KR101379365B1 - 매크로사이클릭 ｃ형 간염 세린 프로테아제 억제제 - Google Patents

매크로사이클릭 ｃ형 간염 세린 프로테아제 억제제 Download PDF

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Publication number
KR101379365B1
KR101379365B1 KR1020090086079A KR20090086079A KR101379365B1 KR 101379365 B1 KR101379365 B1 KR 101379365B1 KR 1020090086079 A KR1020090086079 A KR 1020090086079A KR 20090086079 A KR20090086079 A KR 20090086079A KR 101379365 B1 KR101379365 B1 KR 101379365B1
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South Korea
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pyrrolo
dioxo
replicon
value
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Expired - Fee Related
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KR1020090086079A
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English (en)
Korean (ko)
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KR20100031092A (ko
Inventor
이인 쿠
키스 에프. 맥대니얼
후이-쥐 천
제이슨 피. 쉔리
데일 제이. 켐프
데이비드 제이. 그람포브닉
잉 쑨
둥 류
융화 가이
야트 쑨 오르
세블 에이치. 와고
켄 엥스트롬
팀 그림
Original Assignee
이난타 파마슈티칼스, 인코포레이티드
아보트 러보러터리즈
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Application filed by 이난타 파마슈티칼스, 인코포레이티드, 아보트 러보러터리즈 filed Critical 이난타 파마슈티칼스, 인코포레이티드
Publication of KR20100031092A publication Critical patent/KR20100031092A/ko
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Publication of KR101379365B1 publication Critical patent/KR101379365B1/ko
Assigned to 애브비 바하마스 리미티드 reassignment 애브비 바하마스 리미티드 권리지분의 전부이전등록 Assignors: 아보트 러보러터리즈
Assigned to 애브비 아일랜드 언리미티드 컴퍼니 reassignment 애브비 아일랜드 언리미티드 컴퍼니 권리지분의 전부이전등록 Assignors: 애브비 바하마스 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • AIDS & HIV (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020090086079A 2008-09-11 2009-09-11 매크로사이클릭 ｃ형 간염 세린 프로테아제 억제제 Expired - Fee Related KR101379365B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19172508P 2008-09-11 2008-09-11
US61/191,725 2008-09-11
US20968909P 2009-03-10 2009-03-10
US61/209,689 2009-03-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR20120025541A Division KR101487726B1 (ko) 2008-09-11 2012-03-13 매크로사이클릭 ｃ형 간염 세린 프로테아제 억제제

Publications (2)

Publication Number Publication Date
KR20100031092A KR20100031092A (ko) 2010-03-19
KR101379365B1 true KR101379365B1 (ko) 2014-03-31

Family

ID=42005677

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020090086079A Expired - Fee Related KR101379365B1 (ko) 2008-09-11 2009-09-11 매크로사이클릭 ｃ형 간염 세린 프로테아제 억제제
KR20120025541A Expired - Fee Related KR101487726B1 (ko) 2008-09-11 2012-03-13 매크로사이클릭 ｃ형 간염 세린 프로테아제 억제제
KR1020140034200A Ceased KR20140056195A (ko) 2008-09-11 2014-03-24 매크로사이클릭 ｃ형 간염 세린 프로테아제 억제제

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR20120025541A Expired - Fee Related KR101487726B1 (ko) 2008-09-11 2012-03-13 매크로사이클릭 ｃ형 간염 세린 프로테아제 억제제
KR1020140034200A Ceased KR20140056195A (ko) 2008-09-11 2014-03-24 매크로사이클릭 ｃ형 간염 세린 프로테아제 억제제

Country Status (41)

Country Link
US (3) US8420596B2 (https=)
EP (5) EP2468287B1 (https=)
JP (4) JP5259537B2 (https=)
KR (3) KR101379365B1 (https=)
CN (3) CN103896950A (https=)
AR (3) AR073568A1 (https=)
AU (1) AU2009292182B2 (https=)
BR (2) BR122012005261A8 (https=)
CA (1) CA2736895C (https=)
CL (2) CL2011000512A1 (https=)
CO (1) CO6341565A2 (https=)
CR (1) CR20140180A (https=)
CY (6) CY1115137T1 (https=)
DK (5) DK2468285T3 (https=)
DO (1) DOP2011000077A (https=)
EA (2) EA022891B1 (https=)
EC (2) ECSP11010879A (https=)
ES (5) ES2525922T3 (https=)
GT (2) GT201100056AA (https=)
HR (5) HRP20140494T1 (https=)
HU (2) HUE039478T2 (https=)
IL (2) IL218441A (https=)
LT (2) LT2805726T (https=)
LU (1) LU92667I2 (https=)
MX (1) MX2011002486A (https=)
MY (1) MY159820A (https=)
NL (1) NL300730I1 (https=)
NO (1) NO2015014I1 (https=)
NZ (2) NZ592170A (https=)
PA (1) PA8842201A1 (https=)
PE (3) PE20121312A1 (https=)
PL (5) PL2468286T3 (https=)
PT (5) PT2468285E (https=)
SG (1) SG179414A1 (https=)
SI (5) SI2340029T1 (https=)
SM (1) SMT201800407T1 (https=)
TR (1) TR201809771T4 (https=)
TW (3) TWI429449B (https=)
UY (3) UY32099A (https=)
WO (1) WO2010030359A2 (https=)
ZA (2) ZA201101558B (https=)

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