JPH08504102A - 組換えウイルスベクター系 - Google Patents
組換えウイルスベクター系Info
- Publication number
- JPH08504102A JPH08504102A JP6514263A JP51426394A JPH08504102A JP H08504102 A JPH08504102 A JP H08504102A JP 6514263 A JP6514263 A JP 6514263A JP 51426394 A JP51426394 A JP 51426394A JP H08504102 A JPH08504102 A JP H08504102A
- Authority
- JP
- Japan
- Prior art keywords
- dna
- recombinant
- sequence
- aav
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.図9(配列番号1)に示した165塩基対の逆方向末端反復配列を含む、精 製および単離された核酸分子。 2.対象のタンパク質をコードするDNAヌクレオチド配列および図9(配列番 号1)に示した165塩基対の逆方向末端反復配列を含む組換えDNAベクター 。 3.AAVのREPおよびCAPタンパク質をコードするDNAヌクレオチド配 列をさらに含む、請求項2に記載の組換えDNAベクター。 4.図10(配列番号2)に示した細菌のγδリゾルベースにより認識されるD NAヌクレオチド配列をさらに含む、請求項2に記載の組換えDNAベクター。 5.図10(配列番号2)に示した細菌のγδリゾルベースにより認識されるD NAヌクレオチド配列をさらに含む、請求項3に記載の組換えDNAベクター。 6.組換えDNA分子を複製し、AAV粒子へキャプシド化する方法であって、 ヘルパーウイルス、AAVのREPおよびCAPタンパク質をコードする組換え 核酸、および対象のDNA配列と図9(配列番号1)に示した165塩基対の逆 方向末端反復配列を含む組換え核酸を含有す真核細胞を培養することにより、1 65塩基対の逆方向末端反復配列および対象のDNA配列を含む該核酸を複製し 、AAV粒子へ集合させることからなる方法。 7.ヘルパーウイルスがアデノウイルスである、請求項6に記載の方法。 8.ヘルパーウイルスが単純ヘルペスウイルスである、請求項6に記載の方法。 9.AAVのREPおよびCAPタンパク質をコードする組換え核酸が、 (a)AAVのREPおよびCAP RNAの発現を制御するプロモーター 、 (b)REPおよびCAP mRNAのための転写開始シグナル、 (c)REPおよびCAPタンパク質をコードするDNA配列、 および (d)転写終止シグナル、 を含むプラスミドベクターである、請求項6に記載の方法。 10.対象のDNA配列および165塩基対の逆方向末端反復配列を含む組換え核 酸が、 (a)プロモーター、 (b)該プロモーターの制御下で転写される対象のDNA配列、 および (c)図9(配列番号1)に示した165塩基対の逆方向末端反復配列、 を含むプラスミドベクターである、請求項6に記載の方法。 11.組換えDNA分子を複製し、ウイルス粒子へキャプシド化する方法であって 、 (a) (i)対象の遺伝子を含む組換えウイルスベクター、 (ii)ヘルパー機能をもたらすウイルス遺伝子、および(iii)該ウイルスベ クター配列の隣に位置する2つの図10(配列番号 2)に示した細菌γδリゾルベース認識配列、を含む組換え核酸を増殖し、 (b)増殖した核酸を細菌γδリゾルベースで処理し、そして (c)ヘルパーウイルスおよび該リゾルベース処理組換え核酸 を含む真核細胞を培養することにより、該分割した組換えDNAを複製し、ウイ ルス粒子へキャプシド化する、 ことからなる方法。 12.組換えDNA分子を複製し、AAV粒子へキャプシド化する方法であって、 (a)図9(配列番号1)に示した165塩基対の逆方向末端反復配列およ び図10(配列番号2)に示した細菌γδリゾルベース認識配列を含む組換え核 酸を、細菌のγδリゾルベース酵素で処理し、そして (b)ヘルパーウイルスおよび該リゾルベース処理組換え核酸を含む真核細 胞を培養することにより、該分割した組換えDNAを複製し、AAV粒子へキャ プシド化する、 ことからなる方法。 13.ヘルパーウイルスがアデノウイルスである、請求項12に記載の方法。 14.ヘルパーウイルスが単純ヘルペスウイルスである、請求項12に記載の方法 。 15.細菌γδリゾルベース認識配列を含む組換え核酸が、 (a)細菌γδリゾルベース認識配列、 (b)プロモーター、 (c)該プロモーターの制御下で転写される対象のDNA配列、 および (d)図9(配列番号1)に示した165塩基対の逆方向末端反復配列、 を含むプラスミドベクターである、請求項12に記載の方法。 16.細菌γδリゾルベース認識配列を含む組換え核酸が、 (a)細菌γδリゾルベース認識配列、 (b)プロモーター、 (c)該プロモーターの制御下で転写される対象のDNA配列、 (d)図9(配列番号1)に示した165塩基対の逆方向末端反復配列、お よび (e)AAVのREPおよびCAPタンパク質をコードするDNAヌクレオ チド配列、 を含むプラスミドベクターである、請求項12に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US989,841 | 1992-12-04 | ||
