JP6792556B2 - 液体サンプルを分析するためのデバイス - Google Patents

液体サンプルを分析するためのデバイス Download PDF

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Publication number
JP6792556B2
JP6792556B2 JP2017535632A JP2017535632A JP6792556B2 JP 6792556 B2 JP6792556 B2 JP 6792556B2 JP 2017535632 A JP2017535632 A JP 2017535632A JP 2017535632 A JP2017535632 A JP 2017535632A JP 6792556 B2 JP6792556 B2 JP 6792556B2
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Japan
Prior art keywords
fluid
sample
flow
region
substrate
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Expired - Fee Related
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JP2017535632A
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Japanese (ja)
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JP2017529218A (ja
JP2017529218A5 (enExample
Inventor
サリバン，ベンジャミン
ズミーナ，スティーブ
リー，メリッサ
ウェステルベリ，ブランドン
ダニエル ソロモン，マシュー
ダニエル ソロモン，マシュー
ポツナー，クリスチャン
ガルスト，セバスチャン
スプリンガー，マシュー
ヘイズ，ジェイソン
マンスター，ピーター
クレイグ ハーベイ，エロル
クレイグ ハーベイ，エロル
ウィルキンソン，マイケル
スロウィンスカ，ジョアンナ
リー，デレック
ライフェン，ピーター ファン
ライフェン，ピーター ファン
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ティアラブ リサーチ，インク．
ティアラブ リサーチ，インク．
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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    • G01N25/04—Investigating or analyzing materials by the use of thermal means by investigating changes of state or changes of phase; by investigating sintering of melting point; of freezing point; of softening point
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Fluid Mechanics (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Eye Examination Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2017535632A 2014-09-23 2015-09-23 液体サンプルを分析するためのデバイス Expired - Fee Related JP6792556B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462053923P 2014-09-23 2014-09-23
US62/053,923 2014-09-23
PCT/US2015/051772 WO2016049221A1 (en) 2014-09-23 2015-09-23 Systems and methods for integration of microfluidic tear collection and lateral flow analysis of analytes of interest

Publications (3)

Publication Number Publication Date
JP2017529218A JP2017529218A (ja) 2017-10-05
JP2017529218A5 JP2017529218A5 (enExample) 2018-11-01
JP6792556B2 true JP6792556B2 (ja) 2020-11-25

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JP2017535632A Expired - Fee Related JP6792556B2 (ja) 2014-09-23 2015-09-23 液体サンプルを分析するためのデバイス

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US (1) US11536707B2 (enExample)
EP (2) EP3792615A1 (enExample)
JP (1) JP6792556B2 (enExample)
KR (1) KR20170072188A (enExample)
CN (1) CN106716116B (enExample)
AU (1) AU2015320685B2 (enExample)
BR (1) BR112017005121A2 (enExample)
CA (1) CA2959073A1 (enExample)
CO (1) CO2017002710A2 (enExample)
ES (1) ES2828278T3 (enExample)
MX (1) MX2017003454A (enExample)
WO (1) WO2016049221A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112017005121A2 (pt) 2014-09-23 2018-07-31 Tearlab Res Inc sistemas e métodos para integração de coleta de lágrima microfluídica e análise de fluxo lateral de analitos de interesse.
US10060838B2 (en) 2015-04-09 2018-08-28 Ut-Battelle, Llc Capture probe
US9632066B2 (en) * 2015-04-09 2017-04-25 Ut-Battelle, Llc Open port sampling interface
WO2018148236A1 (en) * 2017-02-07 2018-08-16 Arizona Board Of Regents On Behalf Of Arizona State University Electrochemical osmolarity or osmolality sensor for clinical assessment
EP3580566A1 (en) 2017-02-10 2019-12-18 Quidel Corporation Lateral flow assay with substrate having channels for controlled fluid flow
US10969395B2 (en) * 2017-06-02 2021-04-06 Northwestern University Epidermal microfluidic sensor for sweat collection and analysis from aquatic athletes
CN107202891B (zh) * 2017-06-27 2019-06-28 江苏大学 一种黄曲霉毒素b1免疫快速检测装置和检测方法
