JP7282521B2 - Car t細胞療法のための方法および組成物 - Google Patents
Car t細胞療法のための方法および組成物 Download PDFInfo
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- JP7282521B2 JP7282521B2 JP2018553142A JP2018553142A JP7282521B2 JP 7282521 B2 JP7282521 B2 JP 7282521B2 JP 2018553142 A JP2018553142 A JP 2018553142A JP 2018553142 A JP2018553142 A JP 2018553142A JP 7282521 B2 JP7282521 B2 JP 7282521B2
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023081216A JP7631410B2 (ja) | 2016-04-08 | 2023-05-17 | Car t細胞療法のための方法および組成物 |
| JP2025017467A JP2025084765A (ja) | 2016-04-08 | 2025-02-05 | Car t細胞療法のための方法および組成物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662320183P | 2016-04-08 | 2016-04-08 | |
| US62/320,183 | 2016-04-08 | ||
| US201662323971P | 2016-04-18 | 2016-04-18 | |
| US62/323,971 | 2016-04-18 | ||
| PCT/US2017/026618 WO2017177149A2 (en) | 2016-04-08 | 2017-04-07 | Methods and compositions for car t cell therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023081216A Division JP7631410B2 (ja) | 2016-04-08 | 2023-05-17 | Car t細胞療法のための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019513764A JP2019513764A (ja) | 2019-05-30 |
| JP2019513764A5 JP2019513764A5 (enExample) | 2020-05-21 |
| JP7282521B2 true JP7282521B2 (ja) | 2023-05-29 |
Family
ID=60001557
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018553142A Active JP7282521B2 (ja) | 2016-04-08 | 2017-04-07 | Car t細胞療法のための方法および組成物 |
| JP2023081216A Active JP7631410B2 (ja) | 2016-04-08 | 2023-05-17 | Car t細胞療法のための方法および組成物 |
| JP2025017467A Withdrawn JP2025084765A (ja) | 2016-04-08 | 2025-02-05 | Car t細胞療法のための方法および組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023081216A Active JP7631410B2 (ja) | 2016-04-08 | 2023-05-17 | Car t細胞療法のための方法および組成物 |
| JP2025017467A Withdrawn JP2025084765A (ja) | 2016-04-08 | 2025-02-05 | Car t細胞療法のための方法および組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US12144850B2 (enExample) |
| EP (1) | EP3439675A4 (enExample) |
| JP (3) | JP7282521B2 (enExample) |
| CN (1) | CN109195611A (enExample) |
| CA (1) | CA3019835A1 (enExample) |
| WO (1) | WO2017177149A2 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4282419A1 (en) | 2012-12-20 | 2023-11-29 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| CA3013479A1 (en) | 2016-02-16 | 2017-08-24 | Carl NOVINA | Immunotherapy compositions and methods |
| US11925696B2 (en) | 2016-03-16 | 2024-03-12 | Purdue Research Foundation | Carbonic anhydrase IX targeting agents and methods |
| JP2019515880A (ja) * | 2016-03-16 | 2019-06-13 | エンドサイト・インコーポレイテッドEndocyte, Inc. | 炭酸無水酵素ix阻害剤抱合体およびその使用 |
| JP7282521B2 (ja) | 2016-04-08 | 2023-05-29 | パーデュー・リサーチ・ファウンデイション | Car t細胞療法のための方法および組成物 |
| CN110612119B (zh) | 2017-02-07 | 2024-10-29 | 西雅图儿童医院(Dba西雅图儿童研究所) | 磷脂醚(ple)car t细胞肿瘤靶向(ctct)剂 |
| WO2018160622A1 (en) * | 2017-02-28 | 2018-09-07 | Endocyte, Inc. | Compositions and methods for car t cell therapy |
| EP3730612A4 (en) * | 2017-12-24 | 2021-09-01 | Noile-Immune Biotech, Inc. | IMMUNOCOMPETENT CELL THAT EXPRESSES A CELL SURFACE MOLECULE THAT SPECIFICALLY RECOGNIZES HUMAN MESOTHELIN, IL-7 AND CCL19 |
| CN120154716A (zh) * | 2018-01-22 | 2025-06-17 | 恩多塞特公司 | Car t细胞的使用方法 |
| CN111936518A (zh) | 2018-02-06 | 2020-11-13 | 西雅图儿童医院(Dba西雅图儿童研究所) | 对fl-ple标记的肿瘤表现出最佳的t细胞功能的荧光素特异性car |
| TW202000229A (zh) * | 2018-02-23 | 2020-01-01 | 美商安德賽特公司 | Car t細胞療法之順序方法 |
| CA3096458A1 (en) | 2018-04-12 | 2019-10-17 | Umoja Biopharma, Inc. | Viral vectors and packaging cell lines |
| WO2020006312A1 (en) | 2018-06-28 | 2020-01-02 | Dana-Farber Cancer Institute, Inc. | Targeting of multiple antigens with multiplex car t cells in solid and liquid malignancies |
| JP2021531312A (ja) * | 2018-07-26 | 2021-11-18 | パーデュー・リサーチ・ファウンデーションPurdue Research Foundation | 抗インフルエンザ化学療法および免疫療法のための低分子リガンド標的指向性薬物結合体 |
| KR20210042125A (ko) * | 2018-08-07 | 2021-04-16 | 퍼듀 리서치 파운데이션 | Car t 세포의 회생 |
| CN109134467B (zh) * | 2018-08-09 | 2022-01-21 | 中国医学科学院北京协和医院 | 用于控制嵌合抗原受体t细胞激活/抑制的连接臂及其应用 |
| EP3620464A1 (en) * | 2018-09-10 | 2020-03-11 | Miltenyi Biotec GmbH | Car cell having crosslinked disulfide bridge on antigen recognizing moiety |
| US20220249565A1 (en) * | 2019-06-27 | 2022-08-11 | Eutilex Co., Ltd. | Chimeric antigen receptor with 4-ibb costimulatory domain |
| JP2022546101A (ja) * | 2019-09-01 | 2022-11-02 | エクスマ バイオテック コーポレイション | リンパ球の改変および送達のための方法および組成物 |
| CN115087460A (zh) * | 2020-02-17 | 2022-09-20 | 美天施生物科技有限两合公司 | 用于提供具有针对肿瘤微环境细胞的嵌合抗原受体(car)的个性化细胞的方法 |
| US20230295277A1 (en) * | 2020-07-13 | 2023-09-21 | University Of Southern California | Universal car-nk cell targeting various epitopes of hiv-1 gp160 |
| MX2024007261A (es) | 2021-12-17 | 2024-08-06 | Umoja Biopharma Inc | Celula linfoide innata citotoxica y usos de la misma. |
| EP4525899A1 (en) | 2022-05-17 | 2025-03-26 | Umoja Biopharma, Inc. | Manufacturing viral particles |
| IL317466A (en) | 2022-06-09 | 2025-02-01 | Umoja Biopharma Inc | Compounds and methods for NK cell differentiation |
| IL317532A (en) | 2022-06-10 | 2025-02-01 | Umoja Biopharma Inc | Engineered stem cells and their uses |
| JP2025526380A (ja) | 2022-07-27 | 2025-08-13 | ウモジャ バイオファーマ インコーポレイテッド | 懸濁培養における幹細胞の分化 |
| WO2024098038A2 (en) | 2022-11-04 | 2024-05-10 | Umoja Biopharma, Inc. | Polynucleotide construct and related viral vectors and methods |
| TW202434735A (zh) | 2022-11-04 | 2024-09-01 | 美商烏莫賈生物製藥股份有限公司 | 展示黏著分子融合的顆粒 |
| WO2025129084A1 (en) | 2023-12-13 | 2025-06-19 | Umoja Biopharma, Inc. | Engineered induced stem cell derived myeloid cells and methods of differentiating and using same |
| WO2025231174A1 (en) | 2024-04-30 | 2025-11-06 | Umoja Biopharma, Inc. | Manufacturing viral particles |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014504294A (ja) | 2010-12-14 | 2014-02-20 | ユニバーシティ オブ メリーランド,ボルチモア | 汎用の抗タグキメラ抗原受容体発現t細胞及びがんを治療する方法 |
| US20150320799A1 (en) | 2012-12-20 | 2015-11-12 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| WO2016025322A1 (en) | 2014-08-09 | 2016-02-18 | Purdue Research Foundation | Design and development of neurokinin-1 receptor-binding agent delivery conjugates |
Family Cites Families (395)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3650625T2 (de) | 1985-01-28 | 1997-10-02 | Xoma Corp | AraB-Promoter und Verfahren zur Herstellung von Polypeptiden einschliesslich Cecropinen mittels mikrobiologischer Verfahren |
| US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| IN165717B (enExample) | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US6004781A (en) | 1988-01-22 | 1999-12-21 | The General Hospital Corporation | Nucleic acid encoding Ig-CD4 fusion proteins |
| US5906936A (en) | 1988-05-04 | 1999-05-25 | Yeda Research And Development Co. Ltd. | Endowing lymphocytes with antibody specificity |
| IL86278A (en) | 1988-05-04 | 2003-06-24 | Yeda Res & Dev | Endowing cells with antibody specificity using chimeric t cell receptor |
| US6406697B1 (en) | 1989-02-23 | 2002-06-18 | Genentech, Inc. | Hybrid immunoglobulins |
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| US5216132A (en) | 1990-01-12 | 1993-06-01 | Protein Design Labs, Inc. | Soluble t-cell antigen receptor chimeric antigens |
| US20020004052A1 (en) | 1990-05-08 | 2002-01-10 | David Berd | Composition comprising a tumor cell extract and method of using the composition |
