IT1262899B - Processo per l'isolamento di fattore ix, fattore x e fattore ii altamente purificati dal complesso protrombinico o dal plasma umano - Google Patents
Processo per l'isolamento di fattore ix, fattore x e fattore ii altamente purificati dal complesso protrombinico o dal plasma umanoInfo
- Publication number
- IT1262899B IT1262899B ITFI920078A ITFI920078A IT1262899B IT 1262899 B IT1262899 B IT 1262899B IT FI920078 A ITFI920078 A IT FI920078A IT FI920078 A ITFI920078 A IT FI920078A IT 1262899 B IT1262899 B IT 1262899B
- Authority
- IT
- Italy
- Prior art keywords
- factor
- human plasma
- complex
- protrombinic
- insulation
- Prior art date
Links
- 229960004222 factor ix Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000009413 insulation Methods 0.000 title 1
- 108010094028 Prothrombin Proteins 0.000 abstract 2
- 102100022641 Coagulation factor IX Human genes 0.000 abstract 1
- 108010076282 Factor IX Proteins 0.000 abstract 1
- 108010014173 Factor X Proteins 0.000 abstract 1
- 102100027378 Prothrombin Human genes 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 abstract 1
- 238000004255 ion exchange chromatography Methods 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 229940039716 prothrombin Drugs 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
E' descritto un processo per la purificazione di Fattore IX, Fattore X e Fattore II a partire da plasma umano, o sue frazioni, in cui una soluzione contenente fattori costituenti il complesso protrombinico è purificata utilizzando cromatografie a scambio ionico ed una cromatografia ad assorbimento su ioni metallici.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITFI920078A IT1262899B (it) | 1992-03-27 | 1992-03-27 | Processo per l'isolamento di fattore ix, fattore x e fattore ii altamente purificati dal complesso protrombinico o dal plasma umano |
EP93104633A EP0617049B1 (en) | 1992-03-22 | 1993-03-22 | Process for the isolation of highly purified factors IX, X and II from prothrombin complex or human plasma |
DE69326227T DE69326227T2 (de) | 1992-03-27 | 1993-03-22 | Verfahren zur Isolation von hoch angereicherten Faktoren IX, X und II vom Prothrombin komplex oder menschlichem Plasma |
AT93104633T ATE184018T1 (de) | 1992-03-27 | 1993-03-22 | Verfahren zur isolation von hoch angereicherten faktoren ix, x und ii vom prothrombin komplex oder menschlichem plasma |
ES93104633T ES2138603T3 (es) | 1992-03-27 | 1993-03-22 | Procedimiento para el aislamiento de los factores ix, x y ii altamente purificados a partir del complejo protrombinico o del plasma humano. |
US08/038,942 US5378365A (en) | 1992-03-27 | 1993-03-26 | Process for the isolation of highly purified factors IX, X and II from prothrombin complex or human plasma |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITFI920078A IT1262899B (it) | 1992-03-27 | 1992-03-27 | Processo per l'isolamento di fattore ix, fattore x e fattore ii altamente purificati dal complesso protrombinico o dal plasma umano |
Publications (3)
Publication Number | Publication Date |
---|---|
ITFI920078A0 ITFI920078A0 (it) | 1992-03-27 |
ITFI920078A1 ITFI920078A1 (it) | 1993-09-27 |
IT1262899B true IT1262899B (it) | 1996-07-22 |
Family
ID=11350034
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITFI920078A IT1262899B (it) | 1992-03-22 | 1992-03-27 | Processo per l'isolamento di fattore ix, fattore x e fattore ii altamente purificati dal complesso protrombinico o dal plasma umano |
Country Status (6)
Country | Link |
---|---|
US (1) | US5378365A (it) |
EP (1) | EP0617049B1 (it) |
AT (1) | ATE184018T1 (it) |
DE (1) | DE69326227T2 (it) |
ES (1) | ES2138603T3 (it) |
IT (1) | IT1262899B (it) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3336631A1 (de) * | 1983-10-08 | 1985-04-18 | Behringwerke Ag, 3550 Marburg | Verfahren zur pasteurisierung von plasma oder von konzentraten der blutgerinnungsfaktoren ii, vii, ix und x |
DE19504852C2 (de) * | 1995-02-15 | 2003-01-23 | Octapharma Ag Lachen | Verfahren zur Reinigung Vitamin K-abhängiger Gerinnungsfaktoren durch Affinitäts-Chromatographie |
US5714583A (en) | 1995-06-07 | 1998-02-03 | Genetics Institute, Inc. | Factor IX purification methods |
DK0796623T3 (da) * | 1996-03-20 | 2005-08-01 | Baxter Ag | Farmaceutisk præparat til behandling af blodkoagulationslidelser |
