KR102467714B1 - 인간 대상체에서 안구 질병을 치료하기 위한 방법 및 장치 - Google Patents
인간 대상체에서 안구 질병을 치료하기 위한 방법 및 장치 Download PDFInfo
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- KR102467714B1 KR102467714B1 KR1020217008160A KR20217008160A KR102467714B1 KR 102467714 B1 KR102467714 B1 KR 102467714B1 KR 1020217008160 A KR1020217008160 A KR 1020217008160A KR 20217008160 A KR20217008160 A KR 20217008160A KR 102467714 B1 KR102467714 B1 KR 102467714B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A—HUMAN NECESSITIES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
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- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Biotechnology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020217034816A KR20210133321A (ko) | 2012-11-08 | 2013-11-08 | 인간 대상체에서 안구 질병을 치료하기 위한 방법 및 장치 |
Applications Claiming Priority (18)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261724144P | 2012-11-08 | 2012-11-08 | |
| US61/724,144 | 2012-11-08 | ||
| US201261734872P | 2012-12-07 | 2012-12-07 | |
| US61/734,872 | 2012-12-07 | ||
| US201261745237P | 2012-12-21 | 2012-12-21 | |
| US61/745,237 | 2012-12-21 | ||
| US201361773124P | 2013-03-05 | 2013-03-05 | |
| US61/773,124 | 2013-03-05 | ||
| US201361785229P | 2013-03-14 | 2013-03-14 | |
| US61/785,229 | 2013-03-14 | ||
| US201361819388P | 2013-05-03 | 2013-05-03 | |
| US61/819,388 | 2013-05-03 | ||
| US201361873660P | 2013-09-04 | 2013-09-04 | |
| US61/873,660 | 2013-09-04 | ||
| US201361898926P | 2013-11-01 | 2013-11-01 | |
| US61/898,926 | 2013-11-01 | ||
| PCT/US2013/069156 WO2014074823A1 (en) | 2012-11-08 | 2013-11-08 | Methods and devices for the treatment of ocular diseases in human subjects |
| KR1020157015062A KR20150083117A (ko) | 2012-11-08 | 2013-11-08 | 인간 대상체에서 안구 질병을 치료하기 위한 방법 및 장치 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157015062A Division KR20150083117A (ko) | 2012-11-08 | 2013-11-08 | 인간 대상체에서 안구 질병을 치료하기 위한 방법 및 장치 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217034816A Division KR20210133321A (ko) | 2012-11-08 | 2013-11-08 | 인간 대상체에서 안구 질병을 치료하기 위한 방법 및 장치 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20210032571A KR20210032571A (ko) | 2021-03-24 |
| KR102467714B1 true KR102467714B1 (ko) | 2022-11-16 |
Family
ID=50685178
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217008160A Active KR102467714B1 (ko) | 2012-11-08 | 2013-11-08 | 인간 대상체에서 안구 질병을 치료하기 위한 방법 및 장치 |
| KR1020157015062A Ceased KR20150083117A (ko) | 2012-11-08 | 2013-11-08 | 인간 대상체에서 안구 질병을 치료하기 위한 방법 및 장치 |
| KR1020217034816A Ceased KR20210133321A (ko) | 2012-11-08 | 2013-11-08 | 인간 대상체에서 안구 질병을 치료하기 위한 방법 및 장치 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157015062A Ceased KR20150083117A (ko) | 2012-11-08 | 2013-11-08 | 인간 대상체에서 안구 질병을 치료하기 위한 방법 및 장치 |
| KR1020217034816A Ceased KR20210133321A (ko) | 2012-11-08 | 2013-11-08 | 인간 대상체에서 안구 질병을 치료하기 위한 방법 및 장치 |
Country Status (15)
| Country | Link |
|---|---|
| US (10) | US20150258120A1 (enExample) |
| EP (3) | EP4566672A3 (enExample) |
| JP (5) | JP6487848B2 (enExample) |
| KR (3) | KR102467714B1 (enExample) |
| CN (2) | CN104884049A (enExample) |
| AU (2) | AU2013342275B2 (enExample) |
| BR (1) | BR112015010566A2 (enExample) |
| CA (3) | CA3240136A1 (enExample) |
| EA (1) | EA034963B1 (enExample) |
| ES (2) | ES2813869T3 (enExample) |
| IL (1) | IL238432B (enExample) |
| MX (2) | MX373894B (enExample) |
| PH (1) | PH12015500986A1 (enExample) |
| SG (1) | SG11201503637SA (enExample) |
| WO (1) | WO2014074823A1 (enExample) |
Families Citing this family (198)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0610308A8 (pt) | 2005-05-26 | 2017-04-25 | Neuron Systems Inc | Composições e métodos para o tratamento de doença retinal |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| EA201692543A1 (ru) | 2005-11-23 | 2017-08-31 | Акселерон Фарма Инк. | Антагонисты активина-actriia и их применение для стимулирования роста кости |
| US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
| EP3252079B8 (en) | 2006-04-07 | 2020-09-09 | Aerpio Therapeutics LLC | Antibodies that bind human protein tyrosine phosphatase beta (hptp-beta) and uses thereof |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| CA2677007A1 (en) | 2007-02-01 | 2008-08-07 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for treating or preventing breast cancer |
| TWI782836B (zh) | 2007-02-02 | 2022-11-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
| CA3039330C (en) | 2007-02-09 | 2021-11-09 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for promoting bone growth in cancer patients |
| CN103877564A (zh) | 2007-09-18 | 2014-06-25 | 阿塞勒隆制药公司 | 活化素-actriia拮抗剂和减少或抑制fsh分泌的用途 |
| JP5922928B2 (ja) | 2008-08-14 | 2016-05-24 | アクセルロン ファーマ, インコーポレイテッド | 赤血球レベルを高めるためのgdfトラップの使用 |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| EP2440577A4 (en) | 2009-06-12 | 2013-01-23 | Acceleron Pharma Inc | SHORTEN ACTRIIB FC FUSION PROTEINS |
| PL2451279T3 (pl) | 2009-07-06 | 2019-09-30 | Aerpio Therapeutics, Inc. | Pochodne benzosulfonamidowe, ich kompozycje i ich zastosowanie w zapobieganiu przerzutom komórek nowotworowych |
| ES2658292T3 (es) | 2009-11-17 | 2018-03-09 | Acceleron Pharma, Inc. | Proteínas ActRIIB y variantes y usos de las mismas con respecto a la inducción de la utrofina para el tratamiento de la distrofia muscular |
| US9814701B2 (en) | 2009-12-11 | 2017-11-14 | Aldeyra Therapeutics, Inc. | Compositions and methods for the treatment of macular degeneration |
| WO2011106702A2 (en) | 2010-02-25 | 2011-09-01 | The Johns Hopkins University | Sustained delivery of therapeutic agents to an eye compartment |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP3431485B2 (en) | 2010-10-01 | 2024-09-04 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| BR112013009205A2 (pt) | 2010-10-15 | 2016-07-26 | Iscience Interventional Corp | dispositivo para colocação na esclera de um olho, método para acessar o espaço supracoroidal de um olho, para acessar o espaço subretinal de um olho e para colocar um orifício dentro de um trato escleral em um olho. |
| CN103298832A (zh) | 2010-11-08 | 2013-09-11 | 阿塞勒隆制药公司 | Actriia结合剂及其用途 |
| WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2763701B1 (en) | 2011-10-03 | 2018-12-19 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| AU2012323856B2 (en) | 2011-10-13 | 2017-05-25 | EyePoint Pharmaceuticals, Inc. | Methods for treating Vascular Leak Syndrome and cancer |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| MX366336B (es) | 2012-11-02 | 2019-07-05 | Celgene Corp | Antagonistas de activina - actrii y usos para el tratar trastornos oseos y otros. |
| CA3240136A1 (en) * | 2012-11-08 | 2014-05-15 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
| CA2892529C (en) | 2012-11-26 | 2023-04-25 | Moderna Therapeutics, Inc. | Terminally modified rna |
| EP2945931A4 (en) * | 2013-01-18 | 2016-10-12 | Advenchen Pharmaceuticals Llc | PROCESS FOR THE PREPARATION OF ANTITUMOR AGENT, 6- (7 - ((1-AMINO-CYCLO-PROPYL) -METHOXY) -6-METHOXYQUINOLIN-4-YLOXY) -N-METHYL-1-NAPHTHAMIDE, AND His crystalline form |
| CN105120866B (zh) | 2013-01-23 | 2020-02-14 | 奥尔德拉医疗公司 | 与毒性醛相关的疾病和治疗 |
| WO2014138085A1 (en) | 2013-03-05 | 2014-09-12 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Thermoresponsive hydrogel containing polymer microparticles for noninvasive ocular drug delivery |
| US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| SG10201702674PA (en) | 2013-05-03 | 2017-06-29 | Clearside Biomedical Inc | Apparatus and methods for ocular injection |
| CA2913092A1 (en) * | 2013-05-24 | 2014-11-27 | Bayer Healthcare Llc | Treatment of polypoidal choroidal vasculopathy |
| EP3003454B1 (en) | 2013-06-03 | 2020-01-08 | Clearside Biomedical, Inc. | Apparatus for drug delivery using multiple reservoirs |
| EP3010525A1 (en) * | 2013-06-20 | 2016-04-27 | Novartis AG | Use of a vegf antagonist in treating choroidal neovascularisation |
| USD756524S1 (en) * | 2013-08-05 | 2016-05-17 | Xialing Zhang | Protective cover for a subdermal needle electrode cable assembly |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EA201690675A1 (ru) | 2013-10-03 | 2016-08-31 | Модерна Терапьютикс, Инк. | Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности |
| WO2015088277A1 (ko) | 2013-12-12 | 2015-06-18 | 삼성메디슨 주식회사 | 초음파 영상 표시 방법 및 장치 |
| US10010447B2 (en) | 2013-12-18 | 2018-07-03 | Novartis Ag | Systems and methods for subretinal delivery of therapeutic agents |
| WO2015108787A2 (en) * | 2014-01-16 | 2015-07-23 | Retinal Therapies LLC | Compositions and methods for the treatment of intraocular neovascularization and/or leakage |
| CN106687078B (zh) | 2014-02-12 | 2019-10-25 | 轨道生物医学有限公司 | 用于治疗剂的脉络膜上施用的方法和设备 |
| US9994560B2 (en) | 2014-03-14 | 2018-06-12 | Aerpio Therapeutics, Inc. | HPTP-β inhibitors |
| WO2015168619A1 (en) * | 2014-05-02 | 2015-11-05 | Mayo Foundation For Medical Education And Research | Individualized treatment of eye disease |
| US9925088B2 (en) | 2014-06-06 | 2018-03-27 | Janssen Biotech, Inc. | Sub-retinal tangential needle catheter guide and introducer |
| US9949874B2 (en) | 2014-06-06 | 2018-04-24 | Janssen Biotech, Inc. | Therapeutic agent delivery device with convergent lumen |
| AU2015274277B2 (en) | 2014-06-13 | 2021-03-18 | Acceleron Pharma, Inc. | Methods and compositions for treating ulcers |
| EP3157463A4 (en) * | 2014-06-17 | 2018-02-21 | Clearside Biomedical, Inc. | Methods and devices for treating posterior ocular disorders |
| RU2710491C2 (ru) | 2014-06-20 | 2019-12-26 | Клиасайд Байомедикал, Инк. | Устройство для инъекции лекарственного средства в глазную ткань и способ инъекции лекарственного средства в глазную ткань |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| ES2969374T3 (es) | 2014-07-30 | 2024-05-17 | Massachusetts Eye & Ear Infirmary | Metotrexato para la vitreorretinopatía proliferativa |