| US5914109A (en) | 1990-06-15 | 1999-06-22 | New York University | Heterohybridomas producing human monoclonal antibodies to HIV-1 |
| US6407221B1 (en) | 1990-12-14 | 2002-06-18 | Cell Genesys, Inc. | Chimeric chains for receptor-associated signal transduction pathways |
| US6319494B1 (en) | 1990-12-14 | 2001-11-20 | Cell Genesys, Inc. | Chimeric chains for receptor-associated signal transduction pathways |
| ATE145428T1 (de) | 1990-12-14 | 1996-12-15 | Cell Genesys Inc | Chimärische ketten zur transduktion von rezeptorverbundenen signalwegen |
| US20020111474A1 (en) | 1990-12-14 | 2002-08-15 | Capon Daniel J. | Chimeric chains for receptor-associated signal transduction pathways |
| US5851828A (en) | 1991-03-07 | 1998-12-22 | The General Hospital Corporation | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
| US6753162B1 (en) | 1991-03-07 | 2004-06-22 | The General Hospital Corporation | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
| US7049136B2 (en) | 1991-03-07 | 2006-05-23 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
| US5912170A (en) | 1991-03-07 | 1999-06-15 | The General Hospital Corporation | Redirection of cellular immunity by protein-tyrosine kinase chimeras |
| US5843728A (en) | 1991-03-07 | 1998-12-01 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
| NZ241855A (en) | 1991-03-07 | 1994-04-27 | Gen Hospital Corp | Use of therapeutic cells to obtain cellular response to infection, tumours or autoimmune-generated cells, cells with chimaeric receptors (with binding component and destruction signal), dna encoding the receptor, vectors and antibodies to receptor |
| US6004811A (en) | 1991-03-07 | 1999-12-21 | The Massachussetts General Hospital | Redirection of cellular immunity by protein tyrosine kinase chimeras |
| EP0575537A1 (en) | 1991-03-08 | 1993-12-29 | Cytomed, Inc. | Soluble cd28 proteins and methods of treatment therewith |
| US6582959B2 (en) | 1991-03-29 | 2003-06-24 | Genentech, Inc. | Antibodies to vascular endothelial cell growth factor |
| ES2150424T3 (es) | 1991-10-21 | 2000-12-01 | Cell Genesys Inc | Terapias celulares e inmunosupresivas combinadas. |
| IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
| US8211422B2 (en) | 1992-03-18 | 2012-07-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric receptor genes and cells transformed therewith |
| US5372930A (en) | 1992-09-16 | 1994-12-13 | The United States Of America As Represented By The Secretary Of The Navy | Sensor for ultra-low concentration molecular recognition |
| DE69334071T2 (de) | 1992-11-05 | 2007-10-25 | Sloan-Kettering Institute For Cancer Research | Prostata-spezifisches membranantigen |
| US7105159B1 (en) | 1992-11-05 | 2006-09-12 | Sloan-Kettering Institute For Cancer Research | Antibodies to prostate-specific membrane antigen |
| US6953668B1 (en) | 1992-11-05 | 2005-10-11 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen |
| US5861156A (en) | 1993-01-08 | 1999-01-19 | Creative Biomolecules | Methods of delivering agents to target cells |
| AU695869B2 (en) | 1993-04-06 | 1998-08-27 | Fred Hutchinson Cancer Research Center | Chimeric cytokine receptors in lymphocytes |
| US6051427A (en) | 1993-06-11 | 2000-04-18 | Cell Genesys, Inc. | Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells |
| US5834256A (en) | 1993-06-11 | 1998-11-10 | Cell Genesys, Inc. | Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells |
| US5525503A (en) | 1993-09-28 | 1996-06-11 | Dana-Farber Cancer Institute, Inc. | Signal transduction via CD28 |
| US5935818A (en) | 1995-02-24 | 1999-08-10 | Sloan-Kettering Institute For Cancer Research | Isolated nucleic acid molecule encoding alternatively spliced prostate-specific membrane antigen and uses thereof |
| KR100373813B1 (ko) | 1994-05-02 | 2003-10-08 | 베른트 그로너 | 이관능성단백질,그의제조및용도 |
| US7354587B1 (en) | 1994-07-06 | 2008-04-08 | Immunomedics, Inc. | Use of immunoconjugates to enhance the efficacy of multi-stage cascade boosting vaccines |
| US5798100A (en) | 1994-07-06 | 1998-08-25 | Immunomedics, Inc. | Multi-stage cascade boosting vaccine |
| US6083751A (en) | 1994-11-01 | 2000-07-04 | Targeted Genetics Corporation | Chimeric receptors for the generation of selectively-activatable TH-independent cytotoxic T cells |
| US6077947A (en) | 1995-02-02 | 2000-06-20 | Cell Genesys, Inc. | DNA encoding an intracellular chimeric receptor comprising Janus kinase |
| US5712149A (en) | 1995-02-03 | 1998-01-27 | Cell Genesys, Inc. | Chimeric receptor molecules for delivery of co-stimulatory signals |
| US6103521A (en) | 1995-02-06 | 2000-08-15 | Cell Genesys, Inc. | Multispecific chimeric receptors |
| EP0812356B1 (en) | 1995-02-24 | 2006-02-08 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen and uses thereof |
| US5830755A (en) | 1995-03-27 | 1998-11-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | T-cell receptors and their use in therapeutic and diagnostic methods |
| WO1997004752A1 (en) | 1995-07-26 | 1997-02-13 | Duramed Pharmaceuticals, Inc. | Pharmaceutical compositions of conjugated estrogens and methods for their use |
| GB9526131D0 (en) | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Recombinant chimeric receptors |
| US6451995B1 (en) | 1996-03-20 | 2002-09-17 | Sloan-Kettering Institute For Cancer Research | Single chain FV polynucleotide or peptide constructs of anti-ganglioside GD2 antibodies, cells expressing same and related methods |
| US6261787B1 (en) | 1996-06-03 | 2001-07-17 | Case Western Reserve University | Bifunctional molecules for delivery of therapeutics |
| US5969102A (en) | 1997-03-03 | 1999-10-19 | St. Jude Children's Research Hospital | Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof |
| US20020018783A1 (en) | 1997-03-20 | 2002-02-14 | Michel Sadelain | Fusion proteins of a single chain antibody and cd28 and uses thereof |
| IL133129A0 (en) | 1997-06-11 | 2001-03-19 | Univ New York | Prenylcysteine carboxyl methyltransferase dna encoding same and a method of screening for inhibistors thereof |
| US6759243B2 (en) | 1998-01-20 | 2004-07-06 | Board Of Trustees Of The University Of Illinois | High affinity TCR proteins and methods |
| US20090011984A1 (en) | 1998-02-23 | 2009-01-08 | Seppo Yla-Herttuala | Biotin-binding receptor molecules |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| CA2343156A1 (en) | 1998-09-04 | 2000-03-16 | Sloan-Kettering Institute For Cancer Research | Fusion receptors specific for prostate-specific membrane antigen and uses thereof |
| US6410319B1 (en) | 1998-10-20 | 2002-06-25 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
| DE69936927T2 (de) | 1998-10-21 | 2008-05-15 | Altor Bioscience Corp., Miramar | Polyspezifische bindemoleküle und deren verwendung |
| US7217421B1 (en) | 1998-11-03 | 2007-05-15 | Cell Genesys, Inc. | Cancer-associated antigens and methods of their identification and use |
| AU3389700A (en) | 1999-03-01 | 2000-09-21 | Cell Genesys, Inc. | Anti-neoplastic compositions and uses thereof |
| WO2000063374A1 (en) | 1999-04-16 | 2000-10-26 | Celltech Therapeutics Limited | Synthetic transmembrane components |
| US6699972B1 (en) | 1999-06-25 | 2004-03-02 | Academia Sinica | Chimeric protein and method of controlling tumor growth using the protein |
| WO2001049318A1 (en) | 2000-01-03 | 2001-07-12 | Tr Associates, L.L.C. | Novel chimeric proteins and methods for using the same |
