 2002-04-15 | 2008-12-23 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
| US6797928B2 (en) * | 2002-04-23 | 2004-09-28 | Ted Pella, Inc. | Method and apparatus for the rapid decalcification and fixation of mineralized tissues |
| US7138226B2 (en) * | 2002-05-10 | 2006-11-21 | The University Of Miami | Preservation of RNA and morphology in cells and tissues |
| DE60328186D1 (de) * | 2002-05-28 | 2009-08-13 | Diapath S P A | Zusammensetzung für die herstellung von histologischen, autopsischen und zytologischen proben |
| US7179424B2 (en) | 2002-09-26 | 2007-02-20 | Biopath Automation, L.L.C. | Cassette for handling and holding tissue samples during processing, embedding and microtome procedures, and methods therefor |
| JP4105164B2 (ja) * | 2002-09-26 | 2008-06-25 | バイオパス・オートメーション・エル・エル・シー | 組織標本のハンドリングおよび包埋を自動化する機器および方法 |
| CN100518940C (zh) | 2002-09-26 | 2009-07-29 | 比欧帕斯自动化公司 | 操作组织样品的盒子、嵌入组件和方法 |
| US7219884B2 (en) * | 2002-10-01 | 2007-05-22 | The University Of Miami | Pathology grossing tool |
| US7541161B2 (en) * | 2002-10-31 | 2009-06-02 | University Of Massachusetts | Method and apparatus for preparing cells for microtome sectioning and archiving nucleic acids and proteins |
| CA2502580C (en) * | 2002-10-31 | 2013-09-10 | University Of Massachusetts | Rapid cell block embedding method and apparatus |
| JP4189484B2 (ja) * | 2002-12-12 | 2008-12-03 | 国立循環器病センター総長 | マイクロ波照射による生体組織の処理方法 |
| WO2004072268A2 (en) * | 2003-02-12 | 2004-08-26 | Mayo Foundation For Medical Education And Research | Pkhdl1, a homolog of the autosomal recessive kidney disease gene |
| KR200327028Y1 (ko) * | 2003-06-17 | 2003-09-19 | 장시창 | 인체조직검사기구 |
| US8554372B2 (en) | 2003-09-29 | 2013-10-08 | Leica Biosystems Melbourne Pty Ltd | System and method for histological tissue specimen processing |
| CA2543043C (en) * | 2003-10-24 | 2013-09-17 | The University Of Miami | Simplified tissue processing |
| KR100458860B1 (ko) * | 2004-04-22 | 2004-12-03 | 송영민 | 생검시료의 검사를 위한 보조기구 |
| WO2005116609A1 (en) * | 2004-05-25 | 2005-12-08 | Vision Biosystems Limited | Method of treatment of tissue processing fluid and apparatus therefor |
| ATE416368T1 (de) * | 2004-06-07 | 2008-12-15 | Milestone Srl | Verfahren und vorrichtung zur mikrowellen- unterstützten automatischen gewebebehandlung |
| US7273720B1 (en) | 2004-12-02 | 2007-09-25 | Collaborative Laboratory Services, Llc | Rapid tissue processing method and apparatus |
| US8236255B2 (en) * | 2004-12-02 | 2012-08-07 | Lab Vision Corporation | Slide treatment apparatus and methods for use |
| US7273587B1 (en) | 2004-12-02 | 2007-09-25 | Collaborative Laboratory Services, Llc | Rapid tissue processing method and apparatus |
| CA2764294C (en) | 2004-12-17 | 2013-12-24 | Ventana Medical Systems, Inc. | Methods and compositions for a microemulsion-based tissue treatment |
| GB0501590D0 (en) * | 2005-01-25 | 2005-03-02 | Ceres Power Ltd | Processing of enhanced performance LSCF fuel cell cathode microstructure and a fuel cell cathode |
| US20060228772A1 (en) * | 2005-04-11 | 2006-10-12 | Donndelinger Thomas M | Compositions and methods for preparing specimens for microscopic analysis |
| CN101203597A (zh) * | 2005-04-21 | 2008-06-18 | 塞莱勒斯诊断公司 | 用于自动快速免疫组织化学的芯吸盒方法和设备 |
| EP1888739B1 (en) | 2005-05-24 | 2021-08-11 | Lee H. Angros | Automated apparatus and method for treating biological specimens on slides |
| KR101289256B1 (ko) * | 2005-06-28 | 2013-07-24 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 오클라호마 | 탄소 나노튜브의 성장 및 수득 방법 |
| WO2007016935A1 (en) | 2005-07-29 | 2007-02-15 | Histogenex Nv | Methods, reagents and instrumentation for preparing impregnated tissue samples suitable for histopathological and molecular studies |
| US20070116612A1 (en) * | 2005-11-02 | 2007-05-24 | Biopath Automation, L.L.C. | Prefix tissue cassette |
| US7769962B2 (en) * | 2005-12-12 | 2010-08-03 | Jeda Technologies, Inc. | System and method for thread creation and memory management in an object-oriented programming environment |
| EP1804045B1 (de) | 2005-12-30 | 2014-03-12 | QIAGEN GmbH | Ein Verfahren und ein Kit zur Behandlung einer biologischen Probe |
| EP1977214A2 (en) * | 2006-01-13 | 2008-10-08 | Ventana Medical Systems, Inc. | Biological sample processing composition and method |
| WO2007141888A1 (ja) * | 2006-06-05 | 2007-12-13 | Jokoh Co., Ltd | 生物組織固定装置 |
| US20080026366A1 (en) * | 2006-06-07 | 2008-01-31 | Newcomer Supply, Inc. | Biological fixative and method of using the biological fixative |
