EA201301171A1 - Композиции и способы ингибирования экспрессии генов eg5 и vegf - Google Patents

Композиции и способы ингибирования экспрессии генов eg5 и vegf

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Publication number
EA201301171A1
EA201301171A1 EA201301171A EA201301171A EA201301171A1 EA 201301171 A1 EA201301171 A1 EA 201301171A1 EA 201301171 A EA201301171 A EA 201301171A EA 201301171 A EA201301171 A EA 201301171A EA 201301171 A1 EA201301171 A1 EA 201301171A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compositions
methods
vegf
inhibiting expression
vegf genes
Prior art date
Application number
EA201301171A
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English (en)
Inventor
Дэвид Бумкрот
Динах Вен-Йи Сах
Иванка Тудьярска
Original Assignee
Элнилэм Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Элнилэм Фармасьютикалз, Инк. filed Critical Элнилэм Фармасьютикалз, Инк.
Publication of EA201301171A1 publication Critical patent/EA201301171A1/ru

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    • A—HUMAN NECESSITIES
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
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  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Изобретение относится к композициям, содержащим двухцепочечную рибонуклеиновую кислоту (дцРНК) в препарате SNALP, и к способам применения таких композиций для ингибирования экспрессии Eg5 и фактора роста эндотелия сосудов (VEGF), а также к способам применения указанных композиций для лечения патологических состояний, опосредуемых экспрессией Eg5 и VEGF, таких как рак.
EA201301171A 2008-03-05 2009-03-05 Композиции и способы ингибирования экспрессии генов eg5 и vegf EA201301171A1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3401908P 2008-03-05 2008-03-05
US8336708P 2008-07-24 2008-07-24
US8638108P 2008-08-05 2008-08-05
US11207908P 2008-11-06 2008-11-06
US15066409P 2009-02-06 2009-02-06

Publications (1)

Publication Number Publication Date
EA201301171A1 true EA201301171A1 (ru) 2014-10-30

Family

ID=40959839

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201301171A EA201301171A1 (ru) 2008-03-05 2009-03-05 Композиции и способы ингибирования экспрессии генов eg5 и vegf
EA201071033A EA019531B1 (ru) 2008-03-05 2009-03-05 КОМПОЗИЦИИ И СПОСОБЫ ИНГИБИРОВАНИЯ ЭКСПРЕССИИ ГЕНОВ Eg5 И VEGF

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201071033A EA019531B1 (ru) 2008-03-05 2009-03-05 КОМПОЗИЦИИ И СПОСОБЫ ИНГИБИРОВАНИЯ ЭКСПРЕССИИ ГЕНОВ Eg5 И VEGF

Country Status (15)

Country Link
US (3) US20100087508A1 (ru)
EP (2) EP2265276A2 (ru)
JP (2) JP2011518117A (ru)
KR (1) KR101397407B1 (ru)
CN (2) CN102014932B (ru)
AU (1) AU2009221775B2 (ru)
BR (1) BRPI0909779A2 (ru)
CA (1) CA2716793A1 (ru)
EA (2) EA201301171A1 (ru)
HK (1) HK1220380A1 (ru)
IL (1) IL207956A0 (ru)
MX (1) MX2010009611A (ru)
NZ (1) NZ588280A (ru)
SG (1) SG188121A1 (ru)
WO (1) WO2009111658A2 (ru)

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