|
US4973679A
(en)
*
|
1981-03-27 |
1990-11-27 |
University Patents, Inc. |
Process for oligonucleo tide synthesis using phosphormidite intermediates
|
|
US5166330A
(en)
*
|
1983-09-06 |
1992-11-24 |
Hoechst Aktiengesellschaft |
Process for the preparation of nucleoside alkyl-aralkyl- and aryl-phosphonites and -phosphonates
|
|
WO1986006726A1
(en)
*
|
1985-05-15 |
1986-11-20 |
Integrated Genetics, Inc. |
Cytidine analogs
|
|
EP0216357A3
(en)
*
|
1985-09-25 |
1988-08-31 |
Nippon Zeon Co., Ltd. |
Phosphoramidite compounds and process for production thereof
|
|
JPH0680071B2
(ja)
|
1985-10-07 |
1994-10-12 |
日本ゼオン株式会社 |
ホスホルアミダイト化合物及びその製造法
|
|
US4959463A
(en)
*
|
1985-10-15 |
1990-09-25 |
Genentech, Inc. |
Intermediates
|
|
DE3788914T2
(de)
*
|
1986-09-08 |
1994-08-25 |
Ajinomoto Kk |
Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere.
|
|
DE3751468T2
(de)
*
|
1986-10-30 |
1996-02-29 |
Daicel Chem |
Verfahren zur herstellung von oligonukleotiden und verbindungen zur bildung hochmolekularer schutzgruppen.
|
|
US4835104A
(en)
*
|
1987-06-16 |
1989-05-30 |
Ajinomoto Co., Inc., Patent & Licensing Department |
Process for producing and purifying 2',3'-dideoxynucleosides, and process for producing 2',3'-dideoxy-2',3'-didehydronucleosides
|
|
US6306647B1
(en)
|
1987-06-16 |
2001-10-23 |
Ajinomoto Co., Inc. |
Process for producing and purifying 2′,3′-dideoxynucleosides, and process for producing 2′,3′-dideoxy-2′,3′-didehydronucleosides
|
|
US5585481A
(en)
*
|
1987-09-21 |
1996-12-17 |
Gen-Probe Incorporated |
Linking reagents for nucleotide probes
|
|
US6031091A
(en)
*
|
1987-09-21 |
2000-02-29 |
Gen-Probe Incorporated |
Non-nucleotide linking reagents for nucleotide probes
|
|
WO1989009221A1
(en)
*
|
1988-03-25 |
1989-10-05 |
University Of Virginia Alumni Patents Foundation |
Oligonucleotide n-alkylphosphoramidates
|
|
WO1989009780A1
(en)
*
|
1988-04-15 |
1989-10-19 |
Chemical Industry Institute Of Toxicology |
Site-specific tritium-labeled oligodeoxynucleotides
|
|
US5750666A
(en)
*
|
1988-05-26 |
1998-05-12 |
Competitve Technologies, Inc. |
Polynucleotide phosphorodithioate compounds
|
|
US5602244A
(en)
*
|
1988-05-26 |
1997-02-11 |
Competitive Technologies, Inc. |
Polynucleotide phosphorodithioate compounds
|
|
JPH0291088A
(ja)
*
|
1988-09-29 |
1990-03-30 |
Central Glass Co Ltd |
ホスファイトおよびヌクレオシド‐3’‐ホスファイト誘導体およびこれを用いるオリゴヌクレオチドの合成法
|
|
CA2000805C
(en)
*
|
1988-10-17 |
1994-01-18 |
Kiyoshi Sudani |
Carbon/metal composite
|
|
US5262530A
(en)
*
|
1988-12-21 |
1993-11-16 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
|
US5047524A
(en)
*
|
1988-12-21 |
1991-09-10 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
|
DE3916871A1
(de)
*
|
1989-05-24 |
1990-11-29 |
Boehringer Mannheim Gmbh |
Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren
|
|
US5545522A
(en)
|
1989-09-22 |
1996-08-13 |
Van Gelder; Russell N. |
Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
|
|
US7049102B1
(en)
|
1989-09-22 |
2006-05-23 |
Board Of Trustees Of Leland Stanford University |
Multi-gene expression profile
|
|
US5646265A
(en)
*
|
1990-01-11 |
1997-07-08 |
Isis Pharmceuticals, Inc. |
Process for the preparation of 2'-O-alkyl purine phosphoramidites
|
|
US5914396A
(en)
*
|
1990-01-11 |
1999-06-22 |
Isis Pharmaceuticals, Inc. |
2'-O-modified nucleosides and phosphoramidites
|
|
US5151510A
(en)
*
|
1990-04-20 |
1992-09-29 |
Applied Biosystems, Inc. |
Method of synethesizing sulfurized oligonucleotide analogs
|
|
EP0592434B1
(en)
*
|
1990-10-26 |
1998-10-07 |
Genta Incorporated |
Improved process for the synthesis of oligomers
|
|
US6335434B1
(en)
|
1998-06-16 |
2002-01-01 |
Isis Pharmaceuticals, Inc., |
Nucleosidic and non-nucleosidic folate conjugates
|
|
US5594121A
(en)
*
|
1991-11-07 |
1997-01-14 |
Gilead Sciences, Inc. |
Enhanced triple-helix and double-helix formation with oligomers containing modified purines
|
|
US8153602B1
(en)
|
1991-11-19 |
2012-04-10 |
Isis Pharmaceuticals, Inc. |
Composition and methods for the pulmonary delivery of nucleic acids
|
|
TW393513B
(en)
*
|
1991-11-26 |
2000-06-11 |
Isis Pharmaceuticals Inc |
Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
|
|
US6235887B1
(en)
|
1991-11-26 |
2001-05-22 |
Isis Pharmaceuticals, Inc. |
Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
|
|
EP1256589A3
(en)
*
|
1991-11-26 |
2003-09-17 |
Isis Pharmaceuticals, Inc. |
Oligomers containing modified pyrimidines
|
|
ZA929351B
(en)
*
|
1991-12-11 |
1993-06-04 |
Igen Inc |
Electrochemiluminescent label for DNA assays.
