EA201491460A1 - ПРИМЕНЕНИЕ ЛАХИНИМОДА В ЛЕЧЕНИИ ПАЦИЕНТОВ С БОЛЕЗНЬЮ КРОНА, У КОТОРЫХ НЕ ЭФФЕКТИВНА ТЕРАПИЯ ПЕРВОЙ ЛИНИИ АНТИ-TNFα - Google Patents
ПРИМЕНЕНИЕ ЛАХИНИМОДА В ЛЕЧЕНИИ ПАЦИЕНТОВ С БОЛЕЗНЬЮ КРОНА, У КОТОРЫХ НЕ ЭФФЕКТИВНА ТЕРАПИЯ ПЕРВОЙ ЛИНИИ АНТИ-TNFαInfo
- Publication number
- EA201491460A1 EA201491460A1 EA201491460A EA201491460A EA201491460A1 EA 201491460 A1 EA201491460 A1 EA 201491460A1 EA 201491460 A EA201491460 A EA 201491460A EA 201491460 A EA201491460 A EA 201491460A EA 201491460 A1 EA201491460 A1 EA 201491460A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- patient
- disease
- crohn
- tnfα
- lachinimode
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Настоящая заявка предлагает способ лечения пациента, страдающего анти-TNFα рефрактерной формой болезни Крона, лечения пациента, страдающего нестенозирующей формой болезни Крона, и лечения пациента, не получавшего хирургического лечения по поводу болезни Крона, способ включает периодическое введение пациенту лахинимода или его фармацевтически приемлемой соли в количестве, эффективном для лечения пациента. Настоящая заявка предлагает способ индукции или поддержания клинической ремиссии у пациента с болезнью Крона, включающий периодическое введение пациенту лахинимода в количестве, эффективном для индукции или поддержания клинической ремиссии у пациента, указанное количество лахинимода составляет менее 0,5 мг/день.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261595006P | 2012-02-03 | 2012-02-03 | |
PCT/US2013/024356 WO2013116657A1 (en) | 2012-02-03 | 2013-02-01 | USE OF LAQUINIMOD FOR TREATING CROHN'S DISEASE PATIENTS WHO FAILED FIRST-LINE ANTI-TNFα THERAPY |
Publications (1)
Publication Number | Publication Date |
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EA201491460A1 true EA201491460A1 (ru) | 2015-01-30 |
Family
ID=48903432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201491460A EA201491460A1 (ru) | 2012-02-03 | 2013-02-01 | ПРИМЕНЕНИЕ ЛАХИНИМОДА В ЛЕЧЕНИИ ПАЦИЕНТОВ С БОЛЕЗНЬЮ КРОНА, У КОТОРЫХ НЕ ЭФФЕКТИВНА ТЕРАПИЯ ПЕРВОЙ ЛИНИИ АНТИ-TNFα |
Country Status (16)
Country | Link |
---|---|
US (3) | US9161935B2 (ru) |
EP (1) | EP2811832A4 (ru) |
JP (2) | JP2015505564A (ru) |
KR (1) | KR20140138694A (ru) |
CN (2) | CN104093310A (ru) |
AR (1) | AR089862A1 (ru) |
AU (2) | AU2013214909A1 (ru) |
BR (1) | BR112014018485A8 (ru) |
CA (1) | CA2862865A1 (ru) |
EA (1) | EA201491460A1 (ru) |
HK (1) | HK1202776A1 (ru) |
IL (1) | IL233557A0 (ru) |
MX (1) | MX2014009373A (ru) |
SG (1) | SG11201404214QA (ru) |
TW (1) | TW201345527A (ru) |
WO (1) | WO2013116657A1 (ru) |
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US20130259856A1 (en) | 2012-03-27 | 2013-10-03 | Teva Pharmaceutical Industries, Ltd. | Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate |
AR090885A1 (es) | 2012-05-02 | 2014-12-10 | Teva Pharma | Uso de laquinimod en alta dosis para el tratamiento de la esclerosis multiple |
TW201350467A (zh) | 2012-05-08 | 2013-12-16 | Teva Pharma | N-乙基-4-羥基-1-甲基-5-(甲基(2,3,4,5,6-五羥基己基)胺基)-2-側氧-n-苯基-1,2-二氫喹啉-3-甲醯胺 |
TW201400117A (zh) | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
WO2014004733A1 (en) | 2012-06-26 | 2014-01-03 | The Regents Of The University Of California | Composition for lupus nephritis and methods of making and using the same |
AR091706A1 (es) | 2012-07-11 | 2015-02-25 | Teva Pharma | Formulaciones de laquinimod sin agentes alcalinizantes |