| US10219936B2 (en) | 2014-09-11 | 2019-03-05 | Orbit Biomedical Limited | Therapeutic agent delivery device with advanceable cannula and needle |
| US10258502B2 (en) | 2014-09-18 | 2019-04-16 | Orbit Biomedical Limited | Therapeutic agent delivery device |
| AU2015345322A1 (en) | 2014-11-10 | 2017-04-06 | F. Hoffmann-La Roche Ag | Anti-PDGF-B antibodies and methods of use |
| CA2963606A1 (en) | 2014-11-10 | 2016-05-19 | F.Hoffmann-La Roche Ag | Anti-ang2 antibodies and methods of use |
| SG11201703428SA (en) | 2014-11-10 | 2017-05-30 | Hoffmann La Roche | Bispecific antibodies and methods of use in ophthalmology |
| WO2016075034A1 (en) | 2014-11-10 | 2016-05-19 | F. Hoffmann-La Roche Ag | ANTI-IL-1beta ANTIBODIES AND METHODS OF USE |
| JPWO2016093299A1 (ja) * | 2014-12-10 | 2017-09-21 | 千寿製薬株式会社 | 水性液剤 |
| TWI597051B (zh) * | 2015-04-16 | 2017-09-01 | 林伯剛 | 高半胱胺酸用於偵測及診斷人類眼部之息肉狀脈絡膜血管病變的用途及方法 |
| TWI773641B (zh) | 2015-05-08 | 2022-08-11 | 日商活效製藥股份有限公司 | 含有糖皮質類固醇(glucocorticoids)之奈米微粒子之水性懸浮液劑 |
| WO2016200688A1 (en) * | 2015-06-06 | 2016-12-15 | Cloudbreak Therapeutics, Llc | Compositions and methods for treating pterygium |
| EP3103491A1 (en) * | 2015-06-10 | 2016-12-14 | Sanofi-Aventis Deutschland GmbH | A device for attachment to a drug delivery device |
| WO2016205334A1 (en) | 2015-06-16 | 2016-12-22 | Vascular Strategies Llc | Drug delivery and imaging chemical conjugate, formulations and methods of use thereof |
| TWI700085B (zh) * | 2015-06-22 | 2020-08-01 | 新源生物科技股份有限公司 | 酪胺酸激酶抑制劑之眼用調配物的用途 |
| KR101778004B1 (ko) * | 2015-06-22 | 2017-09-15 | (주) 에빅스젠 | 이마티닙을 유효성분으로 포함하는 안구 건조 질환 예방 및 치료용 약학 조성물 |
| WO2016209972A1 (en) * | 2015-06-26 | 2016-12-29 | Amgen Inc. | Biomarker of survival in the treatment of renal cell carcinoma with a vegfr inhibitor and an ang2 inhibitor |
| WO2017015604A1 (en) * | 2015-07-23 | 2017-01-26 | Envisia Therapeutics, Inc. | Intravitreal drug delivery systems for the treatment of ocular conditions |
| BR112018001853A2 (pt) * | 2015-07-31 | 2018-09-25 | Astrazeneca Pharmaceuticals Lp | métodos para tratamento de um distúrbio e para melhoria do tratamento de um distúrbio |
| WO2017035077A1 (en) | 2015-08-21 | 2017-03-02 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
| CN113713101B (zh) | 2015-09-23 | 2023-07-28 | 视点制药公司 | 用tie-2的激活剂治疗眼内压的方法 |
| EP3368074A2 (en) * | 2015-10-30 | 2018-09-05 | Hoffmann-La Roche AG | Anti-factor d antibodies and conjugates |
| CN108295072A (zh) * | 2015-12-09 | 2018-07-20 | 瑞阳(苏州)生物科技有限公司 | 尼达尼布防治眼部疾病的用途 |
| CN119857095A (zh) * | 2015-12-17 | 2025-04-22 | 林科杰诺米克斯股份有限公司 | 脉络膜新生血管抑制剂或玻璃膜疣抑制剂及其评价或筛选方法 |
| CN105496957A (zh) * | 2015-12-22 | 2016-04-20 | 中山大学中山眼科中心 | 一种吡非尼酮缓释滴眼液 |
| WO2017117464A1 (en) | 2015-12-30 | 2017-07-06 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
| WO2017120600A1 (en) * | 2016-01-08 | 2017-07-13 | Clearside Biomedical, Inc. | Compositions and methods of treating wet age-related macular degeneration |
| EP3400014A1 (en) * | 2016-01-08 | 2018-11-14 | Clearside Biomedical, Inc. | Methods and devices for treating posterior ocular disorderswith aflibercept and other biologics |
| BR112018014467A2 (en) * | 2016-02-04 | 2018-12-11 | Ni Jinsong | drug-antibody synergism technology for disease treatment |
| CN109069530A (zh) | 2016-02-28 | 2018-12-21 | 奥尔德拉医疗公司 | 用环糊精治疗过敏性眼部病状 |
| US10478553B2 (en) | 2016-03-09 | 2019-11-19 | Orbit Biomedical Limited | Apparatus for subretinal administration of therapeutic agent via a curved needle |
| KR102802736B1 (ko) * | 2016-03-10 | 2025-05-02 | 비엘라 바이오, 인크. | Ilt7 결합 분자 및 이의 사용 방법 |
| WO2017165449A1 (en) * | 2016-03-22 | 2017-09-28 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Thermoresponsive hydrogel containing polymer microparticles for noninvasive ocular biologic delivery |
| MA44873A (fr) | 2016-04-15 | 2019-03-13 | Univ Pennsylvania | Composition pour le traitement de la dégénérescence maculaire liée a l'âge exsudative |
| JP2019514581A (ja) | 2016-05-02 | 2019-06-06 | クリアサイド バイオメディカル,インコーポレイテッド | 眼の薬物送達のためのシステムおよび方法 |
| CA3022665A1 (en) * | 2016-05-09 | 2017-11-16 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
| KR102408596B1 (ko) | 2016-06-02 | 2022-06-13 | 에이디에스 테라퓨틱스 엘엘씨 | 비정상적 신생혈관이 있는 안구 질환 치료를 위한, 닌테다닙을 사용하는 조성물 및 방법 |
| US11000410B2 (en) | 2016-06-17 | 2021-05-11 | Gyroscope Therapeutics Limited | Guide apparatus for tangential entry into suprachoroidal space |
| US10646374B2 (en) | 2016-06-17 | 2020-05-12 | Orbit Biomedical Limited | Apparatus and method to form entry bleb for subretinal delivery of therapeutic agent |
| US10806629B2 (en) | 2016-06-17 | 2020-10-20 | Gyroscope Therapeutics Limited | Injection device for subretinal delivery of therapeutic agent |
| WO2018017714A1 (en) | 2016-07-20 | 2018-01-25 | Aerpio Therapeutics, Inc. | HUMANIZED MONOCLONAL ANTIBODIES THAT TARGET VE-PTP (HPTP-ß) |
| US11278546B2 (en) * | 2016-07-22 | 2022-03-22 | Aiviva Biopharma, Inc. | Multikinase inhibitors and uses in ocular fibrosis |
| IL264764B2 (en) | 2016-08-12 | 2024-02-01 | Clearside Biomedical Inc | Devices and methods for adjusting the insertion depth of a drug administration needle |
| US10772885B2 (en) | 2016-09-26 | 2020-09-15 | Reyoung (Suzhou) Biology Science & Technology Co., Ltd. | Composition for treating ocular diseases and methods of usage and making |
| KR20190134591A (ko) * | 2016-12-15 | 2019-12-04 | 프로젠 피지500 시리즈 피티와이 리미티드 | 조성물 및 그의 용도 |
| EP3554582A4 (en) | 2016-12-16 | 2020-06-24 | The Brigham and Women's Hospital, Inc. | System and method for resistance-dependent, self-regulated medical penetration |
| US11273072B2 (en) | 2017-01-13 | 2022-03-15 | Gyroscope Therapeutics Limited | Suprachoroidal injection device |
| SG11201906852XA (en) | 2017-02-01 | 2019-08-27 | Univ Yale | Treatment of diuretic resistance |
| WO2018162271A1 (en) * | 2017-03-05 | 2018-09-13 | Rita Dobmeyer | Nanoparticles for the treatment of macular degeneration |
| US11076984B2 (en) | 2017-03-13 | 2021-08-03 | Gyroscope Therapeutics Limited | Method of performing subretinal drainage and agent delivery |
| CN110431130A (zh) | 2017-03-16 | 2019-11-08 | 奥尔德拉医疗公司 | 多晶型化合物和其用途 |
| RU2643955C1 (ru) * | 2017-04-19 | 2018-02-06 | Галина Мэлсовна Чернакова | Способ отбора и подготовки пробы клеток конъюнктивы для проведения бактериологического, вирусологического и иммунологического исследований |
| WO2018204515A1 (en) * | 2017-05-02 | 2018-11-08 | Georgia Tech Research Corporation | Targeted drug delivery methods using a microneedle |
| WO2018207182A1 (en) * | 2017-05-08 | 2018-11-15 | Hadasit Medical Research Services & Development Ltd. | Biomarker for anti-tnf therapy in retinal diseases |
| JP7278969B2 (ja) * | 2017-05-30 | 2023-05-22 | エキシモア・リミテッド | ドライアイ症候群を治療するための抗生物質マクロライドを送達する組成物および方法 |
| US11786607B2 (en) | 2017-06-15 | 2023-10-17 | Modernatx, Inc. | RNA formulations |
| WO2019018350A1 (en) * | 2017-07-17 | 2019-01-24 | Keith Roizman | TOPICAL ADMINISTRATION OF THERAPEUTIC AGENTS COMPRISING CELL PENETRATION PEPTIDES, FOR USE IN THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION AND OTHER OCULAR DISEASES |
| MX2020002348A (es) | 2017-08-31 | 2020-10-08 | Modernatx Inc | Métodos de elaboración de nanopartículas lipídicas. |
| WO2019055594A1 (en) | 2017-09-13 | 2019-03-21 | North Carolina State University | BRUSHING ADIPOSE TISSUE INDUCED LOCALLY BY MICRO-NEEDLE STAMPS FOR THE TREATMENT OF OBESITY |
| EP3681471B1 (en) * | 2017-09-15 | 2025-03-05 | Oxular Limited | Ophthalmic delivery device |
| US11883541B2 (en) | 2017-10-02 | 2024-01-30 | The Johns Hopkins University | Nonviral gene transfer to the suprachoroidal space |
| CN111356451A (zh) | 2017-10-10 | 2020-06-30 | 奥尔德拉医疗公司 | 炎性病症的治疗 |
| CN107815453B (zh) * | 2017-10-23 | 2020-08-07 | 中山大学中山眼科中心 | 一种核酸适配子及其用途 |
| US20200316225A1 (en) * | 2017-11-29 | 2020-10-08 | Copernicus Therapeutics, Inc. | Gene Therapy For Ocular Improvement |
| CN111512160B (zh) * | 2017-12-21 | 2024-04-09 | 豪夫迈·罗氏有限公司 | Htra1 rna拮抗剂的伴随诊断 |
| US11844919B2 (en) | 2018-01-03 | 2023-12-19 | The Trustees Of Columbia University In The City Of New York | Microneedle for local delivery of therapeutic agent |
| SG11202006157VA (en) | 2018-01-05 | 2020-07-29 | Corvidia Therapeutics Inc | Methods for treating il-6 mediated inflammation without immunosuppression |
| US20200345637A1 (en) * | 2018-01-19 | 2020-11-05 | Aiviva Biopharma, Inc. | Suspension compositions of multi-target inhibitors |
| US11524053B2 (en) | 2018-01-26 | 2022-12-13 | The Regents Of The University Of California | Methods and compositions for treatment of angiogenic disorders using anti-VEGF agents |
| WO2019161272A1 (en) | 2018-02-15 | 2019-08-22 | North Carolina State University | Synthesis of micron and nanoscale carbon spheres and structures using hydrothemal carbonization |
| BR112020017872A2 (pt) | 2018-03-02 | 2020-12-22 | Kodiak Sciences Inc. | Anticorpos de il-6 e construtos de fusão e conjugados dos mesmos |
| CN108452309B (zh) * | 2018-03-05 | 2019-08-23 | 佳木斯大学附属第一医院 | 一种用于预防或治疗视神经炎的药物组合物及其制备方法 |
| US20190269702A1 (en) * | 2018-03-05 | 2019-09-05 | Clearside Biomedical, Inc. | Compositions and methods for treating noninfectious uveitis |
| JP7484708B2 (ja) * | 2018-04-18 | 2024-05-16 | 株式会社ニコン | 画像処理方法、プログラム、及び画像処理装置 |
| WO2019217678A1 (en) * | 2018-05-09 | 2019-11-14 | North Carolina State University | Applicator for corneal therapeutics |
| NZ770284A (en) | 2018-05-10 | 2025-11-28 | Regeneron Pharma | High concentration vegf receptor fusion protein containing formulations |
| JP7365056B6 (ja) * | 2018-05-25 | 2023-12-15 | エーディーエス・セラピューティクス・エルエルシー | 眼充血を治療するための組成物およびそれを用いて眼充血を治療するための方法 |
| CN113194964A (zh) * | 2018-08-01 | 2021-07-30 | 纳米神经元治疗学股份有限公司 | 神经保护性组合物及其用途 |
