JPS60358B2 - ベンゾモルフアン化合物の製法 - Google Patents

ベンゾモルフアン化合物の製法

Info

Publication number
JPS60358B2
JPS60358B2 JP50092995A JP9299575A JPS60358B2 JP S60358 B2 JPS60358 B2 JP S60358B2 JP 50092995 A JP50092995 A JP 50092995A JP 9299575 A JP9299575 A JP 9299575A JP S60358 B2 JPS60358 B2 JP S60358B2
Authority
JP
Japan
Prior art keywords
formula
formulas
compound
tetrahydrofurfuryl
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP50092995A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5139673A (en
Inventor
メルツ ヘルベルト
ランクバイン アドルフ
バルテル ゲルハルト
シユトツクハウス クラウス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
C.H. Boehringer Sohn AG and Co KG
Original Assignee
C.H. Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C.H. Boehringer Sohn AG and Co KG filed Critical C.H. Boehringer Sohn AG and Co KG
Publication of JPS5139673A publication Critical patent/JPS5139673A/ja
Publication of JPS60358B2 publication Critical patent/JPS60358B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP50092995A 1974-08-05 1975-07-30 ベンゾモルフアン化合物の製法 Expired JPS60358B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2437610A DE2437610A1 (de) 1974-08-05 1974-08-05 Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
DE2437610.1 1974-08-05

Publications (2)

Publication Number Publication Date
JPS5139673A JPS5139673A (en) 1976-04-02
JPS60358B2 true JPS60358B2 (ja) 1985-01-07

Family

ID=5922448

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50092995A Expired JPS60358B2 (ja) 1974-08-05 1975-07-30 ベンゾモルフアン化合物の製法

Country Status (27)

Country Link
US (1) US3982005A (enExample)
JP (1) JPS60358B2 (enExample)
AT (1) AT348140B (enExample)
BE (1) BE832099R (enExample)
BG (3) BG25090A3 (enExample)
CA (1) CA1049008A (enExample)
CH (7) CH613963A5 (enExample)
CS (1) CS189717B2 (enExample)
DD (1) DD122685A5 (enExample)
DE (1) DE2437610A1 (enExample)
DK (1) DK138992C (enExample)
ES (6) ES452765A1 (enExample)
FI (1) FI63229C (enExample)
FR (1) FR2320096A2 (enExample)
GB (1) GB1513950A (enExample)
HU (1) HU177952B (enExample)
IE (1) IE42216B1 (enExample)
IL (1) IL47860A (enExample)
LU (1) LU73138A1 (enExample)
NL (1) NL7509249A (enExample)
NO (1) NO143460C (enExample)
PH (1) PH13687A (enExample)
PL (3) PL99819B1 (enExample)
RO (3) RO67390A (enExample)
SE (1) SE425392B (enExample)
SU (3) SU591147A3 (enExample)
ZA (1) ZA754997B (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087532A (en) * 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
GB1575009A (en) * 1976-06-21 1980-09-17 Acf Chemiefarma Nv 6,7-benzomorphan derivatives
DE2716687A1 (de) * 1977-04-15 1978-10-19 Boehringer Sohn Ingelheim 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
NL7804509A (nl) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
JPS5636521A (en) * 1979-08-31 1981-04-09 Shin Etsu Chem Co Ltd Production of alkenyloxy group-containing organopolysiloxane
JP5451611B2 (ja) 2007-07-26 2014-03-26 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１のサイクリックインヒビター
US8859580B2 (en) 2007-11-16 2014-10-14 Boehringer Ingelheim International Gmbh Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
CA2708303A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
WO2009094169A1 (en) 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8598160B2 (en) 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
TW201004945A (en) 2008-05-01 2010-02-01 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
KR20110002492A (ko) 2008-05-01 2011-01-07 비타이 파마슈티컬즈, 인코포레이티드 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제
EP2291370B1 (en) 2008-05-01 2013-11-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8765780B2 (en) 2008-05-13 2014-07-01 Boehringer Ingelheim International Gmbh Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
WO2010011314A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
US8846668B2 (en) 2008-07-25 2014-09-30 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
UA109255C2 (ru) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
WO2011011123A1 (en) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
AR078887A1 (es) 2009-11-06 2011-12-07 Boehringer Ingelheim Int Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina y composiciones farmaceuticas que los contienen.
EP2582698B1 (en) 2010-06-16 2016-09-14 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
US8735585B2 (en) 2011-08-17 2014-05-27 Boehringer Ingelheim International Gmbh Indenopyridine derivatives
KR20230112134A (ko) 2020-11-26 2023-07-26 신에쓰 가가꾸 고교 가부시끼가이샤 실온경화성 오르가노폴리실록산 조성물 및 물품 그리고 가수분해성 오르가노실란 화합물 및 그 제조 방법
EP4397695A4 (en) 2021-09-03 2025-09-10 Shinetsu Chemical Co ORGANOPOLYSILOXANE COMPOUND, ROOM TEMPERATURE CURABLE ORGANOPOLYSILOXANE COMPOSITION AND ARTICLE

