JPH0645639B2 - ペプチド誘導体 - Google Patents

ペプチド誘導体

Info

Publication number
JPH0645639B2
JPH0645639B2 JP62257047A JP25704787A JPH0645639B2 JP H0645639 B2 JPH0645639 B2 JP H0645639B2 JP 62257047 A JP62257047 A JP 62257047A JP 25704787 A JP25704787 A JP 25704787A JP H0645639 B2 JPH0645639 B2 JP H0645639B2
Authority
JP
Japan
Prior art keywords
group
peptide
compound
resin
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP62257047A
Other languages
English (en)
Japanese (ja)
Other versions
JPS63101399A (ja
Inventor
ライネル・アルベルト
ビルフリード・バウエル
フランソワ・カルディノー
モニカ・メルグレル
ジャノ・プレズ
ワルター・プリコスゾビッチ
Original Assignee
サンド・アクチエンゲゼルシャフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by サンド・アクチエンゲゼルシャフト filed Critical サンド・アクチエンゲゼルシャフト
Publication of JPS63101399A publication Critical patent/JPS63101399A/ja
Publication of JPH0645639B2 publication Critical patent/JPH0645639B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP62257047A 1986-10-13 1987-10-12 ペプチド誘導体 Expired - Lifetime JPH0645639B2 (ja)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
DE3634826.0 1986-10-13
DE3634825 1986-10-13
DE3634797 1986-10-13
DE3634825.2 1986-10-13
DE3634797.3 1986-10-13
DE3634826 1986-10-13
DE3712626.1 1987-04-14
DE3712626 1987-04-14
CH3634797.3 1987-08-17
CH3712626.1 1987-08-17
CH3153/87-6 1987-08-17
CH315387 1987-08-17
CH3634826.0 1987-08-17
CH3634825.2 1987-08-17

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2147161A Division JP2744910B2 (ja) 1986-10-13 1990-06-04 ペプチド誘導体類

Publications (2)

Publication Number Publication Date
JPS63101399A JPS63101399A (ja) 1988-05-06
JPH0645639B2 true JPH0645639B2 (ja) 1994-06-15

Family

ID=27509117

Family Applications (2)

Application Number Title Priority Date Filing Date
JP62257047A Expired - Lifetime JPH0645639B2 (ja) 1986-10-13 1987-10-12 ペプチド誘導体
JP2147161A Expired - Lifetime JP2744910B2 (ja) 1986-10-13 1990-06-04 ペプチド誘導体類

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2147161A Expired - Lifetime JP2744910B2 (ja) 1986-10-13 1990-06-04 ペプチド誘導体類

Country Status (23)