DE102017211451B4 (de) 2017-07-05 2019-03-21 Robert Bosch Gmbh Mikromechanische Sensorvorrichtung und entsprechendes Herstellungsverfahren
EP3713477B1 (en) 2017-11-21 2022-07-06 MX3 Diagnostics, Inc. Saliva testing system and method
CN108414034A (zh) * 2018-02-05 2018-08-17 大连理工大学 一种基于毛细-蒸发效应可实时监测汗液流量的微泵
JP7042140B2 (ja) * 2018-03-30 2022-03-25 株式会社Provigate センサチップ
CA3121035C (en) * 2018-11-28 2024-01-23 2Pi-Sigma Corp. Lateral flow assay with controlled conjugate and controlled flow time
WO2020117707A1 (en) * 2018-12-02 2020-06-11 Polymer Technology Systems, Inc. Systems and methods for an e-gating feature in an electrochemical test strip
US11701036B2 (en) 2019-07-10 2023-07-18 MX3 Diagnostics, Inc. Saliva test strip and method
EP4003146B1 (en) * 2019-07-24 2025-09-03 Timpel Medical B.V. Systems and methods for determining a fluid and tissue volume estimations using electrical property tomography
US12123865B2 (en) * 2020-01-15 2024-10-22 MX3 Diagnostics, Inc. Assessment of biomarker concentration in a fluid
CN111366518B (zh) * 2020-01-22 2022-08-16 苏州大学 一种测定聚合物膜渗透性能的方法及装置
WO2021154846A1 (en) 2020-01-30 2021-08-05 MX3 Diagnostics, Inc. Biological fluid sample assessment
CN111766181B (zh) * 2020-06-29 2023-05-12 东北电力大学 原位水生态营养盐沉积物-上覆水界面迁移转化模拟系统
CN117063068A (zh) * 2021-01-07 2023-11-14 科尼库公司 检测空气中挥发性有机化合物的系统和方法
CN112973815B (zh) * 2021-03-09 2022-06-03 西北大学 一种聚集非球形微游泳体的微流管道及一种过滤方法
EP4288211A4 (en) * 2021-03-12 2025-01-29 University of Utah Research Foundation MICROFLUIDIC MICROPARTICLE LABELLED IMPEDANCE SENSOR ARRANGEMENT TO IMPROVE BIOASSAY SENSITIVITY
CN115178310A (zh) * 2021-04-07 2022-10-14 中国科学院上海微系统与信息技术研究所 用于采样与检测的液滴式微流控采样针及其制备方法
US12435357B2 (en) 2022-12-22 2025-10-07 Kanso Diagnostics Ltd. Diagnostic device for detecting a target nucleic acid molecule in a biological sample
CN116660546A (zh) * 2023-05-31 2023-08-29 北京大学第三医院（北京大学第三临床医学院） 一种泪液检测系统

Family Cites Families (215)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622871A (en) 1987-04-27 1997-04-22 Unilever Patent Holdings B.V. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
US4028931A (en) 1976-02-13 1977-06-14 Cardio Pulminary Laboratory Research Foundation Osmotic pressure sensing head
US4123701A (en) 1976-07-01 1978-10-31 United States Surgical Corporation Disposable sample card having a well with electrodes for testing a liquid sample
JPS5443267Y2 (enExample) 1976-07-02 1979-12-14
US4134730A (en) 1977-09-20 1979-01-16 Quame Babington A Spotting systems and methods pertaining thereto
JPS5489797A (en) 1977-12-27 1979-07-17 Hokkaido Daigakuchiyou Needle shaped colloid osmosis pressure meter
CH645391A5 (de) 1978-02-21 1984-09-28 Ciba Geigy Ag Polymere mit succinylobernsteinsaeureester-resten.
US4150564A (en) 1978-04-10 1979-04-24 Wescor, Inc. Osmometer for colloid osmometry
JPS5542048A (en) 1978-09-19 1980-03-25 Kyoto Daiichi Kagaku:Kk Method of and apparatus for measuring freezing point depression using ultrasonic wave
US4269197A (en) 1979-04-05 1981-05-26 Gilbard Jeffrey P Method of measuring tear osmolarity and apparatus therefor
US4301412A (en) 1979-10-29 1981-11-17 United States Surgical Corporation Liquid conductivity measuring system and sample cards therefor
US4436094A (en) 1981-03-09 1984-03-13 Evreka, Inc. Monitor for continuous in vivo measurement of glucose concentration
DE3110183C2 (de) 1981-03-17 1983-12-01 Franz Dr.-Ing. 1000 Berlin Wallner Membranosmometer
JPS5810645A (ja) 1981-07-13 1983-01-21 Fuji Photo Film Co Ltd フイルム状イオン選択電極及びこれを用いるイオン濃度測定法
US4448207A (en) 1981-11-03 1984-05-15 Vital Metrics, Inc. Medical fluid measuring system
US4449538A (en) 1982-01-25 1984-05-22 John Corbitt Medical-electronic body fluid accounting system
US4475556A (en) 1983-01-03 1984-10-09 Reiff Theodore R Rapid measurement of colloid osmotic equilibrium pressure
GB8306353D0 (en) 1983-03-08 1983-04-13 Stuart J F B Monitoring of drug levels
