JP6125430B2 - 低親和性血液脳関門受容体抗体及びその使用 - Google Patents

低親和性血液脳関門受容体抗体及びその使用 Download PDF

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JP6125430B2
JP6125430B2 JP2013542109A JP2013542109A JP6125430B2 JP 6125430 B2 JP6125430 B2 JP 6125430B2 JP 2013542109 A JP2013542109 A JP 2013542109A JP 2013542109 A JP2013542109 A JP 2013542109A JP 6125430 B2 JP6125430 B2 JP 6125430B2
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antibody
tfr
bbb
bace1
compound
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JP2014500886A5 (lt
JP2014500886A (ja
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マーク デニス,
マーク デニス,
ライアン ジェファーソン ワッツ,
ライアン ジェファーソン ワッツ,
ユンホア ジョイ ユイ,
ユンホア ジョイ ユイ,
イン チャン,
イン チャン,
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ジェネンテック, インコーポレイテッド
ジェネンテック, インコーポレイテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6849Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2881Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
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    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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JP2013542109A 2010-11-30 2011-11-29 低親和性血液脳関門受容体抗体及びその使用 Active JP6125430B2 (ja)

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US41822310P 2010-11-30 2010-11-30
US61/418,223 2010-11-30
PCT/US2011/062445 WO2012075037A1 (en) 2010-11-30 2011-11-29 Low affinity blood brain barrier receptor antibodies and uses therefor

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JP2014500886A JP2014500886A (ja) 2014-01-16
JP2014500886A5 JP2014500886A5 (lt) 2015-01-08
JP6125430B2 true JP6125430B2 (ja) 2017-05-10

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JP2017001025A Active JP6490721B2 (ja) 2010-11-30 2017-01-06 低親和性血液脳関門受容体抗体及びその使用
JP2019032385A Active JP6800260B2 (ja) 2010-11-30 2019-02-26 低親和性血液脳関門受容体抗体及びその使用

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US (5) US20120171120A1 (lt)
EP (2) EP3208282A1 (lt)
JP (3) JP6125430B2 (lt)
KR (3) KR102188544B1 (lt)
CN (2) CN110251668A (lt)
AR (1) AR084020A1 (lt)
AU (2) AU2011336716B2 (lt)
BR (1) BR112013013083A2 (lt)
CA (1) CA2818173C (lt)
CL (1) CL2013001535A1 (lt)
CO (1) CO6721052A2 (lt)
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DK (1) DK2646470T3 (lt)
EA (1) EA034333B1 (lt)
EC (1) ECSP13012724A (lt)
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IL (1) IL282877A (lt)
LT (1) LT2646470T (lt)
MA (1) MA34749B1 (lt)
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PT (1) PT2646470T (lt)
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SG (1) SG190900A1 (lt)
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