| US20210290727A1 (en) * | 2018-08-01 | 2021-09-23 | University Of Maryland, Baltimore | MODULATION OF mTORCI ACTIVITY AND AUTOPHAGY VIA CIB2-RHEB INTERACTION |
| US12006298B2 (en) | 2018-08-06 | 2024-06-11 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| CN112805023A (zh) * | 2018-08-21 | 2021-05-14 | 加州理工学院 | 无渗漏或最小渗漏的脉络膜或视网膜血管再生 |
| CN109187987B (zh) * | 2018-08-23 | 2021-05-11 | 中国人民解放军第三0九医院 | Ms4a3蛋白作为标志物在诊断活动性结核病中的应用 |
| US12090235B2 (en) | 2018-09-20 | 2024-09-17 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| US11197821B2 (en) | 2018-09-25 | 2021-12-14 | Aldeyra Therapeutics, Inc. | Formulations for treatment of dry eye disease |
| CN109172128A (zh) * | 2018-09-28 | 2019-01-11 | 宜邻医疗科技(上海)有限公司 | 一种用于细胞和基因药物注入治疗的精准注射系统 |
| CN110840893A (zh) * | 2018-12-13 | 2020-02-28 | 安罗格制药有限责任公司 | 含克莱拉尼的药物组合物及其用途 |
| CA3124945A1 (en) * | 2018-12-27 | 2020-07-02 | Surface Ophthalmics, Inc. | Ophthalmic pharmaceutical compositions and methods for treating ocular surface disease |
| CN109799216B (zh) * | 2018-12-29 | 2021-11-12 | 佛山科学技术学院 | 一种基于吲哚箐绿纳米的荧光oct双模成像方法和装置 |
| WO2020161342A1 (en) | 2019-02-08 | 2020-08-13 | Curevac Ag | Coding rna administered into the suprachoroidal space in the treatment of ophtalmic diseases |
| JP7706758B2 (ja) | 2019-03-26 | 2025-07-14 | アルデイラ セラピューティクス, インコーポレイテッド | 眼科用製剤およびその使用 |
| JP7668227B2 (ja) * | 2019-04-08 | 2025-04-24 | バイオクライスト ファーマシューティカルズ, インコーポレイテッド | 血漿カリクレイン阻害剤および眼障害におけるその使用方法 |
| CA3136814A1 (en) * | 2019-04-16 | 2020-10-22 | Clearside Biomedical, Inc. | Injectable triamcinolone formulations |
| WO2020223209A1 (en) | 2019-04-29 | 2020-11-05 | Aerpio Pharmaceuticals, Inc. | Tie-2 activators targeting the schlemm's canal |
| CN109999032A (zh) * | 2019-04-30 | 2019-07-12 | 南昌大学 | 雷帕霉素在制备降眼内压的局部滴眼给药药物中的应用 |
| CA3137301A1 (en) | 2019-05-02 | 2020-11-05 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| US12098132B2 (en) | 2019-05-02 | 2024-09-24 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
| WO2020227341A1 (en) * | 2019-05-06 | 2020-11-12 | 9 Meters Biopharma, Inc. | Compositions and methods for treating sjogren's syndrome |
| LT3773558T (lt) * | 2019-05-10 | 2022-09-12 | Synact Pharma Aps | Kompleksinis artrito gydymas |
| US11883525B2 (en) | 2019-05-31 | 2024-01-30 | Dose Medical Corporation | Bioerodible polyester polymer axitinib ocular implants and related methods of use |
| WO2021051003A1 (en) | 2019-09-13 | 2021-03-18 | Aldeyra Therapeutics, Inc. | Ophthalmic formulations of methotrexate |
| WO2021072265A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| IL293131A (en) | 2019-11-25 | 2022-07-01 | Univ California | Long-acting vegf inhibitors for intraocular neovascularization |
| MX2022006439A (es) * | 2019-12-19 | 2022-07-19 | Active Biotech Ab | Compuestos para el tratamiento de enfermedades oculares asociadas con la vascularizacion excesiva. |
| US20230049974A1 (en) * | 2020-01-06 | 2023-02-16 | Shilpa Medicare Ltd | Fingolimod extended release injectable suspension |
| CA3166738A1 (en) | 2020-02-06 | 2021-08-12 | Charles D. Blizzard | Travoprost compositions and methods for treating ocular diseases |
| EP4106755A4 (en) * | 2020-02-19 | 2024-03-27 | Clearside Biomedical, Inc. | COMPOSITIONS CONTAINING AXITINIB AND METHODS FOR TREATING OCULAR DISEASES |
| FI3884929T3 (fi) * | 2020-03-25 | 2023-08-07 | Ocular Therapeutix Inc | Tyrosiinikinaasi-inhibiittoria sisältävä silmäimplantti |
| CN115803009A (zh) | 2020-05-08 | 2023-03-14 | 瑞泽恩制药公司 | 用于治疗眼病和癌症的vegf阱和微阱及方法 |
| EP4149470A4 (en) | 2020-05-13 | 2024-04-24 | Aldeyra Therapeutics, Inc. | Pharmaceutical formulations and uses thereof |
| CN113797164B (zh) * | 2020-06-17 | 2023-07-14 | 成都瑞沐生物医药科技有限公司 | 一种眼用制剂的载体或辅料及其制备方法和应用 |
| CN112168487B (zh) * | 2020-10-30 | 2024-12-17 | 重庆南坪爱尔眼科医院有限公司 | 一种反向青光眼滤过泡疤痕探通器 |
| JP2024507326A (ja) * | 2021-01-22 | 2024-02-19 | チョンドゥー ルイムー バイオファーマスーティカルズ カンパニー リミテッド | 点眼投与により乾燥型黄斑変性症および網膜光障害を予防・治療するための眼科用製剤 |
| US20240199752A1 (en) * | 2021-04-23 | 2024-06-20 | Kirk William Johnson | Treatment of ophthalmic diseases |
| JP2024515220A (ja) | 2021-04-26 | 2024-04-05 | セラニーズ・イーブイエイ・パフォーマンス・ポリマーズ・エルエルシー | 高分子薬剤化合物の持続放出用の埋め込み型デバイス |
| US12440510B2 (en) | 2021-05-10 | 2025-10-14 | Surface Ophthalmics, Inc. | Use of chondroitin sulfate for relieving ocular pain |
| WO2022240598A1 (en) | 2021-05-10 | 2022-11-17 | Surface Ophthalmics, Inc. | Use of chondroitin sulfate for relieving ocular pain |
| WO2022236778A1 (en) | 2021-05-13 | 2022-11-17 | Beijing Sightnovo Medical Technology Co., Ltd | Medical penetration device and system |
| WO2022236779A1 (en) | 2021-05-13 | 2022-11-17 | Beijing Sightnovo Medical Technology Co., Ltd | Medical penetration and drainage for glaucoma treatment |
| US20240342155A1 (en) * | 2021-07-21 | 2024-10-17 | Slbst Pharma, Inc. | Hydroxychloroquine formulations, dosage forms, and methods of use |
| WO2023039168A1 (en) * | 2021-09-09 | 2023-03-16 | The Board Of Trustees Of The Leland Stanford Junior University | Use of verteporfin to modulate wound healing after an ocular surgical procedure or ocular injury |
| EP4147709A1 (en) * | 2021-09-14 | 2023-03-15 | The Provost, Fellows, Foundation Scholars, and The Other Members of Board, of The College of The Holy and Undivided Trinity of Queen Elizabeth | A composition comprising il-36 and/or il-18 for use in treating ocular disorders |
| CN114134195B (zh) * | 2021-11-03 | 2024-06-11 | 南方科技大学 | 预防前列腺癌的药剂的筛选方法、硝唑尼特在制药中的应用 |
| CN114099515A (zh) * | 2021-12-27 | 2022-03-01 | 中山大学中山眼科中心 | 氨甲蝶呤在制备治疗视网膜色素变性的药物方面的应用 |
| USD1037439S1 (en) | 2022-01-17 | 2024-07-30 | EyePoint Pharamaceuticals, Inc. | Ocular injector |
| CA3249878A1 (en) * | 2022-01-24 | 2023-07-27 | Celanese Eva Performance Polymers Llc | METHOD FOR PREVENTING AND/OR TREATING AN EYE CONDITION |
| JP2025517691A (ja) * | 2022-05-10 | 2025-06-10 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 網膜疾患を処置するための超低用量のゾレドロン酸 |
| CN117100874B (zh) * | 2022-05-16 | 2025-10-31 | 苏州维益生物科技有限公司 | 纳米颗粒、其制备和应用、及包括其的眼疾药物及其制备 |
| WO2024044745A2 (en) * | 2022-08-26 | 2024-02-29 | Asclepix Therapeutics, Inc. | Formulations for intraocular delivery of peptides derived from type iv collagen |
| CN117100845A (zh) * | 2022-10-24 | 2023-11-24 | 景泽生物医药(合肥)股份有限公司 | 重组人奥克纤溶酶在制备治疗脉络膜血管疾病药物中的用途 |
| EP4615449A1 (en) * | 2022-11-07 | 2025-09-17 | Weinberg, Assa | Method to prevent and treat diabetic retinopathy by calcium channel blockers, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers |
| EP4615377A1 (en) | 2022-11-11 | 2025-09-17 | Beijing Sightnovo Medical Technology Co., Ltd | Drug-containing devices, suprachoroidal space implants, and adapters for injection |
| US11911385B1 (en) | 2022-12-14 | 2024-02-27 | Aldeyra Therapeutics, Inc. | Methotrexate treatment methods |
| CN120897764A (zh) | 2023-04-11 | 2025-11-04 | 视尔普斯眼科公司 | 包含阿西替尼多晶型物iv的眼部植入物 |
| WO2024226533A1 (en) * | 2023-04-24 | 2024-10-31 | Clearside Biomedical, Inc. | Methods for treating ocular disorders with integrin antagonist composition |
| CN117224314B (zh) * | 2023-08-28 | 2024-04-26 | 叶绿体(北京)生物医药有限公司 | 一种可降解式自密封眼球给药微针及其制备方法与应用 |
| CN119925562B (zh) * | 2023-11-03 | 2025-11-28 | 中国科学院上海药物研究所 | 趋化因子受体2拮抗剂在制备治疗糖尿病并发焦虑症的应用 |
| KR20250119466A (ko) * | 2024-01-31 | 2025-08-07 | (주)노보메디슨 | 캐스파제 저해제의 용도 |
| WO2025169089A1 (en) | 2024-02-05 | 2025-08-14 | Sun Pharmaceutical Industries Limited | Ophthalmic compositions of tyrosine kinase inhibitors and their uses |
| WO2025217214A2 (en) | 2024-04-08 | 2025-10-16 | Regenxbio Inc. | Recombinant adeno-associated viruses and uses thereof |
| WO2025217230A1 (en) | 2024-04-08 | 2025-10-16 | Regenxbio Inc. | Vectorized anti-complement antibodies and complement agents and administration thereof |
| CN119331126B (zh) * | 2024-10-22 | 2025-10-24 | 江南大学 | 一种用于溃疡性结肠炎治疗的口服纳米给药系统 |
Family Cites Families (418)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2008700A (en) | 1930-05-12 | 1935-07-23 | Jr John Hays Hammond | Reediting of talking films |
| US2187259A (en) | 1936-07-11 | 1940-01-16 | George E Barnhart | Hypodermic needle |
| US2841145A (en) | 1956-05-07 | 1958-07-01 | John A Epps | Syringe |
| US2939459A (en) | 1957-01-11 | 1960-06-07 | Jorge A Lazarte | Tandem syringe |
| US3477432A (en) | 1964-07-21 | 1969-11-11 | Joseph Denman Shaw | Combination mixing and injecting medical syringe |
| US3376999A (en) | 1967-05-31 | 1968-04-09 | Gen Dynamics Corp | Packaging, mixing and dispensing apparatus |
| US3892311A (en) | 1969-01-31 | 1975-07-01 | Vincent R Sneider | Disposable syringe kit |
| AT318132B (de) | 1969-08-01 | 1974-09-25 | Dentaire Ivoclar Ets | Mischbehälter für die Aufnahme von miteinander reagierenden Substanzen für die Herstellung von gebrauchsfertigen pastenförmigen Dentalpräparaten |
| US3762540A (en) | 1970-05-19 | 1973-10-02 | Dentaire Ivoclar Ets | Receptacle having at least three chambers |
| US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
| US3838690A (en) | 1971-07-14 | 1974-10-01 | B Friedman | Replaceable cartridge hypodermic syringe having sterile maintenance of needle |
| US3788320A (en) | 1972-02-25 | 1974-01-29 | Kendall & Co | Spinal needle |
| US3962430A (en) | 1974-08-07 | 1976-06-08 | Merck & Co., Inc. | Sterilization of solid non-electrolyte medicinal agents employing sodium chloride |
| US4226328A (en) | 1979-04-09 | 1980-10-07 | Baxter Travenol Laboratories, Inc. | Catheterization package |
| US4383530A (en) | 1981-06-05 | 1983-05-17 | John Bruno | Hypodermic needle and method of making needles |
| US4377897A (en) | 1981-08-04 | 1983-03-29 | Ocular Associates | Ophthalmic needle and method for manufacturing the same |
| US4432964A (en) | 1981-08-24 | 1984-02-21 | Alza Corporation | Topical composition containing steroid in two forms released independently from polymeric carrier |
| US4525346A (en) * | 1981-09-28 | 1985-06-25 | Alcon Laboratories, Inc. | Aqueous antimicrobial ophthalmic solutions |