|
|
WO1993012135A1
(en)
|
1991-12-12 |
1993-06-24 |
Gilead Sciences, Inc. |
Nuclease stable and binding competent oligomers and methods for their use
|
|
US5795714A
(en)
*
|
1992-11-06 |
1998-08-18 |
Trustees Of Boston University |
Method for replicating an array of nucleic acid probes
|
|
US6436635B1
(en)
*
|
1992-11-06 |
2002-08-20 |
Boston University |
Solid phase sequencing of double-stranded nucleic acids
|
|
US6194144B1
(en)
|
1993-01-07 |
2001-02-27 |
Sequenom, Inc. |
DNA sequencing by mass spectrometry
|
|
US5547835A
(en)
|
1993-01-07 |
1996-08-20 |
Sequenom, Inc. |
DNA sequencing by mass spectrometry
|
|
US5605798A
(en)
*
|
1993-01-07 |
1997-02-25 |
Sequenom, Inc. |
DNA diagnostic based on mass spectrometry
|
|
US5955591A
(en)
*
|
1993-05-12 |
1999-09-21 |
Imbach; Jean-Louis |
Phosphotriester oligonucleotides, amidites and method of preparation
|
|
US5428149A
(en)
*
|
1993-06-14 |
1995-06-27 |
Washington State University Research Foundation |
Method for palladium catalyzed carbon-carbon coulping and products
|
|
WO1995000638A2
(en)
*
|
1993-06-23 |
1995-01-05 |
Genesys Pharma Inc. |
Antisense oligonucleotides and therapeutic use thereof in human immunodeficiency virus infection
|
|
US5614621A
(en)
*
|
1993-07-29 |
1997-03-25 |
Isis Pharmaceuticals, Inc. |
Process for preparing oligonucleotides using silyl-containing diamino phosphorous reagents
|
|
US6294664B1
(en)
|
1993-07-29 |
2001-09-25 |
Isis Pharmaceuticals, Inc. |
Synthesis of oligonucleotides
|
|
US6001982A
(en)
|
1993-07-29 |
1999-12-14 |
Isis Pharmaceuticals, Inc. |
Synthesis of oligonucleotides
|
|
US5571902A
(en)
*
|
1993-07-29 |
1996-11-05 |
Isis Pharmaceuticals, Inc. |
Synthesis of oligonucleotides
|
|
AU679566B2
(en)
|
1993-09-03 |
1997-07-03 |
Isis Pharmaceuticals, Inc. |
Amine-derivatized nucleosides and oligonucleosides
|
|
US6639061B1
(en)
|
1999-07-07 |
2003-10-28 |
Isis Pharmaceuticals, Inc. |
C3′-methylene hydrogen phosphonate oligomers and related compounds
|
|
US5510476A
(en)
*
|
1994-07-07 |
1996-04-23 |
Isis Pharmaceuticals, Inc. |
Carbocation scavenging during oligonucleotide synthesis
|
|
US6558633B1
(en)
*
|
1994-09-21 |
2003-05-06 |
Isis Pharmaceuticals, Inc. |
Chemical reaction apparatus and methods
|
|
USRE43097E1
(en)
|
1994-10-13 |
2012-01-10 |
Illumina, Inc. |
Massively parallel signature sequencing by ligation of encoded adaptors
|
|
US5604097A
(en)
|
1994-10-13 |
1997-02-18 |
Spectragen, Inc. |
Methods for sorting polynucleotides using oligonucleotide tags
|
|
US6428955B1
(en)
|
1995-03-17 |
2002-08-06 |
Sequenom, Inc. |
DNA diagnostics based on mass spectrometry
|
|
US20060063193A1
(en)
*
|
1995-04-11 |
2006-03-23 |
Dong-Jing Fu |
Solid phase sequencing of double-stranded nucleic acids
|
|
US7803529B1
(en)
*
|
1995-04-11 |
2010-09-28 |
Sequenom, Inc. |
Solid phase sequencing of biopolymers
|
|
US5750341A
(en)
|
1995-04-17 |
1998-05-12 |
Lynx Therapeutics, Inc. |
DNA sequencing by parallel oligonucleotide extensions
|
|
US5830655A
(en)
|
1995-05-22 |
1998-11-03 |
Sri International |
Oligonucleotide sizing using cleavable primers
|
|
US6111095A
(en)
*
|
1995-06-07 |
2000-08-29 |
Merck & Co., Inc. |
Capped synthetic RNA, analogs, and aptamers
|
|
JP4293634B2
(ja)
|
1995-06-07 |
2009-07-08 |
ソレクサ・インコーポレイテッド |
分類および同定のためのオリゴヌクレオチドタグ
|
|
US6146854A
(en)
*
|
1995-08-31 |
2000-11-14 |
Sequenom, Inc. |
Filtration processes, kits and devices for isolating plasmids
|
|
WO1997014706A1
(en)
*
|
1995-10-19 |
1997-04-24 |
Nexstar Pharmaceuticals, Inc. |
Method for solution phase synthesis of oligonucleotides
|
|
US6160109A
(en)
*
|
1995-10-20 |
2000-12-12 |
Isis Pharmaceuticals, Inc. |
Preparation of phosphorothioate and boranophosphate oligomers
|
|
US5734041A
(en)
*
|
1995-10-20 |
1998-03-31 |
Mcgill University |
Preparation of chiral phosphorothioate oligomers
|
|
US6476216B1
(en)
*
|
1995-10-20 |
2002-11-05 |
Mcgill University |
Preparation of phosphorothioate oligomers
|
|
US5705621A
(en)
*
|
1995-11-17 |
1998-01-06 |
Isis Pharmaceuticals, Inc. |
Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing same
|
|
US20030119724A1
(en)
*
|
1995-11-22 |
2003-06-26 |
Ts`O Paul O.P. |
Ligands to enhance cellular uptake of biomolecules
|
|
US5808035A
(en)
*
|
1995-12-08 |
1998-09-15 |
Usher; David A. |
Protected nucleoside and method for its synthesis
|
|
CA2250923A1
(en)
*
|
1996-03-26 |
1997-10-02 |
Gabriella Zupi |
Oligonucleotide treatments and compositions for human melanoma
|
|
US5959100A
(en)
*
|
1996-03-27 |
1999-09-28 |
Nexstar Pharmaceuticals, Inc. |
Pyrimidine nucleosides as therapeutic and diagnostic agents
|
|
US20040203024A1
(en)
*
|
1996-06-06 |
2004-10-14 |
Baker Brenda F. |
Modified oligonucleotides for use in RNA interference
|
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
|
US20040147022A1
(en)
*
|
1996-06-06 |
2004-07-29 |
Baker Brenda F. |
2'-methoxy substituted oligomeric compounds and compositions for use in gene modulations
|
|
US20050053976A1
(en)
*
|
1996-06-06 |
2005-03-10 |
Baker Brenda F. |
Chimeric oligomeric compounds and their use in gene modulation
|
|
US5898031A
(en)
*
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US20050119470A1
(en)
*
|
1996-06-06 |
2005-06-02 |
Muthiah Manoharan |
Conjugated oligomeric compounds and their use in gene modulation
|
|
US20040171031A1
(en)
*
|
1996-06-06 |
2004-09-02 |
Baker Brenda F. |
Sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
|
US20070275921A1
(en)
*
|
1996-06-06 |
2007-11-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric Compounds That Facilitate Risc Loading
|
|
US7812149B2
(en)
*
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
|
US5777324A
(en)
|
1996-09-19 |
1998-07-07 |
Sequenom, Inc. |
Method and apparatus for maldi analysis
|
|
US6140053A
(en)
*
|
1996-11-06 |
2000-10-31 |
Sequenom, Inc. |
DNA sequencing by mass spectrometry via exonuclease degradation
|
|
US6133436A
(en)
|
1996-11-06 |
2000-10-17 |
Sequenom, Inc. |
Beads bound to a solid support and to nucleic acids
|
|
US7285422B1
(en)
|
1997-01-23 |
2007-10-23 |
Sequenom, Inc. |
Systems and methods for preparing and analyzing low volume analyte array elements
|
|
JP3516146B2
(ja)
|
1996-11-06 |
2004-04-05 |
シークエノム・インコーポレーテツド |
核酸の高密度固定化
|
|
EP1164203B1
(en)
|
1996-11-06 |
2007-10-10 |
Sequenom, Inc. |
DNA Diagnostics based on mass spectrometry
|
|
US6024925A
(en)
|
1997-01-23 |
2000-02-15 |
Sequenom, Inc. |
Systems and methods for preparing low volume analyte array elements
|
|
US6060240A
(en)
*
|
1996-12-13 |