| WO2001060317A2 (en) | 2000-02-14 | 2001-08-23 | The Regents Of The University Of California | Kidney-specific tumor vaccine directed against kidney tumor antigen g-250 |
| US6770749B2 (en) | 2000-02-22 | 2004-08-03 | City Of Hope | P53-specific T cell receptor for adoptive immunotherapy |
| PL211872B1 (pl) | 2000-03-31 | 2012-07-31 | Purdue Research Foundation | Kompozycja farmaceutyczna |
| AU2001255580A1 (en) | 2000-04-21 | 2001-12-11 | Rutgers, The State University Of New Jersey | Methods and compositions for the diagnosis of schizophrenia |
| US6524572B1 (en) | 2000-06-26 | 2003-02-25 | Rainbow Therapeutic Company | Targeting recombinant virus with a bispecific fusion protein ligand in coupling with an antibody to cells for gene therapy |
| CA2417570C (en) | 2000-07-31 | 2010-12-07 | Kyogo Itoh | Tumor-specific t cell activation by peptide antigens |
| US7666424B2 (en) | 2001-10-17 | 2010-02-23 | Sloan-Kettering Institute For Cancer Research | Methods of preparing and using single chain anti-tumor antibodies |
| ATE338124T1 (de) | 2000-11-07 | 2006-09-15 | Hope City | Cd19-spezifische umgezielte immunzellen |
| US20020132983A1 (en) | 2000-11-30 | 2002-09-19 | Junghans Richard P. | Antibodies as chimeric effector cell receptors against tumor antigens |
| US7723111B2 (en) | 2001-03-09 | 2010-05-25 | The United States Of America As Represented By The Department Of Health And Human Services | Activated dual specificity lymphocytes and their methods of use |
| US7070995B2 (en) | 2001-04-11 | 2006-07-04 | City Of Hope | CE7-specific redirected immune cells |
| US7514537B2 (en) | 2001-04-30 | 2009-04-07 | City Of Hope | Chimeric immunoreceptor useful in treating human gliomas |
| AU2002256390B2 (en) | 2001-04-30 | 2007-08-30 | City Of Hope | Chimeric immunoreceptor useful in treating human cancers |
| US20090257994A1 (en) | 2001-04-30 | 2009-10-15 | City Of Hope | Chimeric immunoreceptor useful in treating human cancers |
| US20070031438A1 (en) | 2001-12-10 | 2007-02-08 | Junghans Richard P | Antibodies as chimeric effector cell receptors against tumor antigens |
| US7939059B2 (en) | 2001-12-10 | 2011-05-10 | California Institute Of Technology | Method for the generation of antigen-specific lymphocytes |
| US20030170238A1 (en) | 2002-03-07 | 2003-09-11 | Gruenberg Micheal L. | Re-activated T-cells for adoptive immunotherapy |
| US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| WO2004016643A2 (en) | 2002-08-16 | 2004-02-26 | Yeda Research And Development Co. Ltd. | Tumor associated antigen, peptides thereof, and use of same as anti-tumor vaccines |
| WO2004021861A2 (en) | 2002-09-03 | 2004-03-18 | Vit Lauermann | Targeted release |
| DE10244457A1 (de) | 2002-09-24 | 2004-04-01 | Johannes-Gutenberg-Universität Mainz | Verfahren zur rationalen Mutagenese von alpha/beta T-Zell Rezeptoren und entsprechend mutierte MDM2-Protein spezifische alpha/beta T-Zell Rezeptoren |
| US20050129671A1 (en) | 2003-03-11 | 2005-06-16 | City Of Hope | Mammalian antigen-presenting T cells and bi-specific T cells |
| US20060018878A1 (en) | 2003-03-11 | 2006-01-26 | City Of Hope | Dual antigen specific T cells with trafficking ability |
| US7348004B2 (en) | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| US7435596B2 (en) | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
| US20130266551A1 (en) | 2003-11-05 | 2013-10-10 | St. Jude Children's Research Hospital, Inc. | Chimeric receptors with 4-1bb stimulatory signaling domain |
| US20050113564A1 (en) | 2003-11-05 | 2005-05-26 | St. Jude Children's Research Hospital | Chimeric receptors with 4-1BB stimulatory signaling domain |
| US8652484B2 (en) | 2004-02-13 | 2014-02-18 | Immunomedics, Inc. | Delivery system for cytotoxic drugs by bispecific antibody pretargeting |
| US7196062B2 (en) | 2004-02-18 | 2007-03-27 | Wisconsin Alumni Research Foundation | Method for treating glaucoma |
| EP2044960B1 (en) | 2004-03-02 | 2013-11-20 | Cellectar, Inc. | Phospholipid analogue for the in vivo diagnosis of cancers |
| ES2678094T3 (es) | 2004-07-10 | 2018-08-08 | Fox Chase Cancer Center | Líneas de células asesinas naturales genéticamente modificadas |
| TWI309240B (en) | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
| US7994298B2 (en) | 2004-09-24 | 2011-08-09 | Trustees Of Dartmouth College | Chimeric NK receptor and methods for treating cancer |
| CA2590401C (en) | 2004-10-08 | 2015-04-21 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Adoptive immunotherapy with enhanced t lymphocyte survival |
| AU2005335714B2 (en) | 2004-11-10 | 2012-07-26 | Macrogenics, Inc. | Engineering Fc antibody regions to confer effector function |
| WO2007044033A2 (en) | 2004-12-07 | 2007-04-19 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Therapeutic and diagnostic cloned mhc-unrestricted receptor specific for the muc1 tumor associated antigen |
| US20070036773A1 (en) | 2005-08-09 | 2007-02-15 | City Of Hope | Generation and application of universal T cells for B-ALL |
| US8466263B2 (en) | 2005-12-02 | 2013-06-18 | Dana-Farber Cancer Institute, Inc. | Carbonic anhydrase IX (G250) anitbodies |
| US7919079B2 (en) | 2006-03-31 | 2011-04-05 | Biosante Pharmaceuticals, Inc. | Cancer immunotherapy compositions and methods of use |
| NZ596865A (en) | 2006-06-12 | 2013-07-26 | Emergent Product Dev Seattle | Single-chain multivalent binding proteins with effector function |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| EP1900752A1 (en) | 2006-09-15 | 2008-03-19 | DOMPE' pha.r.ma s.p.a. | Human anti-folate receptor alpha antibodies and antibody fragments for the radioimmunotherapy of ovarian carcinoma |
| US20100105136A1 (en) | 2006-10-09 | 2010-04-29 | The General Hospital Corporation | Chimeric t-cell receptors and t-cells targeting egfrviii on tumors |
| US9334330B2 (en) | 2006-10-10 | 2016-05-10 | Universite De Nantes | Use of monoclonal antibodies specific to the O-acetylated form of GD2 ganglioside for the treatment of certain cancers |
| EP2087337A4 (en) | 2006-11-03 | 2010-09-08 | Purdue Research Foundation | METHOD AND DEVICE FOR EX-VIVO FLOW CYTOMETRY |
| CA2667414C (en) | 2006-11-13 | 2015-12-29 | Sangamo Biosciences, Inc. | Methods and compositions for modification of the human glucocorticoid receptor locus |
| US20080131415A1 (en) | 2006-11-30 | 2008-06-05 | Riddell Stanley R | Adoptive transfer of cd8 + t cell clones derived from central memory cells |
| US8748405B2 (en) | 2007-01-26 | 2014-06-10 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
| WO2008093688A1 (ja) | 2007-01-30 | 2008-08-07 | Forerunner Pharma Research Co., Ltd. | キメラFcγレセプター及び該レセプターを用いたADCC活性測定方法 |
| LT2126054T (lt) | 2007-01-31 | 2016-10-10 | Yeda Research And Development Company Limited | Peradresuotos, genetiškai modifikuotos t reguliavimo ląstelės ir jų naudojimas autoimuninės ir uždegiminės ligos slopinimui |
| US8859229B2 (en) | 2007-02-02 | 2014-10-14 | Yale University | Transient transfection with RNA |
| US8865169B2 (en) | 2007-02-20 | 2014-10-21 | Tufts University | Methods and systems for multi-antibody therapies |
| EP2141997B1 (en) | 2007-03-30 | 2012-10-31 | Memorial Sloan-Kettering Cancer Center | Constitutive expression of costimulatory ligands on adoptively transferred t lymphocytes |
| JPWO2009020093A1 (ja) | 2007-08-09 | 2010-11-04 | 第一三共株式会社 | デスドメイン含有受容体発現細胞にアポトーシスを誘導するイムノリポソーム |
