JP6404822B2 - アプタマーおよびその使用 - Google Patents

アプタマーおよびその使用 Download PDF

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JP6404822B2
JP6404822B2 JP2015538586A JP2015538586A JP6404822B2 JP 6404822 B2 JP6404822 B2 JP 6404822B2 JP 2015538586 A JP2015538586 A JP 2015538586A JP 2015538586 A JP2015538586 A JP 2015538586A JP 6404822 B2 JP6404822 B2 JP 6404822B2
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cancer
tumor
fluid
sample
aptamer
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JP2016506716A5 (cg-RX-API-DMAC7.html
JP2016506716A (ja
Inventor
デイビッド ハルバート
デイビッド ハルバート
バレリー ドメニュク
バレリー ドメニュク
デイビッド スペッツラー
デイビッド スペッツラー
タッシロ ホーナング
タッシロ ホーナング
フランク シェーファー
フランク シェーファー
ニック シャオ
ニック シャオ
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カリス ライフ サイエンシズ スウィッツァーランド ホールディングス ゲーエムベーハー
カリス ライフ サイエンシズ スウィッツァーランド ホールディングス ゲーエムベーハー
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Publication of JP2016506716A publication Critical patent/JP2016506716A/ja
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Priority to JP2021133939A priority patent/JP7442483B2/ja
Priority to JP2024023399A priority patent/JP2024059757A/ja
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/13—Applications; Uses in screening processes in a process of directed evolution, e.g. SELEX, acquiring a new function
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
JP2015538586A 2012-10-23 2013-10-23 アプタマーおよびその使用 Active JP6404822B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2018171131A JP6933619B2 (ja) 2012-10-23 2018-09-13 アプタマーおよびその使用
JP2021133939A JP7442483B2 (ja) 2012-10-23 2021-08-19 アプタマーおよびその使用
JP2024023399A JP2024059757A (ja) 2012-10-23 2024-02-20 アプタマーおよびその使用

Applications Claiming Priority (43)

Application Number Priority Date Filing Date Title
US201261717566P 2012-10-23 2012-10-23
US61/717,566 2012-10-23
US201261731419P 2012-11-29 2012-11-29
US61/731,419 2012-11-29
US201261735915P 2012-12-11 2012-12-11
US61/735,915 2012-12-11
US201361748437P 2013-01-02 2013-01-02
US61/748,437 2013-01-02
US201361749773P 2013-01-07 2013-01-07
US61/749,773 2013-01-07
US201361750331P 2013-01-08 2013-01-08
US61/750,331 2013-01-08
US201361754471P 2013-01-18 2013-01-18
US61/754,471 2013-01-18
US201361767131P 2013-02-20 2013-02-20
US61/767,131 2013-02-20
US201361769064P 2013-02-25 2013-02-25
US61/769,064 2013-02-25
US201361805365P 2013-03-26 2013-03-26
US61/805,365 2013-03-26
US201361808144P 2013-04-03 2013-04-03
US61/808,144 2013-04-03
US201361820419P 2013-05-07 2013-05-07
US61/820,419 2013-05-07
US201361826957P 2013-05-23 2013-05-23
US61/826,957 2013-05-23
US201361838762P 2013-06-24 2013-06-24
US61/838,762 2013-06-24
US201361843256P 2013-07-05 2013-07-05
US61/843,256 2013-07-05
US201361862809P 2013-08-06 2013-08-06
US61/862,809 2013-08-06
US201361863828P 2013-08-08 2013-08-08
US61/863,828 2013-08-08
US201361866014P 2013-08-14 2013-08-14
US61/866,014 2013-08-14
US201361867978P 2013-08-20 2013-08-20
US61/867,978 2013-08-20
US201361871107P 2013-08-28 2013-08-28
US61/871,107 2013-08-28
US201361874621P 2013-09-06 2013-09-06
US61/874,621 2013-09-06
PCT/IB2013/003092 WO2014068408A2 (en) 2012-10-23 2013-10-23 Aptamers and uses thereof

Related Child Applications (1)

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JP2018171131A Division JP6933619B2 (ja) 2012-10-23 2018-09-13 アプタマーおよびその使用

Publications (3)

Publication Number Publication Date
JP2016506716A JP2016506716A (ja) 2016-03-07
JP2016506716A5 JP2016506716A5 (cg-RX-API-DMAC7.html) 2016-12-08
JP6404822B2 true JP6404822B2 (ja) 2018-10-17

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Family Applications (4)

Application Number Title Priority Date Filing Date
JP2015538586A Active JP6404822B2 (ja) 2012-10-23 2013-10-23 アプタマーおよびその使用
JP2018171131A Active JP6933619B2 (ja) 2012-10-23 2018-09-13 アプタマーおよびその使用
JP2021133939A Active JP7442483B2 (ja) 2012-10-23 2021-08-19 アプタマーおよびその使用
JP2024023399A Withdrawn JP2024059757A (ja) 2012-10-23 2024-02-20 アプタマーおよびその使用

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JP2018171131A Active JP6933619B2 (ja) 2012-10-23 2018-09-13 アプタマーおよびその使用
JP2021133939A Active JP7442483B2 (ja) 2012-10-23 2021-08-19 アプタマーおよびその使用
JP2024023399A Withdrawn JP2024059757A (ja) 2012-10-23 2024-02-20 アプタマーおよびその使用

Country Status (11)

Country Link
US (1) US9958448B2 (cg-RX-API-DMAC7.html)
EP (2) EP2912182B1 (cg-RX-API-DMAC7.html)
JP (4) JP6404822B2 (cg-RX-API-DMAC7.html)
KR (1) KR20150090072A (cg-RX-API-DMAC7.html)
CN (1) CN105452466A (cg-RX-API-DMAC7.html)
AU (3) AU2013340414B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015009138A2 (cg-RX-API-DMAC7.html)
CA (1) CA2928520C (cg-RX-API-DMAC7.html)
ES (1) ES2912033T3 (cg-RX-API-DMAC7.html)
IL (2) IL238408B (cg-RX-API-DMAC7.html)
WO (1) WO2014068408A2 (cg-RX-API-DMAC7.html)

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