2000-05-09 |
Arcaris, Inc. |
Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
|
|
US6172217B1
(en)
|
1996-12-27 |
2001-01-09 |
Isis Pharmaceuticals Inc. |
Method of synthesizing phosphorothioate oligonucleotides
|
|
US5902881A
(en)
|
1997-03-03 |
1999-05-11 |
Isis Pharmaceuticals, Inc. |
Reagent useful for synthesizing sulfurized oligonucleotide analogs
|
|
US5760209A
(en)
*
|
1997-03-03 |
1998-06-02 |
Isis Pharmaceuticals, Inc. |
Protecting group for synthesizing oligonucleotide analogs
|
|
US6207370B1
(en)
|
1997-09-02 |
2001-03-27 |
Sequenom, Inc. |
Diagnostics based on mass spectrometric detection of translated target polypeptides
|
|
US6268131B1
(en)
|
1997-12-15 |
2001-07-31 |
Sequenom, Inc. |
Mass spectrometric methods for sequencing nucleic acids
|
|
US7427678B2
(en)
*
|
1998-01-08 |
2008-09-23 |
Sigma-Aldrich Co. |
Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
|
|
US6326479B1
(en)
|
1998-01-27 |
2001-12-04 |
Boston Probes, Inc. |
Synthetic polymers and methods, kits or compositions for modulating the solubility of same
|
|
US6020475A
(en)
*
|
1998-02-10 |
2000-02-01 |
Isis Pharmeuticals, Inc. |
Process for the synthesis of oligomeric compounds
|
|
US7273933B1
(en)
|
1998-02-26 |
2007-09-25 |
Isis Pharmaceuticals, Inc. |
Methods for synthesis of oligonucleotides
|
|
US6531590B1
(en)
|
1998-04-24 |
2003-03-11 |
Isis Pharmaceuticals, Inc. |
Processes for the synthesis of oligonucleotide compounds
|
|
US7875440B2
(en)
|
1998-05-01 |
2011-01-25 |
Arizona Board Of Regents |
Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
|
|
US6780591B2
(en)
*
|
1998-05-01 |
2004-08-24 |
Arizona Board Of Regents |
Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
|
|
US6723564B2
(en)
|
1998-05-07 |
2004-04-20 |
Sequenom, Inc. |
IR MALDI mass spectrometry of nucleic acids using liquid matrices
|
|
US6274725B1
(en)
|
1998-06-02 |
2001-08-14 |
Isis Pharmaceuticals, Inc. |
Activators for oligonucleotide synthesis
|
|
US6335439B1
(en)
|
1998-06-11 |
2002-01-01 |
Isis Pharmaceuticals, Inc. |
Method of preparing phosphoramidites
|
|
WO1999064434A1
(en)
|
1998-06-11 |
1999-12-16 |
Isis Pharmaceuticals, Inc. |
Synthetic methods and intermediates for triester oligonucleotides
|
|
US6326478B1
(en)
|
1998-07-08 |
2001-12-04 |
Isis Pharmaceuticals, Inc. |
Process for the synthesis of oligomeric compounds
|
|
US6242589B1
(en)
|
1998-07-14 |
2001-06-05 |
Isis Pharmaceuticals, Inc. |
Phosphorothioate oligonucleotides having modified internucleoside linkages
|
|
US6867294B1
(en)
*
|
1998-07-14 |
2005-03-15 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
|
US6124484A
(en)
|
1998-07-17 |
2000-09-26 |
Isis Pharmaceuticals, Inc. |
Recovery of triarylmethyl halide protecting groups cleaved during oligonucleotide synthesis
|
|
US6043352A
(en)
|
1998-08-07 |
2000-03-28 |
Isis Pharmaceuticals, Inc. |
2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
|
|
US6673912B1
(en)
|
1998-08-07 |
2004-01-06 |
Isis Pharmaceuticals, Inc. |
2′-O-aminoethyloxyethyl-modified oligonucleotides
|
|
US20040009938A1
(en)
*
|
1998-08-07 |
2004-01-15 |
Muthiah Manoharan |
Methods of enhancing renal uptake of oligonucleotides
|
|
US6335437B1
(en)
|
1998-09-07 |
2002-01-01 |
Isis Pharmaceuticals, Inc. |
Methods for the preparation of conjugated oligomers
|
|
US6069243A
(en)
*
|
1998-10-06 |
2000-05-30 |
Isis Pharmaceuticals, Inc. |
Process for oligonucleotide synthesis
|
|
US6153411A
(en)
*
|
1998-10-30 |
2000-11-28 |
American Water Works Company, Inc. |
Methods and kits for detection of Cryptosporidium parvum using immunomagnetic separation and amplification
|
|
US6169177B1
(en)
|
1998-11-06 |
2001-01-02 |
Isis Pharmaceuticals, Inc. |
Processes for the synthesis of oligomeric compounds
|
|
US6264891B1
(en)
*
|
1998-12-22 |
2001-07-24 |
Eos Biotechnology, Inc. |
Apparatus and method for concurrent chemical synthesis
|
|
US6380378B1
(en)
|
1998-12-24 |
2002-04-30 |
Toagosei Company, Ltd. |
Nucleotide compound, nucleotide block oligonucleotide, and method for producing them
|
|
US6465628B1
(en)
*
|
1999-02-04 |
2002-10-15 |
Isis Pharmaceuticals, Inc. |
Process for the synthesis of oligomeric compounds
|
|
US6207819B1
(en)
|
1999-02-12 |
2001-03-27 |
Isis Pharmaceuticals, Inc. |
Compounds, processes and intermediates for synthesis of mixed backbone oligomeric compounds
|
|
US6225061B1
(en)
|
1999-03-10 |
2001-05-01 |
Sequenom, Inc. |
Systems and methods for performing reactions in an unsealed environment
|
|
US20040082774A1
(en)
*
|
1999-03-16 |
2004-04-29 |
Guzaev Andrei P. |
Novel phosphate and thiophosphate protecting groups
|
|
US6121437A
(en)
*
|
1999-03-16 |
2000-09-19 |
Isis Pharmaceuticals, Inc. |
Phosphate and thiophosphate protecting groups
|
|
US6399765B1
(en)
*
|
1999-03-17 |
2002-06-04 |
Isis Pharmaceuticals, Inc. |
Methods for removing dimethoxytrityl groups from oligonucleotides
|
|
US6965041B1
(en)
|
1999-03-24 |
2005-11-15 |
The United States Of America As Represented By The Department Of Health And Human Services |
N-acylphosphoramidites and their use in oligonucleotide synthesis
|
|
US6610842B1
(en)
*
|
1999-05-06 |
2003-08-26 |
Isis Pharmaceuticals, Inc. |
Processes for the synthesis of oligomers using phosphoramidite compositions
|
|
US6221635B1
(en)
|
1999-05-06 |
2001-04-24 |
The Wistar Institute |
Methods for solid-phase amplification of DNA template (SPADT) using multiarrays
|
|
US20070059752A1
(en)
*
|
1999-06-09 |
2007-03-15 |
Biosearch Technologies, Inc. |
Fluorescence energy transfer probes with stabilized conformations
|
|
US7501245B2
(en)
*
|
1999-06-28 |
2009-03-10 |
Helicos Biosciences Corp. |
Methods and apparatuses for analyzing polynucleotide sequences
|
|
US6818395B1
(en)
*
|
1999-06-28 |
2004-11-16 |
California Institute Of Technology |
Methods and apparatus for analyzing polynucleotide sequences
|
|
US6414135B1
(en)
|
1999-07-07 |
2002-07-02 |
Isis Pharmaceuticals, Inc. |
C3′-methylene hydrogen phosphonate monomers and related compounds
|
|
US6593466B1
(en)
|
1999-07-07 |
2003-07-15 |
Isis Pharmaceuticals, Inc. |
Guanidinium functionalized nucleotides and precursors thereof
|
|
US6147200A
(en)
*
|
1999-08-19 |
2000-11-14 |
Isis Pharmaceuticals, Inc. |
2'-O-acetamido modified monomers and oligomers
|
|
US6114518A
(en)
*
|
1999-09-30 |
2000-09-05 |
Becton, Dickinson And Company |
Synthesis and use of labelled phosphoramidite compositions
|
|
US7019129B1
(en)
|
2000-05-09 |
2006-03-28 |
Biosearch Technologies, Inc. |
Dark quenchers for donor-acceptor energy transfer
