ATE407353T1 - Hochqualitatives durchlaufendes verfahren zur fixierung, dehydratisierung, entfettung und imprägnation von geweben - Google Patents

Hochqualitatives durchlaufendes verfahren zur fixierung, dehydratisierung, entfettung und imprägnation von geweben

Info

Publication number
ATE407353T1
ATE407353T1 AT98940811T AT98940811T ATE407353T1 AT E407353 T1 ATE407353 T1 AT E407353T1 AT 98940811 T AT98940811 T AT 98940811T AT 98940811 T AT98940811 T AT 98940811T AT E407353 T1 ATE407353 T1 AT E407353T1
Authority
AT
Austria
Prior art keywords
vessel
tissue specimens
dehydrated
defatted
fixed
Prior art date
Application number
AT98940811T
Other languages
English (en)
Inventor
Ervin Essenfeld
Harold Essenfeld
Azorides Morales
Original Assignee
Univ Miami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Miami filed Critical Univ Miami
Application granted granted Critical
Publication of ATE407353T1 publication Critical patent/ATE407353T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/50—Clamping means, tongs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/44—Sample treatment involving radiation, e.g. heat
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N2001/305—Fixative compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N2001/315—Basket-type carriers for tissues
AT98940811T 1997-08-20 1998-08-19 Hochqualitatives durchlaufendes verfahren zur fixierung, dehydratisierung, entfettung und imprägnation von geweben ATE407353T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5610297P 1997-08-20 1997-08-20

Publications (1)

Publication Number Publication Date
ATE407353T1 true ATE407353T1 (de) 2008-09-15

Family

ID=22002161

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98940811T ATE407353T1 (de) 1997-08-20 1998-08-19 Hochqualitatives durchlaufendes verfahren zur fixierung, dehydratisierung, entfettung und imprägnation von geweben

Country Status (12)

Country Link
US (4) US6207408B1 (de)
EP (2) EP2199774B1 (de)
JP (2) JP4164232B2 (de)
KR (1) KR20010023070A (de)
AT (1) ATE407353T1 (de)
AU (1) AU746497B2 (de)
CA (2) CA2635001C (de)
DE (1) DE69839963D1 (de)
DK (1) DK1005633T3 (de)
ES (1) ES2313752T3 (de)
TW (1) TW571100B (de)
WO (1) WO1999009390A1 (de)

Families Citing this family (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451551B1 (en) * 1994-03-11 2002-09-17 Biogenex Laboratories Releasing embedding media from tissue specimens
US6793890B2 (en) 1997-08-20 2004-09-21 The University Of Miami Rapid tissue processor
US6207408B1 (en) * 1997-08-20 2001-03-27 University Of Miami High quality, continuous throughput, tissue fixation-dehydration-fat removal-impregnation method
ATE268470T1 (de) * 1998-06-30 2004-06-15 Lamina Inc Zytologische und histologische fixier- zusammensetzung und verfahren zur verwendung
AU4812600A (en) * 1999-04-29 2000-11-17 Arcturus Engineering, Inc. Processing technology for lcm samples
US7951612B2 (en) * 1999-07-08 2011-05-31 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
US8298485B2 (en) * 1999-07-08 2012-10-30 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
WO2001004634A1 (en) * 1999-07-08 2001-01-18 Lee Angros Antigen recovery and/or staining apparatus and method
US7897106B2 (en) * 1999-07-08 2011-03-01 Lee Angros Situ heat induced antigen recovery and staining apparatus and method
US6916608B2 (en) * 1999-09-10 2005-07-12 Becton, Dickinson And Company Composition for providing long term stability to cells for diagnostic testing
DE19945621A1 (de) * 1999-09-23 2001-04-05 Aurel Popa Geräteanordnung zur Präparation und Analyse von Gewebe für mirkoskopische Untersuchungen
WO2001044784A1 (en) * 1999-12-14 2001-06-21 University Of Miami Microwave unit and system for tissue processing
JP4441174B2 (ja) 2000-06-09 2010-03-31 ザユニバーシティー オブ マイアミ 病理学用組織採取ボード
CA2436910C (en) * 2000-12-01 2014-06-17 Response Genetics, Inc. Method of determining epidermal growth factor receptor and her2-neu gene expression and correlation of levels thereof with survival rates
US6518416B1 (en) 2000-12-01 2003-02-11 Response Genetics, Inc. Method of determining a chemotherapeutic regimen based on ERCC1 expression
US6602670B2 (en) * 2000-12-01 2003-08-05 Response Genetics, Inc. Method of determining a chemotherapeutic regimen based on ERCC1 expression