| WO2009091826A2 (en) | 2008-01-14 | 2009-07-23 | The Board Of Regents Of The University Of Texas System | Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car) |
| WO2009117117A1 (en) | 2008-03-19 | 2009-09-24 | Altor Bioscience Corporation | T cell receptor fusions and conjugates and methods of use there of |
| JP5779090B2 (ja) | 2008-04-09 | 2015-09-16 | マックスサイト インコーポレーティッド | 新規に単離された細胞の治療組成物の操作および送達 |
| CN105198997B (zh) | 2008-04-11 | 2018-08-31 | 阿普拜佛研发有限责任公司 | Cd37免疫治疗剂及其与双功能化学治疗剂的联合 |
| US20090324630A1 (en) | 2008-04-21 | 2009-12-31 | Jensen Michael C | Fusion multiviral chimeric antigen |
| EP4032552B1 (en) | 2008-08-26 | 2023-10-04 | City of Hope | Method and compositions for enhanced anti-tumor effector functioning of t cells |
| JP5675619B2 (ja) | 2008-09-17 | 2015-02-25 | エンドサイト, インク.Endocyte, Inc. | 葉酸拮抗薬の葉酸受容体結合性コンジュゲート |
| US8236503B2 (en) | 2008-11-07 | 2012-08-07 | Sequenta, Inc. | Methods of monitoring conditions by sequence analysis |
| EP2398466B1 (en) | 2008-11-24 | 2021-02-17 | Massachusetts Institute of Technology | Methods and compositions for localized nanoparticle delivery to a tumor |
| WO2010132532A1 (en) | 2009-05-15 | 2010-11-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | B cell surface reactive antibodies |
| US20100322909A1 (en) | 2009-06-17 | 2010-12-23 | The University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Th1-associated micrornas and their use for tumor immunotherapy |
| US8465743B2 (en) | 2009-10-01 | 2013-06-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer |
| EP2494038B1 (en) | 2009-10-27 | 2019-06-26 | Immunicum AB | Method for proliferation of antigen-specific t cells |
| US9181527B2 (en) | 2009-10-29 | 2015-11-10 | The Trustees Of Dartmouth College | T cell receptor-deficient T cell compositions |
| US9273283B2 (en) | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
| PT2496698T (pt) | 2009-11-03 | 2019-04-18 | Hope City | Recetor de fator de crescimento epidermal truncado (egfrt) para seleção de células t transduzidas |
| CA2783550A1 (en) | 2009-12-08 | 2011-06-16 | Wilson Wolf Manufacturing Corporation | Improved methods of cell culture for adoptive cell therapy |
| US8956860B2 (en) | 2009-12-08 | 2015-02-17 | Juan F. Vera | Methods of cell culture for adoptive cell therapy |
| JP2013517798A (ja) | 2010-01-28 | 2013-05-20 | ザ チルドレンズ ホスピタル オブ フィラデルフィア | ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター |
| EP2531216B1 (en) | 2010-02-04 | 2019-03-27 | The Trustees Of The University Of Pennsylvania | Icos critically regulates the expansion and function of inflammatory human th17 cells |
| JP6034696B2 (ja) | 2010-02-12 | 2016-11-30 | オンコメッド ファーマシューティカルズ インコーポレイテッド | ポリペプチド発現細胞の同定及び単離の方法 |
| SA111320200B1 (ar) | 2010-02-17 | 2014-02-16 | ديبيوفارم اس ايه | مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة |
| EP2558128B1 (en) | 2010-04-14 | 2016-12-21 | Roger Williams Medical Center | Methods and compositions for treating hiv |
| ES2686424T5 (es) | 2010-05-04 | 2023-03-27 | Yeda Res & Dev | Inmunoterapia con células alogénicas redireccionadas |
| US9089520B2 (en) | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
| US9242014B2 (en) | 2010-06-15 | 2016-01-26 | The Regents Of The University Of California | Receptor tyrosine kinase-like orphan receptor 1 (ROR1) single chain Fv antibody fragment conjugates and methods of use thereof |
| US9163258B2 (en) | 2010-07-23 | 2015-10-20 | Fred Hutchinson Cancer Research Center | Method for the treatment of obesity |
| DE102010036122A1 (de) | 2010-09-01 | 2012-03-01 | Nora Systems Gmbh | Bodenbelag |
| US9493740B2 (en) | 2010-09-08 | 2016-11-15 | Baylor College Of Medicine | Immunotherapy of cancer using genetically engineered GD2-specific T cells |
| EP2614077B1 (en) | 2010-09-08 | 2016-08-17 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Chimeric antigen receptors with an optimized hinge region |
| WO2012136231A1 (en) | 2010-09-08 | 2012-10-11 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Interleukin 15 as selectable marker for gene transfer in lymphocytes |
| WO2012040012A1 (en) | 2010-09-21 | 2012-03-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-ssx-2 t cell receptors and related materials and methods of use |
| WO2012040550A1 (en) | 2010-09-26 | 2012-03-29 | Da Yu Enterprises, L.L.C. | Method of recombinant macromolecular production |
| US9845362B2 (en) | 2010-10-08 | 2017-12-19 | The University Of North Carolina At Charlotte | Compositions comprising chimeric antigen receptors, T cells comprising the same, and methods of using the same |
| WO2012054825A1 (en) | 2010-10-22 | 2012-04-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-mage-a3 t cell receptors and related materials and methods of use |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2012076059A1 (en) | 2010-12-09 | 2012-06-14 | Stichting Het Nederlands Kanker Instituut | Immune restricted peptides with increased efficacy |
| MX2013008376A (es) | 2011-01-18 | 2013-08-12 | Univ Pennsylvania | Composiciones y metodos para el tratamiento de cancer. |
| WO2012109659A1 (en) | 2011-02-11 | 2012-08-16 | Memorial Sloan-Kettering Cancer Center | Hla-restricted, peptide-specific antigen binding proteins |
| JP6203705B2 (ja) | 2011-03-23 | 2017-09-27 | フレッド ハッチンソン キャンサー リサーチ センター | 細胞免疫療法のための方法および組成物 |
| EP2502934B1 (en) | 2011-03-24 | 2018-01-17 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz | Single chain antigen recognizing constructs (scARCs) stabilized by the introduction of novel disulfide bonds |
| PE20141271A1 (es) | 2011-04-01 | 2014-10-08 | Sloan Kettering Inst Cancer | Anticuerpos tipo receptor de celulas t especificos para un peptido wt1 presentado por hla-a2 |
| TR201815488T4 (tr) | 2011-04-08 | 2018-11-21 | Health | Anti-epidermal büyüme faktör reseptörü varyant III kimerik antijen reseptörleri ve kanser tedavisi için kullanımı. |
| EP2696894B1 (en) | 2011-04-13 | 2017-11-01 | Immunicum AB | Method for priming of t cells |
| CN103502439B (zh) | 2011-04-13 | 2016-10-12 | 因缪尼卡姆股份公司 | 用于抗原特异性t细胞增殖的方法 |
| CN103596985B (zh) | 2011-04-19 | 2016-06-08 | 美国政府(由卫生和人类服务部的部长所代表) | 对磷脂酰肌醇蛋白聚糖3特异的人单克隆抗体及其用途 |
| GB201108236D0 (en) | 2011-05-17 | 2011-06-29 | Ucl Business Plc | Method |
| PE20141520A1 (es) | 2011-07-29 | 2014-11-17 | Univ Pennsylvania | Receptores coestimuladores de cambio |
| CA2844540C (en) | 2011-08-23 | 2018-10-16 | Roche Glycart Ag | Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use |
| US9833476B2 (en) | 2011-08-31 | 2017-12-05 | The Trustees Of Dartmouth College | NKP30 receptor targeted therapeutics |
| AU2012309830B2 (en) | 2011-09-15 | 2017-03-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors recognizing HLA-A1- or HLA-Cw7-restricted mage |
| WO2013040371A2 (en) | 2011-09-16 | 2013-03-21 | Baylor College Of Medicine | Targeting the tumor microenvironment using manipulated nkt cells |
| CA2848410A1 (en) | 2011-09-16 | 2013-03-21 | The Trustees Of The University Of Pennsylvania | Rna engineered t cells for the treatment of cancer |
| WO2013044225A1 (en) | 2011-09-22 | 2013-03-28 | The Trustees Of The University Of Pennsylvania | A universal immune receptor expressed by t cells for the targeting of diverse and multiple antigens |
| KR101956751B1 (ko) | 2011-10-07 | 2019-03-11 | 고쿠리츠다이가쿠호진 미에다이가쿠 | 키메라 항원 수용체 |
| BR112014008849A2 (pt) | 2011-10-20 | 2017-09-12 | Us Health | receptores quiméricos de antígeno anti-cd22 |