GB8313846D0 (en) 1983-05-19 1983-06-22 City Tech Gas sensor
DE3414866A1 (de) 1984-04-19 1985-10-31 Karl Dipl.-Phys. 8011 Pliening Schickle Verfahren und vorrichtung zum messen der osmolaritaet von fluessigkeitsproben
DE3525668A1 (de) 1984-10-31 1986-05-07 Kernforschungsanlage Jülich GmbH, 5170 Jülich Verfahren zur bestimmung des gehaltes an in einem loesungsmittel geloesten stoffen
US4603699A (en) 1984-11-20 1986-08-05 Himpens Jacques M Apparatus and method for measuring osmotic pressure in situ
JPS63500539A (ja) 1985-06-27 1988-02-25 イーオーエス・テクノロジー・コーポレーション イオン選択電極をもつセンサ−
US4867909A (en) 1985-07-02 1989-09-19 Dow Chemical Company Novel catalytic electrically coducting polymeric articles
JPH0689954B2 (ja) 1986-10-09 1994-11-14 株式会社日立製作所 極低温冷凍機の冷却部構造
JPS63148159A (ja) 1986-12-11 1988-06-21 Horiba Ltd イオン濃度等の測定方法
KR900005223B1 (ko) 1986-12-11 1990-07-21 가부시끼가이샤 호리바 세이사꾸쇼 이온농도등의 측정방법과 그 측정에 사용하는 계측기의 교정용시이트 및 교정방법
CA1303983C (en) 1987-03-27 1992-06-23 Robert W. Rosenstein Solid phase assay
ES2150428T3 (es) 1987-04-27 2000-12-01 Unilever Nv Ensayos de union especifica.
US4787963A (en) 1987-05-04 1988-11-29 Syntro Corporation Method and means for annealing complementary nucleic acid molecules at an accelerated rate
US5211055A (en) 1987-10-27 1993-05-18 Kernforschungsanlage Lulich Gesellschaft mit beschrankter Haftung Apparatus for the selective determination of the concentration of a substance dissolved in a solvent
US5132012A (en) 1988-06-24 1992-07-21 Hitachi, Ltd. Liquid chromatograph
AU2684488A (en) 1988-06-27 1990-01-04 Carter-Wallace, Inc. Test device and method for colored particle immunoassay
DE3825208C1 (enExample) 1988-07-25 1989-11-02 Ernst Prof. Dr. 8581 Eckersdorf De Steudle
US5143080A (en) 1988-12-07 1992-09-01 York Kenneth K In vivo osmometer
US4996993A (en) 1988-12-07 1991-03-05 York Kenneth K In vivo osmometer
US4951683A (en) 1989-01-19 1990-08-28 Davis Jeffrey P Device for detecting keratoconjunctivitis sicca
AT403528B (de) 1989-04-04 1998-03-25 Urban Gerald Mikro-mehrelektrodenstruktur für elektrochemische anwendungen und verfahren zu ihrer herstellung
EP0391674B1 (en) 1989-04-05 1996-03-20 New York University A method for characterising particles
US5094959A (en) 1989-04-26 1992-03-10 Foxs Labs Method and material for measurement of oxygen concentration
US5491097A (en) 1989-06-15 1996-02-13 Biocircuits Corporation Analyte detection with multilayered bioelectronic conductivity sensors
JPH0353550A (ja) 1989-07-21 1991-03-07 Nec Corp Ｉｃパッケージ
US5218088A (en) 1989-11-02 1993-06-08 Purdue Research Foundation Process for preparing dithiophosphate oligonucleotide analogs via nucleoside thiophosphoramidite intermediates
US5112622A (en) 1990-01-19 1992-05-12 Kopp Klaus F Intravenous solutions for influencing renal function and for maintenance therapy
US5141850A (en) 1990-02-07 1992-08-25 Hygeia Sciences, Inc. Porous strip form assay device method
CA2043807A1 (en) 1990-07-19 1992-01-20 Matthew K. Musho Conductive sensors and their use in diagnostic assays
US5202261A (en) 1990-07-19 1993-04-13 Miles Inc. Conductive sensors and their use in diagnostic assays
SE466987B (sv) 1990-10-18 1992-05-11 Stiftelsen Ct Foer Dentaltekni Anordning foer djupselektiv icke-invasiv, lokal maetning av elektrisk impedans i organiska och biologiska material samt prob foer maetning av elektrisk impedans
US5230864A (en) 1991-04-10 1993-07-27 Eastman Kodak Company Gravity assisted collection device
US5221457A (en) 1991-09-23 1993-06-22 Porton Diagnostics, Inc. System for analyzing ion levels in fluids
US5849486A (en) 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US6048690A (en) 1991-11-07 2000-04-11 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