|
|
US6936702B2
(en)
*
|
2000-06-07 |
2005-08-30 |
Li-Cor, Inc. |
Charge-switch nucleotides
|
|
EP2226330B1
(en)
|
2000-06-07 |
2013-09-18 |
Pacific Biosciences of California, Inc. |
Charge-switch nucleotides
|
|
US7135565B2
(en)
*
|
2000-07-28 |
2006-11-14 |
Agilent Technologies, Inc. |
Synthesis of polynucleotides using combined oxidation/deprotection chemistry
|
|
ATE432994T1
(de)
|
2000-09-26 |
2009-06-15 |
Boston Probes Inc |
Sonden, sondensätzen,verfahren und kits zur nachweis, identifizierung und/oder die zählung von bakterien
|
|
US6693187B1
(en)
*
|
2000-10-17 |
2004-02-17 |
Lievre Cornu Llc |
Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge
|
|
EP1332000B1
(en)
|
2000-10-30 |
2012-06-20 |
Sequenom, Inc. |
Method for delivery of submicroliter volumes onto a substrate
|
|
CN100406065C
(zh)
|
2000-12-01 |
2008-07-30 |
细胞工厂治疗公司 |
糖基化/半乳糖基化肽、双官能接头和核苷酸单体/多聚体的缀合物以及相关的组合物和使用方法
|
|
US6794141B2
(en)
|
2000-12-22 |
2004-09-21 |
Arcturus Bioscience, Inc. |
Nucleic acid amplification
|
|
EP1368497A4
(en)
*
|
2001-03-12 |
2007-08-15 |
California Inst Of Techn |
METHODS AND APPARATUS FOR ANALYZING ASYNCHRONOUS BASE EXTENSION POLYNUCLEOTIDE SEQUENCES
|
|
US6825338B2
(en)
|
2001-03-30 |
2004-11-30 |
Isis Pharmaceuticals, Inc. |
Labeled oligonucleotides, methods for making same, and compounds useful therefor
|
|
KR20040082273A
(ko)
|
2001-05-21 |
2004-09-24 |
아클라라 바이오사이언시스 인코퍼레이티드 |
단백질 분석을 위한 방법 및 조성물
|
|
US7118907B2
(en)
*
|
2001-06-06 |
2006-10-10 |
Li-Cor, Inc. |
Single molecule detection systems and methods
|
|
AU2002322351A1
(en)
*
|
2001-06-28 |
2003-03-03 |
Ia, Inc. |
Fiber-optic sensor array
|
|
DK1485707T3
(da)
|
2001-07-16 |
2009-05-11 |
Caprotec Bioanalytics Gmbh |
Indsamlingsforbindelser, samlinger deraf og fremgangsmåder til analyse af proteomet og komplekse sammensætninger
|
|
US6822088B2
(en)
|
2001-07-17 |
2004-11-23 |
Isis Pharmaceuticals, Inc. |
Synthesis of oligonucleotides on solid support
|
|
WO2003048179A2
(en)
*
|
2001-12-03 |
2003-06-12 |
The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services |
Thermolabile hydroxyl protecting groups and methods of use
|
|
US7255874B1
(en)
|
2001-12-21 |
2007-08-14 |
Closure Medical Corporation |
Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto
|
|
GB0200526D0
(en)
*
|
2002-01-11 |
2002-02-27 |
Science And Technology The |
Methods
|
|
WO2003062452A2
(en)
*
|
2002-01-23 |
2003-07-31 |
Proligo, Llc |
Methods for the integrated synthesis and purification of oligonucleotides
|
|
AU2003217706A1
(en)
*
|
2002-02-22 |
2003-09-09 |
Honeywell International Inc. |
Methods of producing phosphitylated compounds
|
|
US20040209255A1
(en)
*
|
2002-03-11 |
2004-10-21 |
Hk Pharmaceuticals, Inc. |
Compounds and methods for analyzing the proteome
|
|
CA2477670A1
(en)
*
|
2002-03-15 |
2003-09-25 |
Arcturus Bioscience, Inc. |
Improved nucleic acid amplification
|
|
US7169916B2
(en)
*
|
2002-04-01 |
2007-01-30 |
Isis Pharmaceuticals, Inc. |
Chloral-free DCA in oligonucleotide synthesis
|
|
DE60328674D1
(de)
|
2002-04-17 |
2009-09-17 |
Bioren Inc |
Universelle banken für immunoglobuline
|
|
WO2003102216A2
(en)
*
|
2002-05-31 |
2003-12-11 |
Diversa Corporation |
Multiplexed systems for nucleic acid sequencing
|
|
US6967247B2
(en)
|
2002-07-24 |
2005-11-22 |
Isis Pharmaceuticals, Inc. |
Deprotection of phosphorus in oligonucleotide synthesis
|
|
US20040137469A1
(en)
*
|
2002-09-08 |
2004-07-15 |
Casale Ralph A |
Methods, compositions and libraries pertaining PNA dimer and PNA oligomer synthesis
|
|
US9150606B2
(en)
*
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
|
|
US8604183B2
(en)
*
|
2002-11-05 |
2013-12-10 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
|
US9150605B2
(en)
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
|
WO2004058794A1
(en)
*
|
2002-12-31 |
2004-07-15 |
Proligo Llc |
Methods and compositions for the tandem synthesis of two or more oligonuleotides on the same solid support
|
|
SG153699A1
(en)
*
|
2003-01-16 |
2009-07-29 |
Caprotec Bioanalytics Gmbh |
Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
|
|
US7002006B2
(en)
*
|
2003-02-12 |
2006-02-21 |
Isis Pharmaceuticals, Inc. |
Protection of nucleosides
|
|
US7745116B2
(en)
*
|
2003-04-08 |
2010-06-29 |
Pacific Biosciences Of California, Inc. |
Composition and method for nucleic acid sequencing
|
|
WO2004108081A2
(en)
*
|
2003-06-02 |
2004-12-16 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide synthesis with alternative solvents
|
|
US20050170367A1
(en)
*
|
2003-06-10 |
2005-08-04 |
Quake Stephen R. |
Fluorescently labeled nucleoside triphosphates and analogs thereof for sequencing nucleic acids
|
|
EP1636342A4
(en)
*
|
2003-06-20 |
2008-10-08 |
Isis Pharmaceuticals Inc |
OLIGOMER COMPOUNDS FOR USE IN THE MODULATION OF GENES
|
|
US20050053981A1
(en)
*
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
|
WO2005027962A1
(en)
|
2003-09-18 |
2005-03-31 |
Isis Pharmaceuticals, Inc. |
4’-thionucleosides and oligomeric compounds
|
|
US7125945B2
(en)
*
|
2003-09-19 |
2006-10-24 |
Varian, Inc. |
Functionalized polymer for oligonucleotide purification
|
|
US7169560B2
(en)
*
|
2003-11-12 |
2007-01-30 |
Helicos Biosciences Corporation |
Short cycle methods for sequencing polynucleotides
|
|
ES2535033T3
(es)
|
2003-11-13 |
2015-05-04 |
Isis Pharmaceuticals, Inc. |
Derivados de 5,6 dihidroxi isoindol como conectores para la síntesis de oligómeros en fase sólida
|
|
US20060172408A1
(en)
*
|
2003-12-01 |
2006-08-03 |
Quake Steven R |
Device for immobilizing chemical and biochemical species and methods of using same
|
|
US7691316B2
(en)
*
|
2004-02-12 |
2010-04-06 |
Chemistry & Technology For Genes, Inc. |
Devices and methods for the synthesis of nucleic acids
|
|
EP1716254B1
(en)
|
2004-02-19 |
2010-04-07 |
Helicos Biosciences Corporation |
Methods for analyzing polynucleotide sequences
|
|
US20060046258A1
(en)
*
|
2004-02-27 |
2006-03-02 |
Lapidus Stanley N |
Applications of single molecule sequencing
|
|
WO2005085272A1
(ja)
*
|
2004-03-05 |
2005-09-15 |
Takeshi Wada |
ボラノホスフェートモノマーおよびそれを用いたオリゴヌクレオチド誘導体の製造方法
|
|
JP4814084B2
(ja)
*
|
2004-03-05 |
2011-11-09 |
株式会社キラルジェン |
ボラノホスフェートモノマーおよびそれを用いたオリゴヌクレオチド誘導体の製造方法
|
|
US8569474B2
(en)
*
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
|
US20050239085A1
(en)
*
|
2004-04-23 |
2005-10-27 |
Buzby Philip R |
Methods for nucleic acid sequence determination
|
|
US20050260609A1
(en)
*
|
2004-05-24 |
2005-11-24 |
Lapidus Stanley N |