US6582919B2 (en) 2001-06-11 2003-06-24 Response Genetics, Inc. Method of determining epidermal growth factor receptor and HER2-neu gene expression and correlation of levels thereof with survival rates
US7049059B2 (en) 2000-12-01 2006-05-23 Response Genetics, Inc. Method of determining a chemotherapeutic regimen based on ERCC1 and TS expression
US6956111B2 (en) 2001-03-02 2005-10-18 Response Genetics, Inc. Method of determining dihydropyrimidine dehydrogenase gene expression
US6458598B1 (en) * 2001-08-13 2002-10-01 Dako A/S Process for preparing and presenting a tissue sample for histological study
CN100359313C (zh) * 2001-09-20 2008-01-02 王世峰 一种活体组织脱水盒
CA2462332C (en) * 2001-10-01 2014-12-09 Vision Biosystems Limited Histological tissue specimen treatment
US7468161B2 (en) 2002-04-15 2008-12-23 Ventana Medical Systems, Inc. Automated high volume slide processing system
US11249095B2 (en) 2002-04-15 2022-02-15 Ventana Medical Systems, Inc. Automated high volume slide processing system
US6797928B2 (en) * 2002-04-23 2004-09-28 Ted Pella, Inc. Method and apparatus for the rapid decalcification and fixation of mineralized tissues
US7138226B2 (en) * 2002-05-10 2006-11-21 The University Of Miami Preservation of RNA and morphology in cells and tissues
DE60328186D1 (de) * 2002-05-28 2009-08-13 Diapath S P A Zusammensetzung für die herstellung von histologischen, autopsischen und zytologischen proben
DK2322938T3 (da) 2002-09-26 2013-04-08 Biopath Automation Llc Apparat og fremgangsmåde til automatisk håndtering og indlejring af vævsprøver
US7179424B2 (en) 2002-09-26 2007-02-20 Biopath Automation, L.L.C. Cassette for handling and holding tissue samples during processing, embedding and microtome procedures, and methods therefor
EP1545775B1 (de) 2002-09-26 2010-06-16 BioPath Automation, L.L.C. Kassette und einbettanordnung, stufungsvorrichtungen und verfahren zur handhabung von gewebeproben
US7219884B2 (en) * 2002-10-01 2007-05-22 The University Of Miami Pathology grossing tool
US7541161B2 (en) * 2002-10-31 2009-06-02 University Of Massachusetts Method and apparatus for preparing cells for microtome sectioning and archiving nucleic acids and proteins
EP2237013B1 (de) * 2002-10-31 2012-06-06 University of Massachusetts Verfahren und Vorrichtung zur raschen Zellblockeinbettung
JP4189484B2 (ja) * 2002-12-12 2008-12-03 国立循環器病センター総長 マイクロ波照射による生体組織の処理方法
WO2004072268A2 (en) * 2003-02-12 2004-08-26 Mayo Foundation For Medical Education And Research Pkhdl1, a homolog of the autosomal recessive kidney disease gene
KR200327028Y1 (ko) * 2003-06-17 2003-09-19 장시창 인체조직검사기구
EP1673608A4 (de) 2003-09-29 2008-05-07 Vision Biosystems Ltd System und verfahren zur bearbeitung histologischer gewebeproben
US7470401B2 (en) * 2003-10-24 2008-12-30 The University Of Miami Simplified tissue processing
KR100458860B1 (ko) * 2004-04-22 2004-12-03 송영민 생검시료의 검사를 위한 보조기구
US8409871B2 (en) * 2004-05-25 2013-04-02 Leica Biosystems Melbourne Pty Ltd Method of treatment of tissue processing fluid and apparatus therefor
ATE416368T1 (de) * 2004-06-07 2008-12-15 Milestone Srl Verfahren und vorrichtung zur mikrowellen- unterstützten automatischen gewebebehandlung
US7273587B1 (en) 2004-12-02 2007-09-25 Collaborative Laboratory Services, Llc Rapid tissue processing method and apparatus
US8236255B2 (en) * 2004-12-02 2012-08-07 Lab Vision Corporation Slide treatment apparatus and methods for use
US7273720B1 (en) 2004-12-02 2007-09-25 Collaborative Laboratory Services, Llc Rapid tissue processing method and apparatus
WO2006065442A2 (en) * 2004-12-17 2006-06-22 Ventana Medical Systems, Inc. Methods and compositions for a microemulsion-based tissue treatment
GB0501590D0 (en) * 2005-01-25 2005-03-02 Ceres Power Ltd Processing of enhanced performance LSCF fuel cell cathode microstructure and a fuel cell cathode
US20060228772A1 (en) * 2005-04-11 2006-10-12 Donndelinger Thomas M Compositions and methods for preparing specimens for microscopic analysis
CA2623241A1 (en) * 2005-04-21 2006-11-02 Celerus Diagnostics, Inc. Parallel processing fluidic method and apparatus for automated rapid immunohistochemistry
WO2006127852A2 (en) * 2005-05-24 2006-11-30 Angros Lee H In situ heat induced antigen recovery and staining apparatus and method
