KR100807162B1 - 종양의 치료를 위한 퀴나졸린 유도체 - Google Patents

종양의 치료를 위한 퀴나졸린 유도체 Download PDF

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Publication number
KR100807162B1
KR100807162B1 KR1020027016508A KR20027016508A KR100807162B1 KR 100807162 B1 KR100807162 B1 KR 100807162B1 KR 1020027016508 A KR1020027016508 A KR 1020027016508A KR 20027016508 A KR20027016508 A KR 20027016508A KR 100807162 B1 KR100807162 B1 KR 100807162B1
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KR
South Korea
Prior art keywords
alkyl
group
pyrrolidin
ethoxy
formula
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Expired - Fee Related
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KR1020027016508A
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English (en)
Korean (ko)
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KR20030007859A (ko
Inventor
에네껭로렝프랑스와앙드레
쁠레빠뜨릭
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아스트라제네카 아베
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Application filed by 아스트라제네카 아베 filed Critical 아스트라제네카 아베
Publication of KR20030007859A publication Critical patent/KR20030007859A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020027016508A 2000-06-06 2001-06-01 종양의 치료를 위한 퀴나졸린 유도체 Expired - Fee Related KR100807162B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP00401581 2000-06-06
EP00401581.4 2000-06-06
EP01400297 2001-02-07
EP01400297.6 2001-02-07
EP01400565 2001-03-05
EP01400565.6 2001-03-05
PCT/GB2001/002424 WO2001094341A1 (en) 2000-06-06 2001-06-01 Quinazoline derivatives for the treatment of tumours

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020087002129A Division KR20080015055A (ko) 2000-06-06 2001-06-01 종양의 치료를 위한 퀴나졸린 유도체

Publications (2)

Publication Number Publication Date
KR20030007859A KR20030007859A (ko) 2003-01-23
KR100807162B1 true KR100807162B1 (ko) 2008-02-27

Family

ID=27223613

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020027016508A Expired - Fee Related KR100807162B1 (ko) 2000-06-06 2001-06-01 종양의 치료를 위한 퀴나졸린 유도체
KR1020087002129A Withdrawn KR20080015055A (ko) 2000-06-06 2001-06-01 종양의 치료를 위한 퀴나졸린 유도체

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020087002129A Withdrawn KR20080015055A (ko) 2000-06-06 2001-06-01 종양의 치료를 위한 퀴나졸린 유도체

Country Status (31)

Country Link
US (3) US7049438B2 (OSRAM)
EP (1) EP1292594B1 (OSRAM)
JP (1) JP3774438B2 (OSRAM)
KR (2) KR100807162B1 (OSRAM)
CN (1) CN100345844C (OSRAM)
AR (1) AR030937A1 (OSRAM)
AT (1) ATE275145T1 (OSRAM)
AU (2) AU2001260482B2 (OSRAM)
BG (1) BG65836B1 (OSRAM)
BR (1) BR0111335A (OSRAM)
CA (1) CA2407371C (OSRAM)
CO (1) CO5700751A2 (OSRAM)
CZ (1) CZ301987B6 (OSRAM)
DE (1) DE60105295T2 (OSRAM)
DK (1) DK1292594T3 (OSRAM)
EE (1) EE05481B1 (OSRAM)
ES (1) ES2225545T3 (OSRAM)
HU (1) HU229290B1 (OSRAM)
IL (2) IL152754A0 (OSRAM)
IS (1) IS2114B (OSRAM)
MX (1) MXPA02011765A (OSRAM)
MY (1) MY127369A (OSRAM)
NO (1) NO324838B1 (OSRAM)
NZ (1) NZ522204A (OSRAM)
PL (1) PL210852B1 (OSRAM)
PT (1) PT1292594E (OSRAM)
SI (1) SI1292594T1 (OSRAM)
SK (1) SK286748B6 (OSRAM)
TW (1) TWI288748B (OSRAM)
UA (1) UA73993C2 (OSRAM)
WO (1) WO2001094341A1 (OSRAM)

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