JP5856980B2 - (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス - Google Patents
(R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス Download PDFInfo
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- JP5856980B2 JP5856980B2 JP2012551175A JP2012551175A JP5856980B2 JP 5856980 B2 JP5856980 B2 JP 5856980B2 JP 2012551175 A JP2012551175 A JP 2012551175A JP 2012551175 A JP2012551175 A JP 2012551175A JP 5856980 B2 JP5856980 B2 JP 5856980B2
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- trifluoromethyl
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- benzyloxy
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- 0 *CC(CC1)c2c1c(cc(cc1)OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)c1[n]2 Chemical compound *CC(CC1)c2c1c(cc(cc1)OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)c1[n]2 0.000 description 3
- VVQFLWDFZUIVDL-ZHACJKMWSA-N CCOC(/C=C1/C(N2CCOCC2)=CCC1)=O Chemical compound CCOC(/C=C1/C(N2CCOCC2)=CCC1)=O VVQFLWDFZUIVDL-ZHACJKMWSA-N 0.000 description 1
- MOIBBQFSBRXTDL-UHFFFAOYSA-N CCOC(CC(CC1)c2c1c(cc(cc1)OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)c1[nH]2)=O Chemical compound CCOC(CC(CC1)c2c1c(cc(cc1)OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)c1[nH]2)=O MOIBBQFSBRXTDL-UHFFFAOYSA-N 0.000 description 1
- MVGWUTBTXDYMND-QGZVFWFLSA-N OC(C[C@@H](CC1)c2c1c1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc1[nH]2)=O Chemical compound OC(C[C@@H](CC1)c2c1c1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc1[nH]2)=O MVGWUTBTXDYMND-QGZVFWFLSA-N 0.000 description 1
- JKEHZGXRXDVGJN-UHFFFAOYSA-N [NH-][NH+](c1ccccc1C1CCCC1)[IH]#CC(F)(F)F Chemical compound [NH-][NH+](c1ccccc1C1CCCC1)[IH]#CC(F)(F)F JKEHZGXRXDVGJN-UHFFFAOYSA-N 0.000 description 1
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- C07C17/00—Preparation of halogenated hydrocarbons
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- C07C17/272—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by addition reactions
- C07C17/278—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by addition reactions of only halogenated hydrocarbons
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D209/82—Carbazoles; Hydrogenated carbazoles
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- C07D209/80—[b, c]- or [b, d]-condensed
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33683510P | 2010-01-27 | 2010-01-27 | |
| US61/336,835 | 2010-01-27 | ||
| PCT/US2011/000153 WO2011094008A1 (en) | 2010-01-27 | 2011-01-27 | Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015103394A Division JP2015154782A (ja) | 2010-01-27 | 2015-05-21 | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518106A JP2013518106A (ja) | 2013-05-20 |
| JP2013518106A5 JP2013518106A5 (enExample) | 2014-02-20 |
| JP5856980B2 true JP5856980B2 (ja) | 2016-02-10 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012551175A Active JP5856980B2 (ja) | 2010-01-27 | 2011-01-27 | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
| JP2015103394A Withdrawn JP2015154782A (ja) | 2010-01-27 | 2015-05-21 | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2015103394A Withdrawn JP2015154782A (ja) | 2010-01-27 | 2015-05-21 | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US8853419B2 (enExample) |
