CN103221391B - (R)-2-(7-(4-环戊基-3-(三氟甲基)苄基氧基)-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基)乙酸及其盐的制备方法 - Google Patents

(R)-2-(7-(4-环戊基-3-(三氟甲基)苄基氧基)-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基)乙酸及其盐的制备方法 Download PDF

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CN103221391B
CN103221391B CN201180017115.6A CN201180017115A CN103221391B CN 103221391 B CN103221391 B CN 103221391B CN 201180017115 A CN201180017115 A CN 201180017115A CN 103221391 B CN103221391 B CN 103221391B
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compound
trifluoromethyl
acetic acid
indol
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CN103221391A (zh
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A.G.蒙塔尔班
D.J.布扎德
J.A.德马泰
T.加博伊
S.R.约翰森
A.M.克里什南
Y.M.库尔曼
马友安
M.J.马蒂尼里
S.M.萨托
D.森古普塔
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Arena Pharmaceuticals Inc
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CN201180017115.6A 2010-01-27 2011-01-27 (R)-2-(7-(4-环戊基-3-(三氟甲基)苄基氧基)-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基)乙酸及其盐的制备方法 Active CN103221391B (zh)

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CN201810670853.4A CN108558740B (zh) 2010-01-27 2011-01-27 S1p1受体调节剂及其盐的制备方法

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US33683510P 2010-01-27 2010-01-27
US61/336,835 2010-01-27
PCT/US2011/000153 WO2011094008A1 (en) 2010-01-27 2011-01-27 Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof

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CN106349006B (zh) * 2016-08-26 2019-02-05 大连奇凯医药科技有限公司 3-三氟甲基苯乙腈的制备方法
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CN109678715B (zh) * 2018-11-28 2019-11-12 中国药科大学 2-(1-酰氧正戊基)苯甲酸与碱性氨基酸或氨基胍形成的盐、其制备方法及用途
KR102824401B1 (ko) * 2018-11-30 2025-06-25 아레나 파마슈티칼스, 인크. S1p1 수용체와 관련된 병태의 치료 방법
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KR20220103750A (ko) 2019-11-20 2022-07-22 아레나 파마슈티칼스, 인크. S1p1 수용체와 관련된 상태를 치료하는 방법
CN111763148B (zh) * 2020-06-19 2022-10-28 广州大学 一种含三氟甲基的炔基环戊烯衍生物及其制备方法和应用
CN114105745B (zh) * 2020-08-28 2024-07-23 广东东阳光药业股份有限公司 辛波莫德中间体及其制备方法
JP2023548474A (ja) * 2020-11-09 2023-11-17 アリーナ ファーマシューティカルズ， インコーポレイテッド Ｓ１ｐ１受容体に関連する状態を処置する方法
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