EP1904670B1 (de) * 2005-06-28 2011-09-28 The Board of Regents of the University of Oklahoma Verfahren zur züchtung und entnahme von kohlenstoffnanoröhren
WO2007016935A1 (en) 2005-07-29 2007-02-15 Histogenex Nv Methods, reagents and instrumentation for preparing impregnated tissue samples suitable for histopathological and molecular studies
US20070116612A1 (en) * 2005-11-02 2007-05-24 Biopath Automation, L.L.C. Prefix tissue cassette
US7769962B2 (en) * 2005-12-12 2010-08-03 Jeda Technologies, Inc. System and method for thread creation and memory management in an object-oriented programming environment
EP1804045B1 (de) * 2005-12-30 2014-03-12 QIAGEN GmbH Ein Verfahren und ein Kit zur Behandlung einer biologischen Probe
US20070172911A1 (en) * 2006-01-13 2007-07-26 Michael Farrell Biological sample processing composition and method
WO2007141888A1 (ja) * 2006-06-05 2007-12-13 Jokoh Co., Ltd 生物組織固定装置
US20080026366A1 (en) * 2006-06-07 2008-01-31 Newcomer Supply, Inc. Biological fixative and method of using the biological fixative
AT504371B8 (de) 2006-10-03 2008-09-15 Leica Mikrosysteme Gmbh Vorrichtung zur mikrowellen-gestützten präparation von proben
US7666620B2 (en) * 2006-11-08 2010-02-23 Richard-Allan Scientific Company Rapid tissue processing system
JP5050200B2 (ja) * 2006-11-20 2012-10-17 国立大学法人三重大学 医療検体用ケース
WO2008073387A1 (en) * 2006-12-12 2008-06-19 Biopath Automation, L.L.C. Biopsy support with sectionable resilient cellular material
EP1965190A1 (de) * 2007-02-27 2008-09-03 Qiagen GmbH Fixierung einer biologischen Probe
EP1975595A1 (de) * 2007-03-21 2008-10-01 Diapath S.r.l. Automatische Behandlungsvorrichtung für histologische Proben und ihrer Betrieb
EP2009419B1 (de) * 2007-06-25 2009-12-23 Milestone S.r.l. Messung der Dicke organischer Proben
US7906076B2 (en) * 2007-07-02 2011-03-15 University Of Massachusetts Method and apparatus for biopsy sample processing
JP4059520B1 (ja) * 2007-07-25 2008-03-12 株式会社常光 組織片処理装置
EP2187749A4 (de) * 2007-08-14 2011-04-20 Charm Sciences Inc Verfahren und gerät zum konzentrieren von proben
CA2702790C (en) 2007-10-23 2015-06-09 Becton, Dickinson And Company Tissue container for molecular and histology diagnostics incorporating a breakable membrane
ES2837748T3 (es) * 2007-10-23 2021-07-01 Becton Dickinson Co Sistema de múltiples cámaras de contención de tejido para diagnóstico molecular e histológico
EP2339322B1 (de) * 2007-10-23 2017-02-15 Becton, Dickinson and Company Behältersystem zur gewebestabilisierung
ES2660415T3 (es) 2007-10-23 2018-03-22 Becton, Dickinson And Company Kit cerrado para contención y estabilización de tejidos para diagnósticos moleculares e histopatológicos
AU2013200909B2 (en) * 2007-10-23 2014-04-10 Becton, Dickinson And Company Multi-chambered tissue containment system for molecular and histology diagnostics
BRPI0818068B1 (pt) * 2007-10-23 2019-06-25 Becton, Dickinson And Company Recipiente para tecido com deslocamento de fluido para diagnóstico molecular e histológico
US8158381B2 (en) * 2008-03-27 2012-04-17 Richard-Allan Scientific Company Methods for integrated tissue processing and staining
EP3733871A1 (de) * 2008-05-27 2020-11-04 Dako Denmark A/S Zusammensetzungen und verfahren zur erkennung von chromosomalen abweichungen mit neuen hybridisierungspuffern
US20090298172A1 (en) 2008-05-28 2009-12-03 Steven Paul Wheeler Histological specimen treatment apparatus and method
US20090325273A1 (en) * 2008-06-30 2009-12-31 Chin Pin Chang Chien Multi-functional treating device for treating pathological tissue sections
ES2909653T3 (es) * 2008-08-27 2022-05-09 The Univ Of Miami Cajetín para tejidos y procedimiento para preparar muestras de tejidos
GB2477648B (en) * 2008-08-29 2013-02-20 Lee H Angros In situ heat induced antigen recovery and staining apparatus and method
US8968210B2 (en) 2008-10-01 2015-03-03 Covidien LLP Device for needle biopsy with integrated needle protection
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
US9186128B2 (en) 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
US11298113B2 (en) 2008-10-01 2022-04-12 Covidien Lp Device for needle biopsy with integrated needle protection
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
AU2009313985B2 (en) 2008-11-12 2014-07-31 Ventana Medical Systems, Inc. Methods and apparatuses for heating slides carrying specimens