| EP (3) | EP3378854B1 (enExample) |
| JP (2) | JP5856980B2 (enExample) |
| CN (2) | CN103221391B (enExample) |
| CA (1) | CA2786994C (enExample) |
| ES (1) | ES2937386T3 (enExample) |
| SG (3) | SG182610A1 (enExample) |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015154782A (ja) * | 2010-01-27 | 2015-08-27 | アリーナ ファーマシューティカルズ, インコーポレイテッド | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
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| PT2326621T (pt) | 2008-07-23 | 2016-09-12 | Arena Pharm Inc | Derivados de ácido 1,2,3,4-tetrahidrociclopenta[b]indol-3-il) acético substituídos úteis no tratamento de distúrbios autoimunes e inflamatórios |
| PT2342205T (pt) | 2008-08-27 | 2016-07-28 | Arena Pharm Inc | Derivados de ácido tricíclico substituído como agonistas de recetor s1p1 úteis no tratamento de distúrbios autoimunes e inflamatórios |
| WO2011109471A1 (en) | 2010-03-03 | 2011-09-09 | Arena Pharmaceuticals, Inc. | Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof |
| CN102659664B (zh) * | 2012-03-28 | 2015-01-21 | 中国计量学院 | 合成分离拉洛皮兰及其类似物的方法 |
| PL3242666T3 (pl) * | 2015-01-06 | 2025-02-17 | Arena Pharmaceuticals, Inc. | Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1 |
| DK3310760T3 (da) * | 2015-06-22 | 2022-10-24 | Arena Pharm Inc | Krystallinsk L-argininsalt af (R)-2-(7-(4-cyclopentyl-3-(trifluormethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3- yl)eddikesyre til anvendelse ved S1P1-receptor-associerede lidelser |
| CN106349006B (zh) * | 2016-08-26 | 2019-02-05 | 大连奇凯医药科技有限公司 | 3-三氟甲基苯乙腈的制备方法 |
| US11478448B2 (en) * | 2017-02-16 | 2022-10-25 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations |
| CN110520124A (zh) * | 2017-02-16 | 2019-11-29 | 艾尼纳制药公司 | 用于治疗原发性胆汁性胆管炎的化合物和方法 |
| US11066422B2 (en) | 2017-07-13 | 2021-07-20 | Toray Fine Chemicals Co., Ltd. | Method of producing cycloalkyl(trifluoromethyl)benzene |
| BR112020024762A2 (pt) | 2018-06-06 | 2021-03-23 | Arena Pharmaceuticals, Inc. | métodos de tratamento de condições relacionadas ao receptor s1p1 |
| US11555015B2 (en) | 2018-09-06 | 2023-01-17 | Arena Pharmaceuticals, Inc. | Compounds useful in the treatment of autoimmune and inflammatory disorders |
| WO2020072824A1 (en) | 2018-10-03 | 2020-04-09 | Arena Pharmaceuticals, Inc. | Methods for the treatment of scleroderma |
| CN109529920B (zh) * | 2018-11-12 | 2021-11-02 | 山东科技大学 | 用于轻质烷烃异构化的负载硼化钛催化剂及其制备方法和使用方法 |
| CN109678715B (zh) * | 2018-11-28 | 2019-11-12 | 中国药科大学 | 2-(1-酰氧正戊基)苯甲酸与碱性氨基酸或氨基胍形成的盐、其制备方法及用途 |
| CN118649163A (zh) * | 2018-11-30 | 2024-09-17 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病况的方法 |
| CA3124701A1 (en) | 2019-01-08 | 2020-07-16 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
| KR20220074913A (ko) * | 2019-10-01 | 2022-06-03 | 아레나 파마슈티칼스, 인크. | S1p1 수용체와 관련된 상태를 치료하는 방법 |
| PH12022551043A1 (en) | 2019-10-31 | 2023-05-03 | Idorsia Pharmaceuticals Ltd | Combination of a cxcr7 antagonist with an s1p1 receptor modulator |
| EP4061358B1 (en) | 2019-11-20 | 2025-05-28 | Arena Pharmaceuticals, Inc. | Etrasimod for use in the treatment of eosinophilic esophagitis |
| CN111763148B (zh) * | 2020-06-19 | 2022-10-28 | 广州大学 | 一种含三氟甲基的炔基环戊烯衍生物及其制备方法和应用 |
