KR101799126B1 - 키나아제 조절을 위한 화합물 및 방법, 및 그에 대한 적응증 - Google Patents

키나아제 조절을 위한 화합물 및 방법, 및 그에 대한 적응증 Download PDF

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KR101799126B1
KR101799126B1 KR1020127030470A KR20127030470A KR101799126B1 KR 101799126 B1 KR101799126 B1 KR 101799126B1 KR 1020127030470 A KR1020127030470 A KR 1020127030470A KR 20127030470 A KR20127030470 A KR 20127030470A KR 101799126 B1 KR101799126 B1 KR 101799126B1
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fluoro
formula
pyrrolo
pyrimidin
methanone
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KR20130066621A (ko
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자중 장
프라바 엔. 이브라힘
웨인 스페바크
제임스 차이
토드 유잉
잉 장
차오 장
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플렉시콘 인코퍼레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020127030470A 2010-04-21 2011-04-20 키나아제 조절을 위한 화합물 및 방법, 및 그에 대한 적응증 Expired - Fee Related KR101799126B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32662610P 2010-04-21 2010-04-21
US61/326,626 2010-04-21
PCT/US2011/033192 WO2011133637A2 (en) 2010-04-21 2011-04-20 Compounds and methods for kinase modulation, and indications therefor

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KR20130066621A KR20130066621A (ko) 2013-06-20
KR101799126B1 true KR101799126B1 (ko) 2017-11-17

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US (3) US8901118B2 (enExample)
EP (1) EP2560972B1 (enExample)
JP (2) JP5808793B2 (enExample)
KR (1) KR101799126B1 (enExample)
CN (1) CN102947305B (enExample)
AR (2) AR080940A1 (enExample)
AU (1) AU2011242778B2 (enExample)
BR (1) BR112012026927A2 (enExample)
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