AU677780B2 (en) 1992-05-01 1997-05-08 Trustees Of The University Of Pennsylvania, The Microfabricated detection structures
US5212092A (en) 1992-05-22 1993-05-18 Puritan-Bennett Corporation Storage and calibration solution for multiparameter intravascular blood gas sensor device
JP3101122B2 (ja) 1993-04-16 2000-10-23 松下電器産業株式会社 一体化複合電極
US5505831A (en) 1993-01-26 1996-04-09 Bio-Rad Laboratories, Inc. Concentration of biological samples on a microliter scale and analysis by capillary electrophoresis
US5810725A (en) 1993-04-16 1998-09-22 Matsushita Electric Industrial Co., Ltd. Planar electrode
DE4313481A1 (de) 1993-04-24 1994-10-27 Hoechst Ag Fullerenderivate, Verfahren zur Herstellung und deren Verwendung
US5388449A (en) 1993-07-06 1995-02-14 Leveen; Harry H. Osmolarity sensor
US5821399A (en) 1993-07-16 1998-10-13 I-Stat Corporation Automatic test parameters compensation of a real time fluid analysis sensing device
US5591636A (en) 1993-10-18 1997-01-07 Precision Instrument Design Membrane holder
DE4335961A1 (de) 1993-10-21 1995-04-27 Behringwerke Ag Probenabnahmebesteck zur Gewinnung von Tränenflüssigkeit
US5461699A (en) 1993-10-25 1995-10-24 International Business Machines Corporation Forecasting using a neural network and a statistical forecast
US5489515A (en) 1993-12-09 1996-02-06 Avl Medical Instruments Ag Device for analyzing the metabolism of cells
JP3166471B2 (ja) 1994-02-28 2001-05-14 株式会社島津製作所 導電率測定方法
DE4407637C2 (de) 1994-03-08 1995-12-21 Forschungszentrum Juelich Gmbh Osmometer-Meßeinrichtung und Verfahren zur Bestimmung des Gehaltes des Analyts aus einer Stoffgemisch-Lösung
ES2133166T3 (es) 1994-03-14 1999-09-01 Studiengesellschaft Kohle Mbh Reduccion electroquimica de sales metalicas como metodo de preparar coloides metalicos altamente y agrupaciones de metales fijados a sustratos por reduccion electroquimica de sales metalicas.
US5522805B1 (en) 1994-05-03 1998-06-16 Aquintel Inc Surgical fluid monitor
DE4417079C2 (de) 1994-05-17 1998-06-10 Fraunhofer Ges Forschung Objektträger zum Beobachten von biologischem Material
US5760100B1 (en) 1994-09-06 2000-11-14 Ciba Vision Corp Extended wear ophthalmic lens
AU4146396A (en) 1994-11-08 1996-05-31 Regents Of The University Of California, The Temperature-gradient osmometry
US20010051350A1 (en) 1995-05-02 2001-12-13 Albert Nazareth Diagnostic detection device and method
US6162926A (en) 1995-07-31 2000-12-19 Sphere Biosystems, Inc. Multi-substituted fullerenes and methods for their preparation and characterization
JPH0961312A (ja) 1995-08-30 1997-03-07 Mochida Pharmaceut Co Ltd 簡易測定装置
US5849208A (en) 1995-09-07 1998-12-15 Microfab Technoologies, Inc. Making apparatus for conducting biochemical analyses
US6183714B1 (en) 1995-09-08 2001-02-06 Rice University Method of making ropes of single-wall carbon nanotubes
US5959671A (en) 1995-09-14 1999-09-28 Canon Kabushiki Kaisha Adapter system for connection and disconnection of peripheral equipment with an electric apparatus and having a cam system
US5911131A (en) 1995-12-20 1999-06-08 Vig; Tommy Computer aided calculation, appraisal and valuation of works of art
US5648523A (en) 1995-10-26 1997-07-15 Chiang Long Y Fullerene derivatives as free-radical scavengers
WO1997036681A1 (en) 1996-04-03 1997-10-09 The Perkin-Elmer Corporation Device and method for multiple analyte detection
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
EP1818417B1 (en) 1996-07-29 2014-02-12 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6750016B2 (en) 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US5772585A (en) 1996-08-30 1998-06-30 Emc, Inc System and method for managing patient medical records
US6120460A (en) 1996-09-04 2000-09-19 Abreu; Marcio Marc Method and apparatus for signal acquisition, processing and transmission for evaluation of bodily functions