| AT504371B8 (de) | 2006-10-03 | 2008-09-15 | Leica Mikrosysteme Gmbh | Vorrichtung zur mikrowellen-gestützten präparation von proben |
| US7666620B2 (en) * | 2006-11-08 | 2010-02-23 | Richard-Allan Scientific Company | Rapid tissue processing system |
| JP5050200B2 (ja) * | 2006-11-20 | 2012-10-17 | 国立大学法人三重大学 | 医療検体用ケース |
| ES2788002T3 (es) * | 2006-12-12 | 2020-10-20 | Biopath Automation Llc | Soporte de biopsia con material celular resiliente seccionable |
| EP1965190A1 (en) * | 2007-02-27 | 2008-09-03 | Qiagen GmbH | Fixation of a biological sample |
| EP1975595A1 (en) * | 2007-03-21 | 2008-10-01 | Diapath S.r.l. | Automatic processor for histological samples and its operation |
| EP2009419B1 (en) * | 2007-06-25 | 2009-12-23 | Milestone S.r.l. | Measuring the thickness of organic samples |
| US7906076B2 (en) * | 2007-07-02 | 2011-03-15 | University Of Massachusetts | Method and apparatus for biopsy sample processing |
| JP4059520B1 (ja) * | 2007-07-25 | 2008-03-12 | 株式会社常光 | 組織片処理装置 |
| EP2187749A4 (en) * | 2007-08-14 | 2011-04-20 | Charm Sciences Inc | METHOD AND DEVICE FOR CONCENTRATING SAMPLES |
| ES2422629T3 (es) * | 2007-10-23 | 2013-09-12 | Becton Dickinson Co | Recipiente para tejido con desplazamiento de fluido para diagnóstico molecular e histológico |
| AU2013200912B2 (en) * | 2007-10-23 | 2014-04-17 | Becton, Dickinson And Company | Multi-chambered tissue containment system for molecular and histology diagnostics |
| EP2214827B1 (en) | 2007-10-23 | 2013-05-22 | Becton, Dickinson and Company | Multi-chambered tissue containment system for molecular and histology diagnostics |
| BRPI0817814B1 (pt) | 2007-10-23 | 2019-01-29 | Becton Dickinson Co | kit de partes, sistema, conjunto e método para armazenar e preservar uma amostra biológica |
| ES2805503T3 (es) | 2007-10-23 | 2021-02-12 | Becton Dickinson Co | Recipiente para tejidos para diagnóstico molecular e histológico que incorpora una membrana rompible |
| WO2009055595A1 (en) | 2007-10-23 | 2009-04-30 | Becton, Dickinson And Company | Closed kit for tissue containment and stabilization for molecular and histopathology diagnostics |
| US8158381B2 (en) * | 2008-03-27 | 2012-04-17 | Richard-Allan Scientific Company | Methods for integrated tissue processing and staining |
| EP2285979B2 (en) | 2008-05-27 | 2020-02-19 | Dako Denmark A/S | Hybridization compositions and methods |
| US20090298172A1 (en) | 2008-05-28 | 2009-12-03 | Steven Paul Wheeler | Histological specimen treatment apparatus and method |
| US20090325273A1 (en) * | 2008-06-30 | 2009-12-31 | Chin Pin Chang Chien | Multi-functional treating device for treating pathological tissue sections |
| EP2316010B1 (en) * | 2008-08-27 | 2022-03-16 | The University of Miami | Tissue cassette and method for preparing tissue samples |
| WO2010025425A1 (en) | 2008-08-29 | 2010-03-04 | Angros Lee H | Multiplexed microscope slide staining apparatus |
| US8968210B2 (en) | 2008-10-01 | 2015-03-03 | Covidien LLP | Device for needle biopsy with integrated needle protection |
| US9332973B2 (en) | 2008-10-01 | 2016-05-10 | Covidien Lp | Needle biopsy device with exchangeable needle and integrated needle protection |
| US11298113B2 (en) | 2008-10-01 | 2022-04-12 | Covidien Lp | Device for needle biopsy with integrated needle protection |
| US9186128B2 (en) | 2008-10-01 | 2015-11-17 | Covidien Lp | Needle biopsy device |
| US9782565B2 (en) | 2008-10-01 | 2017-10-10 | Covidien Lp | Endoscopic ultrasound-guided biliary access system |
| WO2010056883A1 (en) | 2008-11-12 | 2010-05-20 | Ventana Medical Systems, Inc. | Methods and apparatuses for heating slides carrying specimens |
| CA2745431A1 (en) | 2008-12-03 | 2010-06-10 | Timothy J. O'leary | Pressure-assisted molecular recovery (pamr) of biomolecules, pressure-assisted antigen retrieval (paar), and pressure-assisted tissue histology (path) |
| CA2749135C (en) | 2009-01-22 | 2017-04-18 | Biopath Automation, L.L.C. | Microtome sectionable biopsy support for orienting tissue samples |
| WO2010097655A1 (en) * | 2009-02-26 | 2010-09-02 | Dako Denmark A/S | Compositions and methods for rna hybridization applications |
| US8640357B2 (en) * | 2009-03-23 | 2014-02-04 | Hasan Huseyin Engin | Laboratory type quick film drying oven |
| DE102009025574A1 (de) * | 2009-06-19 | 2010-12-23 | Leica Biosystems Nussloch Gmbh | Verfahren zum automatischen Bearbeiten von Gewebeproben in einem Gewebeprozessor |
| US9237608B2 (en) | 2009-08-14 | 2016-01-12 | Cem Corporation | Pressure stepped microwave assisted digestion |
| EP2467694B1 (en) * | 2009-08-21 | 2015-01-07 | Roche Diagnostics GmbH | Use of a bis-maleic anhydride cross-linking agent for fixation of a cell or tissue sample |