Methods and devices for sequencing nucleic acids
|
|
US7476734B2
(en)
*
|
2005-12-06 |
2009-01-13 |
Helicos Biosciences Corporation |
Nucleotide analogs
|
|
US20070117103A1
(en)
*
|
2005-11-22 |
2007-05-24 |
Buzby Philip R |
Nucleotide analogs
|
|
ATE507305T1
(de)
*
|
2004-05-25 |
2011-05-15 |
Helicos Biosciences Corp |
Verfahren zur nukleinsäureimmobilisierung
|
|
US20070117104A1
(en)
*
|
2005-11-22 |
2007-05-24 |
Buzby Philip R |
Nucleotide analogs
|
|
US8394947B2
(en)
*
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
|
US20090048192A1
(en)
*
|
2004-06-03 |
2009-02-19 |
Isis Pharmaceuticals, Inc. |
Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
|
|
CA2569419A1
(en)
*
|
2004-06-03 |
2005-12-22 |
Isis Pharmaceuticals, Inc. |
Double strand compositions comprising differentially modified strands for use in gene modulation
|
|
US20060024678A1
(en)
*
|
2004-07-28 |
2006-02-02 |
Helicos Biosciences Corporation |
Use of single-stranded nucleic acid binding proteins in sequencing
|
|
US7427675B2
(en)
*
|
2004-08-23 |
2008-09-23 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for the characterization of oligonucleotides
|
|
US7884086B2
(en)
*
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
|
WO2006047628A2
(en)
*
|
2004-10-25 |
2006-05-04 |
Operon Holdings, Inc. |
Amino or thiol linker building block for the synthesis of amino- or thiol-functionalized nucleic acids and methods of making and use thereof
|
|
ATE505540T1
(de)
|
2004-11-16 |
2011-04-15 |
Qiagen Gmbh |
Genabschaltung (gene silencing) durch hybride sens-dna und antisens-rna konstrukte, gekoppelt an ein peptid zur erleichterten aufnahme in zellen
|
|
US20060118754A1
(en)
*
|
2004-12-08 |
2006-06-08 |
Lapen Daniel C |
Stabilizing a polyelectrolyte multilayer
|
|
WO2006065751A2
(en)
*
|
2004-12-13 |
2006-06-22 |
Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Cpg oligonucleotide prodrugs, compositions thereof and associated therapeutic methods
|
|
US7220549B2
(en)
|
2004-12-30 |
2007-05-22 |
Helicos Biosciences Corporation |
Stabilizing a nucleic acid for nucleic acid sequencing
|
|
US20060172328A1
(en)
*
|
2005-01-05 |
2006-08-03 |
Buzby Philip R |
Methods and compositions for correcting misincorporation in a nucleic acid synthesis reaction
|
|
US7482120B2
(en)
*
|
2005-01-28 |
2009-01-27 |
Helicos Biosciences Corporation |
Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
|
|
US7608433B2
(en)
|
2005-02-09 |
2009-10-27 |
Idexx Laboratories |
Method of detection of classical swine fever
|
|
US20060263790A1
(en)
*
|
2005-05-20 |
2006-11-23 |
Timothy Harris |
Methods for improving fidelity in a nucleic acid synthesis reaction
|
|
US20090270479A1
(en)
*
|
2005-07-12 |
2009-10-29 |
Antonio Giordano |
Genetic and Epigenetic Alterations In the Diagnosis and Treatment of Cancer
|
|
US7666593B2
(en)
|
2005-08-26 |
2010-02-23 |
Helicos Biosciences Corporation |
Single molecule sequencing of captured nucleic acids
|
|
US20070202515A1
(en)
*
|
2005-10-12 |
2007-08-30 |
Pathologica, Llc. |
Promac signature application
|
|
US20070117102A1
(en)
*
|
2005-11-22 |
2007-05-24 |
Buzby Philip R |
Nucleotide analogs
|
|
US20070128610A1
(en)
*
|
2005-12-02 |
2007-06-07 |
Buzby Philip R |
Sample preparation method and apparatus for nucleic acid sequencing
|
|
US7579459B2
(en)
*
|
2005-12-12 |
2009-08-25 |
Ngo Nam Q |
Activator bound solid supports for nucleic acid synthesis via the phosphoramidite approach
|
|
US20090305248A1
(en)
*
|
2005-12-15 |
2009-12-10 |
Lander Eric G |
Methods for increasing accuracy of nucleic acid sequencing
|
|
EP1984381B1
(en)
|
2006-01-27 |
2010-09-29 |
Isis Pharmaceuticals, Inc. |
6-modified bicyclic nucleic acid analogs
|
|
US7569686B1
(en)
|
2006-01-27 |
2009-08-04 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for synthesis of bicyclic nucleic acid analogs
|
|
US7397546B2
(en)
*
|
2006-03-08 |
2008-07-08 |
Helicos Biosciences Corporation |
Systems and methods for reducing detected intensity non-uniformity in a laser beam
|
|
US20080309926A1
(en)
*
|
2006-03-08 |
2008-12-18 |
Aaron Weber |
Systems and methods for reducing detected intensity non uniformity in a laser beam
|
|
AU2007245043A1
(en)
*
|
2006-03-24 |
2007-11-08 |
Archemix Corp. |
Solid support reagents for synthesis
|
|
EP2023940B1
(en)
*
|
2006-05-05 |
2011-06-22 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of sglt2
|
|
DK2066684T3
(da)
*
|
2006-05-11 |
2012-10-22 |
Isis Pharmaceuticals Inc |
5´-Modificerede bicycliske nukleinsyreanaloge
|
|
US7666854B2
(en)
*
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
|
US8053191B2
(en)
|
2006-08-31 |
2011-11-08 |
Westend Asset Clearinghouse Company, Llc |
Iterative nucleic acid assembly using activation of vector-encoded traits
|
|
US7947447B2
(en)
|
2007-01-16 |
2011-05-24 |
Somalogic, Inc. |
Method for generating aptamers with improved off-rates
|
|
AU2008260277C1
(en)
|
2007-05-30 |
2014-04-17 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
|
DK2173760T4
(en)
|
2007-06-08 |
2016-02-08 |
Isis Pharmaceuticals Inc |
Carbocyclic bicyclic nukleinsyreanaloge
|
|
CN101796062B
(zh)
*
|
2007-07-05 |
2014-07-30 |
Isis制药公司 |
6-双取代双环核酸类似物
|
|
US8404830B2
(en)
*
|
2007-07-17 |
2013-03-26 |
Somalogic, Inc. |
Method for generating aptamers with improved off-rates
|
|
WO2009023184A2
(en)
*
|
2007-08-10 |
2009-02-19 |
Protelix, Inc. |
Universal fibronectin type iii binding-domain libraries
|
|
US8680019B2
(en)
*
|
2007-08-10 |
2014-03-25 |
Protelica, Inc. |
Universal fibronectin Type III binding-domain libraries
|
|
US8470966B2
(en)
|
2007-08-10 |
2013-06-25 |
Protelica, Inc. |
Universal fibronectin type III binding-domain libraries
|
|
EP2188298B1
(en)
*
|
2007-08-15 |
2013-09-18 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
|
WO2009039122A2
(en)
|
2007-09-17 |
2009-03-26 |
Sequenom, Inc. |
Integrated robotic sample transfer device
|
|
WO2009067647A1
(en)
*
|
2007-11-21 |
2009-05-28 |
Isis Pharmaceuticals, Inc. |
Carbocyclic alpha-l-bicyclic nucleic acid analogs
|
|
DK2242843T3
(en)
*
|
2007-12-31 |
2015-07-20 |
Xoma Technology Ltd |
Methods and materials for targeted mutagenesis
|
|
EP2265627A2
(en)
*
|
2008-02-07 |
2010-12-29 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
|
WO2009117589A1
(en)
|
2008-03-21 |
2009-09-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising tricyclic nucleosides and methods for their use
|
|
WO2009124238A1
(en)
*
|
2008-04-04 |
2009-10-08 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising neutrally linked terminal bicyclic nucleosides