Country Link
US (1) US5656721A (https=)
JP (2) JPH0645639B2 (https=)
KR (1) KR960016861B1 (https=)
AU (2) AU617986B2 (https=)
BE (1) BE1003752A4 (https=)
CA (1) CA1340985C (https=)
CH (2) CH682632A5 (https=)
DE (1) DE3790635T1 (https=)
DK (1) DK174337B1 (https=)
ES (1) ES2007418A6 (https=)
FI (1) FI874495A7 (https=)
FR (1) FR2609991A1 (https=)
GB (2) GB2199829B (https=)
GR (1) GR871567B (https=)
HU (3) HU206890B (https=)
IE (1) IE912442A1 (https=)
LU (1) LU87014A1 (https=)
NL (1) NL194729C (https=)
NZ (1) NZ222133A (https=)
PL (1) PL157156B1 (https=)
PT (1) PT85904B (https=)
SE (2) SE8703938L (https=)
WO (1) WO1988002756A2 (https=)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL194729C (nl) * 1986-10-13 2003-01-07 Novartis Ag Werkwijze voor de bereiding van peptidealcoholen via vaste fase.
DE3845000C2 (de) * 1987-07-10 1998-11-19 Novartis Ag Anwendung von Octreotid zur Behandlung von Brustkrebs
JPH03502328A (ja) * 1988-02-01 1991-05-30 ジ・アップジョン・カンパニー 極性末端基類を有するレニン抑制ペプチド類
DK163689A (da) * 1988-04-08 1989-10-30 Sandoz Ag Peptidderivater
DE3910667A1 (de) * 1988-04-11 1989-10-19 Sandoz Ag Peptidderivate
GB8813339D0 (en) * 1988-06-06 1988-07-13 Sandoz Ltd Improvements in/relating to organic compounds
BE1003762A3 (fr) * 1988-11-11 1992-06-09 Sandoz Sa Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives.
US5776894A (en) * 1988-12-05 1998-07-07 Novartis Ag Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors
US5753627A (en) * 1988-12-05 1998-05-19 Novartis Ag Use of certain complexed somatostatin peptides for the invivo imaging of somatostatin receptor-positive tumors and metastasis
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
IT1229514B (it) * 1989-01-30 1991-09-03 Farmhispania S A A Montme Glicoconiugati anfifilici sintetici per impiego neurologico.
DK111489D0 (da) * 1989-03-08 1989-03-08 Novo Nordisk As Peptider
DE4206858A1 (de) * 1992-03-05 1993-09-09 Behringwerke Ag Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
IT1260156B (it) * 1992-08-03 1996-03-28 Fidia Spa Derivati dell'acido neuraminico
TW263437B (https=) * 1992-09-24 1995-11-21 Takeda Pharm Industry Co Ltd
US5710244A (en) * 1992-12-31 1998-01-20 Labroo; Virender M. Derivatized calcitonins
US5508387A (en) * 1993-08-04 1996-04-16 Glycomed Incorporated Selectin binding glycopeptides
EP0788509B1 (en) 1993-08-09 2003-05-28 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Therapeutic peptide derivatives
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
JP3896430B2 (ja) * 1996-07-15 2007-03-22 アークレイ株式会社 糖化アミノ化合物の製造方法
IL119029A0 (en) 1996-08-07 1996-11-14 Yeda Res & Dev Long-acting drugs and pharamaceutical compositions comprising them
US7026289B2 (en) 1997-05-13 2006-04-11 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Method and compositions for treating hyperlipidemia and other conditions
AU7655098A (en) 1997-05-13 1998-12-08 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Somatostatin and somatostatin agonists for decreasing body weight
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
EP1053001B1 (en) * 1998-02-13 2010-12-15 Amylin Pharmaceuticals, Inc. Novel mixed amylin activity compounds
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
US20050037490A1 (en) * 1999-10-29 2005-02-17 Lawrence Rosenberg Medium for preparing dedifferentiated cells
HU228811B1 (hu) * 2001-04-23 2013-05-28 Mallinckrodt Llc Technéciummal és réniummal radioaktívan jelölt, glikozilált oktreotidszármazékok
JP3996897B2 (ja) 2001-06-08 2007-10-24 ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス ソマトスタチン−ドーパミンキメラ類似体
EP1480998B1 (en) * 2002-02-27 2006-11-22 Ferring BV Intermediates and methods for making heptapeptide oxytocin analogues
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
CA2620202C (en) 2005-08-26 2016-10-04 The Board Of Trustees Of The Leland Stanford Junior University Therapy procedure for drug delivery for trigeminal pain
PT1787658E (pt) 2005-11-10 2012-06-22 Chemi Spa Formulações de libertação sustentada de análogos de somatostatina inibidores da hormona do crescimento
WO2008011168A2 (en) * 2006-07-21 2008-01-24 Amgen Inc. Glycosylated peptide antagonists of the bradykinin b1 receptor
EP2952522B1 (en) 2007-01-31 2019-10-30 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
AU2008232709C1 (en) 2007-03-28 2015-01-15 President And Fellows Of Harvard College Stitched polypeptides
EP2190857A1 (en) 2007-09-25 2010-06-02 Glycom A/S Glycoproteins and glycosylated cells and a method for the preparation of the same
JP5660898B2 (ja) * 2007-11-09 2015-01-28 ユニバーシティ オブ テネシー リサーチ ファウンデーション 経口投与用の抗炎症性キナ酸誘導体
JP5799397B2 (ja) 2008-06-12 2015-10-28 イプセン・バイオイノベーション・リミテッドＩｐｓｅｎ Ｂｉｏｉｎｎｏｖａｔｉｏｎ Ｌｉｍｉｔｅｄ 癌の抑制
CA2727082C (en) 2008-06-12 2019-02-26 Syntaxin Limited Fusion proteins for use in suppression of acromegaly
US8377891B2 (en) 2008-11-07 2013-02-19 Usv, Ltd. Process for synthesis of cyclic octapeptide
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
KR20170058446A (ko) 2010-08-13 2017-05-26 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
JP6211418B2 (ja) 2011-09-04 2017-10-11 株式会社糖鎖工学研究所 糖鎖付加ポリペプチドおよび当該ポリペプチドを含む医薬組成物
IN2014CN02399A (https=) 2011-09-04 2015-06-19 Glytech Inc
AR088392A1 (es) 2011-10-18 2014-05-28 Aileron Therapeutics Inc Macrociclos peptidomimeticos
CA2862038C (en) 2012-02-15 2021-05-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
BR112015009470A2 (pt) 2012-11-01 2019-12-17 Aileron Therapeutics Inc aminoácidos dissubstituídos e seus métodos de preparação e uso
EP3007704B1 (en) 2013-06-13 2021-01-06 Antisense Therapeutics Ltd Combination therapy for acromegaly
WO2016049359A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
SG11201705591PA (en) 2015-01-07 2017-08-30 Trigemina Inc Magnesium-containing oxytocin formulations and methods of use
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
HUE070412T2 (hu) 2016-04-12 2025-06-28 Tonix Pharma Ltd Magnézium tartalmú oxitocin készítmények és alkamazási eljárásaik
WO2019104225A1 (en) 2017-11-22 2019-05-31 Dauntless 2, Inc. Therapeutic compound formulations
WO2019104214A1 (en) 2017-11-22 2019-05-31 Dauntless 2, Inc. Membrane emulsification device for microsphere creation
WO2020005842A1 (en) 2018-06-25 2020-01-02 Dauntless 2, Inc. Membrane emulsification device with impeller for microsphere creation
EP3956343A1 (en) 2019-04-16 2022-02-23 Bachem Holding AG Manufacture of disulfide bonded peptides
WO2021212010A2 (en) 2020-04-17 2021-10-21 The Trustees Of Indiana University Small molecule antiviral drug treatment for human papillomavirus infections
US20230399373A1 (en) * 2020-10-22 2023-12-14 The Trustees Of Indiana University Molecular designs of glucose-responsive and glucose-cleavable insulin analogues
EP4727553A2 (en) 2023-06-13 2026-04-22 The Trustees of Indiana University Small molecule antiviral drug treatment for human papillomavirus infections
WO2025229200A1 (en) 2024-05-03 2025-11-06 Bachem Holding Ag Manufacture of disulfide bonded peptides

