JP6620018B2 - Ｃｒｉｓｐｒに基づくゲノム修飾および制御 - Google Patents

Ｃｒｉｓｐｒに基づくゲノム修飾および制御 Download PDF

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JP6620018B2
JP6620018B2 JP2015545838A JP2015545838A JP6620018B2 JP 6620018 B2 JP6620018 B2 JP 6620018B2 JP 2015545838 A JP2015545838 A JP 2015545838A JP 2015545838 A JP2015545838 A JP 2015545838A JP 6620018 B2 JP6620018 B2 JP 6620018B2
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protein
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JP2016502840A (ja
JP2016502840A5 (enExample
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フチアン・チェン
グレゴリー・ディ・デイビス
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Sigma Aldrich Co LLC
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/102—Mutagenizing nucleic acids
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    • C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
    • C12Y301/21004—Type II site-specific deoxyribonuclease (3.1.21.4)
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
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    • C12N2310/00—Structure or type of the nucleic acid
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  • Virology (AREA)
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  • Crystallography & Structural Chemistry (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Enzymes And Modification Thereof (AREA)
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JP2015545838A 2012-12-06 2013-12-05 Ｃｒｉｓｐｒに基づくゲノム修飾および制御 Active JP6620018B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201261734256P 2012-12-06 2012-12-06
US61/734,256 2012-12-06
US201361758624P 2013-01-30 2013-01-30
US61/758,624 2013-01-30
US201361761046P 2013-02-05 2013-02-05
US61/761,046 2013-02-05
US201361794422P 2013-03-15 2013-03-15
US61/794,422 2013-03-15
PCT/US2013/073307 WO2014089290A1 (en) 2012-12-06 2013-12-05 Crispr-based genome modification and regulation

Related Child Applications (2)

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JP2017115672A Division JP2017192392A (ja) 2012-12-06 2017-06-13 Ｃｒｉｓｐｒに基づくゲノム修飾および制御
JP2018183815A Division JP2019037231A (ja) 2012-12-06 2018-09-28 Ｃｒｉｓｐｒに基づくゲノム修飾および制御

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JP2016502840A JP2016502840A (ja) 2016-02-01
JP2016502840A5 JP2016502840A5 (enExample) 2017-01-19
JP6620018B2 true JP6620018B2 (ja) 2019-12-11

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JP2017115672A Pending JP2017192392A (ja) 2012-12-06 2017-06-13 Ｃｒｉｓｐｒに基づくゲノム修飾および制御
JP2018183815A Pending JP2019037231A (ja) 2012-12-06 2018-09-28 Ｃｒｉｓｐｒに基づくゲノム修飾および制御
JP2020074283A Pending JP2020120674A (ja) 2012-12-06 2020-04-17 Ｃｒｉｓｐｒに基づくゲノム修飾および制御
JP2021033258A Pending JP2021101706A (ja) 2012-12-06 2021-03-03 Ｃｒｉｓｐｒに基づくゲノム修飾および制御
JP2022076698A Active JP7478772B2 (ja) 2012-12-06 2022-05-06 Ｃｒｉｓｐｒに基づくゲノム修飾および制御

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JP2018183815A Pending JP2019037231A (ja) 2012-12-06 2018-09-28 Ｃｒｉｓｐｒに基づくゲノム修飾および制御
JP2020074283A Pending JP2020120674A (ja) 2012-12-06 2020-04-17 Ｃｒｉｓｐｒに基づくゲノム修飾および制御
JP2021033258A Pending JP2021101706A (ja) 2012-12-06 2021-03-03 Ｃｒｉｓｐｒに基づくゲノム修飾および制御
JP2022076698A Active JP7478772B2 (ja) 2012-12-06 2022-05-06 Ｃｒｉｓｐｒに基づくゲノム修飾および制御

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EP (11) EP3138909A1 (enExample)
JP (6) JP6620018B2 (enExample)
KR (7) KR101844123B1 (enExample)
CN (3) CN105142669B (enExample)
AU (9) AU2013355214B2 (enExample)
BR (1) BR112015012375A2 (enExample)
CA (3) CA3034794A1 (enExample)
DK (6) DK3138911T3 (enExample)
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PT (6) PT3138912T (enExample)
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US10457935B2 (en) 2010-11-12 2019-10-29 Gen9, Inc. Protein arrays and methods of using and making the same
BR112013024337A2 (pt) 2011-03-23 2017-09-26 Du Pont locus de traço transgênico complexo em uma planta, planta ou semente, método para produzir em uma planta um locus de traço transgênico complexo e construto de expressão
EP2734621B1 (en) 2011-07-22 2019-09-04 President and Fellows of Harvard College Evaluation and improvement of nuclease cleavage specificity
EP2748318B1 (en) 2011-08-26 2015-11-04 Gen9, Inc. Compositions and methods for high fidelity assembly of nucleic acids
EP3604555B1 (en) 2011-10-14 2024-12-25 President and Fellows of Harvard College Sequencing by structure assembly
ES2991004T3 (es) 2011-12-22 2024-12-02 Harvard College Métodos para la detección de analitos
WO2014163886A1 (en) 2013-03-12 2014-10-09 President And Fellows Of Harvard College Method of generating a three-dimensional nucleic acid containing matrix
GB201122458D0 (en) 2011-12-30 2012-02-08 Univ Wageningen Modified cascade ribonucleoproteins and uses thereof
US9637739B2 (en) 2012-03-20 2017-05-02 Vilnius University RNA-directed DNA cleavage by the Cas9-crRNA complex
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PT3138911T (pt) 2018-12-28
AU2019201344B2 (en) 2020-09-03

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