|
|
US8636978B2
(en)
*
|
2008-06-23 |
2014-01-28 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Cyclized NGR peptide compounds, compositions, and methods of their use
|
|
EP3067359A1
(en)
|
2008-09-23 |
2016-09-14 |
Scott G. Petersen |
Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating rna interference
|
|
WO2010036698A1
(en)
*
|
2008-09-24 |
2010-04-01 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-l-bicyclic nucleosides
|
|
EP2361256B1
(en)
*
|
2008-09-24 |
2013-04-10 |
Isis Pharmaceuticals, Inc. |
Cyclohexenyl nucleic acid analogs
|
|
US8334372B2
(en)
|
2008-10-15 |
2012-12-18 |
Isis Pharmaceuticals, Inc. |
Modulation of factor 11 expression
|
|
US8987435B2
(en)
|
2008-10-24 |
2015-03-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
|
WO2010048549A2
(en)
|
2008-10-24 |
2010-04-29 |
Isis Pharmaceuticals, Inc. |
5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom
|
|
WO2010064146A2
(en)
|
2008-12-02 |
2010-06-10 |
Chiralgen, Ltd. |
Method for the synthesis of phosphorus atom modified nucleic acids
|
|
WO2010065159A1
(en)
*
|
2008-12-02 |
2010-06-10 |
Oregon Health & Science University |
Inhibition of dna polymerases to augment chemotherapeutic and antimicrobial agents
|
|
CA2749969A1
(en)
|
2009-01-21 |
2010-08-12 |
Vertex Pharmaceuticals Incorporated |
Methods for amplifying hepatitis c virus nucleic acids
|
|
US8536320B2
(en)
|
2009-02-06 |
2013-09-17 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
|
EP2669290A1
(en)
|
2009-03-02 |
2013-12-04 |
Alnylam Pharmaceuticals Inc. |
Nucleic Acid Chemical Modifications
|
|
US7960526B2
(en)
*
|
2009-03-30 |
2011-06-14 |
Berry And Associates, Inc. |
Colorimetric-oxycarbonyl protecting groups for use in organic syntheses
|
|
CA2767253A1
(en)
|
2009-07-06 |
2011-01-13 |
Ontorii, Inc. |
Novel nucleic acid prodrugs and methods of use thereof
|
|
WO2011005861A1
(en)
|
2009-07-07 |
2011-01-13 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotide end caps
|
|
US8927513B2
(en)
|
2009-07-07 |
2015-01-06 |
Alnylam Pharmaceuticals, Inc. |
5′ phosphate mimics
|
|
US9012421B2
(en)
|
2009-08-06 |
2015-04-21 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
|
WO2011051333A1
(en)
|
2009-10-30 |
2011-05-05 |
Novartis Ag |
Universal fibronectin type iii bottom-side binding domain libraries
|
|
US10207240B2
(en)
|
2009-11-03 |
2019-02-19 |
Gen9, Inc. |
Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
|
|
US9216414B2
(en)
|
2009-11-25 |
2015-12-22 |
Gen9, Inc. |
Microfluidic devices and methods for gene synthesis
|
|
WO2011066186A1
(en)
|
2009-11-25 |
2011-06-03 |
Gen9, Inc. |
Methods and apparatuses for chip-based dna error reduction
|
|
WO2011085075A2
(en)
|
2010-01-07 |
2011-07-14 |
Gen9, Inc. |
Assembly of high fidelity polynucleotides
|
|
US8779118B2
(en)
|
2010-01-11 |
2014-07-15 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011094580A2
(en)
|
2010-01-28 |
2011-08-04 |
Alnylam Pharmaceuticals, Inc. |
Chelated copper for use in the preparation of conjugated oligonucleotides
|
|
US8716467B2
(en)
|
2010-03-03 |
2014-05-06 |
Gen9, Inc. |
Methods and devices for nucleic acid synthesis
|
|
US9193752B2
(en)
|
2010-03-17 |
2015-11-24 |
Isis Pharmaceuticals, Inc. |
5′-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011123621A2
(en)
|
2010-04-01 |
2011-10-06 |
Alnylam Pharmaceuticals Inc. |
2' and 5' modified monomers and oligonucleotides
|
|
US8598140B2
(en)
|
2010-04-12 |
2013-12-03 |
Somalogic, Inc. |
Aptamers to β-NGF and their use in treating β-NGF mediated diseases and disorders
|
|
WO2011133871A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
5'-end derivatives
|
|
US10913767B2
(en)
|
2010-04-22 |
2021-02-09 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising acyclic and abasic nucleosides and analogs
|
|
WO2011133868A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
Conformationally restricted dinucleotide monomers and oligonucleotides
|
|
WO2011139699A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
5' modified nucleosides and oligomeric compounds prepared therefrom
|
|
US9156873B2
(en)
|
2010-04-28 |
2015-10-13 |
Isis Pharmaceuticals, Inc. |
Modified 5′ diphosphate nucleosides and oligomeric compounds prepared therefrom
|
|
US8993738B2
(en)
|
2010-04-28 |
2015-03-31 |
Isis Pharmaceuticals, Inc. |
Modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom
|
|
WO2011139911A2
(en)
|
2010-04-29 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Lipid formulated single stranded rna
|
|
WO2011156278A1
(en)
|
2010-06-07 |
2011-12-15 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
EP2580228B1
(en)
|
2010-06-08 |
2016-03-23 |
Ionis Pharmaceuticals, Inc. |
Substituted 2'-amino and 2'-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
US20130236968A1
(en)
|
2010-06-21 |
2013-09-12 |
Alnylam Pharmaceuticals, Inc. |
Multifunctional copolymers for nucleic acid delivery
|
|
CN107903321A
(zh)
|
2010-07-30 |
2018-04-13 |
诺华有限公司 |
纤连蛋白摇篮分子和其库
|
|
WO2012039448A1
(ja)
|
2010-09-24 |
2012-03-29 |
株式会社キラルジェン |
不斉補助基
|
|
WO2012078312A2
(en)
|
2010-11-12 |
2012-06-14 |
Gen9, Inc. |
Methods and devices for nucleic acids synthesis
|
|
EP2637780B1
(en)
|
2010-11-12 |
2022-02-09 |
Gen9, Inc. |
Protein arrays and methods of using and making the same
|
|
JP6126009B2
(ja)
|
2010-11-17 |
2017-05-10 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
α−シヌクレイン発現の調節
|
|
US20130280294A1
(en)
|
2010-12-27 |
2013-10-24 |
Eli Lilly And Company |
Bovine viral diarrhea virus type 1b vaccine compositions and methods
|
|
AR084358A1
(es)
|
2010-12-27 |
2013-05-08 |
Lilly Co Eli |
Composiciones y metodos para identificar y diferenciar componentes virales de vacunas multivalentes de la “fiebre de embarque” (complejo de enfermedad respiratoria bovina (brdc))
|
|
WO2012092596A2
(en)
|
2010-12-30 |
2012-07-05 |
Dow Agrosciences Llc |
Nucleic acid molecules that target the rho1 small gtp-binding protein and confer resistance to coleopteran pests
|
|
WO2012092580A2
(en)
|
2010-12-30 |
2012-07-05 |
Dow Agrosciences Llc |
Nucleic acid molecules that target the vacuolar atpase h subunit and confer resistance to coleopteran pests
|
|
NZ612323A
(en)
|
2010-12-30 |
2015-12-24 |
Dow Agrosciences Llc |
Nucleic acid molecules that confer resistance to coleopteran pests
|
|
MX342845B
(es)
|
2010-12-30 |
2016-10-14 |
Dow Agrosciences Llc |
Moleculas de acido nucleico dirigidas a la subunidad de atpasa c vacuolar y que confieren resistencia a las plagas de coleopteros.