| JPS5875563A (ja) | 1981-10-30 | 1983-05-07 | テルモ株式会社 | 留置カテ−テル用接続具 |
| US4564016A (en) | 1982-05-24 | 1986-01-14 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus for introducing ionized drugs into the posterior segment of the eye and method |
| WO1985000097A1 (fr) | 1983-06-28 | 1985-01-17 | Sterimed Gesellschaft Für Medizinischen Bedarf Mbh | Appareils medicaux avec dispositif d'aide d'introduction |
| US4501363A (en) | 1983-10-25 | 1985-02-26 | Isbey Jr Edward K | Surgical kit |
| NZ212899A (en) | 1984-07-31 | 1987-10-30 | Phillips Pty Ltd N J | Piston operated adjustable volume dose injector for animals |
| US4708147A (en) | 1985-02-25 | 1987-11-24 | Haaga John R | Universal biopsy needle |
| US4826871A (en) | 1985-03-13 | 1989-05-02 | Gressel Philip D | Topical ophthalmic compositions containing one or more retinoids |
| US4689040A (en) | 1985-04-29 | 1987-08-25 | Thompson Robert J | Tip for a phacoemulsification needle |
| US4689042A (en) | 1985-05-20 | 1987-08-25 | Survival Technology, Inc. | Automatic medicament ingredient mixing and injecting apparatus |
| US4826490A (en) | 1985-07-29 | 1989-05-02 | National Research Development Corporation | Safety device for hypodermic needle or the like |
| US4601708A (en) | 1985-09-09 | 1986-07-22 | Pavel Jordan | Automatic injection for syringe needle, and assembly |
| US4736850A (en) | 1986-10-17 | 1988-04-12 | W. L. Gore & Associates, Inc. | Endothelial cell harvesting kit |
| US4966773A (en) | 1986-11-25 | 1990-10-30 | Alcon Laboratories, Inc. | Topical ophthalmic compositions containing microfine retinoid particles |
| US4795432A (en) | 1987-02-19 | 1989-01-03 | Karczmer Claude M | Shield assembly for hypodermic injection devices |
| US4804371A (en) | 1987-05-06 | 1989-02-14 | Vaillancourt Vincent L | Post-injection needle sheath |
| ATE72403T1 (de) | 1987-07-10 | 1992-02-15 | Braun Melsungen Ag | Kanuele. |
| DE3802158A1 (de) | 1987-08-11 | 1989-02-23 | Hoechst Ag | Vorrichtung zur applikation von implantaten |
| US5547467A (en) | 1988-01-21 | 1996-08-20 | Massachusettes Institute Of Technology | Method for rapid temporal control of molecular transport across tissue |
| US5066276A (en) | 1988-06-21 | 1991-11-19 | Alcon Laboratories, Inc. | Method and apparatus for injecting viscous fluid into the eye to lift pre-retinal and post-retinal membrane with linear pressure control |
| DE68922619T2 (de) | 1988-09-23 | 1996-01-18 | Frank Hunter | Klinische messsonde. |
| US5817075A (en) | 1989-08-14 | 1998-10-06 | Photogenesis, Inc. | Method for preparation and transplantation of planar implants and surgical instrument therefor |
| US5164188A (en) | 1989-11-22 | 1992-11-17 | Visionex, Inc. | Biodegradable ocular implants |
| US5024662A (en) | 1990-03-13 | 1991-06-18 | Menes Cesar M | Resistance syringe for epidural anesthesia |
| US5015240A (en) | 1990-05-01 | 1991-05-14 | Ian Campbell Cree | Hypodermic needle shield |
| US5098389A (en) | 1990-06-28 | 1992-03-24 | Becton, Dickinson And Company | Hypodermic needle assembly |
| ES2023597A6 (es) | 1990-11-05 | 1992-01-16 | Rodiera Olive Jose Javier | Aguja para uso medico, en especial para funcion lumbar y anestesia regional. |
| US5273530A (en) | 1990-11-14 | 1993-12-28 | The University Of Rochester | Intraretinal delivery and withdrawal instruments |
| EP0501034A1 (en) | 1991-01-30 | 1992-09-02 | CeramOptec GmbH | Illuminated leading probe device |
| US5206267A (en) * | 1991-05-09 | 1993-04-27 | Morton Shulman | Pain controlling composition and method of preparation |
| US5181909A (en) | 1991-05-15 | 1993-01-26 | Mcfarlane Richard H | Ampule-container medical syringe and methods |
| DE4120173A1 (de) | 1991-06-19 | 1992-12-24 | Hoechst Ag | Positiv arbeitendes strahlungsempfindliches gemisch und damit hergestelltes strahlungsempfindliches aufzeichnungsmaterial |
| US5312361A (en) | 1991-09-13 | 1994-05-17 | Zadini Filiberto P | Automatic cannulation device |
| US5172807A (en) | 1991-09-30 | 1992-12-22 | Centrix, Inc. | Cement mixing capsule |
| AU4282793A (en) | 1992-04-10 | 1993-11-18 | State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | A microneedle for injection of ocular blood vessels |
| CA2138644A1 (en) | 1992-07-08 | 1994-01-20 | Bert M. Glaser | Method of treating ophthalmic disorders using tgf-.beta. |
| US5767079A (en) | 1992-07-08 | 1998-06-16 | Celtrix Pharmaceuticals, Inc. | Method of treating ophthalmic disorders using TGF -β |
| US5295972A (en) | 1992-08-04 | 1994-03-22 | Metatech Corporation | Hypodermic syringe with protective cap |
| US5279564A (en) | 1992-09-11 | 1994-01-18 | Edward Weck Incorporated | Cannula retention device |
| US5300084A (en) | 1992-11-23 | 1994-04-05 | United States Surgical Corporation | Pneumoperitoneum needle |
| CA2150554A1 (en) | 1992-12-02 | 1994-06-09 | Sheng-Wan Tsao | Cyclodextrin and polymer based drug delivery system |
| US5320609A (en) | 1992-12-07 | 1994-06-14 | Habley Medical Technology Corporation | Automatic pharmaceutical dispensing syringe |
| US5681825A (en) | 1993-03-15 | 1997-10-28 | Lindqvist; Bengt | Surgical method |
| US5399159A (en) | 1993-03-30 | 1995-03-21 | Origin Medsystems, Inc. | Apparatus and method for hand-held insufflation |
| US5407070A (en) | 1993-08-18 | 1995-04-18 | Bascos; Christine M. | One-time resealable package for needled medical devices |
| US5415629A (en) | 1993-09-15 | 1995-05-16 | Henley; Julian L. | Programmable apparatus for the transdermal delivery of drugs and method |
| US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| US5354286A (en) | 1993-12-07 | 1994-10-11 | Survival Technology, Inc. | Injection device having polyparaxylylene coated container |
| US5397313A (en) | 1994-01-27 | 1995-03-14 | The Kendall Company | Low friction syringe |
| US5658256A (en) | 1994-08-22 | 1997-08-19 | Shields; Jack W. | Universal sharps shield |
| SE9402816D0 (sv) | 1994-08-24 | 1994-08-24 | Pharmacia Ab | Method and meams for drug administration |
| AU3584895A (en) | 1994-09-28 | 1996-04-19 | Celtrix Pharmaceuticals, Inc. | Method of treating macular degeneration using tgf-beta |
| US5856152A (en) | 1994-10-28 | 1999-01-05 | The Trustees Of The University Of Pennsylvania | Hybrid adenovirus-AAV vector and methods of use therefor |
| US5856153A (en) | 1994-11-17 | 1999-01-05 | Cayla | Suicide genes and new associations of pyrimidine nucleobase and nucleoside analogs with new suicide genes for gene therapy of acquired diseases |
| US5792099A (en) | 1995-02-14 | 1998-08-11 | Decamp; Dennis | Syringe and cannula for insertion of viscoelastic material into an eye and method of using same |
| US5779668A (en) | 1995-03-29 | 1998-07-14 | Abbott Laboratories | Syringe barrel for lyophilization, reconstitution and administration |
| US5968022A (en) | 1995-04-28 | 1999-10-19 | Saito; Yoshikuni | Medical hollow needle and method of production |
| USD383049S (en) | 1995-06-30 | 1997-09-02 | Fiskars Inc. | Tool handle grip |
| US6280470B1 (en) | 1995-10-20 | 2001-08-28 | Gholam A. Peyman | Intrastromal corneal modification |
| US5788679A (en) | 1996-06-26 | 1998-08-04 | Gravlee, Jr.; Joseph F. | Phacoemulsification needle |
| US5976573A (en) * | 1996-07-03 | 1999-11-02 | Rorer Pharmaceutical Products Inc. | Aqueous-based pharmaceutical composition |
| US5911223A (en) | 1996-08-09 | 1999-06-15 | Massachusetts Institute Of Technology | Introduction of modifying agents into skin by electroporation |
| IT237434Y1 (it) | 1997-04-17 | 2000-09-13 | Philco Italiana | Lavatrice con carrello per il suo spostamento |
| WO1998051348A2 (en) | 1997-05-16 | 1998-11-19 | Amgen Inc. | Sustained-release delayed gels |
| AUPO940697A0 (en) | 1997-09-23 | 1997-10-16 | Kaal, Joseph Hermes | Retractable syringe |
| US7273458B2 (en) | 1998-01-12 | 2007-09-25 | Georgia Tech Research Corporation | Method of applying acoustic energy effective to alter transport or cell viability |
| US6059111A (en) | 1998-03-04 | 2000-05-09 | Medtronic, Inc. | Medical device packaging system |
| US6309347B1 (en) | 1998-03-17 | 2001-10-30 | Fuji Photo Optical Co., Ltd. | Air and water supply system for endoscopes |
| JP2951938B1 (ja) | 1998-03-19 | 1999-09-20 | 日本ケミカルリサーチ株式会社 | 薬剤溶解機構を内蔵した注射器 |
| US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
| US6540725B1 (en) | 1998-06-04 | 2003-04-01 | Biosense Webster, Inc. | Injection catheter with controllably extendable injection needle |
| US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
| US6936053B1 (en) | 1998-07-02 | 2005-08-30 | Jeffrey N. Weiss | Ocular implant needle |
| US6309374B1 (en) | 1998-08-03 | 2001-10-30 | Insite Vision Incorporated | Injection apparatus and method of using same |
| US6378526B1 (en) | 1998-08-03 | 2002-04-30 | Insite Vision, Incorporated | Methods of ophthalmic administration |
| WO2000015822A1 (en) | 1998-09-17 | 2000-03-23 | University Of Florida | Methods for treatment of degenerative retinal diseases |
| FR2784034B1 (fr) | 1998-10-01 | 2000-12-15 | Marc Brunel | Dispositif d'injection a usage unique destine a etre pre-rempli |
| US6219575B1 (en) | 1998-10-23 | 2001-04-17 | Babak Nemati | Method and apparatus to enhance optical transparency of biological tissues |
| US20040141925A1 (en) * | 1998-11-12 | 2004-07-22 | Elan Pharma International Ltd. | Novel triamcinolone compositions |
| US6670321B1 (en) | 1998-12-30 | 2003-12-30 | The Children's Medical Center Corporation | Prevention and treatment for retinal ischemia and edema |
| WO2000040262A1 (en) | 1999-01-05 | 2000-07-13 | The Flinders University Of South Australia | Novel agents and methods for treatment and diagnosis of ocular disorders |
| US6699210B2 (en) | 1999-04-27 | 2004-03-02 | The Arizona Board Of Regents | Glaucoma shunt and a method of making and surgically implanting the same |