US6544193B2 (en) 1996-09-04 2003-04-08 Marcio Marc Abreu Noninvasive measurement of chemical substances
EP0845670B1 (en) 1996-12-02 2000-09-06 Ngk Spark Plug Co., Ltd Method and apparatus for measuring NOx gas concentration
US6695964B1 (en) 1996-12-02 2004-02-24 Ngk Spark Plug Co., Ltd. Method and apparatus for measuring NOx gas concentration
NO311817B1 (no) 1996-12-23 2002-01-28 Lifecare As Fremgangsmåte for registrering av endringene i nivået av en osmotisk aktiv komponent i kroppsv¶ske og innretning for utförelseav fremgangsmåten
ATE227844T1 (de) 1997-02-06 2002-11-15 Therasense Inc Kleinvolumiger sensor zur in-vitro bestimmung
PT975800E (pt) 1997-02-27 2003-10-31 Ingeneus Corp Doseamento de nucleotidos em solucao usando sondas anp
US6344272B1 (en) 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
US5798031A (en) 1997-05-12 1998-08-25 Bayer Corporation Electrochemical biosensor
US6010454A (en) 1997-05-29 2000-01-04 Aquintel, Inc. Fluid and electrolyte balance monitoring system for surgical and critically ill patients
US6090251A (en) 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
US6886421B2 (en) 1997-07-21 2005-05-03 Vijay Mathur Modular film sensors with record memory for modular automated diagnostic apparatus
AU735912B2 (en) 1997-08-29 2001-07-19 Avery Dennison Corporation Biological fluid absorbing pressure sensitive adhesives
US6117643A (en) 1997-11-25 2000-09-12 Ut Battelle, Llc Bioluminescent bioreporter integrated circuit
US5997817A (en) 1997-12-05 1999-12-07 Roche Diagnostics Corporation Electrochemical biosensor test strip
ATE205300T1 (de) 1997-12-17 2001-09-15 Ecole Polytech Positionierung und elektrophysiologische charakterisierung einzelner zellen und rekonstituierter membransysteme auf mikrostrukturierten trägern
US7021122B1 (en) 1998-03-19 2006-04-04 Orgenics Biosensors Ltd. Device for the determination of blood clotting by capacitance or resistance
DE69942146D1 (de) 1998-03-19 2010-04-29 Inverness Medical Switzerland GERÄT ZUR BESTIMMUNG DER BLUT-KOAGULATION mittels Widerstandsmessungen
ATE220936T1 (de) 1998-05-13 2002-08-15 Cygnus Therapeutic Systems Sammelvorrichtungen für transdermale probennahmesysteme
WO1999058051A1 (en) 1998-05-13 1999-11-18 Cygnus, Inc. Monitoring of physiological analytes
AU5482099A (en) 1998-08-12 2000-07-03 Ocular Research Of Boston, Inc. Measurement of tear film break-up-time
US6259518B1 (en) 1999-08-10 2001-07-10 Novartis Ag Wetcell device for inspection
US6740518B1 (en) 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
US6602469B1 (en) 1998-11-09 2003-08-05 Lifestream Technologies, Inc. Health monitoring and diagnostic device and network-based health assessment and medical records maintenance system
US6558945B1 (en) 1999-03-08 2003-05-06 Aclara Biosciences, Inc. Method and device for rapid color detection
US6403317B1 (en) 1999-03-26 2002-06-11 Affymetrix, Inc. Electronic detection of hybridization on nucleic acid arrays
DE19916921A1 (de) 1999-04-14 2000-10-19 Fraunhofer Ges Forschung Elektrisches Sensorarray
US6245297B1 (en) 1999-04-16 2001-06-12 Pe Corporation (Ny) Apparatus and method for transferring small volumes of substances
AU4701200A (en) 1999-05-07 2000-11-21 Quantum Dot Corporation A method of detecting an analyte using semiconductor nanocrystals
US6514689B2 (en) 1999-05-11 2003-02-04 M-Biotech, Inc. Hydrogel biosensor
US20030027204A1 (en) 1999-09-03 2003-02-06 Yokogawa Electric Corporation, A Japan Corporation Method and apparatus for producing biochips
DK1221046T3 (da) 1999-10-01 2006-06-12 Sophion Bioscience As Samling og fremgangsmåde til bestemmelse og/eller overvågning af elektrofysiologiske egenskaber ved ionkanaler
WO2001034764A2 (en) 1999-11-08 2001-05-17 Cytion S.A. Apparatus and methods for positioning and analyzing biological membranous objects