| US10539487B2 (en) | 2010-03-04 | 2020-01-21 | Ventana Medical Systems, Inc. | Systems and methods for monitoring tissue sample processing |
| US10126216B2 (en) | 2011-02-17 | 2018-11-13 | Ventana Medical Systems, Inc. | Method for tissue sample fixation |
| US10267769B2 (en) | 2010-03-04 | 2019-04-23 | Ventana Medical Systems, Inc. | Processing system for processing specimens using acoustic energy |
| US8227233B2 (en) * | 2010-06-09 | 2012-07-24 | Ford Global Technologies, Llc | Method of making foamed mycelium structure |
| US20120171694A1 (en) * | 2010-07-30 | 2012-07-05 | Vermillion, Inc. | Predictive markers and biomarker panels for ovarian cancer |
| DE102011055120B4 (de) * | 2011-04-20 | 2016-04-14 | Leica Biosystems Nussloch Gmbh | Verfahren zur Verarbeitung zumindest einer histologischen Probe und Vorrichtung zum Behandeln einer histologischen Probe. |
| GB2490202B (en) * | 2011-04-20 | 2015-06-24 | Leica Biosystems Nussloch Gmbh | Method of detaching and/or isolating a histological sample |
| US10444124B2 (en) | 2011-05-20 | 2019-10-15 | Riken | Clarifying reagent for biological materials and use thereof |
| US8920720B2 (en) * | 2011-06-03 | 2014-12-30 | Rushabh Instruments, Inc. | Rotary tissue processor with configurable stations |
| RU2499242C2 (ru) * | 2011-08-29 | 2013-11-20 | Андрей Викторович Иванченко | Способ подготовки образцов биологических тканей к гистологическим исследованиям |
| JP6189306B2 (ja) * | 2011-09-29 | 2017-08-30 | ザ ユニバーシティ オブ マイアミＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉａｍｉ | 凍結切片の代用としての超迅速診断用組織調製法 |
| WO2013046033A1 (en) | 2011-09-30 | 2013-04-04 | Dako Denmark A/S | Hybridization compositions and methods using formamide |
| EP3252173A1 (en) | 2011-10-21 | 2017-12-06 | Dako Denmark A/S | Hybridization compositions and methods |
| US20140341871A1 (en) * | 2011-12-30 | 2014-11-20 | Paul R. Morris | Regenerative tissue matrix |
| CA2876682A1 (en) | 2012-06-22 | 2013-12-27 | Leica Biosystems Nussloch Gmbh | Biopsy tissue sample transport device and method of using thereof |
| WO2013192607A1 (en) | 2012-06-22 | 2013-12-27 | Leica Biosystems Nussloch Gmbh | Tissue sample container and methods |
| JP6274443B2 (ja) * | 2012-10-30 | 2018-02-07 | 学校法人金沢医科大学 | 透明化生物標本作製用キット及び透明化生物標本作製方法 |
| US9052256B2 (en) | 2013-03-15 | 2015-06-09 | Leica Biosystems Nussloch Gmbh | Method for processing and embedding tissue |
| CA2845832C (en) | 2013-03-15 | 2020-09-22 | Leica Biosystems Nussloch Gmbh | Tissue cassette with biasing element |
| US9097629B2 (en) | 2013-03-15 | 2015-08-04 | Leica Biosystems Nussloch Gmbh | Tissue cassette with retractable member |
| EP3035026A4 (en) | 2013-08-14 | 2017-04-26 | Riken | Composition for preparing biomaterial with excellent light-transmitting property, and use thereof |
| WO2015085175A1 (en) * | 2013-12-05 | 2015-06-11 | Shidham Vinod B | Cell blocks for cytopathology and surgical pathology specimens |
| US9733162B2 (en) * | 2014-02-11 | 2017-08-15 | Ihor Turkevych | Universal system, method and solution for the acceleration of the process of fixing, dehydrating and clearing the structure of biological tissue |
| US9766171B2 (en) | 2014-03-17 | 2017-09-19 | Columbia Insurance Company | Devices, systems and method for flooring performance testing |
| CN106211762B (zh) | 2014-04-04 | 2020-08-14 | 麻省理工学院 | 向带电基质中、在带电基质中和/或从带电基质中主动转运带电分子 |
| US10591392B2 (en) | 2014-07-03 | 2020-03-17 | Applikate Technologies Llc | Simultaneous dehydration and staining of tissue for deep imaging |
| JP6383619B2 (ja) * | 2014-09-22 | 2018-08-29 | 株式会社トスカバノック | 病理検体の管理方法 |
| JP6781421B2 (ja) * | 2015-03-18 | 2020-11-04 | 国立研究開発法人理化学研究所 | 生物材料の観察方法および透明化方法 |
| US10365189B2 (en) | 2015-05-07 | 2019-07-30 | Steven Wheeler | Histological specimen treatment |
| US12366508B2 (en) | 2015-07-30 | 2025-07-22 | Qiagen Gmbh | Method of preparing a frozen biological sample |
| KR101765460B1 (ko) * | 2016-01-11 | 2017-08-07 | 주식회사 메딕슨 | 카트리지형 극초단파 생체시료 고정장치 |
| CN105606437B (zh) * | 2016-03-01 | 2018-06-19 | 青岛锴锦医疗器械有限公司 | 一种快速病理组织脱水机 |
| ITUA20162517A1 (it) * | 2016-04-12 | 2017-10-12 | Andrea Fantozzi | Composizione per la conservazione/fissazione di materiale biologico |
| CN106053126A (zh) * | 2016-05-27 | 2016-10-26 | 中国水产科学研究院淡水渔业研究中心 | 一种福瑞鲤成熟卵巢组织冷冻切片的制作方法 |
| KR101866249B1 (ko) | 2016-11-29 | 2018-06-12 | 박순현 | 생체 조직 투명화용 조성물 및 이를 이용한 생체 조직 투명화 방법 |
| JP7028979B2 (ja) * | 2017-12-29 | 2022-03-02 | エフ．ホフマン－ラ ロシュ アーゲー | 組織試料調製システム |