|
|
WO2012170347A1
(en)
|
2011-06-09 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
CN103796657B
(zh)
|
2011-07-19 |
2017-07-11 |
波涛生命科学有限公司 |
合成官能化核酸的方法
|
|
JP2014526899A
(ja)
|
2011-08-26 |
2014-10-09 |
ジェン9・インコーポレイテッド |
核酸の高忠実度アセンブリのための組成物および方法
|
|
EP3533873A1
(en)
|
2011-09-14 |
2019-09-04 |
Translate Bio MA, Inc. |
Multimeric oligonucleotide compounds
|
|
WO2013090457A2
(en)
|
2011-12-12 |
2013-06-20 |
Oncoimmunin Inc. |
In vivo delivery of oligonucleotides
|
|
US9150853B2
(en)
|
2012-03-21 |
2015-10-06 |
Gen9, Inc. |
Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
|
|
WO2013154799A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
|
US9221864B2
(en)
|
2012-04-09 |
2015-12-29 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
|
AU2013251701A1
(en)
|
2012-04-24 |
2014-10-30 |
Gen9, Inc. |
Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
|
|
ES2683707T3
(es)
|
2012-05-02 |
2018-09-27 |
Ibis Biosciences, Inc. |
Secuenciación de ADN
|
|
ES2833524T3
(es)
|
2012-05-02 |
2021-06-15 |
Ibis Biosciences Inc |
Secuenciación de ADN
|
|
BR112014028631A2
(pt)
|
2012-05-16 |
2017-10-17 |
Rana Therapeutics Inc |
composições e métodos para modulação da expressão da família de genes da hemoglobina
|
|
CA2873797A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics Inc. |
Compositions and methods for modulating utrn expression
|
|
DK2850186T3
(en)
|
2012-05-16 |
2019-04-08 |
Translate Bio Ma Inc |
COMPOSITIONS AND PROCEDURES FOR MODULATING SMN GENFAMILY EXPRESSION
|
|
US10837014B2
(en)
|
2012-05-16 |
2020-11-17 |
Translate Bio Ma, Inc. |
Compositions and methods for modulating SMN gene family expression
|
|
CA2873779A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics Inc. |
Compositions and methods for modulating mecp2 expression
|
|
AU2013262699A1
(en)
|
2012-05-16 |
2015-01-22 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating ATP2A2 expression
|
|
EP2850086B1
(en)
|
2012-05-18 |
2023-07-05 |
Pacific Biosciences Of California, Inc. |
Heteroarylcyanine dyes
|
|
CA2877823A1
(en)
|
2012-06-25 |
2014-01-03 |
Gen9, Inc. |
Methods for nucleic acid assembly and high throughput sequencing
|
|
CA2879066C
(en)
|
2012-07-13 |
2019-08-13 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant
|
|
JP6453212B2
(ja)
|
2012-07-13 |
2019-01-16 |
ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. |
キラル制御
|
|
WO2014010250A1
(en)
|
2012-07-13 |
2014-01-16 |
Chiralgen, Ltd. |
Asymmetric auxiliary group
|
|
KR102237882B1
(ko)
|
2012-08-15 |
2021-04-07 |
아이오니스 파마수티컬즈, 인코포레이티드 |
변형된 캡핑 프로토콜을 이용하는 올리고머 화합물 제조 방법
|
|
CN104781271B
(zh)
|
2012-08-20 |
2018-07-06 |
加利福尼亚大学董事会 |
具有生物可逆的基团的多核苷酸
|
|
JP2015529469A
(ja)
|
2012-09-14 |
2015-10-08 |
ラナ セラピューティクス インコーポレイテッド |
多量体オリゴヌクレオチド化合物
|
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
EP2909341A2
(en)
|
2012-10-18 |
2015-08-26 |
Oslo Universitetssykehus HF |
Biomarkers for cervical cancer
|
|
US10174373B2
(en)
|
2012-10-18 |
2019-01-08 |
Idexx Laboratories, Inc. |
Nucleic acid amplification controls and kits and methods of use thereof
|
|
DK2951191T3
(en)
|
2013-01-31 |
2019-01-14 |
Ionis Pharmaceuticals Inc |
PROCEDURE FOR MANUFACTURING OLIGOMERIC COMPOUNDS USING MODIFIED CLUTCH PROTOCOLS
|
|
EP2971034B1
(en)
|
2013-03-13 |
2020-12-02 |
Gen9, Inc. |
Compositions, methods and apparatus for oligonucleotides synthesis
|
|
RU2670614C9
(ru)
|
2013-05-01 |
2018-11-23 |
Ионис Фармасьютикалз, Инк. |
Композиции и способы модулирования экспрессии hbv и ttr
|
|
CA2921459A1
(en)
|
2013-08-16 |
2015-02-19 |
Rana Therapeutics, Inc. |
Oligonucleotides targeting euchromatin regions of genes
|
|
CA2921457A1
(en)
*
|
2013-08-16 |
2015-02-19 |
Rana Therapeutics, Inc. |
Heterochromatin forming non-coding rnas
|
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
|
US9758546B2
(en)
|
2013-10-21 |
2017-09-12 |
Ionis Pharmaceuticals, Inc. |
Method for solution phase detritylation of oligomeric compounds
|
|
CN105658658B
(zh)
|
2013-11-21 |
2019-11-05 |
私募蛋白质体公司 |
胞苷-5-甲酰胺修饰的核苷酸组合物及其相关方法
|
|
BR102014031844A2
(pt)
|
2013-12-20 |
2015-10-06 |
Dow Agrosciences Llc |
ras oposto (rop) e moléculas de ácido nucleico relacionadas que conferem resistência a pragas de coleópteros e hemípteros
|
|
JP2017510246A
(ja)
|
2013-12-20 |
2017-04-13 |
ダウ アグロサイエンシィズ エルエルシー |
鞘翅目害虫に対する抵抗性を付与するrnapII−140核酸分子
|
|
WO2015108047A1
(ja)
|
2014-01-15 |
2015-07-23 |
株式会社新日本科学 |
免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
|
|
JPWO2015108048A1
(ja)
|
2014-01-15 |
2017-03-23 |
株式会社新日本科学 |
抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
|
|
JPWO2015108046A1
(ja)
|
2014-01-15 |
2017-03-23 |
株式会社新日本科学 |
抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
|
|
KR20230152178A
(ko)
|
2014-01-16 |
2023-11-02 |
웨이브 라이프 사이언시스 리미티드 |
키랄 디자인
|
|
US10036019B2
(en)
|
2014-03-17 |
2018-07-31 |
Ionis Pharmaceuticals, Inc. |
Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2015143245A1
(en)
|
2014-03-19 |
2015-09-24 |
Isis Pharmaceuticals, Inc. |
Methods for modulating ataxin 2 expression
|
|
ES2890677T3
(es)
|
2014-03-19 |
2022-01-21 |
Ionis Pharmaceuticals Inc |
Composiciones para modular la expresión de ataxina 2
|
|
NZ724100A
(en)
|
2014-04-01 |
2022-12-23 |
Biogen Ma Inc |
Compositions for modulating sod-1 expression
|
|
WO2015164693A1
(en)
|
2014-04-24 |
2015-10-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising alpha-beta-constrained nucleic acid
|
|
EP3647318B1
(en)
|
2014-04-28 |
2021-06-30 |
Ionis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds
|
|
CA2943894A1
(en)
|
2014-05-01 |
2015-11-05 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating complement factor b expression
|
|
EP4223315A3
(en)
|
2014-05-01 |
2023-08-23 |
Ionis Pharmaceuticals, Inc. |
Method for synthesis of reactive conjugate clusters
|
|
MX2016014313A
(es)
|
2014-05-07 |
2017-06-30 |
Dow Agrosciences Llc |
Moleculas de acido nucleico dre4 que confieren resistencia a las plagas de coleopteros.
|
|
US10093967B2
(en)
|
2014-08-12 |
2018-10-09 |
The Regents Of The University Of Michigan |
Detection of nucleic acids
|
|
BR112017004056A2
(pt)
|
2014-09-12 |
2017-12-05 |
Biogen Ma Inc |
composições e métodos para detecção da proteína smn em um indivíduo e tratamento de um indivíduo
|
|
US20160194658A1
(en)
|
2014-12-22 |
2016-07-07 |
Dow Agrosciences Llc |
Nucampholin nucleic acid molecules to control coleopteran insect pests
|
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
|
WO2016112132A1
(en)
|
2015-01-06 |
2016-07-14 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
|
US10538763B2
(en)
|
2015-01-16 |
2020-01-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of DUX4
|
|
WO2016130943A1
(en)
|
2015-02-13 |
2016-08-18 |
Rana Therapeutics, Inc. |
Hybrid oligonucleotides and uses thereof
|
|
EP3262181B1
(en)
|
2015-02-23 |
2024-04-10 |
Ionis Pharmaceuticals, Inc. |
Method for solution phase detritylation of oligomeric compounds
|
|
US11129844B2
(en)
|
2015-03-03 |
2021-09-28 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating MECP2 expression
|
|
EP3067424A1
(en)
|
2015-03-13 |
2016-09-14 |
Dow AgroSciences LLC |
Rna polymerase i1 nucleic acid molecules to control insect pests
|
|
US10407678B2
(en)
|
2015-04-16 |