CA2745431A1 (en) * 2008-12-03 2010-06-10 Timothy J. O'leary Pressure-assisted molecular recovery (pamr) of biomolecules, pressure-assisted antigen retrieval (paar), and pressure-assisted tissue histology (path)
US8329120B2 (en) 2009-01-22 2012-12-11 Biopath Automation, L.L.C. Microtome sectionable biopsy support for orienting tissue samples
WO2010097655A1 (en) 2009-02-26 2010-09-02 Dako Denmark A/S Compositions and methods for rna hybridization applications
WO2010108930A2 (en) * 2009-03-23 2010-09-30 Engin Hasan Hueseyin Laboratory type quick film drying oven
DE102009025574A1 (de) * 2009-06-19 2010-12-23 Leica Biosystems Nussloch Gmbh Verfahren zum automatischen Bearbeiten von Gewebeproben in einem Gewebeprozessor
US9237608B2 (en) 2009-08-14 2016-01-12 Cem Corporation Pressure stepped microwave assisted digestion
WO2011020612A1 (en) * 2009-08-21 2011-02-24 Roche Diagnostics Gmbh Use of a bis-maleic anhydride cross-linking agent for fixation of a cell or tissue sample
US10539487B2 (en) 2010-03-04 2020-01-21 Ventana Medical Systems, Inc. Systems and methods for monitoring tissue sample processing
US10126216B2 (en) 2011-02-17 2018-11-13 Ventana Medical Systems, Inc. Method for tissue sample fixation
CA2788664C (en) 2010-03-04 2023-04-11 Ventana Medical Systems, Inc. Processing system for processing specimens using acoustic energy
US8227233B2 (en) * 2010-06-09 2012-07-24 Ford Global Technologies, Llc Method of making foamed mycelium structure
US20120171694A1 (en) * 2010-07-30 2012-07-05 Vermillion, Inc. Predictive markers and biomarker panels for ovarian cancer
DE102011055120B4 (de) 2011-04-20 2016-04-14 Leica Biosystems Nussloch Gmbh Verfahren zur Verarbeitung zumindest einer histologischen Probe und Vorrichtung zum Behandeln einer histologischen Probe.
GB2490202B (en) * 2011-04-20 2015-06-24 Leica Biosystems Nussloch Gmbh Method of detaching and/or isolating a histological sample
CN103562702A (zh) 2011-05-20 2014-02-05 独立行政法人理化学研究所 生物材料用透明化试剂、及其利用
US8920720B2 (en) * 2011-06-03 2014-12-30 Rushabh Instruments, Inc. Rotary tissue processor with configurable stations
RU2499242C2 (ru) * 2011-08-29 2013-11-20 Андрей Викторович Иванченко Способ подготовки образцов биологических тканей к гистологическим исследованиям
EP2761268A4 (de) * 2011-09-29 2015-08-12 Univ Miami Ultraschnelle diagnostische gewebepräparation als alternative zu gefrierschnitt
US10662465B2 (en) 2011-09-30 2020-05-26 Agilent Technologies, Inc. Hybridization compositions and methods using formamide
EP2768974B1 (de) 2011-10-21 2017-07-19 Dako Denmark A/S Hybridisierungszusammensetzungen und -verfahren
WO2013102048A2 (en) * 2011-12-30 2013-07-04 University Of Miami Regenerative tissue matrix
JP6487320B2 (ja) 2012-06-22 2019-03-20 ライカ ビオズュステムス ヌスロッホ ゲーエムベーハー 組織サンプル容器及び方法
CN104583384B (zh) 2012-06-22 2020-03-17 莱卡生物系统努斯洛赫有限责任公司 活检组织样本运送装置和其使用方法
EP2926658B1 (de) * 2012-10-30 2018-08-29 Kanazawa Medical University Kit zur herstellung transparentierter biologischer proben und verfahren zur herstellung transparentierter biologischer proben
US9389154B2 (en) 2013-03-15 2016-07-12 Leica Biosystems Nussloch Gmbh Tissue cassette with biasing element
CA2845830C (en) 2013-03-15 2020-10-27 Leica Biosystems Nussloch Gmbh Tissue cassette with retractable member
US9052256B2 (en) 2013-03-15 2015-06-09 Leica Biosystems Nussloch Gmbh Method for processing and embedding tissue
US10267714B2 (en) 2013-08-14 2019-04-23 Riken Composition for preparing biomaterial with excellent light-transmitting property, and use thereof
WO2015085175A1 (en) * 2013-12-05 2015-06-11 Shidham Vinod B Cell blocks for cytopathology and surgical pathology specimens
US9733162B2 (en) * 2014-02-11 2017-08-15 Ihor Turkevych Universal system, method and solution for the acceleration of the process of fixing, dehydrating and clearing the structure of biological tissue
US9766171B2 (en) 2014-03-17 2017-09-19 Columbia Insurance Company Devices, systems and method for flooring performance testing
WO2015154000A1 (en) 2014-04-04 2015-10-08 Massachusetts Institute Of Technology Active transport of charged molecules into, within, and/or from charged matrices
US10591392B2 (en) 2014-07-03 2020-03-17 Applikate Technologies Llc Simultaneous dehydration and staining of tissue for deep imaging