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4254023A (en) * 1979-10-16 1981-03-03 Pennwalt Corporation Synthesis of peptide alcohols by the solid phase method
US4280953A (en) * 1979-11-08 1981-07-28 The Salk Institute For Biological Studies Glycosylated analogs of somatostatin
EP0029579B1 (en) * 1979-11-27 1983-02-16 Sandoz Ag Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use
FR2522967B1 (fr) * 1982-03-15 1986-03-07 Anvar Conjugues d'haptenes et de muramyl-peptides, doues d'activite immunogene et compositions les contenant
US4444683A (en) * 1982-11-17 1984-04-24 University Of Utah Glycosylated insulin derivatives
US4483792A (en) * 1982-11-17 1984-11-20 Kim Wan S Glycosylated insulin derivatives
FR2546163B1 (fr) * 1983-05-16 1987-10-09 Centre Nat Rech Scient Nouveaux derives acyles hydrosolubles de peptides ou d'amino-acides, leur preparation et leur application
FR2548673B1 (fr) * 1983-07-05 1985-10-04 Essilor Int Polymeres supports de produits actifs relargables et leur procede de preparation
LU85269A1 (fr) * 1984-03-26 1985-10-14 Techland S A Composes nouveaux de somatostatine,procede pour leur synthese,preparation a usage veterinaire contenant lesdits composes et procede pour le traitement d'animaux
US4564998A (en) * 1984-10-19 1986-01-21 Westinghouse Electric Corp. Coil winding methods and apparatus
DE3439610A1 (de) * 1984-10-30 1986-04-30 Boehringer Mannheim Gmbh, 6800 Mannheim Immunogene, verfahren zu deren herstellung sowie damit gewonnene antikoerper gegen glykosiliertes haemoglobin
FI860708A7 (fi) * 1985-02-20 1986-08-21 Ciba Geigy Ag Acylerade hexosderivat och foerfarande foer deras framstaellning.
JPS61264260A (ja) * 1985-05-17 1986-11-22 Rikagaku Kenkyusho アルデヒド化多孔性高分子材料によるタンパク質の除去方法
AU597909B2 (en) * 1985-10-09 1990-06-14 Procter & Gamble Company, The Granular detergent compositions having improved solubility
SE8506094D0 (sv) * 1985-12-20 1985-12-20 Astra Laekemedel Ab New antibacterial agents and intermediates therefor
JPS63165410A (ja) * 1986-09-11 1988-07-08 Tokyo Organ Chem Ind Ltd アルデヒド基を有する架橋共重合体の製造方法
JPS63165411A (ja) * 1986-09-11 1988-07-08 Tokyo Organ Chem Ind Ltd アルデヒド基を有する架橋共重合体の製法
NL194729C (nl) * 1986-10-13 2003-01-07 Novartis Ag Werkwijze voor de bereiding van peptidealcoholen via vaste fase.
US4859736A (en) * 1987-03-30 1989-08-22 Ciba-Geigy Corporation Synthetic polystyrene resin and its use in solid phase peptide synthesis
CH679045A5 (https=) * 1987-06-29 1991-12-13 Sandoz Ag