2019-09-10 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
|
BR102016012010A2
(pt)
|
2015-05-29 |
2020-03-24 |
Dow Agrosciences Llc |
Molécula de ácido nucleico, de ácido ribonucleico (rna) e de ácido ribonucleico de filamento duplo (dsrna), usos de célula, planta e semente, produto primário, bem como métodos para controlar uma população de pragas coleópteras e/ou hemípteras, para melhorar o rendimento de uma cultura, e para produzir uma célula vegetal transgênica e uma planta transgênica
|
|
MA43072A
(fr)
|
2015-07-22 |
2018-05-30 |
Wave Life Sciences Ltd |
Compositions d'oligonucléotides et procédés associés
|
|
WO2017053781A1
(en)
|
2015-09-25 |
2017-03-30 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating ataxin 3 expression
|
|
EP3389670A4
(en)
|
2015-12-04 |
2020-01-08 |
Ionis Pharmaceuticals, Inc. |
METHODS OF TREATING BREAST CANCER
|
|
US20190002887A1
(en)
|
2015-12-31 |
2019-01-03 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing ataxin-2 expression
|
|
WO2017120365A1
(en)
|
2016-01-05 |
2017-07-13 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing lrrk2 expression
|
|
WO2017161168A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of dyrk1b expression
|
|
AU2017234678A1
(en)
|
2016-03-16 |
2018-08-16 |
Ionis Pharmaceuticals, Inc. |
Methods of modulating KEAP1
|
|
US11236339B2
(en)
|
2016-06-17 |
2022-02-01 |
Ionis Pharmaceuticals, Inc. |
Modulation of GYS1 expression
|
|
EP3500581A4
(en)
|
2016-08-17 |
2021-10-06 |
Solstice Biologics, Ltd. |
POLYNUCLEOTID CONSTRUCTIONS
|
|
WO2018055577A1
(en)
|
2016-09-23 |
2018-03-29 |
Synthena Ag |
Mixed tricyclo-dna, 2'-modified rna oligonucleotide compositions and uses thereof
|
|
WO2018067900A1
(en)
|
2016-10-06 |
2018-04-12 |
Ionis Pharmaceuticals, Inc. |
Method of conjugating oligomeric compounds
|
|
JOP20190104A1
(ar)
|
2016-11-10 |
2019-05-07 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن atxn3
|
|
CA3040728A1
(en)
|
2016-11-10 |
2018-05-17 |
Dow Agrosciences Llc |
Cytochrome b (cytb) nucleic acid molecules that control pathogens
|
|
JP7296882B2
(ja)
|
2016-11-23 |
2023-06-23 |
ウェイブ ライフ サイエンシズ リミテッド |
ホスホラミダイト及びオリゴヌクレオチド合成のための組成物及び方法
|
|
US11033570B2
(en)
|
2016-12-02 |
2021-06-15 |
Cold Spring Harbor Laboratory |
Modulation of Lnc05 expression
|
|
EP3342780A1
(en)
|
2016-12-30 |
2018-07-04 |
Dow AgroSciences LLC |
Pre-mrna processing factor 8 (prp8) nucleic acid molecules to control insect pests
|
|
US12460249B2
(en)
|
2017-03-08 |
2025-11-04 |
The Regents Of The University Of Michigan |
Protein analyte detection by analizing time-dependent signals from transient binding events of labeled low-affinity probes
|
|
WO2018165564A1
(en)
|
2017-03-09 |
2018-09-13 |
Ionis Pharmaceuticals, Inc. |
Morpholino modified oligomeric compounds
|
|
EP3645546A4
(en)
|
2017-06-30 |
2021-12-01 |
Solstice Biologics, Ltd. |
CHIRAL PHOSPHORAMIDITIS AUXILIARIES AND THEIR METHODS OF USE
|
|
CA3071033A1
(en)
|
2017-08-18 |
2019-02-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of the notch signaling pathway for treatment of respiratory disorders
|
|
WO2019051173A1
(en)
|
2017-09-08 |
2019-03-14 |
Ionis Pharmaceuticals, Inc. |
MODULATORS OF SMAD7 EXPRESSION
|
|
TWI809004B
(zh)
|
2017-11-09 |
2023-07-21 |
美商Ionis製藥公司 |
用於降低snca表現之化合物及方法
|
|
WO2019126641A2
(en)
|
2017-12-21 |
2019-06-27 |
Ionis Pharmaceuticals, Inc. |
Modulation of frataxin expression
|
|
CN111902537A
(zh)
|
2018-01-15 |
2020-11-06 |
Ionis制药公司 |
Dnm2表达的调节剂
|
|
TWI840345B
(zh)
|
2018-03-02 |
2024-05-01 |
美商Ionis製藥公司 |
Irf4表現之調節劑
|
|
EP3759127A4
(en)
|
2018-03-02 |
2022-03-30 |
Ionis Pharmaceuticals, Inc. |
COMPOUNDS AND METHODS FOR MODULATING AMYLOID BETA PRECURSOR PROTEIN
|
|
EP3768694A4
(en)
|
2018-03-22 |
2021-12-29 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating fmr1 expression
|
|
EP3775204A4
(en)
|
2018-04-11 |
2021-12-29 |
Ionis Pharmaceuticals, Inc. |
Modulators of ezh2 expression
|
|
SG11202008827XA
(en)
|
2018-04-13 |
2020-10-29 |
Bristol Myers Squibb Co |
Novel phosphorous (v)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (v) compounds
|
|
CA3098136A1
(en)
|
2018-05-09 |
2019-11-14 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing fxi expression
|
|
JOP20200283A1
(ar)
|
2018-05-09 |
2020-11-08 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير الوراثي عن atxn3
|
|
US11833168B2
(en)
|
2018-06-14 |
2023-12-05 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for increasing STMN2 expression
|
|
TWI833770B
(zh)
|
2018-06-27 |
2024-03-01 |
美商Ionis製藥公司 |
用於減少 lrrk2 表現之化合物及方法
|
|
MX2021000922A
(es)
|
2018-07-25 |
2021-03-31 |
Ionis Pharmaceuticals Inc |
Compuestos y metodos para reducir la expresion de la atxn2.
|
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
|
CA3119456A1
(en)
|
2018-11-15 |
2020-05-22 |
Ionis Pharmaceuticals, Inc. |
Modulators of irf5 expression
|
|
US12281305B2
(en)
|
2018-11-21 |
2025-04-22 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing prion expression
|
|
MX2021008918A
(es)
|
2019-01-31 |
2021-08-24 |
Ionis Pharmaceuticals Inc |
Moduladores de expresion yap1.
|
|
SG11202108450SA
(en)
|
2019-02-27 |
2021-09-29 |
Ionis Pharmaceuticals Inc |
Modulators of malat1 expression
|
|
CN117431244A
(zh)
|
2019-03-29 |
2024-01-23 |
Ionis制药公司 |
用于调节ube3a-ats的化合物和方法
|
|
HRP20251033T1
(hr)
|
2019-07-26 |
2025-10-24 |
Ionis Pharmaceuticals, Inc. |
Spojevi i postupci za moduliranje gfap
|
|
WO2021030778A1
(en)
|
2019-08-15 |
2021-02-18 |
Ionis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds and uses thereof
|
|
CN111039977B
(zh)
*
|
2019-12-31 |
2022-11-08 |
广州同隽医药科技有限公司 |
一种亚磷酰化试剂及其在寡核苷酸合成中的应用
|
|
AR121446A1
(es)
|
2020-02-28 |
2022-06-08 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para modular smn2
|
|
WO2021222768A2
(en)
|
2020-05-01 |
2021-11-04 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating atxn1
|
|
BR112022024206A2
(pt)
|
2020-06-29 |
2023-01-03 |
Ionis Pharmaceuticals Inc |
Compostos e métodos para modular plp1
|
|
UY39344A
(es)
|
2020-07-28 |
2022-02-25 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para reducir la expresión de app
|
|
TW202221123A
(zh)
|
2020-08-07 |
2022-06-01 |
美商Ionis製藥公司 |
調節scn2a之化合物及方法
|
|
MX2023005736A
(es)
|
2020-11-18 |
2023-05-25 |
Ionis Pharmaceuticals Inc |
Compuestos y metodos para modular la expresion de angiotensinogeno.
|
|
IL303800A
(en)
|
2020-12-18 |
2023-08-01 |
Ionis Pharmaceuticals Inc |
Compounds and methods for modulating factor xii
|
|
US20240279828A1
(en)
|
2021-05-31 |
2024-08-22 |
Genscript Usa Inc. |
Electrografted films for dna synthesis
|
|
AU2022293556A1
(en)
|
2021-06-18 |
2024-01-18 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing ifnar1 expression
|
|
WO2024035952A1
(en)
|
2022-08-12 |
2024-02-15 |
Remix Therapeutics Inc. |
Methods and compositions for modulating splicing at alternative splice sites
|
|
KR20250075637A
(ko)
|
2022-09-23 |
2025-05-28 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Mecp2 발현을 감소시키기 위한 화합물 및 방법(compounds and methods for reducing mecp2 expression)
|
|
US12168674B1
(en)
|
2023-12-08 |
2024-12-17 |
Oligo Foundry, Inc. |
Reagents and methods for the highly-efficient synthesis and purification of biopolymers
|