| US6159218A (en) | 1999-05-19 | 2000-12-12 | Aramant; Robert B. | Retinal tissue implantation tool |
| US6319240B1 (en) | 1999-05-25 | 2001-11-20 | Iomed, Inc. | Methods and apparatus for ocular iontophoresis |
| US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| US6611707B1 (en) | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
| US6256533B1 (en) | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
| FR2794650B1 (fr) | 1999-06-10 | 2001-09-14 | Marc Brunel | Dispositif d'injection a usage unique |
| FR2801795B1 (fr) | 1999-12-07 | 2002-07-05 | Plastef Investissements | Dispositif de support de securite pour une seringue et ensemble d'un tel dispositif et d'une seringue |
| JP2003530144A (ja) | 1999-12-10 | 2003-10-14 | アイサイエンス コーポレイション | 眼の病気の治療 |
| US20010051798A1 (en) | 1999-12-28 | 2001-12-13 | Hochman Mark N. | Method of performing an injection using a bi-directional rotational insertion technique |
| US6726676B2 (en) | 2000-01-05 | 2004-04-27 | Grieshaber & Co. Ag Schaffhausen | Method of and device for improving the flow of aqueous humor within the eye |
| RU14351U1 (ru) | 2000-02-15 | 2000-07-20 | Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" | Игла-направитель для пункции ретробульбарного пространства |
| JP4372310B2 (ja) | 2000-04-10 | 2009-11-25 | ニプロ株式会社 | 混注用アダプター |
| US6622864B1 (en) | 2000-06-01 | 2003-09-23 | Osteotech, Inc. | Moisture resistant package for storing sterile items |
| JP4187922B2 (ja) | 2000-09-14 | 2008-11-26 | テルモ株式会社 | 液体注入針および液体注入装置 |
| CA2426600A1 (en) | 2000-10-31 | 2002-05-23 | Smith & Nephew, Inc. | Packaging and delivery system for bone graft particles |
| US20030060447A1 (en) | 2002-04-24 | 2003-03-27 | Mutlu Karakelle | Non-aspirating transitional viscoelastics for use in surgery |
| US6915901B2 (en) | 2000-12-11 | 2005-07-12 | Marc Feinberg | Packaging assembly for surgical use |
| WO2002064193A2 (en) | 2000-12-14 | 2002-08-22 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
| US6387078B1 (en) | 2000-12-21 | 2002-05-14 | Gillespie, Iii Richard D. | Automatic mixing and injecting apparatus |
| US20030171722A1 (en) | 2001-01-04 | 2003-09-11 | Michel Paques | Microsurgical injection and/or distending instruments and surgical method and apparatus utilizing same |
| AU2002243612A1 (en) | 2001-01-18 | 2002-07-30 | The Regents Of The University Of California | Minimally invasive glaucoma surgical instrument and method |
| US6378849B1 (en) * | 2001-04-13 | 2002-04-30 | General Electric Company | Methods and apparatus for mounting motors |
| US20090088721A1 (en) | 2001-04-17 | 2009-04-02 | Eyegate Pharma S.A.S. | Enhanced retinal delivery of a nucleic acid through iontophoresis |
| US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US7041068B2 (en) | 2001-06-12 | 2006-05-09 | Pelikan Technologies, Inc. | Sampling module device and method |
| US20030073609A1 (en) | 2001-06-29 | 2003-04-17 | Pinkerton Thomas C. | Enhanced pharmacokinetic profile of intradermally delivered substances |
| US6749792B2 (en) | 2001-07-09 | 2004-06-15 | Lifescan, Inc. | Micro-needles and methods of manufacture and use thereof |
| AU2002317573B2 (en) | 2001-07-24 | 2007-07-26 | Artes Medical, Inc. | Elongated syringe |
| JP2003052819A (ja) | 2001-08-10 | 2003-02-25 | Seikagaku Kogyo Co Ltd | 薬剤充填注射器包装物およびその滅菌または殺菌方法 |
| US8361037B2 (en) | 2001-09-19 | 2013-01-29 | Valeritas, Inc. | Microneedles, microneedle arrays, and systems and methods relating to same |
| EP1471953B1 (en) | 2001-09-21 | 2011-02-16 | Valeritas, Inc. | Gas pressure actuated microneedle arrays, and systems and methods relating to same |
| US7429258B2 (en) | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
| US7569035B1 (en) | 2001-11-02 | 2009-08-04 | Meridian Medical Technologies, Inc. | Automatic injector with anti-coring needle |
| CA2467993C (en) | 2001-11-22 | 2011-01-11 | Eduard Anton Haefliger | Device and method for the performance of ophthalmological operations |
| US7204823B2 (en) | 2001-12-19 | 2007-04-17 | Medtronic Minimed, Inc. | Medication delivery system and monitor |
| US6821286B1 (en) | 2002-01-23 | 2004-11-23 | Cardica, Inc. | System for preparing a graft vessel for anastomosis |
| US20050033230A1 (en) | 2002-02-15 | 2005-02-10 | Alchas Paul G. | Prefillable intradermal delivery device with hidden needle and passive shielding |
| DK1484054T3 (da) | 2002-02-22 | 2012-11-26 | Santen Pharmaceutical Co Ltd | Lægemiddelafgivelsessystem til subkonjunktival indgivelse af fine korn |
| OA12790A (en) | 2002-03-13 | 2006-07-10 | Janssen Pharmaceutica Nv | New inhibitors of histone deacetylase. |
| JP2005536189A (ja) | 2002-04-12 | 2005-12-02 | セルジーン・コーポレーション | 血管新生のモジュレーターの同定方法、それにより見出された化合物および該化合物を使用する治療方法 |
| US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
| EP1511528A4 (en) | 2002-05-16 | 2008-07-02 | Scott Lab Inc | MECHANISMS FOR PENETRATION IN A MEDICINAL CONTAINER, AND ASSOCIATED METHOD |
| US6945952B2 (en) | 2002-06-25 | 2005-09-20 | Theraject, Inc. | Solid solution perforator for drug delivery and other applications |
| US7316676B2 (en) | 2002-08-20 | 2008-01-08 | Gholam A. Peyman | Treatment of retinal detachment |
| DE10242984B4 (de) | 2002-09-17 | 2010-09-23 | Sanatis Gmbh | Vorrichtung zum Herstellen von Gemischen aus zwei Komponenten |
| PL223153B1 (pl) | 2002-09-18 | 2016-10-31 | Allergan Inc | Urządzenie do wszczepiania implantu okulistycznego |
| US20050143363A1 (en) | 2002-09-29 | 2005-06-30 | Innorx, Inc. | Method for subretinal administration of therapeutics including steroids; method for localizing pharmacodynamic action at the choroid of the retina; and related methods for treatment and/or prevention of retinal diseases |
| EP1590034B1 (en) | 2002-10-07 | 2014-05-14 | Biovalve Technologies, Inc. | Microneedle array patch |
| US6883222B2 (en) | 2002-10-16 | 2005-04-26 | Bioject Inc. | Drug cartridge assembly and method of manufacture |
| EP1568359A4 (en) | 2002-12-04 | 2011-05-18 | Santen Pharmaceutical Co Ltd | DRUG DELIVERY SYSTEM HAVING SUB-CONJUNCTIVAL DEPOSIT |
| JP2004196787A (ja) | 2002-12-04 | 2004-07-15 | Santen Pharmaceut Co Ltd | 結膜下デポによるドラッグデリバリーシステム |
| WO2004057959A2 (en) | 2002-12-20 | 2004-07-15 | Generipharm, Inc. | Intracutaneous injection |
| US8328772B2 (en) | 2003-01-21 | 2012-12-11 | Carmel Pharma Ab | Needle for penetrating a membrane |
| GB0301934D0 (en) | 2003-01-28 | 2003-02-26 | Sundar Satish | Delivery apparatus and location method |
| AU2003227802A1 (en) | 2003-02-24 | 2004-10-11 | Becton Dickinson France | Plate for holding a group of syringe body objects |
| US20040186084A1 (en) | 2003-03-21 | 2004-09-23 | Akorn, Inc. | Triamcinolone formulations and methods for their preparation and use |
| US20040199130A1 (en) | 2003-04-03 | 2004-10-07 | Chornenky Victor I. | Apparatus and method for treatment of macular degeneration |
| US7533514B2 (en) | 2003-04-25 | 2009-05-19 | Boston Scientific Scimed, Inc. | Method and apparatus for automated handling of medical devices during manufacture |
| US8403941B2 (en) | 2003-06-02 | 2013-03-26 | Abbott Medical Optics Inc. | Intraocular lens and cartridge packaging with lens-loading function |
| US7435237B2 (en) | 2003-06-02 | 2008-10-14 | Boston Scientific Scimed, Inc. | Mixing syringes with breakable septums |
| EP1633250A2 (en) | 2003-06-04 | 2006-03-15 | Georgia Tech Research Corporation | Drilling microneedle device |
| DE10327119A1 (de) | 2003-06-13 | 2004-12-30 | Aventis Pharma Deutschland Gmbh | Kappe für Injektionsvorrichtungen |
| US7914803B2 (en) | 2003-06-13 | 2011-03-29 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of three polymers |
| US7207965B2 (en) | 2003-06-16 | 2007-04-24 | Solx, Inc. | Shunt for the treatment of glaucoma |
| BRPI0412021A (pt) | 2003-06-30 | 2006-08-15 | Alza Corp | método para revestir microprojeções de perfuração de pele |
| USD499153S1 (en) | 2003-07-08 | 2004-11-30 | Test Rite International Company, Ltd | Handle for jump rope |
| US20050009910A1 (en) | 2003-07-10 | 2005-01-13 | Allergan, Inc. | Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug |
| US20050065137A1 (en) * | 2003-09-23 | 2005-03-24 | Alcon, Inc. | Triamcinolone acetonide and anecortave acetate formulations for injection |
| US20070224278A1 (en) | 2003-11-12 | 2007-09-27 | Lyons Robert T | Low immunogenicity corticosteroid compositions |
| US20050101882A1 (en) | 2003-11-12 | 2005-05-12 | Leira Enrique C. | Safety pressure device for body fluid extraction |
| US20090148527A1 (en) | 2007-12-07 | 2009-06-11 | Robinson Michael R | Intraocular formulation |
| US20060141049A1 (en) * | 2003-11-12 | 2006-06-29 | Allergan, Inc. | Triamcinolone compositions for intravitreal administration to treat ocular conditions |
| US20050101582A1 (en) | 2003-11-12 | 2005-05-12 | Allergan, Inc. | Compositions and methods for treating a posterior segment of an eye |
| US7967772B2 (en) | 2004-01-12 | 2011-06-28 | Iscience Interventional Corporation | Injector for viscous materials |
| WO2005072701A1 (en) | 2004-01-20 | 2005-08-11 | Allergan, Inc. | Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid |
| DE10168535T1 (de) | 2004-01-23 | 2011-03-17 | Iscience Interventional Corp., Menlo Park | Zusammengesetzte Ophthalmische Mikrokanuele |
| US7678077B2 (en) | 2004-02-20 | 2010-03-16 | Boston Scientific Scimed, Inc. | Variable depth injection device and method |
| US7361168B2 (en) * | 2004-04-21 | 2008-04-22 | Acclarent, Inc. | Implantable device and methods for delivering drugs and other substances to treat sinusitis and other disorders |
| US20080058704A1 (en) | 2004-04-29 | 2008-03-06 | Michael Hee | Apparatus and Method for Ocular Treatment |
| US20100173866A1 (en) | 2004-04-29 | 2010-07-08 | Iscience Interventional Corporation | Apparatus and method for ocular treatment |
