JP6224084B2 - 糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体 - Google Patents
糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体 Download PDFInfo
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- JP6224084B2 JP6224084B2 JP2015512016A JP2015512016A JP6224084B2 JP 6224084 B2 JP6224084 B2 JP 6224084B2 JP 2015512016 A JP2015512016 A JP 2015512016A JP 2015512016 A JP2015512016 A JP 2015512016A JP 6224084 B2 JP6224084 B2 JP 6224084B2
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- dpp
- nephropathy
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- YLTXBUGZVMPESA-OAHLLOKOSA-N Cc1ccnc(CN(C(c([n]2CC#CC)c(N3C)nc2N(CCC2)C[C@@H]2N)=O)C3=O)n1 Chemical compound Cc1ccnc(CN(C(c([n]2CC#CC)c(N3C)nc2N(CCC2)C[C@@H]2N)=O)C3=O)n1 YLTXBUGZVMPESA-OAHLLOKOSA-N 0.000 description 1
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- A61K31/33—Heterocyclic compounds
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12167953.4 | 2012-05-14 | ||
| EP12167953 | 2012-05-14 | ||
| EP12170888.7 | 2012-06-05 | ||
| EP12170888 | 2012-06-05 | ||
| EP12006812 | 2012-09-28 | ||
| EP12006812.7 | 2012-09-28 | ||
| EP12190447.8 | 2012-10-29 | ||
| EP12190447 | 2012-10-29 | ||
| PCT/EP2013/059831 WO2013171167A1 (en) | 2012-05-14 | 2013-05-13 | A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017194101A Division JP6473208B2 (ja) | 2012-05-14 | 2017-10-04 | 糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015516456A JP2015516456A (ja) | 2015-06-11 |
| JP2015516456A5 JP2015516456A5 (https=) | 2016-06-30 |
| JP6224084B2 true JP6224084B2 (ja) | 2017-11-01 |
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ID=48430775
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015512016A Active JP6224084B2 (ja) | 2012-05-14 | 2013-05-13 | 糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体 |
| JP2017194101A Active JP6473208B2 (ja) | 2012-05-14 | 2017-10-04 | 糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体 |
| JP2019009897A Active JP6759373B2 (ja) | 2012-05-14 | 2019-01-24 | 糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017194101A Active JP6473208B2 (ja) | 2012-05-14 | 2017-10-04 | 糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体 |
| JP2019009897A Active JP6759373B2 (ja) | 2012-05-14 | 2019-01-24 | 糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体 |
Country Status (4)
| Country | Link |
|---|---|
| US (6) | US20130303462A1 (https=) |
| EP (2) | EP2849755A1 (https=) |
| JP (3) | JP6224084B2 (https=) |
| WO (1) | WO2013171167A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| KR101452915B1 (ko) | 2006-05-04 | 2014-10-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 다형태 |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| JP2012512848A (ja) | 2008-12-23 | 2012-06-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 有機化合物の塩の形態 |
| KR20240090632A (ko) | 2009-11-27 | 2024-06-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 리나글립틴과 같은 dpp-iv 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료 |
| CA3070513C (en) | 2010-05-05 | 2023-01-03 | Boehringer Ingelheim International Gmbh | A dpp-4 inhibitor for use in treatment of skin-alterations or necrosis |
| KR20130093012A (ko) | 2010-06-24 | 2013-08-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 당뇨병 요법 |
| AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