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| IL302816A (en) * | 2020-11-09 | 2023-07-01 | Arena Pharm Inc | Methods of treating conditions related to the s1p1 receptor |
| KR20240013810A (ko) * | 2021-07-02 | 2024-01-30 | 아레나 파마슈티칼스, 인크. | 간 손상을 갖는 개체에의 화합물의 투여 |
| CN118541151A (zh) | 2022-01-13 | 2024-08-23 | 艾尼纳制药公司 | 与激素治疗组合的用于治疗s1p1受体相关病症的伊曲莫德 |
| EP4212156A1 (en) | 2022-01-13 | 2023-07-19 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator |
| WO2023214312A1 (en) | 2022-05-06 | 2023-11-09 | Arena Pharmaceuticals, Inc. | Methods of treating atopic dermatitis with etrasimod |
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| CH480410A (de) | 1967-01-09 | 1969-10-31 | Geigy Ag J R | Verfahren zur Herstellung von wasserlöslichen Azopyrimidinfarbstoffen |
| CA961052A (en) | 1967-01-12 | 1975-01-14 | Max Schellenbaum | N-2-ethylhexyl-n'-aryl ureas and preparation containing them |
| US3608087A (en) | 1968-06-21 | 1971-09-21 | Merck & Co Inc | Feed compositions |
| US3887329A (en) | 1969-05-05 | 1975-06-03 | Ciba Geigy Ag | Hexamethyl phosphotriamide-dye compositions |
| US3686238A (en) | 1970-01-19 | 1972-08-22 | Syntex Corp | Glycerol esterified with 2-naphthyl-acetic acids and fatty acids |
| US3852434A (en) | 1970-09-11 | 1974-12-03 | Merck & Co Inc | Potentiation of ({31 ) cis-1,2-epoxypropyl)phosphonic acid and analogues thereof |
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| US3966744A (en) | 1971-01-11 | 1976-06-29 | Syva Company | Spin labeled compounds |
| DE2106585A1 (de) | 1971-02-11 | 1972-08-24 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Aminothiodiazole und Thiodiazol-Azofarbstoffe |
| DE2226703A1 (de) | 1972-05-25 | 1973-12-13 | Schering Ag | Neue tetrahydrocarbazolderivate und verfahren zu ihrer herstellung |
| US3966764A (en) | 1972-07-10 | 1976-06-29 | Syva Company | Ligand determination of spin labeled compounds by receptor displacement-amphetamine analogs |
| US3849420A (en) | 1972-10-20 | 1974-11-19 | Dow Chemical Co | Bis-(alkylthio-and alkylsulfonyl)-pentachloroquinolines |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015154782A (ja) * | 2010-01-27 | 2015-08-27 | アリーナ ファーマシューティカルズ, インコーポレイテッド | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
Also Published As
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|---|---|
| SG182610A1 (en) | 2012-08-30 |
| CN108558740A (zh) | 2018-09-21 |
| CN103221391B (zh) | 2018-07-06 |
| SG10201906876PA (en) | 2019-09-27 |
| CA2786994C (en) | 2018-01-16 |
| EP4148045A1 (en) | 2023-03-15 |
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| EP3378854B1 (en) | 2022-12-21 |
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| US20120295947A1 (en) | 2012-11-22 |
| CA2786994A1 (en) | 2011-08-04 |
| EP2528894A1 (en) | 2012-12-05 |
| US20140357690A1 (en) | 2014-12-04 |
| US20160016904A1 (en) | 2016-01-21 |
| CN103221391A (zh) | 2013-07-24 |
| WO2011094008A1 (en) | 2011-08-04 |
| US9175320B2 (en) | 2015-11-03 |
| ES2937386T3 (es) | 2023-03-28 |
| CN108558740B (zh) | 2021-10-19 |
| JP2013518106A (ja) | 2013-05-20 |
| SG10201500639TA (en) | 2015-03-30 |
| US8853419B2 (en) | 2014-10-07 |
| US20170159088A1 (en) | 2017-06-08 |
| JP2015154782A (ja) | 2015-08-27 |
| US11149292B2 (en) | 2021-10-19 |
| US11674163B2 (en) | 2023-06-13 |
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