JP6383619B2 (ja) * 2014-09-22 2018-08-29 株式会社トスカバノック 病理検体の管理方法
WO2016147812A1 (ja) * 2015-03-18 2016-09-22 国立研究開発法人理化学研究所 生物材料の観察方法および透明化方法
US10365189B2 (en) 2015-05-07 2019-07-30 Steven Wheeler Histological specimen treatment
KR101765460B1 (ko) * 2016-01-11 2017-08-07 주식회사 메딕슨 카트리지형 극초단파 생체시료 고정장치
CN105606437B (zh) * 2016-03-01 2018-06-19 青岛锴锦医疗器械有限公司 一种快速病理组织脱水机
ITUA20162517A1 (it) * 2016-04-12 2017-10-12 Andrea Fantozzi Composizione per la conservazione/fissazione di materiale biologico
CN106053126A (zh) * 2016-05-27 2016-10-26 中国水产科学研究院淡水渔业研究中心 一种福瑞鲤成熟卵巢组织冷冻切片的制作方法
KR101866249B1 (ko) 2016-11-29 2018-06-12 박순현 생체 조직 투명화용 조성물 및 이를 이용한 생체 조직 투명화 방법
TWI616525B (zh) * 2017-01-26 2018-03-01 Scl Biotech Ltd 初代細胞萃取設備及其使用方法
EP3732461A1 (de) * 2017-12-29 2020-11-04 F. Hoffmann-La Roche AG System zur vorbereitung von gewebeproben
CN108387419A (zh) * 2018-02-09 2018-08-10 青岛锴锦医疗器械有限公司 一种新型环保快速生物组织处理液
CN108344608B (zh) * 2018-02-09 2021-06-22 李西启 一种快速微波病理组织处理专用试剂及其制备方法
CN108387421B (zh) * 2018-02-09 2021-05-07 青岛锴锦医疗器械有限公司 一种用于病理切片的新型环保快速组织处理液
CN110954385B (zh) * 2019-12-17 2021-05-25 李惠 一种病理组织脱水仪
RU209703U1 (ru) * 2021-07-15 2022-03-18 Федеральное государственное автономное образовательное учреждение высшего образования «Дальневосточный федеральный университет» (ДВФУ) Инкубационная установка для длительного содержания переживающих срезов
WO2023076000A1 (en) * 2021-11-01 2023-05-04 Novodiax, Inc. A method and apparatus for rapid circulating tissue pretreatment
CN114295446A (zh) * 2021-12-28 2022-04-08 中国林业科学研究院木材工业研究所 一种利用包埋剂改善木质文物脆裂的徒手切片方法

Family Cites Families (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2698809A (en) * 1955-01-04 Preserving plant and animal tissues
US2150757A (en) 1937-06-22 1939-03-14 Agfa Ansco Corp Film drier
US2684925A (en) 1949-03-16 1954-07-27 Technicon Chemical Company Inc Liquid for treating tissue in histologic processing
US3546334A (en) * 1965-05-21 1970-12-08 Lerner Lab Inc Composition for fixing and protecting a smear of body cells and method of applying same
US3389052A (en) 1965-11-02 1968-06-18 Ehrenreich Theodore Fixing and drying cytological smears
GB1321712A (en) * 1970-03-17 1973-06-27 Shandon Elliott Ltd Sequential processing apparatus for processing an article by immersion
US3961097A (en) * 1971-10-28 1976-06-01 Gravlee Jr Joseph F Method of preparing tissue for microscopic examination
GB1454510A (en) 1973-05-22 1976-11-03 Tetronics Research Dev Co Ltd Laying blood traces
US3892197A (en) 1974-04-22 1975-07-01 Thomas D Kinney Light microscopy processing apparatus
IT1062484B (it) 1975-08-08 1984-10-10 Gen Electric Combinazione di fluido colorante e incollante per vetrini da microscopio
US4099483A (en) 1976-04-07 1978-07-11 Shandon Southern Products Limited Tissue processing apparatus
US4199558A (en) 1976-04-07 1980-04-22 Shandon Southern Products Limited Tissue processing method
US4141312A (en) 1977-05-16 1979-02-27 Fisher Scientific Company Apparatus for histological tissue processing
US4221823A (en) 1978-04-21 1980-09-09 Phillips Petroleum Company Process for mounting palynological specimens
DE2906650A1 (de) 1979-02-21 1980-08-28 Pfrimmer Pharma Verfahren zur herstellung von transplantatkonserven
US4670386A (en) * 1980-05-23 1987-06-02 Stephen Sugaar Cancer tests using tumor antigen generated lymphokines and compositions
US4578282A (en) 1982-02-04 1986-03-25 Harrison James S Composition for diagnostic reagents
US4545831A (en) 1982-09-13 1985-10-08 The Mount Sinai School Of Medicine Method for transferring a thin tissue section
US4681996A (en) 1982-12-16 1987-07-21 Cem Corporation Analytical process in which materials to be analyzed are directly and indirectly heated and dried by microwave radiation
DE3319564A1 (de) 1983-05-30 1984-12-06 Arthur Pfeiffer Vakuumtechnik Wetzlar Gmbh, 6334 Asslar Verfahren zur herstellung flexibler, dauerhaltbargemachter nicht konservierter und konservierter biologischer materialien
DE8509640U1 (de) 1985-03-30 1985-05-30 AGW Analysen-Geräte GmbH, 7970 Leutkirch Küvette
SE8501959L (sv) * 1985-04-23 1986-10-24 Henrik Gerhard Renvall Framstellning av ett vevnadspreparat
US4839194A (en) * 1985-07-05 1989-06-13 Bone Diagnostic Center Methods of preparing tissue samples
