KR102861303B1 - Ｋｒａｓ ｇ12ｃ 억제제 - Google Patents

Ｋｒａｓ ｇ12ｃ 억제제

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Publication number
KR102861303B1
KR102861303B1 KR1020207016494A KR20207016494A KR102861303B1 KR 102861303 B1 KR102861303 B1 KR 102861303B1 KR 1020207016494 A KR1020207016494 A KR 1020207016494A KR 20207016494 A KR20207016494 A KR 20207016494A KR 102861303 B1 KR102861303 B1 KR 102861303B1
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mmol
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optionally substituted
formula
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KR20200100632A (ko
Inventor
제임스 에프. 블레이크
로렌스 이. 버제스
마크 조셉 차카렐리
제임스 게일 크리스텐센
아담 쿡
제이 브래드포드 펠
존 피. 피셔
매튜 아놀드 마르크스
마케도니아 제이. 메지아
파벨 사베첸코프
가이 피.에이. 비저스
크리스토퍼 로날드 스미스
마르다 이. 로드리게즈
Original Assignee
미라티 테라퓨틱스, 인크.
어레이 바이오파마 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020207016494A 2017-11-15 2018-11-14 Ｋｒａｓ ｇ12ｃ 억제제 Active KR102861303B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762586775P 2017-11-15 2017-11-15
US62/586,775 2017-11-15
PCT/US2018/061060 WO2019099524A1 (en) 2017-11-15 2018-11-14 Kras g12c inhibitors

Publications (2)

Publication Number Publication Date
KR20200100632A KR20200100632A (ko) 2020-08-26
KR102861303B1 true KR102861303B1 (ko) 2025-09-17

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EP (3) EP3710439B1 (https=)
JP (2) JP7322019B2 (https=)
KR (1) KR102861303B1 (https=)
CN (2) CN111989321B (https=)
AU (1) AU2018369759B2 (https=)
BR (1) BR112020009818A2 (https=)
CA (1) CA3082579A1 (https=)
CL (1) CL2020001271A1 (https=)
CO (1) CO2020007244A2 (https=)
CY (2) CY1125974T1 (https=)
DK (1) DK3710439T3 (https=)
EA (1) EA202091186A1 (https=)
ES (2) ES2944547T3 (https=)
FI (2) FI3710439T3 (https=)
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HR (1) HRP20230377T1 (https=)
HU (2) HUE061599T2 (https=)
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LT (2) LT3710439T (https=)
MX (1) MX2020005063A (https=)
MY (1) MY200356A (https=)
NL (1) NL301279I2 (https=)
PH (1) PH12020550622A1 (https=)
PL (1) PL3710439T3 (https=)
PT (1) PT3710439T (https=)
RS (1) RS64182B1 (https=)
SA (1) SA520411982B1 (https=)
SG (1) SG11202004427TA (https=)
SI (1) SI3710439T1 (https=)
TW (1) TWI809005B (https=)
UA (1) UA125802C2 (https=)
WO (2) WO2019099524A1 (https=)
ZA (1) ZA202002105B (https=)

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