| CN108344608B (zh) * | 2018-02-09 | 2021-06-22 | 李西启 | 一种快速微波病理组织处理专用试剂及其制备方法 |
| CN108387421B (zh) * | 2018-02-09 | 2021-05-07 | 青岛锴锦医疗器械有限公司 | 一种用于病理切片的新型环保快速组织处理液 |
| CN108387419A (zh) * | 2018-02-09 | 2018-08-10 | 青岛锴锦医疗器械有限公司 | 一种新型环保快速生物组织处理液 |
| CN110954385B (zh) * | 2019-12-17 | 2021-05-25 | 李惠 | 一种病理组织脱水仪 |
| GB2600091B (en) * | 2020-10-12 | 2025-02-19 | Cellpath Ltd | Cassette assembly and processing method |
| RU209703U1 (ru) * | 2021-07-15 | 2022-03-18 | Федеральное государственное автономное образовательное учреждение высшего образования «Дальневосточный федеральный университет» (ДВФУ) | Инкубационная установка для длительного содержания переживающих срезов |
| WO2023076000A1 (en) * | 2021-11-01 | 2023-05-04 | Novodiax, Inc. | A method and apparatus for rapid circulating tissue pretreatment |
| CN114295446B (zh) * | 2021-12-28 | 2024-07-09 | 中国林业科学研究院木材工业研究所 | 一种利用包埋剂改善木质文物脆裂的徒手切片方法 |
| CN117147251B (zh) * | 2023-08-16 | 2024-04-26 | 四川大学 | 一种人类离体牙髓组织透明化方法 |
Family Cites Families (125)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2698809A (en) * | 1955-01-04 | Preserving plant and animal tissues | ||
| US2150757A (en) | 1937-06-22 | 1939-03-14 | Agfa Ansco Corp | Film drier |
| US2684925A (en) | 1949-03-16 | 1954-07-27 | Technicon Chemical Company Inc | Liquid for treating tissue in histologic processing |
| US3546334A (en) * | 1965-05-21 | 1970-12-08 | Lerner Lab Inc | Composition for fixing and protecting a smear of body cells and method of applying same |
| US3389052A (en) | 1965-11-02 | 1968-06-18 | Ehrenreich Theodore | Fixing and drying cytological smears |
| GB1321712A (en) * | 1970-03-17 | 1973-06-27 | Shandon Elliott Ltd | Sequential processing apparatus for processing an article by immersion |
| US3961097A (en) | 1971-10-28 | 1976-06-01 | Gravlee Jr Joseph F | Method of preparing tissue for microscopic examination |
| GB1454510A (en) | 1973-05-22 | 1976-11-03 | Tetronics Research Dev Co Ltd | Laying blood traces |
| US3892197A (en) | 1974-04-22 | 1975-07-01 | Thomas D Kinney | Light microscopy processing apparatus |
| FR2320544A1 (fr) | 1975-08-08 | 1977-03-04 | Gen Electric | Formulation et procede de coloration et de scellement d'un echantillon biologique |
| US4199558A (en) | 1976-04-07 | 1980-04-22 | Shandon Southern Products Limited | Tissue processing method |
| US4099483A (en) | 1976-04-07 | 1978-07-11 | Shandon Southern Products Limited | Tissue processing apparatus |
| US4141312A (en) | 1977-05-16 | 1979-02-27 | Fisher Scientific Company | Apparatus for histological tissue processing |
| US4221823A (en) | 1978-04-21 | 1980-09-09 | Phillips Petroleum Company | Process for mounting palynological specimens |
| DE2906650A1 (de) | 1979-02-21 | 1980-08-28 | Pfrimmer Pharma | Verfahren zur herstellung von transplantatkonserven |
| US4670386A (en) * | 1980-05-23 | 1987-06-02 | Stephen Sugaar | Cancer tests using tumor antigen generated lymphokines and compositions |
| US4578282A (en) * | 1982-02-04 | 1986-03-25 | Harrison James S | Composition for diagnostic reagents |
| JPS58219167A (ja) | 1982-06-15 | 1983-12-20 | Sumitomo Chem Co Ltd | 置換フェニルヒダントイン誘導体およびそれを有効成分とする除草剤 |
| JPS5973A (ja) | 1982-06-25 | 1984-01-05 | 立花 俊郎 | 超音波搬送管 |
| US4545831A (en) | 1982-09-13 | 1985-10-08 | The Mount Sinai School Of Medicine | Method for transferring a thin tissue section |
| US4681996A (en) | 1982-12-16 | 1987-07-21 | Cem Corporation | Analytical process in which materials to be analyzed are directly and indirectly heated and dried by microwave radiation |
| DE3319564A1 (de) | 1983-05-30 | 1984-12-06 | Arthur Pfeiffer Vakuumtechnik Wetzlar Gmbh, 6334 Asslar | Verfahren zur herstellung flexibler, dauerhaltbargemachter nicht konservierter und konservierter biologischer materialien |
| JPS6025973A (ja) | 1983-07-20 | 1985-02-08 | Chisso Corp | ピリミジン類 |
| DE8509640U1 (de) * | 1985-03-30 | 1985-05-30 | AGW Analysen-Geräte GmbH, 7970 Leutkirch | Küvette |
| SE8501959L (sv) * | 1985-04-23 | 1986-10-24 | Henrik Gerhard Renvall | Framstellning av ett vevnadspreparat |
| US4839194A (en) * | 1985-07-05 | 1989-06-13 | Bone Diagnostic Center | Methods of preparing tissue samples |
| US5023187A (en) | 1985-09-13 | 1991-06-11 | Fisher Scientific Company | Method and device for accelerated treatment of thin sample on surface |
| US4820504A (en) * | 1986-02-12 | 1989-04-11 | City Of Hope | Multi-specimen tissue blocks and slides |
| US4656047A (en) * | 1986-03-06 | 1987-04-07 | Kok Lanbrecht P | Rapid method for cell block preparation |
| JPH0525347Y2 (enExample) | 1986-07-04 | 1993-06-25 | ||