US5023187A (en) 1985-09-13 1991-06-11 Fisher Scientific Company Method and device for accelerated treatment of thin sample on surface
US4820504A (en) * 1986-02-12 1989-04-11 City Of Hope Multi-specimen tissue blocks and slides
US4656047A (en) 1986-03-06 1987-04-07 Kok Lanbrecht P Rapid method for cell block preparation
US4835354A (en) 1987-03-30 1989-05-30 Cem Corporation Microwave heating apparatus for laboratory analyses
FR2616273B1 (fr) 1987-06-05 1989-10-20 Thomson Csf Resonateur hyperfrequence en mode de chuchotement en galerie
US5782897A (en) 1987-06-26 1998-07-21 Microwave Medical Systems, Inc. Microwave heating apparatus for rapid tissue fixation
US4857300A (en) 1987-07-27 1989-08-15 Cytocorp, Inc. Cytological and histological fixative formulation and methods for using same
US4882128A (en) 1987-07-31 1989-11-21 Parr Instrument Company Pressure and temperature reaction vessel, method, and apparatus
US4946669A (en) 1987-10-09 1990-08-07 Siegfried Barry A Histological fixatives
US4911915A (en) 1987-10-13 1990-03-27 Richard-Allan Medical Industries Method of processing tissue specimens and dehydrant solvent for use therein
US5544650A (en) 1988-04-08 1996-08-13 Neuromedical Systems, Inc. Automated specimen classification system and method
US4891239A (en) 1988-07-05 1990-01-02 Raytheon Company Method and apparatus for ultrafast microwave tissue fixation
WO1990003840A1 (en) 1988-10-10 1990-04-19 Commonwealth Scientific And Industrial Research Organisation Method and apparatus for continuous chemical reactions
US5104640A (en) * 1989-03-17 1992-04-14 Wescor, Inc. Fixative composition for fixing blood smears to slides
EP0476004B1 (de) 1989-06-07 1993-05-26 MOSHAMMER, Wolfgang, Dipl.-Ing. Verfahren und vorrichtung zur einstrahlung von mikrowellenenergie in wasserhaltige oder mit wasser versetzte materie
US5089288A (en) * 1989-06-24 1992-02-18 Berger Hermann J Method for impregnating tissue samples in paraffin
US5230865A (en) 1989-09-08 1993-07-27 Cem Corporation Ventable rupture diaphragm-protected container for heating contained materials by microwave radiation
US5049510A (en) 1990-01-05 1991-09-17 Fisher Scientific Company Process for histological tissue specimen treatment that includes variable sensitivity level control
US5030929A (en) 1990-01-09 1991-07-09 General Atomics Compact waveguide converter apparatus
US5086288A (en) * 1990-05-18 1992-02-04 Borroughs Tool & Equipment Corporation VATS interrogator accessory
US5068086A (en) 1990-06-12 1991-11-26 Raytheon Company Method and apparatus for batch fixating tissue specimens
DE4018955A1 (de) 1990-06-13 1991-12-19 Werner Lautenschlaeger Probenbehaelter zum aufschliessen bzw. analysieren von probenmaterial
US5244787A (en) 1991-01-31 1993-09-14 Biogenex Laboratories Antigen retrieval in formalin-fixed tissues using microwave energy
DE4143541C2 (de) 1991-02-19 1999-03-04 Mls Gmbh Vorrichtung zum Extrahieren von Proben mittels eines Lösungsmittels bei erhöhter Temperatur
US5256571A (en) 1991-05-01 1993-10-26 Cytyc Corporation Cell preservative solution
WO1992019952A1 (en) 1991-05-07 1992-11-12 Wescor, Inc. Improved staining method for histology and cytology specimens
US5460797A (en) 1991-05-08 1995-10-24 Streck Laboratories, Inc. Method for fixing tissues and cells for analysis using oxazolidine compounds
US5849517A (en) 1991-05-08 1998-12-15 Streck Laboratories, Inc. Method and composition for preserving antigens and nucleic acids and process for utilizing cytological material produced by same
US5696887A (en) 1991-08-05 1997-12-09 Biotek Solutions, Incorporated Automated tissue assay using standardized chemicals and packages
US5289140A (en) 1991-08-16 1994-02-22 Dako Japan Co., Ltd. Consistent diagnostic test method using microwaves
DE4136416C2 (de) 1991-11-05 1994-01-13 Gossler Kg Oscar Vorrichtung zur Mikrowellen-Bestrahlung von Materialien
WO1994004906A1 (en) * 1992-08-12 1994-03-03 Biogenex Laboratories Enhancement of immunochemical staining in aldehyde-fixed tissues
US5422277A (en) * 1992-03-27 1995-06-06 Ortho Diagnostic Systems Inc. Cell fixative composition and method of staining cells without destroying the cell surface
DE4223116A1 (de) 1992-04-30 1993-11-04 Mikrowellen Labor Systeme Vorrichtung zur verdampfungsbehandlung von vorzugsweise fluessigen stoffen, insbesondere reagenzstoffen, oder zum aufbereiten oder analysieren von probenmaterial