| CN101052434A (zh) | 2004-04-29 | 2007-10-10 | I科学干预公司 | 用于治疗眼睛的装置和方法 |
| US20050244469A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
| BRPI0509334A (pt) | 2004-04-30 | 2007-10-16 | Eyegate Pharma S A | dispositivo de iontoforese ocular, que diminui as irritações |
| US20050244462A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Devices and methods for treating a mammalian eye |
| US20050244463A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
| US8685435B2 (en) | 2004-04-30 | 2014-04-01 | Allergan, Inc. | Extended release biodegradable ocular implants |
| WO2006004595A2 (en) | 2004-05-28 | 2006-01-12 | Georgia Tech Research Corporation | Methods and devices for thermal treatment |
| US8323227B2 (en) | 2004-07-02 | 2012-12-04 | C. R. Bard, Inc. | Tip configurations for a multi-lumen catheter |
| AU2005271700B2 (en) | 2004-07-12 | 2010-11-11 | Allergan, Inc. | Opthalmic compositions and methods for treating ophthalmic conditions |
| US7615041B2 (en) | 2004-07-29 | 2009-11-10 | Boston Scientific Scimed, Inc. | Vial adaptor |
| US7503920B2 (en) | 2004-08-11 | 2009-03-17 | Tzony Siegal | Spinal surgery system and method |
| US7722669B2 (en) | 2004-08-13 | 2010-05-25 | Richard Foulkes | Method and insert for modifying eye color |
| US8114110B2 (en) | 2004-09-22 | 2012-02-14 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Transseptal puncture needle and needle assemblies |
| US7947267B2 (en) | 2004-10-08 | 2011-05-24 | Potentia Pharmaceuticals, Inc. | Viral complement control proteins for eye disorders |
| US7627938B2 (en) | 2004-10-15 | 2009-12-08 | Board Of Regents, The Univeristy Of Texas System | Tapered hollow metallic microneedle array assembly and method of making and using the same |
| US7097776B2 (en) | 2004-10-22 | 2006-08-29 | Hewlett-Packard Development Company, L.P. | Method of fabricating microneedles |
| US7604647B2 (en) | 2004-10-22 | 2009-10-20 | Medical Instrument Development Laboratories, Inc. | Ophthalmic cannula insertion tool and method |
| US8246949B2 (en) | 2004-10-27 | 2012-08-21 | Aciont, Inc. | Methods and devices for sustained in-vivo release of an active agent |
| US20080008762A1 (en) | 2004-11-17 | 2008-01-10 | Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services | Steroid Formulation And Methods Of Treatment Using Same |
| ATE501684T1 (de) | 2004-11-23 | 2011-04-15 | Edward Wong | Medizinische vorrichtung zur temperaturregelung und behandlung des auges sowie des umgebenden gewebes |
| US8262715B2 (en) | 2004-11-23 | 2012-09-11 | Eye Delivery System, Llc | Medical device and method for temperature control and treatment of the eye and surrounding tissues via magnetic drug therapy |
| US20060173418A1 (en) | 2004-12-13 | 2006-08-03 | Arrow International, Inc. | Loss of resistance syringe |
| US20060169664A1 (en) | 2004-12-28 | 2006-08-03 | Holopack International Corp. | Vial for filling a syringe |
| US7803142B2 (en) | 2005-02-02 | 2010-09-28 | Summit Access Llc | Microtaper needle and method of use |
| WO2007059187A1 (en) | 2005-11-14 | 2007-05-24 | Pactiv Corporation | Container having internal reservoir |
| TW200640443A (en) | 2005-02-23 | 2006-12-01 | Alcon Inc | Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors |
| US20060233858A1 (en) | 2005-03-08 | 2006-10-19 | Allergan, Inc. | Systems and methods providing targeted intraocular drug delivery |
| BRPI0609206A2 (pt) | 2005-03-11 | 2010-03-02 | Alcon Inc | inibiÇço mediada por rnai de proteÍna relacionada frizzled-1 para tratamento de glaucoma |
| CA2601864A1 (en) | 2005-04-08 | 2006-10-19 | Surmodics, Inc. | Sustained release implants and methods for subretinal delivery of bioactive agents to treat or prevent retinal disease |
| US7645264B2 (en) | 2005-04-11 | 2010-01-12 | Becton, Dickinson And Company | Injection device with secondary reservoir |
| US7722581B2 (en) | 2005-04-11 | 2010-05-25 | Gholam A. Peyman | Crystalline lens drug delivery |
| AU2006239308C1 (en) | 2005-04-26 | 2010-06-03 | Biolase, Inc. | Methods for treating eye conditions |
| US20060259008A1 (en) | 2005-04-27 | 2006-11-16 | Allergan, Inc. | Apparatus and methods useful for intravitreal injection of drugs |
| CN100463668C (zh) | 2005-05-09 | 2009-02-25 | 凌沛学 | 可逆性热凝胶化水性药物组合物 |
| US20080269666A1 (en) | 2005-05-25 | 2008-10-30 | Georgia Tech Research Corporation | Microneedles and Methods for Microinfusion |
| WO2006138719A2 (en) | 2005-06-17 | 2006-12-28 | Georgia Tech Research Corporation | Coated microstructures and method of manufacture thereof |
| CN100430069C (zh) | 2005-07-28 | 2008-11-05 | 凌沛学 | 一种中药及其复方的可逆性热凝胶化水性药物组合物 |
| WO2007038687A2 (en) | 2005-09-27 | 2007-04-05 | Aciont, Inc. | Ocular administration of immunosuppressive agents |
| US20090082321A1 (en) | 2007-09-21 | 2009-03-26 | Allergan, Inc. | Steroid containing drug delivery systems |
| US20070093877A1 (en) | 2005-10-26 | 2007-04-26 | Beecham Michael C | System for maintaining normal health of retinal cells and promoting regeneration of retinal cells |
| US20070123947A1 (en) | 2005-11-30 | 2007-05-31 | Wenger William K | Medical device packaging system |
| JP4886789B2 (ja) | 2005-12-23 | 2012-02-29 | キャスリックス リミテッド | 洗浄カテーテル |
| EP3338743A1 (en) | 2006-01-17 | 2018-06-27 | Novartis Ag | Drug delivery treatment device |
| US20070185495A1 (en) | 2006-01-30 | 2007-08-09 | Howmedica International S. De R. L. | Plug-in syringe stand |
| US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
| BR122019014009B1 (pt) | 2006-04-27 | 2019-11-12 | Ecolab Inc | alojamento de produto para uso como um produto sólido, um dosador de produto sólido e um corta vácuo |
| US8197435B2 (en) | 2006-05-02 | 2012-06-12 | Emory University | Methods and devices for drug delivery to ocular tissue using microneedle |
| US7918814B2 (en) | 2006-05-02 | 2011-04-05 | Georgia Tech Research Corporation | Method for drug delivery to ocular tissue using microneedle |
| US20070270768A1 (en) | 2006-05-17 | 2007-11-22 | Bruno Dacquay | Mechanical Linkage Mechanism For Ophthalmic Injection Device |
| US20070270745A1 (en) | 2006-05-18 | 2007-11-22 | Camran Nezhat | Vacuum actuated tissue lifting device |
| USD598543S1 (en) | 2006-06-13 | 2009-08-18 | Angiomed Gmbh & Co. Medizintechnik Kg | Handle for a medical delivery device |
| US8668676B2 (en) | 2006-06-19 | 2014-03-11 | Allergan, Inc. | Apparatus and methods for implanting particulate ocular implants |
| US8802128B2 (en) | 2006-06-23 | 2014-08-12 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
| US8852137B2 (en) | 2010-11-15 | 2014-10-07 | Aquesys, Inc. | Methods for implanting a soft gel shunt in the suprachoroidal space |
| US8974511B2 (en) | 2010-11-15 | 2015-03-10 | Aquesys, Inc. | Methods for treating closed angle glaucoma |
| US8663303B2 (en) | 2010-11-15 | 2014-03-04 | Aquesys, Inc. | Methods for deploying an intraocular shunt from a deployment device and into an eye |
| EP2046437A2 (en) | 2006-07-20 | 2009-04-15 | Neurosystec Corporation | Devices, systems and methods for ophthalmic drug delivery |
| US20080097335A1 (en) | 2006-08-04 | 2008-04-24 | Allergan, Inc. | Ocular implant delivery assemblies |
| US20080058717A1 (en) | 2006-09-04 | 2008-03-06 | Spector David M | Oral cavity liquid delivery system including pre-angled needle guidance assembly and method for using the same |
| US7998108B2 (en) | 2006-09-12 | 2011-08-16 | Psivida Us, Inc. | Injector apparatus and method of use |
| US8944069B2 (en) | 2006-09-12 | 2015-02-03 | Vidacare Corporation | Assemblies for coupling intraosseous (IO) devices to powered drivers |
| US20080097346A1 (en) | 2006-09-19 | 2008-04-24 | Alcon, Inc. | Trocar cannula |
| US20080097390A1 (en) | 2006-09-27 | 2008-04-24 | Alcon Manufacturing, Ltd. | Spring actuated delivery system |
| AU2007319383A1 (en) | 2006-11-10 | 2008-05-22 | Glaukos Corporation | Uveoscleral shunt and methods for implanting same |
| US8969415B2 (en) | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
| WO2008070479A2 (en) | 2006-12-01 | 2008-06-12 | Allergan, Inc. | Method for determining optimum intraocular locations for drug delivery systems |
| RU2344767C2 (ru) | 2006-12-18 | 2009-01-27 | Наталья Александровна Уракова | Способ внутриартериальной инъекции по а.л. уракову |
| TWI457336B (zh) | 2006-12-28 | 2014-10-21 | Kinex Pharmaceuticals Llc | 調節激酶級聯之組成物及方法 |
| DK2124857T3 (en) | 2007-01-09 | 2017-07-03 | Fovea Pharmaceuticals | DEVICE FOR INTRAOCULAR INJECTION |
| US20080177239A1 (en) | 2007-01-18 | 2008-07-24 | Yong Li | Trocar cannula system |
| DE102007018696A1 (de) | 2007-04-18 | 2008-10-23 | Sanofi-Aventis Deutschland Gmbh | Injektionsvorrichtung zur Abgabe eines Medikaments |
| USD590690S1 (en) | 2007-05-24 | 2009-04-21 | Domino S.P.A. | Handlebar hand grip |
| US20090030381A1 (en) | 2007-07-23 | 2009-01-29 | Lind Casey J | Arced Hypodermic Needle |
| CA2695996A1 (en) | 2007-08-16 | 2009-02-19 | East Carolina University | Smart injection syringe systems providing real-time user feedback of correct needle position |
| CA2639322C (en) | 2007-09-07 | 2016-11-08 | Becton, Dickinson And Company | Pen needle hub having increased contact area |
| KR20100058620A (ko) | 2007-09-07 | 2010-06-03 | 큐엘티 플러그 딜리버리, 인코포레이티드 | 눈물 임플랜트용 삽입 및 적출 기구 |
| US20090076463A1 (en) | 2007-09-17 | 2009-03-19 | Jurg Attinger | Trocar Cannula |
| US20090081277A1 (en) | 2007-09-21 | 2009-03-26 | Allergan, Inc. | Pharmaceutical formulations and methods for treating ocular conditions |
| US8083759B2 (en) | 2007-11-02 | 2011-12-27 | Refocus Ocular, Inc. | Apparatuses and methods for forming incisions in ocular tissue |
| US8448786B2 (en) | 2009-06-30 | 2013-05-28 | Medline Industries, Inc. | Catheter tray, packaging system, instruction insert, and associated methods |
| US8631935B2 (en) | 2009-06-03 | 2014-01-21 | Medline Industries, Inc. | Catheter tray, packaging system, and associated methods |
