BR112012026927A2 - composto e métodos para modulação de cinase, e indicações para os mesmos. - Google Patents

composto e métodos para modulação de cinase, e indicações para os mesmos.

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Publication number
BR112012026927A2
BR112012026927A2 BR112012026927A BR112012026927A BR112012026927A2 BR 112012026927 A2 BR112012026927 A2 BR 112012026927A2 BR 112012026927 A BR112012026927 A BR 112012026927A BR 112012026927 A BR112012026927 A BR 112012026927A BR 112012026927 A2 BR112012026927 A2 BR 112012026927A2
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Brazil
Prior art keywords
disease
cancer
methods
pain
compound
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BR112012026927A
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English (en)
Inventor
Zhang Chao
Tsai James
Zhang Jiazhong
N Ibrahim Prabha
Ewing Todd
Spevak Wayne
Zhang Ying
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Plexxikon Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44816304&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112012026927(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of BR112012026927A2 publication Critical patent/BR112012026927A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Neurology (AREA)
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  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
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  • Psychiatry (AREA)
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  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

composto e métodos para modulação de cinase, e indicações para os mesmos. a presente invenção refere-se aos compostos e sais dos mesmos, formulações dos mesmos, conjugados dos mesmos, derivados dos mesmos, formas dos mesmos e usos dos mesmos são descritos. em certos aspectos e modalidades, os compostos descritos ou sais dos mesmos, formulações dos mesmos, conjugados dos mesmos, derivados dos mesmos, formas dos mesmos, são ativos em uma ou mais das proteínas cinase fms, kit, flt3, trkb e trkc. também descritos são métodos de uso dos mesmos para tratar doenças e condições, incluindo doenças e condições associadas com a atividade de uma ou mais de fms, kit, flt3, trka, trkb e trkc, incluindo artrite reumatoide, osteoartrite, osteoporose, osteólise periprotética, esclerose sistêmica, distúrbios desmielinizantes, esclerose múltipla, síndrome de charcot marie tooth, esclerose lateral amiotrófica, doença de alzheimer, doença de parkison, isquemia global, colite ulcerativa, doença de crohn, púrpura trombocitopênica imune, aterosclerose, lúpus sistêmico eritematoso, mielopreparação para transplantação autóloga, rejeição de transplante, glomerulonefrite, nefrite lúpica, necrose tubular, nefropatia diabética, hipertrofia renal, diabetes do tipo i, dor aguda, dor inflamatória, dor neropática, leucemia mieloide aguda, melanoma, mieloma múltiplo, câncer de mama, câncer de próstata, câncer pancreático, câncer pulmonar, câncer ovarino, gliomas, gliblastoma, neurofibromatose, metástase osteolíca do osso, metástase cerebral, tumores estromais gastrintestinais, e tumores de célula gigante.
BR112012026927A 2010-04-21 2011-04-20 composto e métodos para modulação de cinase, e indicações para os mesmos. BR112012026927A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32662610P 2010-04-21 2010-04-21
PCT/US2011/033192 WO2011133637A2 (en) 2010-04-21 2011-04-20 Compounds and methods for kinase modulation, and indications therefor

Publications (1)

Publication Number Publication Date
BR112012026927A2 true BR112012026927A2 (pt) 2017-10-10

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ID=44816304

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BR112012026927A BR112012026927A2 (pt) 2010-04-21 2011-04-20 composto e métodos para modulação de cinase, e indicações para os mesmos.

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US (3) US8901118B2 (pt)
EP (1) EP2560972B1 (pt)
JP (2) JP5808793B2 (pt)
KR (1) KR101799126B1 (pt)
CN (1) CN102947305B (pt)
AR (2) AR080940A1 (pt)
AU (1) AU2011242778B2 (pt)
BR (1) BR112012026927A2 (pt)
CA (1) CA2796998C (pt)
CL (1) CL2012002937A1 (pt)
CO (1) CO6620045A2 (pt)
CR (1) CR20120536A (pt)
CY (1) CY1120554T1 (pt)
DK (1) DK2560972T3 (pt)
EA (1) EA028105B1 (pt)
EC (1) ECSP12012245A (pt)
ES (1) ES2641643T3 (pt)
GE (1) GEP20156251B (pt)
HR (1) HRP20171660T1 (pt)
HU (1) HUE036461T2 (pt)
IL (1) IL222498A (pt)
LT (1) LT2560972T (pt)
MA (1) MA34229B1 (pt)
MX (1) MX336056B (pt)
MY (1) MY160780A (pt)
NZ (2) NZ603087A (pt)
PE (1) PE20130240A1 (pt)
PL (1) PL2560972T3 (pt)
PT (1) PT2560972T (pt)
RS (1) RS56588B1 (pt)
SG (2) SG10201505606QA (pt)
SI (1) SI2560972T1 (pt)
TW (2) TWI619713B (pt)
UA (1) UA109128C2 (pt)
UY (1) UY33346A (pt)
WO (1) WO2011133637A2 (pt)
ZA (1) ZA201207898B (pt)

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MA34229B1 (fr) 2013-05-02
US20110263595A1 (en) 2011-10-27
KR101799126B1 (ko) 2017-11-17
EP2560972A4 (en) 2013-11-20
SG10201505606QA (en) 2015-08-28
WO2011133637A2 (en) 2011-10-27
CY1120554T1 (el) 2019-07-10
ECSP12012245A (es) 2012-11-30
ES2641643T3 (es) 2017-11-10
EP2560972A2 (en) 2013-02-27

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