JPH06182718A (ja) * 1992-05-21 1994-07-05 Nara Pref Gov 樹脂含浸竹材の製造方法、およびこの樹脂含浸竹材の製造方法によって製造された樹脂含浸竹材、ならびにこの樹脂含浸竹材を用いて製造した編み針
US5401625A (en) 1993-06-24 1995-03-28 E. K. Industries, Inc. Histological composition for light microscopy
US5830417A (en) 1993-09-24 1998-11-03 Duquesne University Of The Holy Ghost Method and apparatus for microwave assisted chemical reactions
EP0728038B1 (de) 1993-11-11 1998-07-08 LAUTENSCHLÄGER, Werner Vorrichtung zum auslösen und/oder fördern chemischer oder physikalischer prozesse in einem material, insbesondere probenmaterial
US5432056A (en) * 1993-11-15 1995-07-11 Ventana Medical Systems, Inc. Bisulfite-based tissue fixative
US5431952A (en) 1994-02-28 1995-07-11 Board Of Trustees Operating Michigan State University Method for preservation of biological tissue
US6451551B1 (en) 1994-03-11 2002-09-17 Biogenex Laboratories Releasing embedding media from tissue specimens
EP0751809B1 (de) 1994-03-22 1998-11-11 LAUTENSCHLÄGER, Werner Vorrichtung zum aufbereiten und/oder extrahieren von proben mittels eines verdampfungsfähigen mittels bei erhöhter temperatur
CA2147593C (en) 1994-04-22 2008-07-29 Hyman C. Birnboim Dual purpose tissue fixative
US5532462A (en) 1994-04-29 1996-07-02 Communications & Power Industries Method of and apparatus for heating a reaction vessel with microwave energy
US5712605A (en) 1994-05-05 1998-01-27 Hewlett-Packard Co. Microwave resonator
CA2153215A1 (en) 1994-07-06 1996-01-07 Lu Wang Treatment of paraffin embedded tissue for gene analysis
WO1996021075A1 (de) 1995-01-05 1996-07-11 Lautenschlaeger Werner Vorrichtung zur wärmebehandlung von materialien in einer heizkammer
DE19503591A1 (de) 1995-02-03 1996-08-08 Werner Lautenschlaeger Verfahren und Vorrichtung zur Extraktions-Behandlung einer Probe
US5625706A (en) 1995-05-31 1997-04-29 Neopath, Inc. Method and apparatus for continously monitoring and forecasting slide and specimen preparation for a biological specimen population
US5796080A (en) 1995-10-03 1998-08-18 Cem Corporation Microwave apparatus for controlling power levels in individual multiple cells
US6072086A (en) 1996-04-12 2000-06-06 Intergen Company Method and composition for controlling formaldehyde fixation by delayed quenching
ES2119535T3 (es) 1996-08-02 1998-10-01 Milestone Srl Procedimiento para procesar muestras organicas.
DE19639021A1 (de) 1996-09-23 1998-03-26 Mikrowellen Systeme Mws Gmbh Vorrichtung und Verfahren zum Behandeln einer chemischen Substanz durch Erhitzen unter Druck
DE19639022B4 (de) 1996-09-23 2013-03-21 Mwt Mikrowellen Labor Technik Ag Verfahren und Vorrichtung zum Herstellen hochreiner flüssiger Chemikalien
US5679333A (en) * 1996-10-25 1997-10-21 Dunphy; Brian William Formaldehyde-free tissue preservative compositions
DE19652339A1 (de) 1996-12-17 1998-06-18 Microm Laborgeraete Gmbh Vorrichtung zur Behandlung von Objekten
DE19652784A1 (de) 1996-12-19 1998-06-25 Dade Behring Marburg Gmbh Vorrichtung (Küvette) zur Aufnahme und Speicherung von Flüssigkeiten und zur Durchführung optischer Messungen
AU3615297A (en) 1997-07-15 1999-02-10 Bernard Pajak Method for fixing and embedding tissues for histological preparations
US6207408B1 (en) * 1997-08-20 2001-03-27 University Of Miami High quality, continuous throughput, tissue fixation-dehydration-fat removal-impregnation method
US6793890B2 (en) 1997-08-20 2004-09-21 The University Of Miami Rapid tissue processor
US6017725A (en) 1997-08-21 2000-01-25 Aaper Alcohol And Chemical Company Cytological fixative and dehydrating agent for treating histological and cytological tissue
US6183995B1 (en) 1997-09-05 2001-02-06 Lifespan Biosciences, Inc. Methods of measuring gene expression using wax-embedded tissue specimens
US6033912A (en) 1997-11-13 2000-03-07 Milestone S.R.L. Method of controlling a chemical process heated by microwave radiation
DK1080228T3 (da) 1998-05-18 2010-08-16 Igenex Inc In situ hybridiseringsfremgangsmåde til detektering af target-nukleinsyrer
ATE268470T1 (de) 1998-06-30 2004-06-15 Lamina Inc Zytologische und histologische fixier- zusammensetzung und verfahren zur verwendung
US6054695A (en) 1998-07-30 2000-04-25 Milestone S.R.L. Apparatus for condensing gases within a microwave radiation field