| JP6074435B2 (ja) | 2011-10-26 | 2017-02-01 | ナショナル キャンサー センター | 変異ctla4遺伝子移入t細胞及びこれを含む抗がん免疫治療用組成物 |
| WO2013063019A1 (en) | 2011-10-28 | 2013-05-02 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for enhancing the therapeutic effect of anti-tumor t cells |
| US9272002B2 (en) | 2011-10-28 | 2016-03-01 | The Trustees Of The University Of Pennsylvania | Fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting |
| EP2773651B1 (en) | 2011-11-03 | 2020-12-23 | The Trustees of the University of Pennsylvania | Isolated b7-h4 specific compositions and methods of use thereof |
| WO2013070468A1 (en) | 2011-11-08 | 2013-05-16 | The Trustees Of The University Of Pennsylvania | Glypican-3-specific antibody and uses thereof |
| US10208086B2 (en) | 2011-11-11 | 2019-02-19 | Fred Hutchinson Cancer Research Center | Cyclin A1-targeted T-cell immunotherapy for cancer |
| JP2015500648A (ja) | 2011-12-16 | 2015-01-08 | ターゲットジーン バイオテクノロジーズ リミテッド | 所定の標的核酸配列を修飾するための組成物及び方法 |
| JP2015502397A (ja) | 2011-12-23 | 2015-01-22 | ファイザー・インク | 部位特異的コンジュゲーションのための操作された抗体定常領域、ならびにそのための方法および使用 |
| JP2015506372A (ja) | 2012-01-27 | 2015-03-02 | グリックニック インコーポレイテッド | IgG2ヒンジドメインを含む融合タンパク質 |
| EP2814846B1 (en) | 2012-02-13 | 2020-01-08 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| EP2817331B1 (en) | 2012-02-22 | 2023-08-30 | The Trustees of the University of Pennsylvania | Use of the cd2 signaling domain in second-generation chimeric antigen receptors |
| EP3747898B1 (en) | 2012-02-22 | 2023-03-15 | The Trustees of the University of Pennsylvania | Use of icos-based cars to enhance antitumor activity and car persistence |
| WO2013126726A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Double transgenic t cells comprising a car and a tcr and their methods of use |
| EP3421489B1 (en) | 2012-03-23 | 2021-05-05 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Anti-mesothelin chimeric antigen receptors |
| HK1203393A1 (en) | 2012-04-11 | 2015-10-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric antigen receptors targeting b-cell maturation antigen |
| US9156915B2 (en) | 2012-04-26 | 2015-10-13 | Thomas Jefferson University | Anti-GCC antibody molecules |
| RU2018130123A (ru) | 2012-05-03 | 2018-11-07 | Фред Хатчинсон Кансэр Рисёч Сентер | Клетка, экспрессирующая t-клеточный рецептор (tcr), для применения в клеточной иммунотерапии |
| US9790278B2 (en) | 2012-05-07 | 2017-10-17 | The Trustees Of Dartmouth College | Anti-B7-H6 antibody, fusion proteins, and methods of using the same |
| US9487573B2 (en) | 2012-05-22 | 2016-11-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Murine anti-NY-ESO-1 T cell receptors |
| PE20150400A1 (es) | 2012-05-22 | 2015-03-27 | Genentech Inc | Benzamidas n-sustituidas y su uso en el tratamiento del dolor |
| KR102437522B1 (ko) | 2012-05-25 | 2022-08-26 | 셀렉티스 | 면역요법을 위한 동종이형 및 면역억제제 저항성인 t 세포의 조작 방법 |
| SG11201407972RA (en) | 2012-06-01 | 2015-01-29 | Us Health | High-affinity monoclonal antibodies to glypican-3 and use thereof |
| CA2875451A1 (en) | 2012-06-08 | 2013-12-12 | Kinki University | Antibody against transporter and use thereof |
| JP5863585B2 (ja) | 2012-07-11 | 2016-02-16 | 三菱電機株式会社 | 大信号等価回路モデルを用いたトランジスタ特性計算装置 |
| CN104583230A (zh) | 2012-07-13 | 2015-04-29 | 宾夕法尼亚大学董事会 | 通过共同引入双特异性抗体增强car t细胞的活性 |
| WO2014011987A1 (en) | 2012-07-13 | 2014-01-16 | The Trustees Of The University Of Pennsylvania | Compositions and methods for regulating car t cells |
| WO2014011996A1 (en) | 2012-07-13 | 2014-01-16 | The Trustees Of The University Of Pennsylvania | Methods of assessing the suitability of transduced t cells for administration |
| BR112015000660A8 (pt) | 2012-07-13 | 2019-07-16 | The Trustees Of The Univ Of Pennsylvania E The Childrens Hospital Of Philadelphia | uso de uma terapia de primeira linha e uma terapia de segunda linha para tratamento de um paciente possuindo uma doença, desordem ou condição associada com uma expressão elevada de um antígeno de tumor, e de uma composição para reduzir ou evitar um efeito adverso associado com a administração de uma célula geneticamente modificada para expressar um car. |
| CN102775500A (zh) | 2012-08-03 | 2012-11-14 | 郑骏年 | 嵌合抗原受体iRGD-scFv(G250)-CD8-CD28-CD137-CD3ζ及其用途 |
| PH12019550223A1 (en) | 2012-08-20 | 2024-02-19 | Fred Hutchinson Cancer Center | Method and compositions for cellular immunotherapy |
| AU2013306076B2 (en) | 2012-08-21 | 2018-01-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Mesothelin domain-specific monoclonal antibodies and use thereof |
| WO2014039523A1 (en) | 2012-09-04 | 2014-03-13 | Cellectis | Multi-chain chimeric antigen receptor and uses thereof |
| KR102370307B1 (ko) | 2012-09-14 | 2022-03-04 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | Mhc ii형 제한된 mage-a3을 인식하는 t 세포 수용체 |
| US9416190B2 (en) | 2012-09-27 | 2016-08-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Mesothelin antibodies and methods for eliciting potent antitumor activity |
| AR092745A1 (es) | 2012-10-01 | 2015-04-29 | Univ Pennsylvania | Composiciones que comprenden un dominio de union anti-fap y metodos para hacer blanco en celulas estromales para el tratamiento del cancer |
| JP6441802B2 (ja) | 2012-10-02 | 2018-12-19 | メモリアル スローン ケタリング キャンサー センター | 免疫療法のための組成物および方法 |
| WO2014055657A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
| WO2014055771A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Human alpha-folate receptor chimeric antigen receptor |
| JP6401704B2 (ja) | 2012-10-10 | 2018-10-10 | サンガモ セラピューティクス, インコーポレイテッド | T細胞を修飾する化合物およびその使用 |
| US20140120136A1 (en) | 2012-10-12 | 2014-05-01 | The Babraham Institute | Mir-155 enhancement of cd8+ t cell immunity |
| UY35103A (es) | 2012-10-29 | 2014-05-30 | Glaxo Group Ltd | Compuestos de cefem 2-sustituidos |
| WO2014099671A1 (en) | 2012-12-20 | 2014-06-26 | Bluebird Bio, Inc. | Chimeric antigen receptors and immune cells targeting b cell malignancies |
| AU2013204922B2 (en) | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
| US9511092B2 (en) | 2013-01-28 | 2016-12-06 | St. Jude Children's Research Hospital, Inc. | Chimeric receptor with NKG2D specificity for use in cell therapy against cancer and infectious disease |
| ES2748398T3 (es) | 2013-02-06 | 2020-03-16 | Celgene Corp | Linfocitos T modificados con especificidad mejorada |
| JO3529B1 (ar) | 2013-02-08 | 2020-07-05 | Amgen Res Munich Gmbh | مضاد التصاق خلايا الدم البيض من أجل التخفيف من الاثار السلبية الممكنة الناتجة عن مجالات ارتباط cd3- المحدد |
| SI3613439T1 (sl) | 2013-02-15 | 2021-11-30 | The Regents Of The University Of California | Himerni antigenski receptor in postopki njegove uporabe |
| KR102685501B1 (ko) | 2013-02-20 | 2024-07-17 | 노파르티스 아게 | 인간화 항-EGFRvIII 키메라 항원 수용체를 사용한 암의 치료 |
| EP2958942B1 (en) | 2013-02-20 | 2020-06-03 | Novartis AG | Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells |
| US9434935B2 (en) | 2013-03-10 | 2016-09-06 | Bellicum Pharmaceuticals, Inc. | Modified caspase polypeptides and uses thereof |
| JP6541639B2 (ja) | 2013-03-14 | 2019-07-10 | ベリカム ファーマシューティカルズ, インコーポレイテッド | T細胞増殖をコントロールするための方法 |
| US9587237B2 (en) | 2013-03-14 | 2017-03-07 | Elwha Llc | Compositions, methods, and computer systems related to making and administering modified T cells |