| US4835354A (en) | 1987-03-30 | 1989-05-30 | Cem Corporation | Microwave heating apparatus for laboratory analyses |
| FR2616273B1 (fr) | 1987-06-05 | 1989-10-20 | Thomson Csf | Resonateur hyperfrequence en mode de chuchotement en galerie |
| US5782897A (en) | 1987-06-26 | 1998-07-21 | Microwave Medical Systems, Inc. | Microwave heating apparatus for rapid tissue fixation |
| US4857300A (en) * | 1987-07-27 | 1989-08-15 | Cytocorp, Inc. | Cytological and histological fixative formulation and methods for using same |
| US4882128A (en) | 1987-07-31 | 1989-11-21 | Parr Instrument Company | Pressure and temperature reaction vessel, method, and apparatus |
| US4946669A (en) | 1987-10-09 | 1990-08-07 | Siegfried Barry A | Histological fixatives |
| US4911915A (en) | 1987-10-13 | 1990-03-27 | Richard-Allan Medical Industries | Method of processing tissue specimens and dehydrant solvent for use therein |
| US5544650A (en) | 1988-04-08 | 1996-08-13 | Neuromedical Systems, Inc. | Automated specimen classification system and method |
| US4891239A (en) | 1988-07-05 | 1990-01-02 | Raytheon Company | Method and apparatus for ultrafast microwave tissue fixation |
| DE68918950T2 (de) | 1988-10-10 | 1995-03-16 | Commw Scient Ind Res Org | Verfahren und vorrichtung für kontinuierliche chemische reaktionen. |
| US5104640A (en) | 1989-03-17 | 1992-04-14 | Wescor, Inc. | Fixative composition for fixing blood smears to slides |
| PT94279A (pt) | 1989-06-07 | 1991-12-31 | Wolfgang Moshammer | Processo e dispositivo para a aplicacao de radiacao de microondas a materias que contem agua ou misturadas com agua |
| US5089288A (en) * | 1989-06-24 | 1992-02-18 | Berger Hermann J | Method for impregnating tissue samples in paraffin |
| US5230865A (en) | 1989-09-08 | 1993-07-27 | Cem Corporation | Ventable rupture diaphragm-protected container for heating contained materials by microwave radiation |
| US5049510A (en) | 1990-01-05 | 1991-09-17 | Fisher Scientific Company | Process for histological tissue specimen treatment that includes variable sensitivity level control |
| US5030929A (en) | 1990-01-09 | 1991-07-09 | General Atomics | Compact waveguide converter apparatus |
| US5086288A (en) * | 1990-05-18 | 1992-02-04 | Borroughs Tool & Equipment Corporation | VATS interrogator accessory |
| US5068086A (en) | 1990-06-12 | 1991-11-26 | Raytheon Company | Method and apparatus for batch fixating tissue specimens |
| DE4018955A1 (de) * | 1990-06-13 | 1991-12-19 | Werner Lautenschlaeger | Probenbehaelter zum aufschliessen bzw. analysieren von probenmaterial |
| US5244787A (en) | 1991-01-31 | 1993-09-14 | Biogenex Laboratories | Antigen retrieval in formalin-fixed tissues using microwave energy |
| DE4143541C2 (de) * | 1991-02-19 | 1999-03-04 | Mls Gmbh | Vorrichtung zum Extrahieren von Proben mittels eines Lösungsmittels bei erhöhter Temperatur |
| US5256571A (en) | 1991-05-01 | 1993-10-26 | Cytyc Corporation | Cell preservative solution |
| WO1992019952A1 (en) | 1991-05-07 | 1992-11-12 | Wescor, Inc. | Improved staining method for histology and cytology specimens |
| US5460797A (en) | 1991-05-08 | 1995-10-24 | Streck Laboratories, Inc. | Method for fixing tissues and cells for analysis using oxazolidine compounds |
| US5849517A (en) | 1991-05-08 | 1998-12-15 | Streck Laboratories, Inc. | Method and composition for preserving antigens and nucleic acids and process for utilizing cytological material produced by same |
| US5696887A (en) | 1991-08-05 | 1997-12-09 | Biotek Solutions, Incorporated | Automated tissue assay using standardized chemicals and packages |
| US5289140A (en) | 1991-08-16 | 1994-02-22 | Dako Japan Co., Ltd. | Consistent diagnostic test method using microwaves |
| DE4136416C2 (de) * | 1991-11-05 | 1994-01-13 | Gossler Kg Oscar | Vorrichtung zur Mikrowellen-Bestrahlung von Materialien |
| JP2996794B2 (ja) | 1991-11-29 | 2000-01-11 | 株式会社千代田製作所 | 一槽式包埋装置の運転方法 |
| US5422277A (en) * | 1992-03-27 | 1995-06-06 | Ortho Diagnostic Systems Inc. | Cell fixative composition and method of staining cells without destroying the cell surface |
| DE4223116A1 (de) * | 1992-04-30 | 1993-11-04 | Mikrowellen Labor Systeme | Vorrichtung zur verdampfungsbehandlung von vorzugsweise fluessigen stoffen, insbesondere reagenzstoffen, oder zum aufbereiten oder analysieren von probenmaterial |
| JPH06182718A (ja) * | 1992-05-21 | 1994-07-05 | Nara Pref Gov | 樹脂含浸竹材の製造方法、およびこの樹脂含浸竹材の製造方法によって製造された樹脂含浸竹材、ならびにこの樹脂含浸竹材を用いて製造した編み針 |
| JP3108099B2 (ja) * | 1992-08-12 | 2000-11-13 | バイオジェネックス ラボラトリーズ | アルデヒド固定組織における免疫化学的染色の増強 |