US6242723B1 (en) 1998-07-30 2001-06-05 Milestone S.R.L. Apparatus for performing chemical and physical processes without sample transfer within a microwave radiation field
US6204375B1 (en) 1998-07-31 2001-03-20 Ambion, Inc. Methods and reagents for preserving RNA in cell and tissue samples
DE19928820A1 (de) 1999-06-17 2000-12-21 Ulrich Groth Fixiermittel für Zellen und Gewebe von Lebewesen
WO2001004634A1 (en) * 1999-07-08 2001-01-18 Lee Angros Antigen recovery and/or staining apparatus and method
US6916608B2 (en) 1999-09-10 2005-07-12 Becton, Dickinson And Company Composition for providing long term stability to cells for diagnostic testing
US6291180B1 (en) 1999-09-29 2001-09-18 American Registry Of Pathology Ultrasound-mediated high-speed biological reaction and tissue processing
US6248535B1 (en) 1999-12-20 2001-06-19 University Of Southern California Method for isolation of RNA from formalin-fixed paraffin-embedded tissue specimens
US6337189B1 (en) * 2000-02-08 2002-01-08 Streck Laboratories, Inc. Fixative system, method and composition for biological testing
US6329645B2 (en) 2000-03-03 2001-12-11 Ted Pella, Inc. Apparatus for dampening standing wave pattern generation in microwave oven
DE10015794A1 (de) 2000-03-27 2001-10-11 Univ Schiller Jena Vorrichtung zur Durchführung chemischer Reaktionen und Prozesse in Hochfrequenzfeldern
ATE237798T1 (de) * 2000-05-18 2003-05-15 Precisa Instr Ag Automatische probenpräparation
DE10037417A1 (de) 2000-07-24 2002-02-07 Friedrich Schiller Uni Jena Bu Vorrichtung zur Durchführung multipler chemischer Reaktionen und Prozesse in Hochfrequenzfeldern
DE10104320A1 (de) * 2001-01-25 2002-08-01 Univ Schiller Jena Vorrichtung zur Erfüllung von Sicherheitsfunktionen in Räumen mit Hochfrequenzstrahlung
US6875583B2 (en) 2001-05-22 2005-04-05 Ted Pella, Inc. Rapid microwave-assisted fixation of fresh tissue
US7297311B2 (en) 2001-06-29 2007-11-20 Sysmex Corporation Automatic smear preparing apparatus and automatic sample analysis system having the same
US6458598B1 (en) 2001-08-13 2002-10-01 Dako A/S Process for preparing and presenting a tissue sample for histological study
US20030127313A1 (en) * 2001-12-20 2003-07-10 Milestone S.R.L. Device for closing a pot-like digestion vessel
DE20120649U1 (de) * 2001-12-20 2002-04-18 Mikrowellen Labor Systeme Vorrichtung zum Verschließen eines topfförmigen Aufschlussbehälters
US20030194352A1 (en) * 2001-12-20 2003-10-16 Milestone S.R.L. Device for closing a plurality of digestion vessesls
US6797928B2 (en) 2002-04-23 2004-09-28 Ted Pella, Inc. Method and apparatus for the rapid decalcification and fixation of mineralized tissues
US7138226B2 (en) 2002-05-10 2006-11-21 The University Of Miami Preservation of RNA and morphology in cells and tissues
EP2237013B1 (de) 2002-10-31 2012-06-06 University of Massachusetts Verfahren und Vorrichtung zur raschen Zellblockeinbettung
EP1455174B1 (de) 2003-03-05 2004-12-15 Milestone S.r.l. Fixierungslösung
EP1464388A1 (de) * 2003-04-04 2004-10-06 Mikrowellen-Systeme MWS GmbH Mikrowellen-Behandlung von chemischen Substanzen in einem Behälter
KR200327028Y1 (ko) 2003-06-17 2003-09-19 장시창 인체조직검사기구
US7470401B2 (en) * 2003-10-24 2008-12-30 The University Of Miami Simplified tissue processing
ATE416368T1 (de) 2004-06-07 2008-12-15 Milestone Srl Verfahren und vorrichtung zur mikrowellen- unterstützten automatischen gewebebehandlung
US7273587B1 (en) 2004-12-02 2007-09-25 Collaborative Laboratory Services, Llc Rapid tissue processing method and apparatus
US7273720B1 (en) 2004-12-02 2007-09-25 Collaborative Laboratory Services, Llc Rapid tissue processing method and apparatus
AT503448B1 (de) * 2006-03-29 2007-10-15 Leica Mikrosysteme Gmbh Gerät zur präparation biologischer proben für die elektronenmikroskopie
AT504371B8 (de) * 2006-10-03 2008-09-15 Leica Mikrosysteme Gmbh Vorrichtung zur mikrowellen-gestützten präparation von proben

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US20010000487A1 (en) 2001-04-26
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US7547538B2 (en) 2009-06-16
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US6207408B1 (en) 2001-03-27
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US6586713B2 (en) 2003-07-01
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