| US9499855B2 (en) | 2013-03-14 | 2016-11-22 | Elwha Llc | Compositions, methods, and computer systems related to making and administering modified T cells |
| US9402888B2 (en) | 2013-03-14 | 2016-08-02 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for treating cancer |
| JP6501270B2 (ja) | 2013-03-14 | 2019-04-17 | ザ カリフォルニア インスティテュート フォー バイオメディカル リサーチ | 標的化剤抗体抱合体およびその使用 |
| US9561291B2 (en) | 2013-03-15 | 2017-02-07 | Imre Kovesdi | Methods of targeting T-cells to tumors |
| CN105518018B (zh) | 2013-03-15 | 2020-04-03 | 细胞基因公司 | 修饰的t淋巴细胞 |
| US9657105B2 (en) | 2013-03-15 | 2017-05-23 | City Of Hope | CD123-specific chimeric antigen receptor redirected T cells and methods of their use |
| US9446105B2 (en) | 2013-03-15 | 2016-09-20 | The Trustees Of The University Of Pennsylvania | Chimeric antigen receptor specific for folate receptor β |
| US9393268B2 (en) | 2013-03-15 | 2016-07-19 | Thomas Jefferson University | Cell-based anti-cancer compositions with reduced toxicity and methods of making and using the same |
| EP2970426B1 (en) | 2013-03-15 | 2019-08-28 | Michael C. Milone | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| WO2014160627A1 (en) | 2013-03-25 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-cd276 polypeptides, proteins, and chimeric antigen receptors |
| CN112795594B (zh) | 2013-05-14 | 2025-09-19 | 得克萨斯州大学系统董事会 | 工程化嵌合抗原受体(car)t细胞的人应用 |
| JP2016521975A (ja) | 2013-05-15 | 2016-07-28 | サンガモ バイオサイエンシーズ, インコーポレイテッド | 遺伝的状態の処置のための方法および組成物 |
| WO2014190273A1 (en) | 2013-05-24 | 2014-11-27 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor-targeting monoclonal antibodies |
| US9890393B2 (en) | 2013-05-29 | 2018-02-13 | Cellectis | Methods for engineering T cells for immunotherapy by using RNA-guided CAS nuclease system |
| ES2883131T3 (es) | 2013-05-29 | 2021-12-07 | Cellectis | Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN |
| DK3004329T3 (da) | 2013-06-05 | 2020-05-18 | Bellicum Pharmaceuticals Inc | Fremgangsmåder til induktion af delvis apoptose under anvendelse af caspasepolypeptider |
| US9738726B2 (en) | 2013-06-11 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | HER2-specific monoclonal antibodies and conjugates thereof |
| EP3656392A1 (en) | 2013-06-25 | 2020-05-27 | Vaccinex, Inc. | Use of semaphorin-4d inhibitory molecules in combination with an immune modulating therapy to inhibit tumor growth and metastases |
| BR112016004095A2 (pt) | 2013-08-30 | 2017-10-17 | Univ Texas | administração de enzimas de empobrecimento de quinurenina para a terapia contra tumores |
| WO2015038579A1 (en) | 2013-09-11 | 2015-03-19 | Equip, Llc | Discrete peg based dyes |
| MX377297B (es) | 2013-10-11 | 2025-03-07 | Us Health | Anticuerpos tem8 y su uso. |
| JP6637415B2 (ja) | 2013-10-15 | 2020-01-29 | ザ スクリプス リサーチ インスティテュート | キメラ抗原受容体t細胞スイッチおよびその使用 |
| KR102339240B1 (ko) | 2013-10-15 | 2021-12-15 | 더 스크립스 리서치 인스티튜트 | 펩타이드 키메라 항원 수용체 t 세포 스위치 및 이의 용도 |
| US10144770B2 (en) | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
| NZ758715A (en) | 2013-10-31 | 2023-01-27 | Seattle Children’S Hospital Dba Seattle Children’S Res Institute | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| CN113307880B (zh) | 2014-01-13 | 2025-07-04 | 希望之城公司 | 在Fc间隔物区中具有突变的嵌合抗原受体(CAR)及其使用方法 |
| EP3094354B1 (en) | 2014-01-14 | 2018-10-17 | Cellectis | Chimeric antigen receptor using antigen recognition domains derived from cartilaginous fish |
| US9694033B2 (en) | 2014-01-24 | 2017-07-04 | The Cleveland Clinic Foundation | IL-9 secreting CD8+ Tc9 cells and methods of treating cancer |
| US20160058852A1 (en) | 2014-02-14 | 2016-03-03 | Immune Design Corp. | Immunotherapy of cancer through combination of local and systemic immune stimulation |
| US10934346B2 (en) | 2014-02-14 | 2021-03-02 | Bellicum Pharmaceuticals, Inc. | Modified T cell comprising a polynucleotide encoding an inducible stimulating molecule comprising MyD88, CD40 and FKBP12 |
| JP6447933B2 (ja) | 2014-02-21 | 2019-01-09 | アイビーシー ファーマスーティカルズ,インコーポレイテッド | Trop−2発現細胞に対する免疫応答を誘発することによる疾患治療 |
| EP3110824A4 (en) | 2014-02-28 | 2017-11-29 | The Royal Institution for the Advancement of Learning / McGill University | Tc-ptp inhibitors as apc activators for immunotherapy |
| GB201403875D0 (en) | 2014-03-05 | 2014-04-16 | Cantargia Ab | Novel antibodies and uses thereof |
| KR101605421B1 (ko) | 2014-03-05 | 2016-03-23 | 국립암센터 | B 세포 림프종 세포를 특이적으로 인지하는 단일클론항체 및 이의 용도 |
| CA2940460A1 (en) | 2014-03-07 | 2015-09-11 | Bellicum Pharmaceuticals, Inc. | Caspase polypeptides having modified activity and uses thereof |
| WO2015142661A1 (en) | 2014-03-15 | 2015-09-24 | Novartis Ag | Regulatable chimeric antigen receptor |
| CN106163547A (zh) | 2014-03-15 | 2016-11-23 | 诺华股份有限公司 | 使用嵌合抗原受体治疗癌症 |
| CN111514283B (zh) | 2014-04-07 | 2025-10-14 | 诺华股份有限公司 | 使用抗cd19嵌合抗原受体治疗癌症 |
| WO2015157299A2 (en) | 2014-04-09 | 2015-10-15 | Seattle Children's Hospital (Dba Seattle Children's Research Institute | Inhibition of lactate dehydrogenase 5 (ldh-5) binding, incorporation, internalization and/or endocytosis to immune cells |
| KR102508166B1 (ko) | 2014-04-10 | 2023-03-13 | 시애틀 칠드런즈 호스피탈 디/비/에이 시애틀 칠드런즈 리서치 인스티튜트 | 세포 면역요법을 위한 방법 및 조성물 |
| CN106459924A (zh) | 2014-04-23 | 2017-02-22 | 得克萨斯州大学系统董事会 | 用于疗法中的嵌合抗原受体(car)及其制备方法 |
| GB2540694A (en) | 2014-04-29 | 2017-01-25 | Seattle Children's Hospital (Dba Seattle Children's Res Institute) | CCR5 disruption of cells expressing anti-hiv chimeric antigen receptor (CAR) derived from broadly neutralizing antibodies |
| US20170210818A1 (en) | 2014-06-06 | 2017-07-27 | The California Institute For Biomedical Research | Constant region antibody fusion proteins and compositions thereof |
| WO2015191874A1 (en) | 2014-06-12 | 2015-12-17 | Children's National Medical Center | Generation of broadly-specific, virus-immune cells targeting multiple hiv antigens for preventive and therapeutic use |
| MX2017001011A (es) | 2014-07-21 | 2018-05-28 | Novartis Ag | Tratamiento de cancer de usando un receptor quimerico de antigeno anti-bcma. |
| KR20170037625A (ko) | 2014-07-21 | 2017-04-04 | 노파르티스 아게 | Cll-1 키메라 항원 수용체를 사용한 암의 치료 |
| EP3172234B1 (en) | 2014-07-21 | 2020-04-08 | Novartis AG | Treatment of cancer using a cd33 chimeric antigen receptor |
| DK3177640T3 (da) | 2014-08-08 | 2020-08-10 | Univ Leland Stanford Junior | Pd-1-midler med høj affinitet og anvendelsesfremgangsmåder |
| CA2957929A1 (en) | 2014-08-12 | 2016-02-18 | Anthrogenesis Corporation | Car-t lymphocytes engineered to home to lymph node b cell zone, skin, or gastrointestinal tract |
| AU2015305531B2 (en) | 2014-08-19 | 2021-05-20 | Novartis Ag | Anti-CD123 chimeric antigen receptor (CAR) for use in cancer treatment |
| EP3189148A4 (en) | 2014-09-02 | 2018-05-02 | Bellicum Pharmaceuticals, Inc. | Costimulation of chimeric antigen receptors by myd88 and cd40 polypeptides |
| BR112017005631A2 (pt) | 2014-09-19 | 2018-06-26 | City Of Hope | células t com receptor de antígeno coestimulador quimérico direcionadas à il13ra2 |
| WO2016054520A2 (en) | 2014-10-03 | 2016-04-07 | The California Institute For Biomedical Research | Engineered cell surface proteins and uses thereof |
| WO2016057850A1 (en) | 2014-10-09 | 2016-04-14 | Seattle Children' S Hospital (Dba Seattle Children' S Research Institute) | Long poly (a) plasmids and methods for introduction of long poly (a) sequences into the plasmid |
