AU2021320236B2 - Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use - Google Patents

Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use Download PDF

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Publication number
AU2021320236B2
AU2021320236B2 AU2021320236A AU2021320236A AU2021320236B2 AU 2021320236 B2 AU2021320236 B2 AU 2021320236B2 AU 2021320236 A AU2021320236 A AU 2021320236A AU 2021320236 A AU2021320236 A AU 2021320236A AU 2021320236 B2 AU2021320236 B2 AU 2021320236B2
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inhibitors
compound
hiv
4alkylene
pharmaceutically acceptable
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AU2021320236A1 (en
Inventor
Daniel H. BYUN
Byoung-Kwon Chun
Michael O. Clarke
Petr Jansa
Devan Naduthambi
Neil H. Squires
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Gilead Sciences Inc
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Gilead Sciences Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/36—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2021320236A 2020-08-07 2021-08-05 Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use Active AU2021320236B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063062899P 2020-08-07 2020-08-07
US63/062,899 2020-08-07
PCT/US2021/044615 WO2022031894A1 (en) 2020-08-07 2021-08-05 Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use

Publications (2)

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AU2021320236A1 AU2021320236A1 (en) 2023-04-13
AU2021320236B2 true AU2021320236B2 (en) 2024-10-03

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US (2) US12110305B2 (https=)
EP (2) EP4192474B1 (https=)
JP (2) JP7712352B2 (https=)
KR (1) KR20230048118A (https=)
CN (1) CN116194144A (https=)
AU (1) AU2021320236B2 (https=)
BR (1) BR112023002164A2 (https=)
CA (1) CA3186054A1 (https=)
CL (1) CL2023000383A1 (https=)
CO (1) CO2023001308A2 (https=)
CR (1) CR20230071A (https=)
DK (1) DK4192474T3 (https=)
DO (1) DOP2023000026A (https=)
ES (1) ES3054072T3 (https=)
FI (1) FI4192474T3 (https=)
HR (1) HRP20251374T1 (https=)
IL (1) IL299980A (https=)
LT (1) LT4192474T (https=)
MX (1) MX2023001507A (https=)
PE (1) PE20230779A1 (https=)
PL (1) PL4192474T3 (https=)
PT (1) PT4192474T (https=)
SI (1) SI4192474T1 (https=)
TW (2) TW202444384A (https=)
WO (1) WO2022031894A1 (https=)

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EP4192474B1 (en) 2020-08-07 2025-09-10 Gilead Sciences, Inc. Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use
CN113528488B (zh) * 2021-08-17 2022-09-27 南昌大学 一种树脂搅拌吸附制备高质量玻璃酸酶粗品的方法
US20240226130A1 (en) 2022-10-04 2024-07-11 Gilead Sciences, Inc. 4'-thionucleoside analogues and their pharmaceutical use
CN118652276B (zh) * 2024-08-19 2024-10-15 成都工业学院 一种用于治疗癌症疾病的化合物的制备工艺
CN119080839B (zh) * 2024-11-07 2025-03-11 上海柯君医药科技有限公司 一种抗病毒药物及其用途

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