Also Published As

Publication number Publication date
GB2199829B (en) 1991-04-17
NL194729C (nl) 2003-01-07
IE912442A1 (en) 1992-02-12
BE1003752A4 (fr) 1992-06-09
SE518630C2 (sv) 2002-11-05
FI874495A0 (fi) 1987-10-12
DK532787D0 (da) 1987-10-12
HU206890B (en) 1993-01-28
CA1340985C (en) 2000-05-09
NL8702345A (nl) 1988-05-02
SE9301172D0 (sv) 1993-04-07
NL194729B (nl) 2002-09-02
PT85904B (pt) 1990-08-31
FR2609991A1 (fr) 1988-07-29
CH682632A5 (de) 1993-10-29
DK174337B1 (da) 2002-12-16
FI874495L (fi) 1988-04-14
SE8703938L (sv) 1988-04-14
FR2609991B1 (https=) 1995-03-10
KR960016861B1 (ko) 1996-12-23
AU8015091A (en) 1991-10-31
PT85904A (en) 1987-11-01
CH680512A5 (https=) 1992-09-15
PL157156B1 (pl) 1992-05-29
JPS63101399A (ja) 1988-05-06
GB2199831B (en) 1991-04-17
IE912442L (en) 1988-04-13
WO1988002756A3 (en) 1988-07-14
SE9301172L (https=) 1900-01-01
US5656721A (en) 1997-08-12
AU634664B2 (en) 1993-02-25
GR871567B (en) 1988-02-16
ES2007418A6 (es) 1989-06-16
HUT46710A (en) 1988-11-28
GB8800537D0 (en) 1988-02-10
DK532787A (da) 1988-04-14
PL268173A1 (en) 1988-09-01
FI874495A7 (fi) 1988-04-14
HU906341D0 (en) 1991-04-29
DE3790635T1 (https=) 1988-10-06
NZ222133A (en) 1993-02-25
SE8703938D0 (sv) 1987-10-12
GB8723737D0 (en) 1987-11-11
JPH0314599A (ja) 1991-01-23
JP2744910B2 (ja) 1998-04-28
GB2199829A (en) 1988-07-20
HU906340D0 (en) 1991-04-29
AU7956487A (en) 1988-04-14
GB2199831A (en) 1988-07-20
WO1988002756A2 (en) 1988-04-21
LU87014A1 (fr) 1988-05-03
AU617986B2 (en) 1991-12-12
KR880005153A (ko) 1988-06-28

Similar Documents

Publication Publication Date Title
JPH0645639B2 (ja) ペプチド誘導体
DE69615838T2 (de) Cyclische wirkstoff-vorläufer verbindungen von peptiden und peptid-nukleicsäuren mit verbesserter metabolischer stabilität und zellmembran permeabilität
US4703034A (en) Novel cyclic tetrapeptide
EP0485458B1 (en) Thioacylating reagents and intermediates, thiopeptides, and methods for preparing and using same
US4405607A (en) Novel pentapeptides, processes for their production, pharmaceutical compositions comprising said pentapeptides and their use
FR2522655A1 (fr) Analogues de la somatostatine possedant une liaison du type hydrazide et medicaments en contenant
US4837305A (en) Derivatives of β-adrenergic antagonists
US7365055B2 (en) Derivatives of morphine-6-glucuronide, pharmaceutical compositions containing them, their preparation method and their uses
WO1995024421A1 (en) Peptide derivative
FR2619566A1 (fr) Procede de preparation d'un peptide-alcool
EP0117089B1 (en) Beta-adrenergic antagonist compounds and derivatives of beta-adrenergic antagonists
AU651557C (en) Thioacylating reagents and intermediates, thiopeptides, and methods for preparing and using same
JP3554399B2 (ja) ペプチド誘導体
EP0001335B1 (en) A peptide, processes for its preparation and compositions containing the same
GB2233652A (en) Synthesis of peptide alcohols
FR2629824A1 (fr) Nouveaux peptides de la somatostatine, leur preparation et leur utilisation comme medicaments
CH677233A5 (en) New sugar derivs. of biologically active peptide(s)
GB2227488A (en) Modified somatostatin
JPH06107681A (ja) ペプチド誘導体
JPS6024120B2 (ja) 新規なソマスタチン同族体
JPH10330399A (ja) 神経伝達ポリペプチド