| DK2731947T3 (en) | 2011-07-15 | 2019-04-23 | Boehringer Ingelheim Int | SUBSTITUTED DIMERIC QUINAZOLINE DERIVATIVE, PREPARATION AND USE thereof IN PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF TYPE I AND TYPE II DIABETES |
| US9561145B2 (en) | 2012-02-07 | 2017-02-07 | Roger P. Jackson | Fail-safe release mechanism for use with patient positioning support apparati |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| WO2013171166A1 (en) | 2012-05-14 | 2013-11-21 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp-4 inhibitor for use in the treatment of sirs and/or sepsis |
| WO2013171167A1 (en) | 2012-05-14 | 2013-11-21 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| EP2968344A1 (en) * | 2013-03-15 | 2016-01-20 | Boehringer Ingelheim International GmbH | Use of linagliptin in cardio- and renoprotective antidiabetic therapy |
| EP3110449B1 (en) | 2014-02-28 | 2023-06-28 | Boehringer Ingelheim International GmbH | Medical use of a dpp-4 inhibitor |
| WO2016016853A1 (en) * | 2014-07-31 | 2016-02-04 | Sun Pharmaceutical Industries Limited | Method of controlling carbamoyl impurity in pharmaceutical compositions of dabigatran |
| US9968659B2 (en) | 2016-03-04 | 2018-05-15 | Novo Nordisk A/S | Liraglutide in cardiovascular conditions |
| JP7221694B2 (ja) | 2016-04-28 | 2023-02-14 | ノヴォ ノルディスク アー/エス | 心血管状態におけるセマグルチド |
| EP4233840A3 (en) | 2016-06-10 | 2023-10-18 | Boehringer Ingelheim International GmbH | Combinations of linagliptin and metformin |
| HRP20250272T1 (hr) | 2017-10-19 | 2025-04-25 | Teijin Pharma Limited | Derivati benzimidazola i njihova uporaba |
| WO2019082912A1 (ja) * | 2017-10-27 | 2019-05-02 | 学校法人北里研究所 | 慢性腎臓病の予防又は治療剤 |
| US10828310B2 (en) * | 2018-02-02 | 2020-11-10 | Bayer Pharma Aktiengesellschaft | Reducing the risk of cardiovascular events |
| CN108358925B (zh) * | 2018-02-24 | 2021-04-06 | 中山大学 | 一种7,8-取代-3-甲基黄嘌呤类化合物及其制备方法和应用 |
| WO2020016230A1 (en) * | 2018-07-17 | 2020-01-23 | Boehringer Ingelheim International Gmbh | Cardio- and renosafe antidiabetic therapy |
| WO2020016232A1 (en) * | 2018-07-17 | 2020-01-23 | Boehringer Ingelheim International Gmbh | Cardiosafe antidiabetic therapy |
| WO2022244846A1 (ja) * | 2021-05-19 | 2022-11-24 | Kagami株式会社 | 細胞増殖の調整のための組成物及び細胞増殖の調整方法 |
| CN115137785B (zh) * | 2022-07-21 | 2023-06-20 | 湖北省中医院 | 用于治疗特发性膜性肾病的膜肾方 |
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2013
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- 2013-05-13 EP EP13722419.2A patent/EP2849755A1/en not_active Withdrawn
- 2013-05-13 EP EP20158414.1A patent/EP3685839A1/en not_active Withdrawn
- 2013-05-13 US US13/892,529 patent/US20130303462A1/en not_active Abandoned
- 2013-05-13 JP JP2015512016A patent/JP6224084B2/ja active Active
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| WO2013171167A1 (en) | 2013-11-21 |
| US20190099427A1 (en) | 2019-04-04 |
| US9526730B2 (en) | 2016-12-27 |
| EP2849755A1 (en) | 2015-03-25 |
| JP2019089797A (ja) | 2019-06-13 |
| JP6473208B2 (ja) | 2019-02-20 |
| JP6759373B2 (ja) | 2020-09-23 |
| US20210379073A1 (en) | 2021-12-09 |
| US20130303462A1 (en) | 2013-11-14 |
| EP3685839A1 (en) | 2020-07-29 |
| US20160082011A1 (en) | 2016-03-24 |
| JP2018030872A (ja) | 2018-03-01 |
| JP2015516456A (ja) | 2015-06-11 |
| US20240299399A1 (en) | 2024-09-12 |
| US20170065595A1 (en) | 2017-03-09 |
| US10195203B2 (en) | 2019-02-05 |
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