US07/989,841 US5478745A (en) | 1992-12-04 | 1992-12-04 | Recombinant viral vector system |
PCT/US1993/011728 WO1994013788A1 (en) | 1992-12-04 | 1993-12-03 | Recombinant viral vector system |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH08504102A true JPH08504102A (ja) | 1996-05-07 |
JP4117023B2 JP4117023B2 (ja) | 2008-07-09 |
Family
ID=25535518
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51426394A Expired - Fee Related JP4117023B2 (ja) | 1992-12-04 | 1993-12-03 | 組換えウイルスベクター系 |
Country Status (9)
Country | Link |
---|---|
US (1) | US5478745A (ja) |
EP (1) | EP0673415B1 (ja) |
JP (1) | JP4117023B2 (ja) |
KR (1) | KR100256890B1 (ja) |
AT (1) | ATE423203T1 (ja) |
DE (1) | DE69334262D1 (ja) |
IL (1) | IL107862A0 (ja) |
TW (1) | TW260708B (ja) |
WO (1) | WO1994013788A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021516953A (ja) * | 2018-03-15 | 2021-07-15 | インターガラクティック セラピューティクス インコーポレイテッド | 合成dnaベクターおよびその使用 |
JP2021528959A (ja) * | 2018-06-22 | 2021-10-28 | アスクレピオス バイオファーマシューティカル, インコーポレイテッド | 細胞内で存続する遺伝子送達のためのベクター |
US11684680B2 (en) | 2019-09-18 | 2023-06-27 | Intergalactic Therapeutics, Inc. | Synthetic DNA vectors and methods of use |
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Cited By (4)
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JP2021516953A (ja) * | 2018-03-15 | 2021-07-15 | インターガラクティック セラピューティクス インコーポレイテッド | 合成dnaベクターおよびその使用 |
JP2021528959A (ja) * | 2018-06-22 | 2021-10-28 | アスクレピオス バイオファーマシューティカル, インコーポレイテッド | 細胞内で存続する遺伝子送達のためのベクター |
US11684680B2 (en) | 2019-09-18 | 2023-06-27 | Intergalactic Therapeutics, Inc. | Synthetic DNA vectors and methods of use |
US11766490B2 (en) | 2019-09-18 | 2023-09-26 | Intergalactic Therapeutics, Inc. | Synthetic DNA vectors and methods of use |
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WO1994013788A1 (en) | 1994-06-23 |
EP0673415B1 (en) | 2009-02-18 |
DE69334262D1 (de) | 2009-04-02 |
EP0673415A4 (en) | 1997-05-21 |
TW260708B (ja) | 1995-10-21 |
US5478745A (en) | 1995-12-26 |
IL107862A0 (en) | 1994-04-12 |
JP4117023B2 (ja) | 2008-07-09 |
EP0673415A1 (en) | 1995-09-27 |
KR100256890B1 (ko) | 2000-05-15 |
ATE423203T1 (de) | 2009-03-15 |
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