| JP7023709B2 (ja) | 2014-10-14 | 2022-02-22 | リプタイド バイオサイエンス,インコーポレイテッド | 抗炎症特性を有するペプチド |
| EP3212772A4 (en) | 2014-10-31 | 2018-10-03 | Massachusetts Institute of Technology | Delivery of biomolecules to immune cells |
| EP3536707A1 (en) | 2014-11-05 | 2019-09-11 | Board of Regents, The University of Texas System | Gene modified immune effector cells and engineered cells for expansion of immune effector cells |
| US9879087B2 (en) | 2014-11-12 | 2018-01-30 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
| CA2964138C (en) | 2014-11-14 | 2023-11-14 | Massachusetts Institute Of Technology | Disruption and field enabled delivery of compounds and compositions into cells |
| EA037519B1 (ru) | 2014-11-17 | 2021-04-07 | Селлектар Байосайенсиз, Инк. | Аналоги простых эфиров фосфолипидов в качестве носителей лекарственных средств, нацеленных на раковые клетки |
| HK1251862A1 (zh) | 2014-12-02 | 2019-04-26 | 普拉斯派克特查特凯尔Rwmc有限责任公司 | 治疗癌症的方法和组合物 |
| EP4219530A1 (en) | 2014-12-05 | 2023-08-02 | City of Hope | Cs1 targeted chimeric antigen receptor-modified t cells |
| HK1245827B (en) | 2014-12-15 | 2020-06-19 | Board Of Regents Of The University Of Texas System | Methods for controlled activation or elimination of therapeutic cells |
| AU2015362748A1 (en) | 2014-12-15 | 2017-04-27 | Bellicum Pharmaceuticals, Inc. | Methods for controlled elimination of therapeutic cells |
| HRP20250129T1 (hr) | 2014-12-15 | 2025-04-11 | The Regents Of The University Of California | Bispecifični or-gate kimerni antigenski receptor koji reagira na cd19 i cd20 |
| WO2016098078A2 (en) | 2014-12-19 | 2016-06-23 | Novartis Ag | Dimerization switches and uses thereof |
| BR112017013690A2 (pt) | 2014-12-24 | 2018-03-06 | Ucl Business Plc | célula |
| CA3197849A1 (en) | 2014-12-29 | 2016-07-07 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| JP6797803B2 (ja) | 2014-12-31 | 2020-12-09 | セルジーン コーポレイション | ナチュラルキラー細胞を用いて血液障害、固形腫瘍、又は感染性疾患を治療する方法 |
| US9765330B1 (en) | 2015-01-09 | 2017-09-19 | Nant Holdings Ip, Llc | Compositions and methods for reduction of allograft recognition and rejection |
| EP3258943B1 (en) | 2015-02-18 | 2021-05-12 | Enlivex Therapeutics Ltd. | Combination immune therapy and cytokine control therapy for cancer treatment |
| JP6784687B2 (ja) | 2015-02-24 | 2020-11-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 結合誘発型転写スイッチ及びその使用方法 |
| KR102133857B1 (ko) | 2015-03-02 | 2020-07-20 | 이노베이티브 셀룰러 테라퓨틱스 코퍼레이션 리미티드 | Pd-l1에 의해 유도된 면역관용의 감소 |
| WO2016149254A1 (en) | 2015-03-17 | 2016-09-22 | Chimera Bioengineering, Inc. | Smart car devices, de car polypeptides, side cars and uses thereof |
| US20180079824A1 (en) | 2015-03-18 | 2018-03-22 | Baylor College Of Medicine | HER2/ErbB2 Chimeric Antigen Receptor |
| US9717745B2 (en) | 2015-03-19 | 2017-08-01 | Zhejiang DTRM Biopharma Co. Ltd. | Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases |
| WO2016154628A1 (en) | 2015-03-26 | 2016-09-29 | Xiuli Wang | Bi-specific targeted chimeric antigen receptor t cells |
| US10800828B2 (en) | 2015-03-26 | 2020-10-13 | The Scripps Research Institute | Switchable non-scFv chimeric receptors, switches, and methods of use thereof to treat cancer |
| GB201505305D0 (en) | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
| WO2016168766A1 (en) | 2015-04-15 | 2016-10-20 | The California Institute For Biomedical Research | Optimized chimeric receptor t cell switches and uses thereof |
| EP3283113A4 (en) | 2015-04-15 | 2018-12-05 | The California Institute for Biomedical Research | Optimized pne-based chimeric receptor t cell switches and uses thereof |
| US9574014B2 (en) | 2015-05-15 | 2017-02-21 | City Of Hope | Chimeric antigen receptor compositions |
| US9636388B2 (en) | 2015-05-19 | 2017-05-02 | Morphogenesis, Inc. | Multi-indication mRNA cancer immunotherapy |
| IL316196A (en) | 2015-05-28 | 2024-12-01 | Us Health | Methods of conditioning patients for t cell therapy |
| CA2983456A1 (en) | 2015-06-12 | 2016-12-15 | Immunomedics, Inc. | Disease therapy with chimeric antigen receptor (car) constructs and t cells (car-t) or nk cells (car-nk) expressing car constructs |
| US9663756B1 (en) | 2016-02-25 | 2017-05-30 | Flodesign Sonics, Inc. | Acoustic separation of cellular supporting materials from cultured cells |
| WO2016210447A1 (en) | 2015-06-26 | 2016-12-29 | University Of Southern California | Masking chimeric antigen receptor t cells for tumor-specific activation |
| GB201514328D0 (en) | 2015-08-12 | 2015-09-23 | Sigmoid Pharma Ltd | Compositions |
| GB201514874D0 (en) | 2015-08-20 | 2015-10-07 | Autolus Ltd | Cell |
| GB201514875D0 (en) | 2015-08-20 | 2015-10-07 | Autolus Ltd | Receptor |
| WO2017035362A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Use of complement pathway inhibitor compounds to mitigate adoptive t-cell therapy associated adverse immune responses |
| WO2017044487A1 (en) | 2015-09-09 | 2017-03-16 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Genetic engineering of macrophages for immunotherapy |
| US9790467B2 (en) | 2015-09-22 | 2017-10-17 | Qt Holdings Corp | Methods and compositions for activation or expansion of T lymphocytes |
| CN108601821B (zh) | 2015-10-05 | 2023-09-19 | 精密生物科学公司 | 包含经修饰的人T细胞受体α恒定区基因的经遗传修饰的细胞 |
| US11466097B2 (en) | 2015-10-06 | 2022-10-11 | City Of Hope | Chimeric antigen receptors targeted to PSCA |
| GB201518816D0 (en) | 2015-10-23 | 2015-12-09 | Autolus Ltd | Receptor |
| GB201518817D0 (en) | 2015-10-23 | 2015-12-09 | Autolus Ltd | Cell |
| CN108697735A (zh) | 2015-11-05 | 2018-10-23 | 希望之城公司 | 用于制备供过继性t细胞疗法用的细胞的方法 |
| WO2017083274A1 (en) | 2015-11-09 | 2017-05-18 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Novel rna-based vector system for transient and stable gene expression |
| TWI724056B (zh) | 2015-11-19 | 2021-04-11 | 美商卡默森屈有限公司 | Cxcr2抑制劑 |
| TWI734715B (zh) | 2015-11-19 | 2021-08-01 | 美商卡默森屈有限公司 | 趨化因子受體調節劑 |
| KR20180087423A (ko) | 2015-12-14 | 2018-08-01 | 벨리쿰 파마슈티컬스, 인크. | 치료 세포 활성화 또는 제거를 위한 이중 제어 |
| US9849092B2 (en) | 2015-12-21 | 2017-12-26 | Gholam A. Peyman | Early cancer detection and enhanced immunotherapy |
| EP4219689A3 (en) | 2015-12-30 | 2023-12-20 | Novartis AG | Immune effector cell therapies with enhanced efficacy |
| SG11201804038VA (en) | 2016-01-08 | 2018-06-28 | Univ California | Conditionally active heterodimeric polypeptides and methods of use thereof |
| NZ743983A (en) | 2016-01-11 | 2025-08-29 | Univ Leland Stanford Junior | Chimeric proteins and methods of regulating gene expression |
| US10919950B2 (en) | 2016-01-14 | 2021-02-16 | Seattle Children's Hospital | Tumor-specific IFNA secretion by car T-cells to reprogram the solid tumor microenvironment |
| CN108779160A (zh) | 2016-02-05 | 2018-11-09 | 希望之城公司 | 施用工程化t细胞以治疗中枢神经系统中的癌症 |
| GB201602563D0 (en) | 2016-02-12 | 2016-03-30 | Autolus Ltd | Signalling system |
| GB201602571D0 (en) | 2016-02-12 | 2016-03-30 | Autolus Ltd | Signalling system |
| CA3013479A1 (en) | 2016-02-16 | 2017-08-24 | Carl NOVINA | Immunotherapy compositions and methods |
| US11219635B2 (en) | 2016-02-19 | 2022-01-11 | City Of Hope | Bi-specific aptamer |
| CU24649B1 (es) | 2016-03-19 | 2023-02-13 | Exuma Biotech Corp | Retrovirus recombinantes incompetentes de replicación para la transducción de linfocitos y expansión regulada de los mismos |
| US11111505B2 (en) | 2016-03-19 | 2021-09-07 | Exuma Biotech, Corp. | Methods and compositions for transducing lymphocytes and regulating the activity thereof |
| CA3018588A1 (en) | 2016-03-22 | 2017-09-28 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Early intervention methods to prevent or ameliorate toxicity |
| JP7282521B2 (ja) | 2016-04-08 | 2023-05-29 | パーデュー・リサーチ・ファウンデイション | Car t細胞療法のための方法および組成物 |
| US11446398B2 (en) | 2016-04-11 | 2022-09-20 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| CN115960251A (zh) | 2016-06-06 | 2023-04-14 | 希望之城 | Baff-r靶向嵌合抗原受体修饰的t细胞及其用途 |
| WO2017214170A2 (en) | 2016-06-06 | 2017-12-14 | City Of Hope | Baff-r antibodies and uses thereof |
| GB201610515D0 (en) | 2016-06-16 | 2016-08-03 | Autolus Ltd | Cell |
| GB201610512D0 (en) | 2016-06-16 | 2016-08-03 | Autolus Ltd | Chimeric antigen receptor |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| CN109789092A (zh) | 2016-07-13 | 2019-05-21 | 哈佛学院院长等 | 抗原呈递细胞模拟支架及其制备和使用方法 |
| CA3033512A1 (en) | 2016-08-09 | 2018-02-15 | City Of Hope | Chimeric poxvirus compositions and uses thereof |
| US9642906B2 (en) | 2016-09-16 | 2017-05-09 | Baylor College Of Medicine | Generation of HPV-specific T-cells |
| CN110267982B (zh) | 2016-10-19 | 2024-02-23 | 斯克利普斯研究所 | 具有人源化靶向部分和/或经过优化的嵌合抗原受体相互作用结构域的嵌合抗原受体效应细胞开关以及其用途 |
| WO2018075813A1 (en) | 2016-10-19 | 2018-04-26 | City Of Hope | Use of endogenous viral vaccine in chimeric antigen receptor t cell therapy |
| WO2018075794A1 (en) | 2016-10-19 | 2018-04-26 | City Of Hope | Use of triplex cmv vaccine in car t cell therapy |
| US10617720B2 (en) | 2016-10-20 | 2020-04-14 | Miltenyi Biotech, GmbH | Chimeric antigen receptor specific for tumor cells |
| CN117568334A (zh) | 2016-10-31 | 2024-02-20 | 西雅图儿童医院(Dba西雅图儿童研究所) | 用具有工程化稳定的内源性foxp3基因表达的cd4 t细胞治疗自身免疫疾病的方法 |
| US20200095547A1 (en) | 2016-12-02 | 2020-03-26 | Darya ALIZADEH | Methods for manufacturing t cells expressing of chimeric antigen receptors and other receptors |
| US11408005B2 (en) | 2016-12-12 | 2022-08-09 | Seattle Children's Hospital | Chimeric transcription factor variants with augmented sensitivity to drug ligand induction of transgene expression in mammalian cells |
| EP3555296A4 (en) | 2016-12-13 | 2020-07-29 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | METHODS OF EXOGENOUS DRUG ACTIVATION OF CHEMICAL-INDUCED SIGNALING COMPLEXES EXPRESSED IN MODIFIED CELLS IN VITRO AND IN VIVO |
| EP3336107A1 (en) | 2016-12-15 | 2018-06-20 | Miltenyi Biotec GmbH | Immune cells expressing an antigen binding receptor and a chimeric costimulatory receptor |
| WO2018115146A1 (en) | 2016-12-21 | 2018-06-28 | Danmarks Tekniske Universitet | Antigen presenting scaffolds for immune-cell manipulation |
| CN110612119B (zh) | 2017-02-07 | 2024-10-29 | 西雅图儿童医院(Dba西雅图儿童研究所) | 磷脂醚(ple)car t细胞肿瘤靶向(ctct)剂 |
| CN118634339B (zh) | 2017-02-17 | 2025-07-01 | 珀杜研究基金会 | 用于细胞疗法的基于靶向性配体-有效负载的药物递送 |
| WO2018160622A1 (en) | 2017-02-28 | 2018-09-07 | Endocyte, Inc. | Compositions and methods for car t cell therapy |
| WO2018165194A1 (en) | 2017-03-06 | 2018-09-13 | University Of Washington | Engineered cells and agent compositions for therapeutic agent delivery and treatments using same |
| US20200405881A1 (en) | 2017-03-06 | 2020-12-31 | University Of Washington | Cell based methods and compositions for therapeutic agent delivery and treatments using same |
| WO2018170150A2 (en) | 2017-03-16 | 2018-09-20 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Engraftable cell-based immunotherapy for long-term delivery of therapeutic proteins |
| EP3600352A1 (en) | 2017-03-20 | 2020-02-05 | City of Hope | Cs1 targeted chimeric antigen receptor-modified t cells for treatment of al amyloidosis |
| EP4613864A2 (en) | 2017-05-17 | 2025-09-10 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | Generating mammalian t cell activation inducible synthetic promoters (syn+pro) to improve t cell therapy |
| US11370842B2 (en) | 2017-08-01 | 2022-06-28 | City Of Hope | Anti-IL1RAP antibodies |
| WO2019033050A1 (en) | 2017-08-11 | 2019-02-14 | City Of Hope | BISPECIFIC MOLECULE FOR BINDING TO ANTIGEN |
| CN120154716A (zh) | 2018-01-22 | 2025-06-17 | 恩多塞特公司 | Car t细胞的使用方法 |
| CN111936518A (zh) | 2018-02-06 | 2020-11-13 | 西雅图儿童医院(Dba西雅图儿童研究所) | 对fl-ple标记的肿瘤表现出最佳的t细胞功能的荧光素特异性car |
| TW202000229A (zh) | 2018-02-23 | 2020-01-01 | 美商安德賽特公司 | Car t細胞療法之順序方法 |
| CA3096458A1 (en) | 2018-04-12 | 2019-10-17 | Umoja Biopharma, Inc. | Viral vectors and packaging cell lines |
| CA3091490A1 (en) | 2018-04-27 | 2019-10-31 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Rapamycin resistant cells |
| JP2021532818A (ja) | 2018-08-06 | 2021-12-02 | シアトル チルドレンズ ホスピタル (ディービーエイ シアトル チルドレンズ リサーチ インスティテュート) | ハプテン標識細胞によりキメラ抗原受容体t細胞を刺激する方法およびそのための組成物 |
| KR20210042125A (ko) | 2018-08-07 | 2021-04-16 | 퍼듀 리서치 파운데이션 | Car t 세포의 회생 |
| EP3884058A1 (en) | 2018-11-21 | 2021-09-29 | Umoja Biopharma, Inc. | Multicistronic vector for surface engineering lentiviral particles |
| CA3145290A1 (en) | 2019-07-05 | 2021-01-14 | Purdue Research Foundation | Design and efficient synthesis of lipid-fluorescein conjugates for car-t cell therapy |
| AU2020348781B2 (en) | 2019-09-17 | 2025-11-27 | Purdue Research Foundation | Fibroblast activation protein (FAP)-targeted imaging and therapy of cancers and other fibrotic and inflammatory diseases |
| US20240122978A1 (en) | 2019-10-16 | 2024-04-18 | Umoja Biopharma, Inc. | Retroviral vector for univeral receptor therapy |
| AU2021213735A1 (en) | 2020-01-30 | 2022-09-22 | Umoja Biopharma, Inc. | Bispecific transduction enhancer |
| WO2021158534A1 (en) | 2020-02-04 | 2021-08-12 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods and compositions for stimulation of chimeric antigen receptor t cells with hapten labelled cells |
| AU2021217003A1 (en) | 2020-02-04 | 2022-09-15 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Anti-dinitrophenol chimeric antigen receptors |
| KR20220153027A (ko) | 2020-03-06 | 2022-11-17 | 퍼듀 리서치 파운데이션 | Car-t 세포 활성을 변형시키기 위한 방법, 화합물 및 조성물 |
| US20230272039A1 (en) | 2020-07-16 | 2023-08-31 | Umoja Biopharma, Inc. | Gated adapter targeting receptor |
| KR20230156687A (ko) | 2020-11-20 | 2023-11-14 | 우모자 바이오파마 인코포레이티드 | 다수 폴리뉴클레오티드들의 전달을 위한 벡터 시스템 및 그의 용도 |
| US20240141375A1 (en) | 2021-01-27 | 2024-05-02 | Umoja Biopharma, Inc. | Lentivirus for generating cells expressing anti-cd19 chimeric antigen receptor |
| IL317466A (en) | 2022-06-09 | 2025-02-01 | Umoja Biopharma Inc | Compounds and methods for NK cell differentiation |
-
2017
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014504294A (ja) | 2010-12-14 | 2014-02-20 | ユニバーシティ オブ メリーランド,ボルチモア | 汎用の抗タグキメラ抗原受容体発現t細胞及びがんを治療する方法 |
| US20150320799A1 (en) | 2012-12-20 | 2015-11-12 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| WO2016025322A1 (en) | 2014-08-09 | 2016-02-18 | Purdue Research Foundation | Design and development of neurokinin-1 receptor-binding agent delivery conjugates |
Non-Patent Citations (2)
| Title |
|---|
| Mol. Pharmaceutics,2016年04月04日,Vol. 13,p. 1618-1625,DOI: 10.1021/acs.molpharmaceut.6b00065 |
| PNAS,2016年01月12日,Vol. 113, No. 4,E450-E458,https://doi.org/10.1073/pnas.1524193113 |
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| US12144850B2 (en) | 2024-11-19 |
| JP7631410B2 (ja) | 2025-02-18 |
| JP2025084765A (ja) | 2025-06-03 |
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