JPS59163313A - 経鼻投与用ペプチドホルモン類組成物 - Google Patents
経鼻投与用ペプチドホルモン類組成物Info
- Publication number
- JPS59163313A JPS59163313A JP58037244A JP3724483A JPS59163313A JP S59163313 A JPS59163313 A JP S59163313A JP 58037244 A JP58037244 A JP 58037244A JP 3724483 A JP3724483 A JP 3724483A JP S59163313 A JPS59163313 A JP S59163313A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- water
- peptide
- absorbing base
- insulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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- 230000000704 physical effect Effects 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
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- 229920005614 potassium polyacrylate Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229940097325 prolactin Drugs 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical compound NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 description 1
- 235000019423 pullulan Nutrition 0.000 description 1
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- 238000003127 radioimmunoassay Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000003079 salivary gland Anatomy 0.000 description 1
- 229960002101 secretin Drugs 0.000 description 1
- OWMZNFCDEHGFEP-NFBCVYDUSA-N secretin human Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 OWMZNFCDEHGFEP-NFBCVYDUSA-N 0.000 description 1
- 229940080237 sodium caseinate Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229960004025 sodium salicylate Drugs 0.000 description 1
- JQWYTSHFVIDUHA-UHFFFAOYSA-M sodium;2-hydroxy-3-methoxybenzoate Chemical compound [Na+].COC1=CC=CC(C([O-])=O)=C1O JQWYTSHFVIDUHA-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229960000874 thyrotropin Drugs 0.000 description 1
- 230000001748 thyrotropin Effects 0.000 description 1
- 229940034199 thyrotropin-releasing hormone Drugs 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229960001322 trypsin Drugs 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58037244A JPS59163313A (ja) | 1983-03-09 | 1983-03-09 | 経鼻投与用ペプチドホルモン類組成物 |
| DE8484301546T DE3476633D1 (en) | 1983-03-09 | 1984-03-08 | Powdery pharmaceutical composition for nasal administration |
| EP84301546A EP0122036B2 (en) | 1983-03-09 | 1984-03-08 | Powdery pharmaceutical composition for nasal administration |
| US06/587,779 US4613500A (en) | 1983-03-09 | 1984-03-09 | Powdery pharmaceutical composition for nasal administration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58037244A JPS59163313A (ja) | 1983-03-09 | 1983-03-09 | 経鼻投与用ペプチドホルモン類組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59163313A true JPS59163313A (ja) | 1984-09-14 |
| JPS6237016B2 JPS6237016B2 (enExample) | 1987-08-10 |
Family
ID=12492205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58037244A Granted JPS59163313A (ja) | 1983-03-09 | 1983-03-09 | 経鼻投与用ペプチドホルモン類組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4613500A (enExample) |
| EP (1) | EP0122036B2 (enExample) |
| JP (1) | JPS59163313A (enExample) |
| DE (1) | DE3476633D1 (enExample) |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61137828A (ja) * | 1984-12-07 | 1986-06-25 | Shionogi & Co Ltd | γ−インタ−フエロン製剤組成物 |
| JPS61194034A (ja) * | 1985-02-25 | 1986-08-28 | Teijin Ltd | 経鼻投与用粉末状組成物 |
| JPS61282320A (ja) * | 1985-06-04 | 1986-12-12 | サンド・アクチエンゲゼルシヤフト | 鼻腔用医薬組成物 |
| JPS63115820A (ja) * | 1986-10-31 | 1988-05-20 | Teijin Ltd | アスコルビン酸類を含有する経鼻投与用粉末状組成物 |
| JPS63115821A (ja) * | 1986-11-04 | 1988-05-20 | Teijin Ltd | 塩基性アミノ酸を含有する経鼻投与用粉末状組成物 |
| JPH01500116A (ja) * | 1986-04-18 | 1989-01-19 | ノボ ノルデイスク アクツイエセルスカプ | インシユリン製剤 |
| WO1990005535A1 (fr) * | 1988-11-14 | 1990-05-31 | Otsuka Pharmaceutical Co., Ltd. | Preparation a base d'interferon pour administration nasale |
| JPH02503915A (ja) * | 1987-05-22 | 1990-11-15 | ダンバイオシスト ユーケー リミテッド | 吸収促進した投与製剤 |
| JPH03503160A (ja) * | 1987-10-10 | 1991-07-18 | ダンバイオシスト ユーケー リミテッド | 薬剤組成物 |