DE19625642A1 (de) * | 1996-06-26 | 1998-01-08 | Max Planck Gesellschaft | Verfahren zur Herstellung einer Antidotausgangssubstanz für natürliche und synthetische Thrombininhibitoren |
AT409334B (de) * | 1997-09-19 | 2002-07-25 | Immuno Ag | Pharmazeutisches präparat enthaltend vitamin k-abhängige einzelfaktoren |
ITBO20010426A1 (it) * | 2001-07-06 | 2003-01-06 | Alfa Wassermann Spa | Processo per la purificazione di proteine farmacologicamente attive mediante cromatografia in scambio cationico |
SE0203551D0 (sv) * | 2002-12-02 | 2002-12-02 | Biovitrum Ab | Prothrombin purification |
GB0614315D0 (en) | 2006-07-19 | 2006-08-30 | Ge Healthcare Bio Sciences Ab | Chromatography columns, systems and methods |
US9597611B2 (en) | 2007-03-09 | 2017-03-21 | Ge Healthcare Bioprocess R&D Ab | Packing system and method for chromatography columns |
US9597610B2 (en) * | 2007-03-09 | 2017-03-21 | Ge Healthcare Bioprocess R&D Ab | Packing system and method for chromatography columns |
GB0704603D0 (en) * | 2007-03-09 | 2007-04-18 | Ge Healthcare Bio Sciences Ab | Packing system and method for chromatography columns |
GB0710321D0 (en) | 2007-05-30 | 2007-07-11 | Nhs Blood & Transplant | Method |
US9956272B2 (en) | 2007-05-30 | 2018-05-01 | Bio Products Laboratory Limited | Methods for preparing factor X, activated factor X, inactivated factor X and inactivated factor Xa, and pharmaceutical compositions comprising same |
US7934704B2 (en) * | 2007-10-16 | 2011-05-03 | Environmental Dynamics, Inc. | Retrievable diffuser module with internal ballast/buoyancy chamber |
ES2576109T3 (es) * | 2008-12-02 | 2016-07-05 | Novo Nordisk Health Care Ag | Purificación de polipéptidos |
BR112012017696A2 (pt) | 2010-01-18 | 2017-10-03 | Novo Nordisk Healthcare Ag | Purificação de fatores de coagulação de sangue |
EP2652491B1 (en) | 2010-12-15 | 2017-11-29 | Baxalta GmbH | Eluate collection using conductivity gradient |
CN107915769A (zh) | 2011-03-29 | 2018-04-17 | 葛兰素史密斯克莱有限责任公司 | 用于蛋白纯化的缓冲液体系 |
US9663553B2 (en) | 2014-01-29 | 2017-05-30 | Hemarus Therapeutics Limited | Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT368883B (de) * | 1980-07-22 | 1982-11-25 | Immuno Ag | Verfahren zur herstellung einer neuen blutgerinnungsfoerdernden praeparation auf basis von humanproteinen |
DE3043857A1 (de) * | 1980-11-21 | 1982-07-08 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ii und vii |
US4470968A (en) * | 1983-01-13 | 1984-09-11 | Miles Laboratories, Inc. | Pasteurized therapeutically active blood coagulation factor concentrates |
US4720385A (en) * | 1983-03-29 | 1988-01-19 | Miles Laboratories, Inc. | Protein compositions substantially free from infectious agents |
AT399095B (de) * | 1986-03-27 | 1995-03-27 | Vukovich Thomas Dr | Verfahren zur auftrennung von proteinen mittels gradientenelution und vorrichtung zur durchführung des verfahrens |
GB8729822D0 (en) * | 1987-12-22 | 1988-02-03 | Central Blood Lab Authority | Chemical process |
US4981952A (en) * | 1988-10-04 | 1991-01-01 | Eli Lilly And Company | Method for the purification of vitamin K-dependent proteins |
DE3914869C1 (it) * | 1989-05-05 | 1990-08-09 | Biotest Pharma Gmbh, 6072 Dreieich, De | |
US5138034A (en) * | 1989-07-12 | 1992-08-11 | The Green Cross Corporation | Method of fractionating plasma proteins |
US5286849A (en) * | 1992-07-14 | 1994-02-15 | Alpha Therapeutic Corporation | Purification of factor IX |
-
1992
- 1992-03-27 IT ITFI920078A patent/IT1262899B/it active IP Right Grant
-
1993
- 1993-03-22 EP EP93104633A patent/EP0617049B1/en not_active Expired - Lifetime
- 1993-03-22 AT AT93104633T patent/ATE184018T1/de active
- 1993-03-22 DE DE69326227T patent/DE69326227T2/de not_active Expired - Lifetime
- 1993-03-22 ES ES93104633T patent/ES2138603T3/es not_active Expired - Lifetime
- 1993-03-26 US US08/038,942 patent/US5378365A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0617049A1 (en) | 1994-09-28 |
ES2138603T3 (es) | 2000-01-16 |
EP0617049B1 (en) | 1999-09-01 |
ITFI920078A1 (it) | 1993-09-27 |
ATE184018T1 (de) | 1999-09-15 |
ITFI920078A0 (it) | 1992-03-27 |
DE69326227T2 (de) | 2000-02-17 |
US5378365A (en) | 1995-01-03 |
DE69326227D1 (de) | 1999-10-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970427 |