DE60231801D1 - Tc und re markierte radioaktive glycosylierte octreotid-derivate - Google Patents
Tc und re markierte radioaktive glycosylierte octreotid-derivateInfo
- Publication number
- DE60231801D1 DE60231801D1 DE60231801T DE60231801T DE60231801D1 DE 60231801 D1 DE60231801 D1 DE 60231801D1 DE 60231801 T DE60231801 T DE 60231801T DE 60231801 T DE60231801 T DE 60231801T DE 60231801 D1 DE60231801 D1 DE 60231801D1
- Authority
- DE
- Germany
- Prior art keywords
- ligands
- sst
- improved
- chelator
- radioisotope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical class C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 title 1
- 230000002285 radioactive effect Effects 0.000 title 1
- 239000003446 ligand Substances 0.000 abstract 6
- 239000002738 chelating agent Substances 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 125000000837 carbohydrate group Chemical group 0.000 abstract 1
- 238000010668 complexation reaction Methods 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 238000009206 nuclear medicine Methods 0.000 abstract 1
- 239000000816 peptidomimetic Chemical group 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01201466 | 2001-04-23 | ||
PCT/US2002/012565 WO2002085418A2 (en) | 2001-04-23 | 2002-04-23 | Tc and re labeler radioactive glycosylated octreotide derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60231801D1 true DE60231801D1 (de) | 2009-05-14 |
Family
ID=8180193
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60231801T Expired - Lifetime DE60231801D1 (de) | 2001-04-23 | 2002-04-23 | Tc und re markierte radioaktive glycosylierte octreotid-derivate |
Country Status (11)
Country | Link |
---|---|
US (2) | US7589061B2 (de) |
EP (1) | EP1381396B1 (de) |
JP (3) | JP5398945B2 (de) |
AT (1) | ATE427125T1 (de) |
AU (1) | AU2002254691B8 (de) |
BR (1) | BR0209074A (de) |
CA (1) | CA2443273C (de) |
CZ (1) | CZ20032872A3 (de) |
DE (1) | DE60231801D1 (de) |
HU (1) | HU228811B1 (de) |
WO (1) | WO2002085418A2 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7956165B2 (en) | 2003-07-24 | 2011-06-07 | Affisink Biotechnology Ltd. | Compositions and methods for purifying and crystallizing molecules of interest |
IL157086A0 (en) * | 2003-07-24 | 2004-02-08 | Guy Patchornik | Multivalent ligand complexes |
CN102253174A (zh) * | 2011-04-27 | 2011-11-23 | 江苏省原子医学研究所 | 一种受体显像剂标记的化学动力学研究的方法 |
CN106146649B (zh) * | 2011-09-04 | 2020-09-01 | 株式会社糖锁工学研究所 | 附加糖链的多肽和含有该多肽的医药组合物 |
WO2013032011A1 (ja) | 2011-09-04 | 2013-03-07 | 株式会社糖鎖工学研究所 | 糖鎖付加ポリペプチドおよび当該ポリペプチドを含む医薬組成物 |
US10919938B2 (en) * | 2014-06-06 | 2021-02-16 | Technische Universität München | Modified cyclopentapeptides and uses thereof |
PL3568205T3 (pl) | 2017-01-12 | 2024-03-18 | Radiomedix Inc. | Leczenie komórek nowotworowych z nadekspresją receptorów somatostatyny z użyciem pochodnych okreotydu chelatowanych z radioizotopami |
AU2022238571A1 (en) | 2021-03-18 | 2023-09-14 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU906340D0 (en) * | 1986-10-13 | 1991-04-29 | Sandoz Ag | Synthesis in solid phase for producing peptonic alcohols |
JP2544159B2 (ja) | 1987-10-07 | 1996-10-16 | ハウス食品株式会社 | 連続蒸煮装置 |
MY106120A (en) * | 1988-12-05 | 1995-03-31 | Novartis Ag | Peptide derivatives. |
US5590656A (en) * | 1992-09-15 | 1997-01-07 | The Ohio State University Research Foundation | Application of peptide/cell receptor kinetics utilizing radiolabeled somatostatin congeners in the in situ, in vivo detection and differentiation of neoplastic tissue |
US5968477A (en) | 1994-01-24 | 1999-10-19 | Neorx Corporation | Radiolabeled annexin conjugates with hexose and a chelator |
EP1486509A3 (de) | 1994-12-07 | 2005-03-23 | Neorx Corporation | Radioaktivmarkierte Annexin-Galaktose Konjugate |
EP0799050B1 (de) | 1994-12-07 | 2004-08-11 | Neorx Corporation | Radioaktivmarkierte annexin-galaktose-cluster konjugate |
US5753206A (en) * | 1995-06-07 | 1998-05-19 | Immunomedics, Inc. | Radiometal-binding analogues of luteinizing hormone releasing hormone |
EP0888381A4 (de) | 1995-12-21 | 2001-10-17 | Scripps Research Inst | Zielgerichtete therapeutische und diagnostische mittel, methoden zu deren herstellung und verwendung |
DE19654764A1 (de) | 1996-12-30 | 1998-07-02 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung eines Peptidgemisches |
IL138093A0 (en) | 1998-03-31 | 2001-10-31 | Du Pont Pharm Co | Pharmaceuticals for the imaging of angiogenic disorders |
DE19910419A1 (de) | 1999-03-10 | 2000-09-21 | Aventis Pharma Gmbh | Zielzellspezifische, multivalente Proteine (MVP) |
-
2002
- 2002-04-23 BR BR0209074-0A patent/BR0209074A/pt not_active IP Right Cessation
- 2002-04-23 CA CA2443273A patent/CA2443273C/en not_active Expired - Fee Related
