KR100771252B1 - 양이온 교환 크로마토그래피를 통한 약리학적 활성단백질의 정제방법 - Google Patents

양이온 교환 크로마토그래피를 통한 약리학적 활성단백질의 정제방법 Download PDF

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KR100771252B1
KR100771252B1 KR1020020037622A KR20020037622A KR100771252B1 KR 100771252 B1 KR100771252 B1 KR 100771252B1 KR 1020020037622 A KR1020020037622 A KR 1020020037622A KR 20020037622 A KR20020037622 A KR 20020037622A KR 100771252 B1 KR100771252 B1 KR 100771252B1
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protein
interferon
purification
solution
buffer solution
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Korean (ko)
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KR20030005005A (ko
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루시아스카폴
기세페클라우디오비스코미
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알파 와셔만 에스. 피. 에이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/811—Interferon

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020020037622A 2001-07-06 2002-06-29 양이온 교환 크로마토그래피를 통한 약리학적 활성단백질의 정제방법 Expired - Fee Related KR100771252B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITBO2001A000426 2001-07-06
IT2001BO000426A ITBO20010426A1 (it) 2001-07-06 2001-07-06 Processo per la purificazione di proteine farmacologicamente attive mediante cromatografia in scambio cationico

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KR20030005005A KR20030005005A (ko) 2003-01-15
KR100771252B1 true KR100771252B1 (ko) 2007-10-30

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US7449116B2 (en) * 2004-10-01 2008-11-11 Agilent Technologies, Inc. Methods and systems for protein separation
KR101288027B1 (ko) * 2006-04-12 2013-07-22 새비언트 파마수티컬즈 인크. 양이온 계면활성제를 이용한 단백질 정제 방법
CA2708291A1 (en) * 2007-12-10 2009-06-18 National Research Council Of Canada Production of recombinant interferon proteins
DE102009032179A1 (de) 2009-07-07 2011-01-13 Biogenerix Ag Verfahren zur Reinigung von Interferon beta
CN101768601B (zh) * 2010-02-01 2013-08-07 山东泉港药业有限公司 一种重组人血白蛋白—干扰素α2b的生产方法
JP6292718B2 (ja) * 2011-07-01 2018-03-14 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 凝集ポリペプチドから単量体ポリペプチドを分離するための方法
US8921113B2 (en) 2012-12-21 2014-12-30 Dionex Corporation Buffer kit and method of generating a linear pH gradient
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CN104236983A (zh) * 2013-06-14 2014-12-24 中国科学院大连化学物理研究所 溶液样品中含长烷基链的离子液体的去除方法
TWI671312B (zh) 2014-01-17 2019-09-11 美商健臻公司 無菌層析法及製法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
WO2016079598A1 (en) * 2014-11-18 2016-05-26 Unichem Laboratories Limited An improved process for the preparation of pharmacopoeial grade interferon alpha 2b
CN106496302B (zh) * 2015-09-08 2021-12-10 三生国健药业（上海）股份有限公司 一种用离子交换层析纯化蛋白质的方法
GB201517450D0 (en) * 2015-10-02 2015-11-18 Ipsen Biopharm Ltd Method
WO2017097869A1 (en) * 2015-12-09 2017-06-15 Basf Se Method of purifying a protein from fermentation solids under desorbing conditions
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BR112021003420A2 (pt) 2018-08-31 2021-05-18 Genzyme Corporation resina cromatográfica estéril e uso da mesma em processos de manufatura
US11022585B2 (en) * 2019-06-09 2021-06-01 Dionex Corporation Methods and systems for optimizing buffer conditions with liquid chromatography
CN111138523A (zh) * 2019-12-10 2020-05-12 天津生机集团股份有限公司 一种从重组鸡干扰素α复性液中纯化制备重组鸡干扰素α的方法
CN113968900B (zh) * 2020-07-23 2023-07-25 中元汇吉生物技术股份有限公司 一种纯化C1q蛋白的方法
CN115918902A (zh) * 2022-12-19 2023-04-07 新疆农业科学院农业质量标准与检测技术研究所 一种通过微水波扩散重力法预处理葡萄脱水并获取高酚葡萄提取物的方法

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CA2388716A1 (en) 2003-01-06
RS51512B (sr) 2011-06-30
SK287827B6 (sk) 2011-11-04
UY27354A1 (es) 2003-04-30
DE60206847D1 (de) 2005-12-01
PL209954B1 (pl) 2011-11-30
CN1396176A (zh) 2003-02-12
CA2388716C (en) 2008-01-08
KR20030005005A (ko) 2003-01-15
EG23150A (en) 2004-05-31
US20030010715A1 (en) 2003-01-16
ITBO20010426A1 (it) 2003-01-06
SI1273592T1 (sl) 2006-02-28
CN100484954C (zh) 2009-05-06
ES2250544T3 (es) 2006-04-16
AR034663A1 (es) 2004-03-03
US6866782B2 (en) 2005-03-15
HRP20020480A2 (en) 2003-02-28
MXPA02006303A (es) 2003-02-10
HU0202124D0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2002-09-28
HRP20020480B1 (en) 2006-11-30
PL354769A1 (en) 2003-01-13
CU23149A3 (es) 2006-06-29
ITBO20010426A0 (it) 2001-07-06
EP1273592A2 (en) 2003-01-08
BR0202431A (pt) 2003-09-09
BG106768A (en) 2003-05-30
EP1273592A3 (en) 2003-03-19
RU2002117383A (ru) 2004-01-27
DZ3236A1 (fr) 2005-04-20
MEP3408A (en) 2010-10-10
EP1273592B1 (en) 2005-10-26
DE60206847T2 (de) 2006-07-06
JP3940037B2 (ja) 2007-07-04
RU2274471C2 (ru) 2006-04-20
SK8592002A3 (en) 2003-01-09
BG65748B1 (bg) 2009-09-30
ATE307824T1 (de) 2005-11-15
YU50502A (sh) 2005-09-19
JP2003096092A (ja) 2003-04-03
DK1273592T3 (da) 2006-01-02
HUP0202124A2 (hu) 2003-10-28

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