| AT396331B (de) * | 1986-08-18 | 1993-08-25 | Sandoz Ag | Verfahren zur herstellung einer octreotid enthaltenden pharmazeutischen zusammensetzung |
| WO1997031626A1 (en) * | 1996-02-27 | 1997-09-04 | Teijin Limited | Powdery composition for nasal administration |
| JP2007504129A (ja) * | 2003-08-29 | 2007-03-01 | デルサイト バイオテクノロジーズ， インコーポレイテッド | 陰イオン性多糖類を含むインサイチュゲルでの生理学的な薬剤の送達 |
| WO2008078730A1 (ja) | 2006-12-26 | 2008-07-03 | Translational Research, Ltd. | 経鼻投与用製剤 |
| US8673360B2 (en) | 2004-08-10 | 2014-03-18 | Shin Nippon Biomedical Laboratories, Ltd. | Compositions that enable rapid-acting and highly absorptive intranasal administration |
| US8827946B2 (en) | 2009-07-31 | 2014-09-09 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal granisetron and nasal applicator |
| USRE45404E1 (en) | 2003-03-27 | 2015-03-03 | Shin Nippon Biomedical Laboratories, Ltd. | Powder medicine applicator for nasal cavity |
| US9101539B2 (en) | 2009-05-15 | 2015-08-11 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical compositions with improved pharmacokinetics |
| US9138410B2 (en) | 2003-02-21 | 2015-09-22 | Shin Nippon Biomedical Laboratories, Ltd. | Compositions for nasal administration of pharmaceuticals |
| US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
Families Citing this family (213)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61267528A (ja) * | 1984-11-26 | 1986-11-27 | Yamanouchi Pharmaceut Co Ltd | 吸収促進剤を含有するカルシトニン経鼻剤 |
| US5643565A (en) * | 1985-09-20 | 1997-07-01 | Chiron Corporation | Human IL-2 as a vaccine adjuvant |
| US5503841A (en) * | 1985-09-20 | 1996-04-02 | Cetus Oncology Corporation | Human IL-2 as a vaccine adjuvant |
| DE3601923A1 (de) * | 1986-01-23 | 1987-07-30 | Behringwerke Ag | Nasal applizierbares arzneimittel, verfahren zu seiner herstellung und seine verwendung |
| US4734401A (en) * | 1986-03-17 | 1988-03-29 | W. R. Grace & Co. | Process for spray drying amino acid compositions |
| CA1291036C (en) * | 1986-04-23 | 1991-10-22 | Edwin I. Stoltz | Nasal administration of drugs |
| CA1257199A (en) * | 1986-05-20 | 1989-07-11 | Paul Y. Wang | Preparation containing bioactive macromolecular substance for multi-months release in vivo |
| US4962091A (en) * | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
| HU198626B (en) * | 1986-05-27 | 1989-11-28 | Sandoz Ag | Process for producing pharmaceutical compositions comprising somatostatin analogues as active ingredient |
| IT1204400B (it) * | 1986-06-20 | 1989-03-01 | Sclavo Spa | Composizioni farmaceutiche contenente una calcitonina |
| USRE35862E (en) * | 1986-08-18 | 1998-07-28 | Emisphere Technologies, Inc. | Delivery systems for pharmacological agents encapsulated with proteinoids |
| US4925673A (en) * | 1986-08-18 | 1990-05-15 | Clinical Technologies Associates, Inc. | Delivery systems for pharmacological agents encapsulated with proteinoids |
| DE3779221D1 (de) | 1986-08-19 | 1992-06-25 | Genentech Inc | Einrichtung und dispersion zum intrapulmonalen eingeben von polypeptidwuchsstoffen und -zytokinen. |
| US6024983A (en) * | 1986-10-24 | 2000-02-15 | Southern Research Institute | Composition for delivering bioactive agents for immune response and its preparation |
| US5075109A (en) * | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| EP0300036A4 (en) * | 1987-01-30 | 1989-06-14 | Biomed Res Consultants Ltd | PHARMACEUTICAL COMPOSITIONS BASED ON VASOPRESSIN. |
| US5690954A (en) * | 1987-05-22 | 1997-11-25 | Danbiosyst Uk Limited | Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material |
| IT1222395B (it) * | 1987-07-30 | 1990-09-05 | Pierrel Spa | Composizione farmaceutica per somministrazione intranasale comprendente l'ormone ghrh,un agonista colinergico e/o un sale biliare |
| US5059587A (en) * | 1987-08-03 | 1991-10-22 | Toyo Jozo Company, Ltd. | Physiologically active peptide composition for nasal administration |
| DE3726324A1 (de) * | 1987-08-07 | 1989-02-16 | Hoechst Ag | Cyclopeptide als resorptionsfoerderer bei applikation auf die schleimhaeute |