US6605453B2 (en) 1999-12-01 2003-08-12 The Regents Of The University Of California Electric-field-assisted fluidic assembly of inorganic and organic materials, molecules and like small things including living cells
US7358079B2 (en) 1999-12-17 2008-04-15 Bayer Technology Services Gmbh Flow cell array and the utilization thereof for multianalyte determination
JP2004501340A (ja) 2000-01-13 2004-01-15 ナノスフェアー　インコーポレイテッド オリゴヌクレオチドを付着させたナノ粒子とその使用方法
GB0001568D0 (en) 2000-01-24 2000-03-15 Isis Innovation Method and apparatus for measuring surface configuration
US6998273B1 (en) * 2000-02-09 2006-02-14 A-Fem Medical Corporation Collection device for lateral flow chromatography
US20040146918A1 (en) 2000-02-18 2004-07-29 Weiner Michael L. Hybrid nucleic acid assembly
US6375627B1 (en) * 2000-03-02 2002-04-23 Agilent Technologies, Inc. Physiological fluid extraction with rapid analysis
DE10015380A1 (de) 2000-03-28 2001-10-11 Nmi Univ Tuebingen Mikrofluidkomponente und Verfahren zur Oberflächenbehandlung einer solchen
CA2407973C (en) 2000-05-03 2011-06-07 Jen-Jr Gau Biological identification system with integrated sensor chip
US6602400B1 (en) 2000-06-15 2003-08-05 Motorola, Inc. Method for enhanced bio-conjugation events
US6529277B1 (en) 2000-07-07 2003-03-04 California Institute Of Technology Optical devices based on resonant configurational effects
JP3909738B2 (ja) 2000-07-13 2007-04-25 松下電器産業株式会社 細胞外記録用一体化複合電極
US6884356B2 (en) 2000-08-07 2005-04-26 Sievers Instruments, Inc. Low-level boron detection and measurement
WO2002017210A2 (en) 2000-08-18 2002-02-28 Cygnus, Inc. Formulation and manipulation of databases of analyte and associated values
AU9657901A (en) * 2000-10-03 2002-04-15 Minerva Biotechnologies Corp Magnetic in situ dilution
DE10050883A1 (de) 2000-10-13 2002-05-16 It Dr Gambert Gmbh Vorrichtung zur Bestimmung von ionalen Bestandteilen in Körperflüssigkeiten
JP2002176999A (ja) 2000-12-12 2002-06-25 Canon Inc 核酸の検出方法
ATE403142T1 (de) 2000-12-21 2008-08-15 Evotec Ag Verfahren zum chrakterisieren von proben von sekundärlicht emittierenden partikeln
US20020119581A1 (en) 2001-01-05 2002-08-29 Daniloff George Y. Detection of analytes
US20020094580A1 (en) 2001-01-16 2002-07-18 Jorgenson James W. Photothermal absorbance detection apparatus and method of using same
WO2002059598A1 (en) 2001-01-26 2002-08-01 Cytion S.A. Method and apparatus for the precise positioning of cells and other small objects
US20050009004A1 (en) 2002-05-04 2005-01-13 Jia Xu Apparatus including ion transport detecting structures and methods of use
CA2441366A1 (en) 2001-03-24 2002-10-03 Aviva Biosciences Corporation Biochips including ion transport detecting structures and methods of use
US20050032204A1 (en) 2001-04-10 2005-02-10 Bioprocessors Corp. Microreactor architecture and methods
CN1529814A (zh) 2001-06-20 2004-09-15 索菲昂生物科学有限公司 一种用于确定和/或监控离子通道电生理学性质的装置和方法
US20030013109A1 (en) 2001-06-21 2003-01-16 Ballinger Clinton T. Hairpin sensors using quenchable fluorescing agents
US6855538B2 (en) 2001-06-27 2005-02-15 The Regents Of The University Of California High-efficiency microarray printing device
CA2453141A1 (en) 2001-07-09 2003-01-23 Arizona Board Of Regents A Body Corporate Acting On Behalf Of Arizona State University Afinity biosensor for monitoring of biological process
WO2003029480A2 (en) 2001-08-31 2003-04-10 The Government Of The United States Of America, Asrepresented By The Secretary Of The Department Of Health And Human Services Measurements of multiple molecules using a cryoarray
CA2458802C (en) 2001-09-06 2016-06-07 Genomic Profiling Systems, Inc. Rapid and sensitive detection of molecules
US20040220089A1 (en) 2001-10-03 2004-11-04 Ellis Edward J. Ophthalmic preparation containing glycoprotein
US6778316B2 (en) 2001-10-24 2004-08-17 William Marsh Rice University Nanoparticle-based all-optical sensors