UY34896A (es) | 2012-07-12 | 2014-02-28 | Teva Pharma | Tratamiento de la esclerosis múltiple con una combinación de laquinimod y fampridina |
TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療gaba媒介之疾病之拉喹莫德(laquinimod) |
TW201410243A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療大麻素受體型1(cb1)媒介之疾病之拉喹莫德(laquinimod) |
BR112015007782A2 (pt) | 2012-10-12 | 2017-07-04 | Teva Pharma | laquinimod para reduzir danos talâmicos na esclerose múltipla |
MX2015005632A (es) | 2012-11-07 | 2016-02-05 | Teva Pharma | Sales de amina de laquinimod. |
AU2014216199A1 (en) | 2013-02-15 | 2015-09-03 | Teva Pharmaceutical Industries Ltd. | Treatment of progressive forms of multiple sclerosis with laquinimod |
NZ630427A (en) | 2013-03-14 | 2017-06-30 | Teva Pharma | Crystals of laquinimod sodium and improved process for the manufacture thereof |
WO2014152009A1 (en) | 2013-03-14 | 2014-09-25 | Teva Pharmaceutical Industries Ltd. | Transdermal formulations of laquinimod |
US20160331742A1 (en) * | 2014-01-17 | 2016-11-17 | Teva Pharmaceutical Industries, Ltd. | Treatment of crohn's disease using low doses of laquinimod |
-
2013
- 2013-02-01 JP JP2014555758A patent/JP2015505564A/ja not_active Withdrawn
- 2013-02-01 WO PCT/US2013/024356 patent/WO2013116657A1/en active Application Filing
- 2013-02-01 US US13/757,004 patent/US9161935B2/en active Active
- 2013-02-01 EP EP13744015.2A patent/EP2811832A4/en not_active Withdrawn
- 2013-02-01 BR BR112014018485A patent/BR112014018485A8/pt not_active IP Right Cessation
- 2013-02-01 EA EA201491460A patent/EA201491460A1/ru unknown
- 2013-02-01 KR KR1020147024856A patent/KR20140138694A/ko not_active Application Discontinuation
- 2013-02-01 SG SG11201404214QA patent/SG11201404214QA/en unknown
- 2013-02-01 MX MX2014009373A patent/MX2014009373A/es unknown
- 2013-02-01 CN CN201380007766.6A patent/CN104093310A/zh active Pending
- 2013-02-01 CA CA2862865A patent/CA2862865A1/en not_active Abandoned
- 2013-02-01 TW TW102104087A patent/TW201345527A/zh unknown
- 2013-02-01 AU AU2013214909A patent/AU2013214909A1/en not_active Abandoned
- 2013-02-01 CN CN201610357641.1A patent/CN106063787A/zh active Pending
- 2013-02-01 AR ARP130100296A patent/AR089862A1/es unknown
-
2014
- 2014-07-08 IL IL233557A patent/IL233557A0/en unknown
-
2015
- 2015-04-10 HK HK15103524.2A patent/HK1202776A1/xx unknown
- 2015-08-25 US US14/835,123 patent/US20150359788A1/en not_active Abandoned
-
2017
- 2017-01-24 AU AU2017200472A patent/AU2017200472A1/en not_active Abandoned
- 2017-05-26 JP JP2017104049A patent/JP2017200926A/ja not_active Withdrawn
- 2017-06-26 US US15/633,132 patent/US20170290822A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN104093310A (zh) | 2014-10-08 |
BR112014018485A8 (pt) | 2017-07-11 |
SG11201404214QA (en) | 2014-08-28 |
EP2811832A1 (en) | 2014-12-17 |
WO2013116657A1 (en) | 2013-08-08 |
BR112014018485A2 (ru) | 2017-06-20 |
AR089862A1 (es) | 2014-09-24 |
AU2017200472A1 (en) | 2017-02-09 |
US9161935B2 (en) | 2015-10-20 |
US20130203807A1 (en) | 2013-08-08 |
JP2015505564A (ja) | 2015-02-23 |
HK1202776A1 (en) | 2015-10-09 |
JP2017200926A (ja) | 2017-11-09 |
US20170290822A1 (en) | 2017-10-12 |
US20150359788A1 (en) | 2015-12-17 |
EP2811832A4 (en) | 2015-09-23 |
MX2014009373A (es) | 2014-08-27 |
AU2013214909A1 (en) | 2014-09-18 |
KR20140138694A (ko) | 2014-12-04 |
CA2862865A1 (en) | 2013-08-08 |
IL233557A0 (en) | 2014-08-31 |
CN106063787A (zh) | 2016-11-02 |
TW201345527A (zh) | 2013-11-16 |
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