| EP0308181A1 (en) * | 1987-09-14 | 1989-03-22 | Novo Nordisk A/S | Trans-mucosal delivery formulations and a method for preparation thereof |
| IT1222734B (it) * | 1987-09-25 | 1990-09-12 | Scalvo S P A | Formulaziopne farmaceutiche e forme di dosaggio per la somminaistarzione rettale di calcitonina |
| KR890006252A (ko) * | 1987-10-15 | 1989-06-12 | 헤르비그 폰 모르체 | 분말형 폴리펩타이드의 비강내 투여용 조성물 및 투여방법 |
| DE3887494T2 (de) * | 1987-11-13 | 1994-05-19 | Smithkline Beecham Farma | Ein Calcitonin sowie ein Glycyrrhizinat als Absorptionsförderer enthaltende Arzneimittel. |
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Cited By (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61137828A (ja) * | 1984-12-07 | 1986-06-25 | Shionogi & Co Ltd | γ−インタ−フエロン製剤組成物 |
| JPS61194034A (ja) * | 1985-02-25 | 1986-08-28 | Teijin Ltd | 経鼻投与用粉末状組成物 |
| US4985242A (en) * | 1985-02-25 | 1991-01-15 | Teljin Limited | Intranasally applicable powdery pharmaceutical composition |
| JPS61282320A (ja) * | 1985-06-04 | 1986-12-12 | サンド・アクチエンゲゼルシヤフト | 鼻腔用医薬組成物 |
| JPH01500116A (ja) * | 1986-04-18 | 1989-01-19 | ノボ ノルデイスク アクツイエセルスカプ | インシユリン製剤 |
| AT396331B (de) * | 1986-08-18 | 1993-08-25 | Sandoz Ag | Verfahren zur herstellung einer octreotid enthaltenden pharmazeutischen zusammensetzung |
| JPS63115820A (ja) * | 1986-10-31 | 1988-05-20 | Teijin Ltd | アスコルビン酸類を含有する経鼻投与用粉末状組成物 |
| JPS63115821A (ja) * | 1986-11-04 | 1988-05-20 | Teijin Ltd | 塩基性アミノ酸を含有する経鼻投与用粉末状組成物 |
| JPH02503915A (ja) * | 1987-05-22 | 1990-11-15 | ダンバイオシスト ユーケー リミテッド | 吸収促進した投与製剤 |
| JPH03503160A (ja) * | 1987-10-10 | 1991-07-18 | ダンバイオシスト ユーケー リミテッド | 薬剤組成物 |
| WO1990005535A1 (fr) * | 1988-11-14 | 1990-05-31 | Otsuka Pharmaceutical Co., Ltd. | Preparation a base d'interferon pour administration nasale |
| AU722319B2 (en) * | 1996-02-27 | 2000-07-27 | Teijin Limited | Powdery composition for nasal administration |
| US8206748B2 (en) | 1996-02-27 | 2012-06-26 | Teijin Limited | Powdery composition for nasal administration |
| US6881423B2 (en) | 1996-02-27 | 2005-04-19 | Teijin Limited | Powdery composition for nasal administration |
| WO1997031626A1 (en) * | 1996-02-27 | 1997-09-04 | Teijin Limited | Powdery composition for nasal administration |
| US7731990B2 (en) | 1996-02-27 | 2010-06-08 | Teijin Limited | Powdery composition for nasal administration |
| US9138410B2 (en) | 2003-02-21 | 2015-09-22 | Shin Nippon Biomedical Laboratories, Ltd. | Compositions for nasal administration of pharmaceuticals |
| USRE45404E1 (en) | 2003-03-27 | 2015-03-03 | Shin Nippon Biomedical Laboratories, Ltd. | Powder medicine applicator for nasal cavity |
| JP4765020B2 (ja) * | 2003-08-29 | 2011-09-07 | ナノセラピューティクス・インコーポレイテッド | 陰イオン性多糖類を含むインサイチュゲルでの生理学的な薬剤の送達 |
| JP2007504129A (ja) * | 2003-08-29 | 2007-03-01 | デルサイト バイオテクノロジーズ， インコーポレイテッド | 陰イオン性多糖類を含むインサイチュゲルでの生理学的な薬剤の送達 |
| US8673360B2 (en) | 2004-08-10 | 2014-03-18 | Shin Nippon Biomedical Laboratories, Ltd. | Compositions that enable rapid-acting and highly absorptive intranasal administration |
| WO2008078730A1 (ja) | 2006-12-26 | 2008-07-03 | Translational Research, Ltd. | 経鼻投与用製剤 |
| US10195139B2 (en) | 2006-12-26 | 2019-02-05 | Shin Nippon Biomedical Laboratories, Ltd. | Preparation for transnasal application |
| US9101539B2 (en) | 2009-05-15 | 2015-08-11 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical compositions with improved pharmacokinetics |
| US8827946B2 (en) | 2009-07-31 | 2014-09-09 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal granisetron and nasal applicator |
| US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
| US12102754B2 (en) | 2017-09-26 | 2024-10-01 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0122036B1 (en) | 1989-02-08 |
| US4613500A (en) | 1986-09-23 |
| EP0122036B2 (en) | 1994-11-02 |
| JPS6237016B2 (enExample) | 1987-08-10 |
| DE3476633D1 (en) | 1989-03-16 |
| EP0122036A1 (en) | 1984-10-17 |
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