| US5401625A (en) | 1993-06-24 | 1995-03-28 | E. K. Industries, Inc. | Histological composition for light microscopy |
| US5830417A (en) | 1993-09-24 | 1998-11-03 | Duquesne University Of The Holy Ghost | Method and apparatus for microwave assisted chemical reactions |
| US5725835A (en) * | 1993-11-11 | 1998-03-10 | Lautenschlaeger; Werner | Device for initiating and/or promoting chemical or physical processes in a material |
| US5432056A (en) * | 1993-11-15 | 1995-07-11 | Ventana Medical Systems, Inc. | Bisulfite-based tissue fixative |
| US5431952A (en) | 1994-02-28 | 1995-07-11 | Board Of Trustees Operating Michigan State University | Method for preservation of biological tissue |
| US6451551B1 (en) * | 1994-03-11 | 2002-09-17 | Biogenex Laboratories | Releasing embedding media from tissue specimens |
| ATE173173T1 (de) * | 1994-03-22 | 1998-11-15 | Werner Lautenschlaeger | Vorrichtung zum aufbereiten und/oder extrahieren von proben mittels eines verdampfungsfähigen mittels bei erhöhter temperatur |
| CA2147593C (en) * | 1994-04-22 | 2008-07-29 | Hyman C. Birnboim | Dual purpose tissue fixative |
| US5532462A (en) | 1994-04-29 | 1996-07-02 | Communications & Power Industries | Method of and apparatus for heating a reaction vessel with microwave energy |
| US5712605A (en) | 1994-05-05 | 1998-01-27 | Hewlett-Packard Co. | Microwave resonator |
| CA2153215A1 (en) | 1994-07-06 | 1996-01-07 | Lu Wang | Treatment of paraffin embedded tissue for gene analysis |
| EP0749513B1 (de) * | 1995-01-05 | 2000-05-17 | LAUTENSCHLÄGER, Werner | Vorrichtung zur wärmebehandlung von materialien in einer heizkammer |
| DE19503591A1 (de) * | 1995-02-03 | 1996-08-08 | Werner Lautenschlaeger | Verfahren und Vorrichtung zur Extraktions-Behandlung einer Probe |
| US5625706A (en) | 1995-05-31 | 1997-04-29 | Neopath, Inc. | Method and apparatus for continously monitoring and forecasting slide and specimen preparation for a biological specimen population |
| US5796080A (en) | 1995-10-03 | 1998-08-18 | Cem Corporation | Microwave apparatus for controlling power levels in individual multiple cells |
| US6072086A (en) | 1996-04-12 | 2000-06-06 | Intergen Company | Method and composition for controlling formaldehyde fixation by delayed quenching |
| DE69600484T2 (de) | 1996-08-02 | 1999-04-01 | Milestone S.R.L., Sorisole | Verfahren zur Bearbeitung von organischen Proben |
| DE19639022B4 (de) * | 1996-09-23 | 2013-03-21 | Mwt Mikrowellen Labor Technik Ag | Verfahren und Vorrichtung zum Herstellen hochreiner flüssiger Chemikalien |
| DE19639021A1 (de) | 1996-09-23 | 1998-03-26 | Mikrowellen Systeme Mws Gmbh | Vorrichtung und Verfahren zum Behandeln einer chemischen Substanz durch Erhitzen unter Druck |
| US5679333A (en) * | 1996-10-25 | 1997-10-21 | Dunphy; Brian William | Formaldehyde-free tissue preservative compositions |
| DE19652339A1 (de) | 1996-12-17 | 1998-06-18 | Microm Laborgeraete Gmbh | Vorrichtung zur Behandlung von Objekten |
| DE19652784A1 (de) | 1996-12-19 | 1998-06-25 | Dade Behring Marburg Gmbh | Vorrichtung (Küvette) zur Aufnahme und Speicherung von Flüssigkeiten und zur Durchführung optischer Messungen |
| AU3615297A (en) * | 1997-07-15 | 1999-02-10 | Bernard Pajak | Method for fixing and embedding tissues for histological preparations |
| US6793890B2 (en) * | 1997-08-20 | 2004-09-21 | The University Of Miami | Rapid tissue processor |
| KR20010023070A (ko) * | 1997-08-20 | 2001-03-26 | 더 유니버시티 오브 마이애미 | 고품질의 연속적인 재료 처리, 조직 고정-탈수-지방제거-함침 방법 |
| US6017725A (en) * | 1997-08-21 | 2000-01-25 | Aaper Alcohol And Chemical Company | Cytological fixative and dehydrating agent for treating histological and cytological tissue |
| US6183995B1 (en) | 1997-09-05 | 2001-02-06 | Lifespan Biosciences, Inc. | Methods of measuring gene expression using wax-embedded tissue specimens |
| US6033912A (en) * | 1997-11-13 | 2000-03-07 | Milestone S.R.L. | Method of controlling a chemical process heated by microwave radiation |
| DK1080228T3 (da) | 1998-05-18 | 2010-08-16 | Igenex Inc | In situ hybridiseringsfremgangsmåde til detektering af target-nukleinsyrer |
| WO2000000813A1 (en) * | 1998-06-30 | 2000-01-06 | Lamina, Inc. | Cytological and histological fixative composition and methods of use |
| US6242723B1 (en) * | 1998-07-30 | 2001-06-05 | Milestone S.R.L. | Apparatus for performing chemical and physical processes without sample transfer within a microwave radiation field |
| US6054695A (en) * | 1998-07-30 | 2000-04-25 | Milestone S.R.L. | Apparatus for condensing gases within a microwave radiation field |