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE582575A (enExample) * 1958-09-22
US3700734A (en) * 1969-01-23 1972-10-24 Merck & Co Inc 2{40 -hydroxy-2,3,5-trimethyl-6,7-benzomorphan
DE2105743C3 (de) * 1971-02-08 1979-11-29 Boehringer Sohn Ingelheim 2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung
CS166803B2 (enExample) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim
DE2200596A1 (de) * 1972-01-07 1973-07-12 Boehringer Sohn Ingelheim N-(furyl-methyl)-2'-hydroxy-5-phenyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung
DE2217420C3 (de) * 1972-04-12 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2229695A1 (de) * 1972-06-19 1974-01-31 Boehringer Sohn Ingelheim 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
IE42216B1 (en) 1980-07-02
HU177952B (en) 1982-02-28
CA1049008A (en) 1979-02-20
IL47860A0 (en) 1975-11-25
SU587858A3 (ru) 1978-01-05
ZA754997B (en) 1977-04-27
BG25088A3 (bg) 1978-07-12
BG25090A3 (bg) 1978-07-12
FR2320096B2 (enExample) 1978-09-01
NL7509249A (nl) 1976-02-09
CH615679A5 (enExample) 1980-02-15
PH13687A (en) 1980-09-01
RO67390A (ro) 1981-06-30
IE42216L (en) 1976-02-05
ES452765A1 (es) 1977-10-16
GB1513950A (en) 1978-06-14
CH616421A5 (enExample) 1980-03-31
DK352875A (da) 1976-02-06
NO143460B (no) 1980-11-10
NO752731L (enExample) 1976-02-06
DE2437610A1 (de) 1976-02-26
FI63229C (fi) 1983-05-10
AU8364675A (en) 1977-02-10
SE425392B (sv) 1982-09-27
CH616420A5 (enExample) 1980-03-31
ES452764A1 (es) 1977-10-16
ES452767A1 (es) 1977-10-01
SU591147A3 (ru) 1978-01-30
PL99819B1 (pl) 1978-08-31
FI752211A7 (enExample) 1976-02-06
NO143460C (no) 1981-02-18
PL99838B1 (pl) 1978-08-31
ES452766A1 (es) 1977-10-01
LU73138A1 (enExample) 1977-04-13
RO72735A (ro) 1982-09-09
PL99816B1 (pl) 1978-08-31
ATA523775A (de) 1978-06-15
JPS5139673A (en) 1976-04-02
CH615678A5 (enExample) 1980-02-15
DD122685A5 (enExample) 1976-10-20
DK138992C (da) 1979-04-30
RO72736A (ro) 1982-09-09
ES452768A1 (es) 1977-10-01
CH615680A5 (enExample) 1980-02-15
AT348140B (de) 1979-01-25
BE832099R (fr) 1976-02-04
IL47860A (en) 1979-01-31
SU587859A3 (ru) 1978-01-05
US3982005A (en) 1976-09-21
BG25089A3 (bg) 1978-07-12
FI63229B (fi) 1983-01-31
SE7508789L (sv) 1976-02-10
DK138992B (da) 1978-11-27
CH615677A5 (enExample) 1980-02-15
CH613963A5 (enExample) 1979-10-31
ES452763A1 (es) 1977-10-01
CS189717B2 (en) 1979-04-30
FR2320096A2 (fr) 1977-03-04

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