KR100475634B1 (ko) 2001-12-24 2005-03-15 주식회사 아이센스 일정 소량의 시료를 빠르게 도입할 수 있는 시료도입부를구비한 바이오 센서
AU2003244811A1 (en) 2002-02-15 2003-09-04 Mcmaster University Deoxyribozymes
US20040023415A1 (en) 2002-03-05 2004-02-05 Konstantin Sokolov Biospecific contrast agents
EP1492448A4 (en) 2002-04-05 2008-03-19 Eyelab Group Llc MONITORING OF BLOOD SUBSTANCES USING SELF-COLLECTED TISSUES
JP3914806B2 (ja) * 2002-04-09 2007-05-16 三菱化学株式会社 分析用チップ
GB0208153D0 (en) 2002-04-09 2002-05-22 Univ Warwick Biosensor
US20030211488A1 (en) 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
US6951728B2 (en) 2002-05-10 2005-10-04 Lifescan, Inc. Multilayer reagent test strips to quantify glycated protein in a physiological sample
US20050106714A1 (en) 2002-06-05 2005-05-19 Zarur Andrey J. Rotatable reactor systems and methods
DE60324738D1 (de) 2002-07-18 2009-01-02 Panasonic Corp Messvorrichtung mit einem Biosensor
CA2494540C (en) 2002-08-06 2014-06-03 The Regents Of The University Of California Tear film osmometry
US7810380B2 (en) 2003-03-25 2010-10-12 Tearlab Research, Inc. Systems and methods for collecting tear film and measuring tear film osmolarity
US7905134B2 (en) 2002-08-06 2011-03-15 The Regents Of The University Of California Biomarker normalization
US8020433B2 (en) 2003-03-25 2011-09-20 Tearlab Research, Inc. Systems and methods for a sample fluid collection device
US7111502B2 (en) 2002-08-06 2006-09-26 Ocusense, Inc. Systems and methods for reducing the effect of corruptive signals during nanoliter osmometry
US7051569B2 (en) 2002-08-06 2006-05-30 Ocusense, Inc. Systems and methods for calibrating osmolarity measuring devices
US7244394B2 (en) 2002-10-03 2007-07-17 Novartis Ag Methods and kits for assays of analytes of interest in tears
US7964390B2 (en) 2002-10-11 2011-06-21 Case Western Reserve University Sensor system
US7449307B2 (en) 2002-10-28 2008-11-11 Transform Pharmaceuticals, Inc. Raised surface assay plate
GB0300820D0 (en) 2003-01-14 2003-02-12 Diagnoswiss Sa Membrane-microchannel strip
JP4073323B2 (ja) 2003-01-23 2008-04-09 日立ソフトウエアエンジニアリング株式会社 機能性ビーズ、その読み取り方法および読み取り装置
JPWO2005024437A1 (ja) 2003-09-05 2007-11-08 日本電気株式会社 測定システム
US7718133B2 (en) 2003-10-09 2010-05-18 3M Innovative Properties Company Multilayer processing devices and methods
EP1678495A4 (en) 2003-10-20 2007-06-27 Univ California TRANSDUCTION SYSTEMS IN THE NANOMASSIC STATION FOR DETECTING MOLECULAR INTERACTIONS
US7129717B2 (en) 2003-11-19 2006-10-31 Ocusense, Inc. Systems and methods for measuring tear film osmolarity
WO2005067651A2 (en) 2004-01-08 2005-07-28 Cappo Anthony P Surface plasmon resonance based nanoliter tear osmometer
US8030057B2 (en) * 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
US8021625B2 (en) * 2004-01-28 2011-09-20 Dnt Scientific Research, Llc Interrupted, gravity-promoted, diffused flow chromatography strip testing device and method
US20050201895A1 (en) 2004-03-12 2005-09-15 Eric Donsky Systems and methods for delivering a sample fluid to a receiving substrate
WO2005089210A2 (en) 2004-03-12 2005-09-29 Ocusense, Inc. Systems and methods for collecting and analysing tear film osmolarity data
WO2005106036A2 (en) 2004-04-12 2005-11-10 Medical College Of Ohio Methods and compositions for assaying analytes
US7763454B2 (en) 2004-07-09 2010-07-27 Church & Dwight Co., Inc. Electronic analyte assaying device
US20060127964A1 (en) 2004-07-30 2006-06-15 Russell Ford Microprocessors, devices, and methods for use in monitoring of physiological analytes
JP2006112881A (ja) 2004-10-14 2006-04-27 Nikkiso Co Ltd 生体物質測定装置および生体物質測定装置用チップ
US8249682B2 (en) * 2005-01-07 2012-08-21 Lacrisciences, Llc Device for measuring concentrations of constituents of tear sample
CN101171346B (zh) 2005-05-06 2011-11-09 三星电子股份有限公司 数字生物盘、数字生物盘驱动器装置及其应用化验方法
