EA201290973A1 - Соединения и способы модулирования киназ и показания по их применению - Google Patents

Соединения и способы модулирования киназ и показания по их применению

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Publication number
EA201290973A1
EA201290973A1 EA201290973A EA201290973A EA201290973A1 EA 201290973 A1 EA201290973 A1 EA 201290973A1 EA 201290973 A EA201290973 A EA 201290973A EA 201290973 A EA201290973 A EA 201290973A EA 201290973 A1 EA201290973 A1 EA 201290973A1
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Prior art keywords
disease
cancer
trkc
trkb
trka
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EA201290973A
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English (en)
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EA028105B1 (ru
Inventor
Цзячжун Чжан
Прабха Н. Ибрахим
Вэйн Спевак
Джеймс Цай
Тодд Эвинг
Ин Чжан
Чао Чжан
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Плексксикон, Инк.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44816304&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201290973(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Плексксикон, Инк. filed Critical Плексксикон, Инк.
Publication of EA201290973A1 publication Critical patent/EA201290973A1/ru
Publication of EA028105B1 publication Critical patent/EA028105B1/ru

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    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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Abstract

Описаны соединения и их соли, препараты, конъюгаты, производные, формы и их применения. В некоторых аспектах и вариантах описанные соединения или их соли, препараты, конъюгаты, производные, формы активны в отношении одной или нескольких протеинкиназ, включая Fms, Kit, Flt3, TrkA, TrkB и TrkC. Описаны также способы их использования для лечения болезней и состояний, включая болезни и состояния, которые ассоциируются с активностью одной или нескольких из Fms, Kit, Flt3, TrkA, TrkB и TrkC, включая ревматоидный артрит, остеоартрит, остеопороз, околопротезный остеолиз, системный склероз, демиелинирующие расстройства, рассеянный склероз, синдром Шарко Мари Туза, боковой амиотрофический склероз, болезнь Альцгеймера, болезнь Паркинсона, тотальную ишемию, язвенный колит, болезнь Крона, иммунную тромботическую пурпуру, атеросклероз, системную красную волчанку, миелоподготовку к аутогенной трансплантации, отторжение трансплантата, гломерулонефрит, интерстициальный нефрит, люпус-нефрит, тубулярный некроз, диабетическую нефропатию, ренальную гипертрофию, диабет типа I, острую боль, боль воспалительного характера, невропатическую боль, острый миелоидный лейкоз, меланому, множественную миелому, рак молочной железы, рак предстательной железы, рак поджелудочной железы, рак легких, рак яичника, глиомы, глиобластомы, нейрофиброматоз, остеолитические метастазы в кости, метастазы в мозг, желудочно-кишечные стромальные опухоли и гигантоклеточные опухоли.
EA201290973A 2010-04-21 2011-04-20 Соединения и способы модулирования киназ и показания по их применению EA028105B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32662610P 2010-04-21 2010-04-21
PCT/US2011/033192 WO2011133637A2 (en) 2010-04-21 2011-04-20 Compounds and methods for kinase modulation, and indications therefor

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EA201290973A1 true EA201290973A1 (ru) 2013-04-30
EA028105B1 EA028105B1 (ru) 2017-10-31

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US (3) US8901118B2 (ru)
EP (1) EP2560972B1 (ru)
JP (2) JP5808793B2 (ru)
KR (1) KR101799126B1 (ru)
CN (1) CN102947305B (ru)
AR (2) AR080940A1 (ru)
AU (1) AU2011242778B2 (ru)
BR (1) BR112012026927A2 (ru)
CA (1) CA2796998C (ru)
CL (1) CL2012002937A1 (ru)
CO (1) CO6620045A2 (ru)
CR (1) CR20120536A (ru)
CY (1) CY1120554T1 (ru)
DK (1) DK2560972T3 (ru)
EA (1) EA028105B1 (ru)
EC (1) ECSP12012245A (ru)
ES (1) ES2641643T3 (ru)
GE (1) GEP20156251B (ru)
HR (1) HRP20171660T1 (ru)
HU (1) HUE036461T2 (ru)
IL (1) IL222498A (ru)
LT (1) LT2560972T (ru)
MA (1) MA34229B1 (ru)
MX (1) MX336056B (ru)
MY (1) MY160780A (ru)
NZ (2) NZ703538A (ru)
PE (1) PE20130240A1 (ru)
PL (1) PL2560972T3 (ru)
PT (1) PT2560972T (ru)
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SG (2) SG10201505606QA (ru)
SI (1) SI2560972T1 (ru)
TW (2) TWI510487B (ru)
UA (1) UA109128C2 (ru)
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ZA201207898B (en) 2016-09-28
DK2560972T3 (da) 2017-11-27
JP2013525363A (ja) 2013-06-20
KR101799126B1 (ko) 2017-11-17
UA109128C2 (ru) 2015-07-27
TW201544506A (zh) 2015-12-01
US20170283423A1 (en) 2017-10-05
MX336056B (es) 2016-01-07
CL2012002937A1 (es) 2013-01-25
AU2011242778A1 (en) 2012-11-22
AU2011242778B2 (en) 2015-09-03
US20110263595A1 (en) 2011-10-27
TWI510487B (zh) 2015-12-01
CO6620045A2 (es) 2013-02-15
EP2560972A2 (en) 2013-02-27
ES2641643T3 (es) 2017-11-10
US9682981B2 (en) 2017-06-20
WO2011133637A3 (en) 2012-02-09
EP2560972B1 (en) 2017-09-20
EA028105B1 (ru) 2017-10-31

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