JP7712352B2 - ホスホンアミドヌクレオチド類似体のプロドラッグ及びその薬学的使用 - Google Patents

ホスホンアミドヌクレオチド類似体のプロドラッグ及びその薬学的使用

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Publication number
JP7712352B2
JP7712352B2 JP2023507948A JP2023507948A JP7712352B2 JP 7712352 B2 JP7712352 B2 JP 7712352B2 JP 2023507948 A JP2023507948 A JP 2023507948A JP 2023507948 A JP2023507948 A JP 2023507948A JP 7712352 B2 JP7712352 B2 JP 7712352B2
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alkylene
pharma
acceptable salt
ceutically acceptable
cycloalkyl
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JP2023536663A5 (https=
JP2023536663A (ja
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ダニエル エイチ． ビュン，
ビョン－クウォン チョン，
マイケル オー． クラーク，
ペーテル ヤンサ，
デヴァン ナドゥサンビ，
ニール エイチ． スクワイアーズ，
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ギリアード サイエンシーズ， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/36—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2023507948A 2020-08-07 2021-08-05 ホスホンアミドヌクレオチド類似体のプロドラッグ及びその薬学的使用 Active JP7712352B2 (ja)

Priority Applications (1)

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JP2025066915A JP2025100739A (ja) 2020-08-07 2025-04-15 ホスホンアミドヌクレオチド類似体のプロドラッグ及びその薬学的使用

Applications Claiming Priority (3)

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US202063062899P 2020-08-07 2020-08-07
US63/062,899 2020-08-07
PCT/US2021/044615 WO2022031894A1 (en) 2020-08-07 2021-08-05 Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use

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JP2023536663A JP2023536663A (ja) 2023-08-28
JP2023536663A5 JP2023536663A5 (https=) 2025-05-01
JP7712352B2 true JP7712352B2 (ja) 2025-07-23

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JP2025066915A Pending JP2025100739A (ja) 2020-08-07 2025-04-15 ホスホンアミドヌクレオチド類似体のプロドラッグ及びその薬学的使用

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US (2) US12110305B2 (https=)
EP (2) EP4192474B1 (https=)
JP (2) JP7712352B2 (https=)
KR (1) KR20230048118A (https=)
CN (1) CN116194144A (https=)
AU (1) AU2021320236B2 (https=)
BR (1) BR112023002164A2 (https=)
CA (1) CA3186054A1 (https=)
CL (1) CL2023000383A1 (https=)
CO (1) CO2023001308A2 (https=)
CR (1) CR20230071A (https=)
DK (1) DK4192474T3 (https=)
DO (1) DOP2023000026A (https=)
ES (1) ES3054072T3 (https=)
FI (1) FI4192474T3 (https=)
HR (1) HRP20251374T1 (https=)
IL (1) IL299980A (https=)
LT (1) LT4192474T (https=)
MX (1) MX2023001507A (https=)
PE (1) PE20230779A1 (https=)
PL (1) PL4192474T3 (https=)
PT (1) PT4192474T (https=)
SI (1) SI4192474T1 (https=)
TW (2) TW202444384A (https=)
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EP4192474B1 (en) 2020-08-07 2025-09-10 Gilead Sciences, Inc. Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use
CN113528488B (zh) * 2021-08-17 2022-09-27 南昌大学 一种树脂搅拌吸附制备高质量玻璃酸酶粗品的方法
US20240226130A1 (en) 2022-10-04 2024-07-11 Gilead Sciences, Inc. 4'-thionucleoside analogues and their pharmaceutical use
CN118652276B (zh) * 2024-08-19 2024-10-15 成都工业学院 一种用于治疗癌症疾病的化合物的制备工艺
CN119080839B (zh) * 2024-11-07 2025-03-11 上海柯君医药科技有限公司 一种抗病毒药物及其用途

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