EP1893278A2 (en) 2005-06-03 2008-03-05 Trans-Dermal Patents Company, LLC Agent delivery system
WO2007002579A2 (en) 2005-06-23 2007-01-04 Bioveris Corporation Assay cartridges and methods for point of care instruments
US7344679B2 (en) * 2005-10-14 2008-03-18 International Business Machines Corporation Method and apparatus for point of care osmolarity testing
JP2007268486A (ja) * 2006-03-31 2007-10-18 Fujifilm Corp マイクロデバイスの流体制御方法及び機構、並びにそれを用いた科学現象の評価装置
WO2007133457A2 (en) 2006-05-08 2007-11-22 Bayer Healthcare Llc Electrochemical test sensor with reduced sample volume
US7914460B2 (en) 2006-08-15 2011-03-29 University Of Florida Research Foundation, Inc. Condensate glucose analyzer
US7908906B2 (en) 2006-08-29 2011-03-22 International Business Machines Corporation Fluidic test apparatus and method
JPWO2008044530A1 (ja) * 2006-10-05 2010-02-12 パナソニック株式会社 多項目成分分析センサおよび多項目成分の測定方法
US8090426B2 (en) 2006-10-27 2012-01-03 Felder Robin A Microelectronic biosensor plug
ES2911114T3 (es) 2006-12-11 2022-05-17 Tearlab Res Inc Sistemas y métodos para recoger la película lagrimal y medir la osmolaridad de la película lagrimal
ITFI20060322A1 (it) 2006-12-13 2008-06-14 Menarini Farma Ind Processo per la preparazione di elettrodi modificati, elettrodi preparati con tale processo, e biosensori enzimatici che li comprendono.
CA2682070C (en) 2007-03-28 2014-02-04 Ocusense, Inc. Systems and methods for a sample fluid collection device
CA2938402C (en) 2007-04-16 2017-07-18 The Regents Of The University Of California Biomarker normalization
WO2008137863A2 (en) 2007-05-04 2008-11-13 Advanced Medical Optics, Inc. Methods and devices for measuring tear film and diagnosing tear disorders
EP2304445B1 (en) * 2008-07-09 2020-06-10 Micropoint Bioscience Inc Analytical cartridge with fluid flow control
JP2010203779A (ja) 2009-02-27 2010-09-16 Konica Minolta Holdings Inc 検査用マイクロチップ
US8898069B2 (en) 2009-08-28 2014-11-25 The Invention Science Fund I, Llc Devices and methods for detecting an analyte in salivary fluid
CN102844176A (zh) * 2009-09-30 2012-12-26 微型实验室诊断股份有限公司 微流体装置中选择性的粘结性降低
GB0919159D0 (en) * 2009-11-02 2009-12-16 Sec Dep For Environment Food A Device and apparatus
CN102762991B (zh) 2010-02-10 2015-08-19 藤森工业株式会社 血小板检测用微芯片及使用该微芯片的血小板检测装置
CN105342552B (zh) * 2010-06-30 2018-10-16 安派科生物医学科技有限公司 疾病检测仪
US8828329B2 (en) 2010-10-01 2014-09-09 Church & Dwight, Co., Inc. Electronic analyte assaying device
US20130008803A1 (en) 2011-01-03 2013-01-10 The Regents Of The University Of Michigan Methods and Systems for Measurement of Tear Glucose Levels
CA2838708C (en) * 2011-06-09 2020-07-21 Gen-Probe Incorporated Diagnostic devices, methods and systems for detecting platelet factor 4 (pf4)/heparin antibodies
JP2013170835A (ja) 2012-02-17 2013-09-02 Sharp Corp イムノクロマト用検査器具、分析装置、および分析方法
US20140088381A1 (en) 2012-09-26 2014-03-27 Google Inc. Facilitation of tear sample collection and testing using a contact lens
US10101342B2 (en) * 2014-02-12 2018-10-16 Church & Dwight Co., Inc. Devices and methods for electronic analyte assaying
BR112017005121A2 (pt) 2014-09-23 2018-07-31 Tearlab Res Inc sistemas e métodos para integração de coleta de lágrima microfluídica e análise de fluxo lateral de analitos de interesse.

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CA2959073A1 (en) 2016-03-31
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CN106716116A (zh) 2017-05-24
KR20170072188A (ko) 2017-06-26
US20170248573A1 (en) 2017-08-31
BR112017005121A2 (pt) 2018-07-31
CN106716116B (zh) 2021-04-27
EP3198257A1 (en) 2017-08-02
EP3792615A1 (en) 2021-03-17
WO2016049221A1 (en) 2016-03-31
AU2015320685A1 (en) 2017-03-30
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MX2017003454A (es) 2017-11-13
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