- 2002-04-23 HU HU0303987A patent/HU228811B1/hu not_active IP Right Cessation
- 2002-04-23 JP JP2002582991A patent/JP5398945B2/ja not_active Expired - Fee Related
- 2002-04-23 CZ CZ20032872A patent/CZ20032872A3/cs unknown
- 2002-04-23 DE DE60231801T patent/DE60231801D1/de not_active Expired - Lifetime
- 2002-04-23 US US10/475,696 patent/US7589061B2/en not_active Expired - Fee Related
- 2002-04-23 WO PCT/US2002/012565 patent/WO2002085418A2/en active IP Right Grant
- 2002-04-23 AU AU2002254691A patent/AU2002254691B8/en not_active Ceased
- 2002-04-23 AT AT02723932T patent/ATE427125T1/de not_active IP Right Cessation
- 2002-04-23 EP EP02723932A patent/EP1381396B1/de not_active Expired - Lifetime
-
2009
- 2009-09-10 US US12/556,698 patent/US8575100B2/en not_active Expired - Fee Related
- 2009-09-30 JP JP2009228998A patent/JP2010001313A/ja not_active Withdrawn
-
2013
- 2013-02-08 JP JP2013023001A patent/JP2013100349A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2002085418A3 (en) | 2003-09-12 |
JP2005514321A (ja) | 2005-05-19 |
EP1381396B1 (de) | 2009-04-01 |
US8575100B2 (en) | 2013-11-05 |
JP2010001313A (ja) | 2010-01-07 |
BR0209074A (pt) | 2004-08-10 |
ATE427125T1 (de) | 2009-04-15 |
CA2443273C (en) | 2011-09-27 |
AU2002254691B8 (en) | 2008-02-14 |
EP1381396A2 (de) | 2004-01-21 |
US7589061B2 (en) | 2009-09-15 |
HU228811B1 (hu) | 2013-05-28 |
US20060165593A1 (en) | 2006-07-27 |
JP5398945B2 (ja) | 2014-01-29 |
WO2002085418A2 (en) | 2002-10-31 |
CA2443273A1 (en) | 2002-10-31 |
JP2013100349A (ja) | 2013-05-23 |
CZ20032872A3 (cs) | 2005-01-12 |
HUP0303987A3 (en) | 2010-03-29 |
US20090324497A1 (en) | 2009-12-31 |
AU2002254691B2 (en) | 2007-06-14 |
HUP0303987A2 (hu) | 2004-03-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Bullok et al. | Characterization of novel histidine-tagged Tat-peptide complexes dual-labeled with 99mTc-tricarbonyl and fluorescein for scintigraphy and fluorescence microscopy | |
Decristoforo et al. | Preparation, 99mTc-labeling, and in vitro characterization of HYNIC and N3S modified RC-160 and [Tyr3] octreotide | |
La Bella et al. | In vitro and in vivo evaluation of a 99mTc (I)-labeled bombesin analogue for imaging of gastrin releasing peptide receptor-positive tumors | |
EP0994724A4 (de) | Verfahren und zusammensetzungen zur behinderung der vervielfältigung von hiv-1 | |
Tran et al. | In vivo evaluation of cysteine-based chelators for attachment of 99mTc to tumor-targeting Affibody molecules | |
SI1105409T1 (sl) | Zascita endogenih peptidov pred peptidazno ucinkovitostjo s konjugacijo na krvne komponente | |
SI1180121T1 (en) | Long lasting insulinotropic peptides | |
AU8269898A (en) | Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor | |
WO2004050016A3 (en) | Delivery of pharmaceutical agents via the human insulin receptor | |
MY106120A (en) | Peptide derivatives. | |
JP2011507497A5 (de) | ||
IL156843A0 (en) | Combined use of factor vii polypeptides and factor viii polypeptides | |
WO2003077727A3 (en) | Technetium-dipyridine complexes, and methods of use thereof | |
DE60231801D1 (de) | Tc und re markierte radioaktive glycosylierte octreotid-derivate | |
ATE178053T1 (de) | N2s2-chelatoren des hydrazino-typs | |
Maschauer et al. | Synthesis of a 68Ga-Labeled peptoid− peptide hybrid for imaging of neurotensin receptor expression in Vivo | |
N Eberle et al. | Synthetic peptide drugs for targeting skin cancer: malignant melanoma and melanotic lesions | |
CA2219492A1 (en) | Peptide radiopharmaceutical applications | |
Bass et al. | Identification of the soluble in vivo metabolites of indium-111-diethylenetriaminepentaacetic acid-D-Phe1-octreotide | |
Chen et al. | α–melanocyte‐stimulating hormone peptide analogs labeled with technetium‐99m and indium‐111 for malignant melanoma targeting | |
Rizvi et al. | Peptide-Drug Conjugates: Design, Chemistry, and Drug Delivery System as a Novel Cancer Theranostic | |
Lee et al. | Drug targeting to the brain using avidin-biotin technology in the mouse (blood-brain barrier, monoclonal antibody, transferrin receptor, Alzheimer's disease) | |
AU2002254691A1 (en) | Tc and Re labeler radioactive glycosylated octreotide derivatives | |
Critical Care Society of South Africa Working Group | Severe sepsis and the role of novel therapeutic agents. Position statement of the Critical Care Society of South Africa on severe sepsis and the role of novel therapeutic agents such as drotrecogin alfa (activated) | |
Nicodemus et al. | In vivo Leukocytes Labeling Using a Platelet Factor 4–Derived Heparin Binding Peptide Technetium Complex |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |