JP6847666B2 - 抗ｇｉｔｒ抗体及びその使用法 - Google Patents

抗ｇｉｔｒ抗体及びその使用法 Download PDF

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JP6847666B2
JP6847666B2 JP2016569715A JP2016569715A JP6847666B2 JP 6847666 B2 JP6847666 B2 JP 6847666B2 JP 2016569715 A JP2016569715 A JP 2016569715A JP 2016569715 A JP2016569715 A JP 2016569715A JP 6847666 B2 JP6847666 B2 JP 6847666B2
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antibody
seq
amino acid
gitr
acid sequence
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JP2017526615A5 (enExample
JP2017526615A (ja
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デニス ジェイ． アンダーウッド，
デニス ジェイ． アンダーウッド，
オリヴィエ レジェ，
オリヴィエ レジェ，
フォルカー シーベルト，
フォルカー シーベルト，
ダイク， マルク ファン
ダイク， マルク ファン
デイビッド スカエル，
デイビッド スカエル，
武正 辻
武正 辻
ゲルト リッター，
ゲルト リッター，
アナ エム． ゴンザレス，
アナ エム． ゴンザレス，
ニコラス エス． ウィルソン，
ニコラス エス． ウィルソン，
ロベルタ ザッパソディ，
ロベルタ ザッパソディ，
タハ メルゴウブ，
タハ メルゴウブ，
ジェド デイビッド ウォルチョク，
ジェド デイビッド ウォルチョク，
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アジェナス インコーポレイテッド
アジェナス インコーポレイテッド
メモリアル スローン ケタリング キャンサー センター
メモリアル スローン ケタリング キャンサー センター
ルドウイグ インスティテュート フォー キャンサー リサーチ エルティーディー
ルドウイグ インスティテュート フォー キャンサー リサーチ エルティーディー
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C—CHEMISTRY; METALLURGY
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US201462004071P 2014-05-28 2014-05-28
US62/004,071 2014-05-28
US201562161250P 2015-05-13 2015-05-13
US62/161,250 2015-05-13
PCT/US2015/032895 WO2015184099A1 (en) 2014-05-28 2015-05-28 Anti-gitr antibodies and methods of use thereof

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