| US8602959B1 (en) | 2010-05-21 | 2013-12-10 | Robert Park | Methods and devices for delivery of radiation to the posterior portion of the eye |
| JP2009183441A (ja) | 2008-02-06 | 2009-08-20 | Ken Kondo | 静脈留置針組立体 |
| CA2716110A1 (en) * | 2008-02-21 | 2009-08-27 | Tim Mcnamara | Ophthalmic nsaids as adjuvants |
| US20100152646A1 (en) | 2008-02-29 | 2010-06-17 | Reshma Girijavallabhan | Intravitreal injection device and method |
| CA2717605C (en) * | 2008-03-11 | 2012-05-15 | Alcon Research Ltd. | Low viscosity, highly flocculated triamcinolone acetonide suspensions for intravitreal injection |
| US20090259180A1 (en) | 2008-04-11 | 2009-10-15 | Jong Soo Choi | Injection method using injector with length-adjustable needle and injection apparatus using the same |
| US20090287161A1 (en) | 2008-05-15 | 2009-11-19 | Allergan, Inc | Metered, multiple dose/aliquot syringe |
| US20090312782A1 (en) | 2008-06-13 | 2009-12-17 | Maxwell Choongwon Park | Method and apparatus for repairing tendons |
| US9022940B2 (en) | 2008-07-18 | 2015-05-05 | Joseph H. Meier | Handheld imaging devices and related methods |
| US8821870B2 (en) | 2008-07-18 | 2014-09-02 | Allergan, Inc. | Method for treating atrophic age related macular degeneration |
| CA2730767C (en) | 2008-07-21 | 2017-08-29 | Smiths Medical Asd, Inc. | Tray assembly |
| JP5854836B2 (ja) | 2008-08-30 | 2016-02-09 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | カートリッジ及びそのための針システム |
| US7678078B1 (en) | 2008-10-21 | 2010-03-16 | KMG Pharma LLC | Intravitreal injection device, system and method |
| US8221353B2 (en) | 2008-10-21 | 2012-07-17 | KMG Pharma, Inc | Intravitreal injection device and system |
| WO2010054660A1 (en) | 2008-11-11 | 2010-05-20 | Herlev Hospital | Double cannula system for anaesthetic needle |
| CA2972136C (en) | 2008-12-05 | 2019-08-06 | Ivantis, Inc. | Cannula for ocular implant delivery system |
| US20110282298A1 (en) | 2008-12-09 | 2011-11-17 | Nadav Agian | Device for injecting fluid isolated from microneedle hub with dead-space-reducing insert |
| US8545554B2 (en) | 2009-01-16 | 2013-10-01 | Allergan, Inc. | Intraocular injector |
| US8425473B2 (en) | 2009-01-23 | 2013-04-23 | Iscience Interventional Corporation | Subretinal access device |
| ES2378012B1 (es) | 2009-01-29 | 2013-02-12 | Innova Salud Desarrollos Sanitarios S.L. | Dispositivo para la administración de productos inyectables con caudal controlado. |
| CA2752018C (en) | 2009-02-10 | 2017-07-04 | Psivida Us, Inc. | Ocular trocar assembly |
| US8057483B2 (en) | 2009-02-14 | 2011-11-15 | Ocular Transplantation Llc | Subretinal implantation instrument |
| CN201356711Y (zh) | 2009-02-23 | 2009-12-09 | 徐学农 | 玻璃体腔冲洗针头 |
| EP2403564B1 (en) | 2009-03-02 | 2018-04-25 | Sanofi-Aventis Deutschland GmbH | Medication delivery device with foldable finger pad |
| US20120116306A1 (en) | 2009-03-05 | 2012-05-10 | Sanofi-Aventis Deutschland Gmbh | Needle unit |
| CA2763555A1 (en) | 2009-03-05 | 2010-09-10 | Sanofi-Aventis Deutschland Gmbh | Needle assembly |
| DK2403570T3 (en) | 2009-03-05 | 2015-10-19 | Sanofi Aventis Deutschland | PHARMACEUTICAL Feed mechanism |
| EP2403569B1 (en) | 2009-03-05 | 2014-04-23 | Sanofi-Aventis Deutschland GmbH | Drug delivery device with retractable needle |
| CA2753994A1 (en) | 2009-03-06 | 2010-09-10 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device with retractable needle |
| US8287494B2 (en) | 2009-03-23 | 2012-10-16 | Colin Ma | Intravitreal injection devices and methods of injecting a substance into the vitreous chamber of the eye |
| SE0900371A1 (sv) | 2009-03-24 | 2010-09-25 | Istvan Bartha | Anordning för distribution av flytande läkemedel |
| JP4505561B1 (ja) | 2009-03-30 | 2010-07-21 | 篤志 今津 | 圧力式穿刺注射器 |
| EP2419005B1 (en) | 2009-04-15 | 2014-11-19 | Koninklijke Philips N.V. | Needle with integrated fibers in the cutting facets of the bevel |
| US20120130207A1 (en) | 2009-04-29 | 2012-05-24 | Janisys Limited | micro-needle device and apparatus and a method for applying a micro-needle element to a site on the skin of a subject |
| KR20120018353A (ko) | 2009-05-15 | 2012-03-02 | 아이싸이언스 인터벤셔날 코포레이션 | 망막하 카테터 삽입을 위한 장치 및 방법 |
| WO2010149734A1 (en) | 2009-06-25 | 2010-12-29 | Sanofi-Aventis Deutschland Gmbh | Cannula assembly for co-delivery of medicaments |
| RU2428956C2 (ru) | 2009-07-13 | 2011-09-20 | Александр Дмитриевич Ромащенко | Способ лечения атрофии зрительного нерва посредством трансплантации аутологичных стволовых клеток |
| US8535333B2 (en) | 2009-07-29 | 2013-09-17 | Transcend Medical, Inc. | Ocular implant applier and methods of use |
| JP5865835B2 (ja) | 2009-08-12 | 2016-02-17 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 携帯用医薬品送達デバイス用キャップ及びそのような医薬品送達デバイス |
| US8221753B2 (en) * | 2009-09-30 | 2012-07-17 | Tracon Pharmaceuticals, Inc. | Endoglin antibodies |
| CA2771489A1 (en) | 2009-08-28 | 2011-03-03 | Sanofi-Aventis Deutschland Gmbh | Assembly kit for preparing of a pre-filled syringe |
| WO2011034627A2 (en) | 2009-09-21 | 2011-03-24 | Harvard Bioscience, Inc. | Methods and apparatus for introducing cells at a tissue site |
| WO2011057065A1 (en) | 2009-11-06 | 2011-05-12 | The Uab Research Foundation | Apparatuses and methods for delivering substances to the inner eye |
| WO2011057334A1 (en) | 2009-11-11 | 2011-05-19 | Unitract Syringe Pty Ltd | Clinical syringe |
| CN102791312B (zh) | 2009-12-22 | 2015-09-30 | 尤尼特拉克特注射器公司 | 具有改进的递送效率和锁定系统的缩回式注射器 |
| US8529492B2 (en) | 2009-12-23 | 2013-09-10 | Trascend Medical, Inc. | Drug delivery devices and methods |
| WO2011084504A1 (en) | 2010-01-05 | 2011-07-14 | Allergan, Inc. | Syringe comprising two plungers with locking means |
| US20110213317A1 (en) | 2010-03-01 | 2011-09-01 | Chen David E-Bin | Cannula for intraocular surgery |
| EP2364740A1 (en) | 2010-03-09 | 2011-09-14 | Sanofi-Aventis Deutschland GmbH | Arrangement for transferring a translation of a drive means to a plunger |
| GB201004102D0 (en) | 2010-03-12 | 2010-04-28 | Liversidge Barry P | Syringe barrels and handling systems |
| US9320647B2 (en) | 2010-03-31 | 2016-04-26 | Ocuject, Llc | Device and method for intraocular drug delivery |
| CA2795096C (en) | 2010-03-31 | 2021-10-26 | Ocuject, Llc | Device and method for intraocular drug delivery |
| CN103037802B (zh) | 2010-03-31 | 2016-08-24 | 奥库杰克特有限责任公司 | 用于眼内药物递送的设备和方法 |
| US9408746B2 (en) | 2010-03-31 | 2016-08-09 | Ocuject, Llc | Device and method for intraocular drug delivery |
| US8430862B2 (en) | 2010-04-08 | 2013-04-30 | KMG Pharma LLC | Subconjunctival agent delivery apparatus, system and method |
| US8652118B2 (en) | 2010-04-08 | 2014-02-18 | Kmg Pharma, Llc | Sub-mucosal agent delivery, apparatus, system and method |
| US8574217B2 (en) | 2010-04-08 | 2013-11-05 | Kmg Pharma, Llc | Sub-mucosal agent delivery method for the eye |
| US8343471B2 (en) | 2010-04-30 | 2013-01-01 | Indian Institute Of Technology Bombay | Nanoparticulate in-situ gels of TPGS, gellan and PVA as vitreous humor substitutes |
| US8632589B2 (en) | 2010-05-04 | 2014-01-21 | Abbott Medical Optics Inc. | IOL insertion system with semi-automatic trailing haptic configuration management |
| AU2011250654B2 (en) | 2010-05-04 | 2013-08-15 | Unitract Syringe Pty Ltd | Syringe barrel adapter and needle assembly |
| US8932258B2 (en) | 2010-05-14 | 2015-01-13 | C. R. Bard, Inc. | Catheter placement device and method |
| US8545430B2 (en) | 2010-06-09 | 2013-10-01 | Transcend Medical, Inc. | Expandable ocular devices |
| EP2600923B1 (en) | 2010-06-10 | 2018-08-08 | Anthony J. Colantonio | Apparatus and method for safely inserting an introducer needle into epidural space |
| US20120004245A1 (en) | 2010-07-02 | 2012-01-05 | Alcon Research, Ltd. | Compounds for the treatment of posterior segment disorders and diseases |
| KR101180032B1 (ko) | 2010-07-12 | 2012-09-05 | 인싸이토(주) | 외형 조절이 가능한 중공형 마이크로니들의 제조방법 |
| TW201216948A (en) | 2010-07-19 | 2012-05-01 | Sanofi Aventis Deutschland | Medicament cartridges with non-standard dimensions |
| HUE054113T2 (hu) | 2010-08-05 | 2021-08-30 | Forsight Vision4 Inc | Injekciós készülék gyógyszerbejuttatáshoz |
| CN103209731A (zh) | 2010-09-30 | 2013-07-17 | 赢创有限公司 | 药物输送刀片及用于将药物储仓输送到目标部位的方法 |
| JP5843870B2 (ja) | 2010-10-01 | 2016-01-13 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 解除機構を備えたニードルアセンブリ |
| EP2438939A1 (en) | 2010-10-08 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Arrangement for coupling a plunger to either a syringe or a stopper |
| BR112013009205A2 (pt) | 2010-10-15 | 2016-07-26 | Iscience Interventional Corp | dispositivo para colocação na esclera de um olho, método para acessar o espaço supracoroidal de um olho, para acessar o espaço subretinal de um olho e para colocar um orifício dentro de um trato escleral em um olho. |
| US20120101475A1 (en) | 2010-10-21 | 2012-04-26 | Meridian Medical Technologies, Inc. | High Efficiency Auto-Injector |
| EP2632516A1 (en) | 2010-10-25 | 2013-09-04 | Sanofi-Aventis Deutschland GmbH | Device for controlling a penetration depth of injection needle |
| EP2446866A1 (en) | 2010-11-02 | 2012-05-02 | Fovea Pharmaceuticals | Apparatus for injection into an eye |
| JP5832547B2 (ja) | 2010-11-03 | 2015-12-16 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬剤を含有する針カニューレ |
| US9241701B2 (en) | 2010-11-11 | 2016-01-26 | Depuy Mitek, Inc. | Cannula system and method for partial thickness rotator cuff repair |
| JP5704389B2 (ja) | 2010-11-29 | 2015-04-22 | ニプロ株式会社 | 医療用中空針および医療用中空針の製造方法 |
| WO2012073180A1 (en) | 2010-12-02 | 2012-06-07 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Subretinal delivery of therapeutic compositions |
| US8608710B2 (en) | 2010-12-09 | 2013-12-17 | Becton Dickinson & Company | Pen needle assembly with different gauge needle cannulas |