| US6204375B1 (en) | 1998-07-31 | 2001-03-20 | Ambion, Inc. | Methods and reagents for preserving RNA in cell and tissue samples |
| DE19928820A1 (de) | 1999-06-17 | 2000-12-21 | Ulrich Groth | Fixiermittel für Zellen und Gewebe von Lebewesen |
| EP1208378B9 (en) * | 1999-07-08 | 2014-12-10 | Lee H. Angros | Antigen recovery and/or staining apparatus and method |
| US6916608B2 (en) * | 1999-09-10 | 2005-07-12 | Becton, Dickinson And Company | Composition for providing long term stability to cells for diagnostic testing |
| US6291180B1 (en) | 1999-09-29 | 2001-09-18 | American Registry Of Pathology | Ultrasound-mediated high-speed biological reaction and tissue processing |
| US6248535B1 (en) | 1999-12-20 | 2001-06-19 | University Of Southern California | Method for isolation of RNA from formalin-fixed paraffin-embedded tissue specimens |
| US6337189B1 (en) * | 2000-02-08 | 2002-01-08 | Streck Laboratories, Inc. | Fixative system, method and composition for biological testing |
| AU2001240034A1 (en) | 2000-03-03 | 2001-09-17 | Ted Pella, Inc. | Apparatus for dampening standing wave pattern generation in microwave oven |
| DE10015794A1 (de) | 2000-03-27 | 2001-10-11 | Univ Schiller Jena | Vorrichtung zur Durchführung chemischer Reaktionen und Prozesse in Hochfrequenzfeldern |
| EP1156309B1 (de) * | 2000-05-18 | 2003-04-16 | Precisa Instruments AG | Automatische Probenpräparation |
| DE10037417A1 (de) * | 2000-07-24 | 2002-02-07 | Friedrich Schiller Uni Jena Bu | Vorrichtung zur Durchführung multipler chemischer Reaktionen und Prozesse in Hochfrequenzfeldern |
| DE10104320A1 (de) * | 2001-01-25 | 2002-08-01 | Univ Schiller Jena | Vorrichtung zur Erfüllung von Sicherheitsfunktionen in Räumen mit Hochfrequenzstrahlung |
| US6875583B2 (en) | 2001-05-22 | 2005-04-05 | Ted Pella, Inc. | Rapid microwave-assisted fixation of fresh tissue |
| US7297311B2 (en) | 2001-06-29 | 2007-11-20 | Sysmex Corporation | Automatic smear preparing apparatus and automatic sample analysis system having the same |
| US6458598B1 (en) * | 2001-08-13 | 2002-10-01 | Dako A/S | Process for preparing and presenting a tissue sample for histological study |
| DE20120649U1 (de) * | 2001-12-20 | 2002-04-18 | MLS Mikrowellen-Labor-Systeme GmbH, 88299 Leutkirch | Vorrichtung zum Verschließen eines topfförmigen Aufschlussbehälters |
| US20030127313A1 (en) * | 2001-12-20 | 2003-07-10 | Milestone S.R.L. | Device for closing a pot-like digestion vessel |
| US20030194352A1 (en) * | 2001-12-20 | 2003-10-16 | Milestone S.R.L. | Device for closing a plurality of digestion vessesls |
| US6797928B2 (en) * | 2002-04-23 | 2004-09-28 | Ted Pella, Inc. | Method and apparatus for the rapid decalcification and fixation of mineralized tissues |
| US7138226B2 (en) | 2002-05-10 | 2006-11-21 | The University Of Miami | Preservation of RNA and morphology in cells and tissues |
| CA2502580C (en) * | 2002-10-31 | 2013-09-10 | University Of Massachusetts | Rapid cell block embedding method and apparatus |
| EP1455174B1 (en) | 2003-03-05 | 2004-12-15 | Milestone S.r.l. | Fixative |
| EP1464388A1 (de) | 2003-04-04 | 2004-10-06 | Mikrowellen-Systeme MWS GmbH | Mikrowellen-Behandlung von chemischen Substanzen in einem Behälter |
| KR200327028Y1 (ko) * | 2003-06-17 | 2003-09-19 | 장시창 | 인체조직검사기구 |
| CA2543043C (en) * | 2003-10-24 | 2013-09-17 | The University Of Miami | Simplified tissue processing |
| ATE416368T1 (de) * | 2004-06-07 | 2008-12-15 | Milestone Srl | Verfahren und vorrichtung zur mikrowellen- unterstützten automatischen gewebebehandlung |
| US7273720B1 (en) * | 2004-12-02 | 2007-09-25 | Collaborative Laboratory Services, Llc | Rapid tissue processing method and apparatus |
| US7273587B1 (en) * | 2004-12-02 | 2007-09-25 | Collaborative Laboratory Services, Llc | Rapid tissue processing method and apparatus |
| AT503448B1 (de) * | 2006-03-29 | 2007-10-15 | Leica Mikrosysteme Gmbh | Gerät zur präparation biologischer proben für die elektronenmikroskopie |
| AT504371B8 (de) * | 2006-10-03 | 2008-09-15 | Leica Mikrosysteme Gmbh | Vorrichtung zur mikrowellen-gestützten präparation von proben |
-
1998
- 1998-08-19 KR KR1020007001688A patent/KR20010023070A/ko not_active Ceased
- 1998-08-19 WO PCT/US1998/016463 patent/WO1999009390A1/en not_active Ceased
- 1998-08-19 DK DK98940811T patent/DK1005633T3/da active
- 1998-08-19 CA CA002301924A patent/CA2301924C/en not_active Expired - Lifetime
- 1998-08-19 JP JP2000510006A patent/JP4164232B2/ja not_active Expired - Lifetime
- 1998-08-19 AU AU89001/98A patent/AU746497B2/en not_active Expired
- 1998-08-19 CA CA2635001A patent/CA2635001C/en not_active Expired - Lifetime
- 1998-08-19 US US09/136,292 patent/US6207408B1/en not_active Expired - Lifetime
- 1998-08-19 EP EP98940811A patent/EP1005633B1/en not_active Expired - Lifetime
- 1998-08-19 EP EP08159241.2A patent/EP2199774B1/en not_active Expired - Lifetime
- 1998-08-19 ES ES98940811T patent/ES2313752T3/es not_active Expired - Lifetime
- 1998-08-19 DE DE69839963T patent/DE69839963D1/de not_active Expired - Lifetime
- 1998-08-19 AT AT98940811T patent/ATE407353T1/de not_active IP Right Cessation
- 1998-09-14 TW TW087113665A patent/TW571100B/zh not_active IP Right Cessation
-
2000
- 2000-12-15 US US09/736,388 patent/US6586713B2/en not_active Expired - Lifetime
-
2003
- 2003-03-27 US US10/400,060 patent/US7547538B2/en not_active Expired - Lifetime
-
2008
- 2008-03-12 US US12/046,465 patent/US8221996B2/en not_active Expired - Lifetime
- 2008-05-30 JP JP2008141794A patent/JP4334601B2/ja not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102015998B1 (ko) * | 2017-01-26 | 2019-08-29 | 에스씨엘 바이오테크 리미티드 | 일차 세포 분리 장치 및 방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1005633B1 (en) | 2008-09-03 |
| JP2008281573A (ja) | 2008-11-20 |
| DE69839963D1 (de) | 2008-10-16 |
| JP4164232B2 (ja) | 2008-10-15 |
| JP2001516869A (ja) | 2001-10-02 |
| TW571100B (en) | 2004-01-11 |
| CA2301924C (en) | 2008-12-09 |
| AU8900198A (en) | 1999-03-08 |
| US6586713B2 (en) | 2003-07-01 |
| ES2313752T3 (es) | 2009-03-01 |
| WO1999009390A1 (en) | 1999-02-25 |
| US8221996B2 (en) | 2012-07-17 |
| EP1005633A1 (en) | 2000-06-07 |
| CA2301924A1 (en) | 1999-02-25 |
| JP4334601B2 (ja) | 2009-09-30 |
| EP2199774A1 (en) | 2010-06-23 |
| EP1005633A4 (en) | 2003-01-22 |
| AU746497B2 (en) | 2002-05-02 |
| EP2199774B1 (en) | 2018-10-03 |
| US6207408B1 (en) | 2001-03-27 |
| CA2635001C (en) | 2012-12-04 |
| DK1005633T3 (da) | 2008-12-15 |
| US7547538B2 (en) | 2009-06-16 |
| CA2635001A1 (en) | 1999-02-25 |
| US20080153127A1 (en) | 2008-06-26 |
| US20040004075A1 (en) | 2004-01-08 |
| ATE407353T1 (de) | 2008-09-15 |
| US20010000487A1 (en) | 2001-04-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR20010023070A (ko) | 고품질의 연속적인 재료 처리, 조직 고정-탈수-지방제거-함침 방법 | |
| KR100743727B1 (ko) | 신속한 조직 프로세서 | |
| CA2543043C (en) | Simplified tissue processing | |
| US6793890B2 (en) | Rapid tissue processor | |
| CA2849908C (en) | Ultra-rapid diagnostic tissue preparation as an alternative to frozen section |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20000218 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20030814 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20050728 Patent event code: PE09021S01D |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20060220 Patent event code: PE09021S01D |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20060824 Patent event code: PE09021S01D |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20070208 Patent event code: PE09021S01D |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20070718 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20080627 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20070718 Comment text: Notification of reason for refusal Patent event code: PE06011S01I Patent event date: 20070208 Comment text: Notification of reason for refusal Patent event code: PE06011S01I Patent event date: 20060824 Comment text: Notification of reason for refusal Patent event code: PE06011S01I Patent event date: 20060220 Comment text: Notification of reason for refusal Patent event code: PE06011S01I Patent event date: 20050728 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |
|
| J201 | Request for trial against refusal decision | ||
| PJ0201 | Trial against decision of rejection |
Patent event date: 20080930 Comment text: Request for Trial against Decision on Refusal Patent event code: PJ02012R01D Patent event date: 20080627 Comment text: Decision to Refuse Application Patent event code: PJ02011S01I Appeal kind category: Appeal against decision to decline refusal Decision date: 20110331 Appeal identifier: 2008101010101 Request date: 20080930 |
|
| J301 | Trial decision |
Free format text: TRIAL DECISION FOR APPEAL AGAINST DECISION TO DECLINE REFUSAL REQUESTED 20080930 Effective date: 20110331 |
|
| PJ1301 | Trial decision |
Patent event code: PJ13011S01D Patent event date: 20110331 Comment text: Trial Decision on Objection to Decision on Refusal Appeal kind category: Appeal against decision to decline refusal Request date: 20080930 Decision date: 20110331 Appeal identifier: 2008101010101 |