| US9968337B2 (en) | 2010-12-20 | 2018-05-15 | Cook Medical Technologies Llc | Coring tissue biopsy needle and method of use |
| RU2591210C2 (ru) * | 2011-03-02 | 2016-07-20 | Аквилус Фармасьютикалз, Инк. | Соединения и способы лечения боли и других расстройств |
| JP2014515012A (ja) * | 2011-03-15 | 2014-06-26 | ユニヴァーシティー オブ ユタ リサーチ ファウンデーション | 血管関連黄斑症およびその症状の診断および治療方法 |
| USD667111S1 (en) | 2011-03-17 | 2012-09-11 | Surgical Innovations Limited | Handle for surgical instrument |
| EP2500002A1 (en) | 2011-03-17 | 2012-09-19 | Sanofi-Aventis Deutschland GmbH | Apparatus for intraocular injection |
| US20140088552A1 (en) | 2011-03-25 | 2014-03-27 | The Curators Of The University Of Missouri | Intravitreal Injection Device |
| EP2510911A1 (en) | 2011-04-13 | 2012-10-17 | Sanofi-Aventis Deutschland GmbH | Apparatus for intraocular injection |
| EP2510902A1 (en) | 2011-04-15 | 2012-10-17 | Sanofi-Aventis Deutschland GmbH | Intraocular injection device |
| EP2514461A1 (en) | 2011-04-20 | 2012-10-24 | Sanofi-Aventis Deutschland GmbH | Needle assembly for a medical device |
| EP2514684A1 (en) | 2011-04-20 | 2012-10-24 | Becton Dickinson France | Packaging for medical containers |
| EP2522318A1 (en) | 2011-05-12 | 2012-11-14 | Sanofi-Aventis Deutschland GmbH | Guide device for intraocular injection |
| WO2012162459A1 (en) | 2011-05-26 | 2012-11-29 | Pepose Jay | Device and method for administering eye medications |
| EP2540261A1 (en) | 2011-06-30 | 2013-01-02 | Sanofi-Aventis Deutschland GmbH | Intraocular medicament delivery device |
| CN103781506B (zh) | 2011-08-05 | 2016-08-31 | 尤尼特拉克特注射器私人有限公司 | 在药物至目标位置的给药中使用的套管及制造套管的方法 |
| JP5933719B2 (ja) | 2011-09-13 | 2016-06-15 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 注射デバイス |
| EP2574355A1 (en) | 2011-09-27 | 2013-04-03 | Sanofi-Aventis Deutschland GmbH | Package for a medicament delivery device |
| EP2578260A1 (en) | 2011-10-07 | 2013-04-10 | Sanofi-Aventis Deutschland GmbH | Apparatus for intraocular injection |
| EP2578190A1 (en) | 2011-10-07 | 2013-04-10 | Sanofi-Aventis Deutschland GmbH | Intraocular injection device |
| EP2578191A1 (en) | 2011-10-07 | 2013-04-10 | Sanofi-Aventis Deutschland GmbH | Apparatus for intraocular injection |
| EP2578189A1 (en) | 2011-10-07 | 2013-04-10 | Sanofi-Aventis Deutschland GmbH | Apparatus for intraocular injection |
| EP2586407A1 (en) | 2011-10-31 | 2013-05-01 | Sanofi-Aventis Deutschland GmbH | Aid device for intraocular injection |
| EP2596826A1 (en) | 2011-11-24 | 2013-05-29 | Sanofi-Aventis Deutschland GmbH | Safety syringe |
| EP2601988A1 (en) | 2011-12-08 | 2013-06-12 | Sanofi-Aventis Deutschland GmbH | Syringe carrier |
| EP2601992A1 (en) | 2011-12-08 | 2013-06-12 | Sanofi-Aventis Deutschland GmbH | Syringe carrier |
| EP2601990A1 (en) | 2011-12-08 | 2013-06-12 | Sanofi-Aventis Deutschland GmbH | Syringe carrier |
| EP2788054B1 (en) | 2011-12-08 | 2018-04-25 | UNL Holdings LLC | Accurate dose control mechanisms and drug delivery syringes |
| MX2014007115A (es) | 2011-12-15 | 2014-09-08 | Sanofi Aventis Deutschland | Deposito, metodo y montaje para un sistema de suministro de farmacos. |
| EP2609952B1 (en) | 2011-12-30 | 2015-01-14 | Q-Med AB | Bruiseless cannula |
| AU344164S (en) | 2012-02-02 | 2012-09-04 | Terumo Corp | Safety device for indwelling needle |
| EP2626096A1 (en) | 2012-02-10 | 2013-08-14 | Sanofi-Aventis Deutschland GmbH | Medicament delivery device with needle assembly removal mechanism |
| CN104159622A (zh) | 2012-02-20 | 2014-11-19 | 泰尔茂株式会社 | 医疗用具包装体 |
| CA2865132A1 (en) | 2012-02-22 | 2013-08-29 | Trustees Of Tufts College | Compositions and methods for ocular delivery of a therapeutic agent |
| CA2865273C (en) | 2012-02-22 | 2018-06-05 | Ira H. Schachar | Device and method for treatment of retinal detachment and other maladies of the eye |
| WO2013126853A2 (en) | 2012-02-23 | 2013-08-29 | Unitract Syringe Pty Ltd | Devices for targeted delivery of therapeutic implants |
| USD672506S1 (en) | 2012-02-28 | 2012-12-11 | Idea Village Products, Inc. | Exfoliating device |
| WO2013127813A1 (en) | 2012-02-29 | 2013-09-06 | Sanofi-Aventis Deutschland Gmbh | Extraction device for a single extraction of a medicament from a container |
| CA2866843C (en) | 2012-03-12 | 2020-04-21 | Unitract Syringe Pty Ltd | Fill-finish cartridges for sterile fluid pathway assemblies and drug delivery devices incorporating fill-finish cartridges |
| EP2641629A1 (en) | 2012-03-22 | 2013-09-25 | Sanofi-Aventis Deutschland GmbH | Medical injection device with injection site pain reduction device |
| US9421129B2 (en) | 2012-04-02 | 2016-08-23 | Ocuject, Llc | Intraocular delivery devices and methods therefor |
| US9833523B2 (en) | 2012-04-24 | 2017-12-05 | The Ohio State University | Pharmacokinetic determination of intravitreal agents |
| WO2013176703A1 (en) | 2012-05-21 | 2013-11-28 | Baxter International, Inc. | Syringe storage tray |
| JP2015520230A (ja) | 2012-06-25 | 2015-07-16 | バイエル・ヘルスケア・エルエルシーBayer HealthCareLLC | アキシチニブを含んでいる眼科用局所医薬組成物 |
| US9956341B2 (en) | 2012-07-03 | 2018-05-01 | Milestone Scientific, Inc. | Drug infusion with pressure sensing and non-continuous flow for identification of and injection into fluid-filled anatomic spaces |
| US8727117B2 (en) | 2012-07-16 | 2014-05-20 | Becton, Dickinson And Company | Package for syringe |
| WO2014028285A1 (en) | 2012-08-13 | 2014-02-20 | The Brigham And Women's Hospital, Inc. | Methods and devices for inserting a needle |
| CA2882184C (en) | 2012-08-27 | 2021-09-07 | Clearside Biomedical, Inc. | Apparatus and methods for drug delivery using microneedles |
| USD715125S1 (en) | 2012-10-08 | 2014-10-14 | The Ames Companies, Inc. | Grip |
| CA3240136A1 (en) | 2012-11-08 | 2014-05-15 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
| US9022968B2 (en) | 2013-01-08 | 2015-05-05 | University Of South Florida | Auto-regulation system for intraocular pressure |
| AU2014236455B2 (en) | 2013-03-14 | 2018-07-12 | Forsight Vision4, Inc. | Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant |
| USD740098S1 (en) | 2013-03-19 | 2015-10-06 | Tong Yah Electronic Technology Co., Ltd. | Vehicular handle |
| US9987163B2 (en) | 2013-04-16 | 2018-06-05 | Novartis Ag | Device for dispensing intraocular substances |
| SG10201702674PA (en) | 2013-05-03 | 2017-06-29 | Clearside Biomedical Inc | Apparatus and methods for ocular injection |
| EP3003454B1 (en) | 2013-06-03 | 2020-01-08 | Clearside Biomedical, Inc. | Apparatus for drug delivery using multiple reservoirs |
| WO2015015467A1 (en) | 2013-08-02 | 2015-02-05 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | A device for delivery of compositions to the eye |
| JP2016528996A (ja) | 2013-08-07 | 2016-09-23 | ユニトラクト シリンジ プロプライエタリイ リミテッドUnitract Syringe Pty Ltd | 注射器用のルアー連結アダプタ |
| AU2014305922A1 (en) | 2013-08-07 | 2016-02-25 | Unitract Syringe Pty Ltd | Luer connection adapters for retractable needle syringes |
| USD718602S1 (en) | 2013-09-09 | 2014-12-02 | Midwest Tool And Cutlery Company | Hand grip for hand tools |
| USD713958S1 (en) | 2013-12-05 | 2014-09-23 | Becton, Dickinson And Company | Pen needle outer cover |
| CA2933900A1 (en) | 2013-12-20 | 2015-06-25 | Georgia Tech Research Corporation | Formulations and methods for targeted ocular delivery of therapeutic agents |
| USD726908S1 (en) | 2014-02-06 | 2015-04-14 | St. Jude Medical, Cardiology Division, Inc. | Catheter handle |
| EP3157463A4 (en) | 2014-06-17 | 2018-02-21 | Clearside Biomedical, Inc. | Methods and devices for treating posterior ocular disorders |
| RU2710491C2 (ru) | 2014-06-20 | 2019-12-26 | Клиасайд Байомедикал, Инк. | Устройство для инъекции лекарственного средства в глазную ткань и способ инъекции лекарственного средства в глазную ткань |
| WO2016042162A1 (en) | 2014-09-19 | 2016-03-24 | Medterials, Inc. | Ophthalmic delivery device |
| WO2016042163A2 (en) | 2014-09-19 | 2016-03-24 | Medterials, Inc. | Ophthalmic drug compositions |
| USD750223S1 (en) | 2014-10-14 | 2016-02-23 | Clearside Biomedical, Inc. | Medical injector for ocular injection |
| EP4279064A3 (en) | 2015-05-12 | 2024-02-28 | Incept, LLC | Drug delivery from hydrogels |
| EP3400014A1 (en) | 2016-01-08 | 2018-11-14 | Clearside Biomedical, Inc. | Methods and devices for treating posterior ocular disorderswith aflibercept and other biologics |
| WO2017120600A1 (en) | 2016-01-08 | 2017-07-13 | Clearside Biomedical, Inc. | Compositions and methods of treating wet age-related macular degeneration |
| EP3413851B1 (en) | 2016-02-10 | 2023-09-27 | Clearside Biomedical, Inc. | Packaging |
| WO2017190142A1 (en) | 2016-04-29 | 2017-11-02 | Clearside Biomedical, Inc. | Formulations and methods for reduction of intraocular pressure |
| JP2019514581A (ja) | 2016-05-02 | 2019-06-06 | クリアサイド バイオメディカル,インコーポレイテッド | 眼の薬物送達のためのシステムおよび方法 |
| IL264764B2 (en) | 2016-08-12 | 2024-02-01 | Clearside Biomedical Inc | Devices and methods for adjusting the insertion depth of a drug administration needle |
| WO2018204515A1 (en) | 2017-05-02 | 2018-11-08 | Georgia Tech Research Corporation | Targeted drug delivery methods using a microneedle |
| KR20200060456A (ko) | 2017-09-27 | 2020-05-29 | 리젠엑스바이오 인크. | 완전-인간 번역후 변형된 항-VEGF Fab를 이용한 안구 질환의 치료 |
| US20190269702A1 (en) | 2018-03-05 | 2019-09-05 | Clearside Biomedical, Inc. | Compositions and methods for treating noninfectious uveitis |
| CA3136814A1 (en) | 2019-04-16 | 2020-10-22 | Clearside Biomedical, Inc. | Injectable triamcinolone formulations |
| EP4106755A4 (en) | 2020-02-19 | 2024-03-27 | Clearside Biomedical, Inc. | COMPOSITIONS CONTAINING AXITINIB AND METHODS FOR TREATING OCULAR DISEASES |
| US20230201371A1 (en) | 2020-03-19 | 2023-06-29 | Clearside Biomedical, Inc. | Compositions and methods for treating ocular disorders |
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