EA201491460A1 - APPLICATION OF LACHINIMODA IN THE TREATMENT OF PATIENTS WITH CRONE'S DISEASE, WHICH ARE NOT EFFECTIVE THERAPY OF THE FIRST LINE ANTI-TNFα - Google Patents

APPLICATION OF LACHINIMODA IN THE TREATMENT OF PATIENTS WITH CRONE'S DISEASE, WHICH ARE NOT EFFECTIVE THERAPY OF THE FIRST LINE ANTI-TNFα

Info

Publication number
EA201491460A1
EA201491460A1 EA201491460A EA201491460A EA201491460A1 EA 201491460 A1 EA201491460 A1 EA 201491460A1 EA 201491460 A EA201491460 A EA 201491460A EA 201491460 A EA201491460 A EA 201491460A EA 201491460 A1 EA201491460 A1 EA 201491460A1
Authority
EA
Eurasian Patent Office
Prior art keywords
patient
disease
crohn
tnfα
lachinimode
Prior art date
Application number
EA201491460A
Other languages
Russian (ru)
Inventor
Нора Тарсик
Аси Хавив
Эран Блаугрунд
Джоэл Кайе
Original Assignee
Тева Фармасьютикал Индастриз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тева Фармасьютикал Индастриз Лтд. filed Critical Тева Фармасьютикал Индастриз Лтд.
Publication of EA201491460A1 publication Critical patent/EA201491460A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Abstract

Настоящая заявка предлагает способ лечения пациента, страдающего анти-TNFα рефрактерной формой болезни Крона, лечения пациента, страдающего нестенозирующей формой болезни Крона, и лечения пациента, не получавшего хирургического лечения по поводу болезни Крона, способ включает периодическое введение пациенту лахинимода или его фармацевтически приемлемой соли в количестве, эффективном для лечения пациента. Настоящая заявка предлагает способ индукции или поддержания клинической ремиссии у пациента с болезнью Крона, включающий периодическое введение пациенту лахинимода в количестве, эффективном для индукции или поддержания клинической ремиссии у пациента, указанное количество лахинимода составляет менее 0,5 мг/день.This application proposes a method for treating a patient suffering from an anti-TNFα refractory form of Crohn's disease, treating a patient suffering from non-nosocilating form of Crohn's disease, and treating a patient not undergoing surgical treatment for Crohn's disease, the method includes periodically administering the patient to Lachinimode or its pharmaceutically acceptable salt an amount effective to treat the patient. This application proposes a method of induction or maintenance of clinical remission in a patient with Crohn's disease, including intermittent administration of lachinimode to the patient in an amount effective to induce or maintain clinical remission in a patient, the indicated amount of lachinimode is less than 0.5 mg / day.

EA201491460A 2012-02-03 2013-02-01 APPLICATION OF LACHINIMODA IN THE TREATMENT OF PATIENTS WITH CRONE'S DISEASE, WHICH ARE NOT EFFECTIVE THERAPY OF THE FIRST LINE ANTI-TNFα EA201491460A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261595006P 2012-02-03 2012-02-03
PCT/US2013/024356 WO2013116657A1 (en) 2012-02-03 2013-02-01 USE OF LAQUINIMOD FOR TREATING CROHN'S DISEASE PATIENTS WHO FAILED FIRST-LINE ANTI-TNFα THERAPY

Publications (1)

Publication Number Publication Date
EA201491460A1 true EA201491460A1 (en) 2015-01-30

Family

ID=48903432

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491460A EA201491460A1 (en) 2012-02-03 2013-02-01 APPLICATION OF LACHINIMODA IN THE TREATMENT OF PATIENTS WITH CRONE'S DISEASE, WHICH ARE NOT EFFECTIVE THERAPY OF THE FIRST LINE ANTI-TNFα

Country Status (16)

Country Link
US (3) US9161935B2 (en)
EP (1) EP2811832A4 (en)
JP (2) JP2015505564A (en)
KR (1) KR20140138694A (en)
CN (2) CN106063787A (en)
AR (1) AR089862A1 (en)
AU (2) AU2013214909A1 (en)
BR (1) BR112014018485A8 (en)
CA (1) CA2862865A1 (en)
EA (1) EA201491460A1 (en)
HK (1) HK1202776A1 (en)
IL (1) IL233557A0 (en)
MX (1) MX2014009373A (en)
SG (1) SG11201404214QA (en)
TW (1) TW201345527A (en)
WO (1) WO2013116657A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2234485T1 (en) 2007-12-20 2014-03-31 Teva Pharmaceutical Industries Ltd. Stable laquinimod preparations
EP4148045A1 (en) 2010-01-27 2023-03-15 Arena Pharmaceuticals, Inc. Intermediate compounds for the preparation of (r)-2-(7-(4-cyclopentyl-3- (trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b] indol-3-yl)acetic acid and salts thereof
US8889627B2 (en) 2011-10-12 2014-11-18 Teva Pharmaceutical Industries, Ltd. Treatment of multiple sclerosis with combination of laquinimod and fingolimod
US9284276B2 (en) 2012-02-16 2016-03-15 Teva Pharmaceutical Industries, Ltd. N-ethyl-N-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide, preparation and uses thereof
TW201400117A (en) 2012-06-05 2014-01-01 Teva Pharma Treatment of ocular inflammatory disease using laquinimod
TW201410244A (en) 2012-08-13 2014-03-16 Teva Pharma Laquinimod for treatment of GABA mediated disorders
MX2015005632A (en) 2012-11-07 2016-02-05 Teva Pharma Amine salts of laquinimod.
NZ630427A (en) 2013-03-14 2017-06-30 Teva Pharma Crystals of laquinimod sodium and improved process for the manufacture thereof
EP3094330A4 (en) * 2014-01-17 2017-09-27 Teva Pharmaceutical Industries Ltd Treatment of crohn's disease using low doses of laquinimod
AU2015253330A1 (en) 2014-04-29 2016-12-01 Teva Pharmaceutical Industries Ltd. Laquinimod for the treatment of relapsing-remitting multiple sclerosis (RRMS) patients with a high disability status
PL3310760T3 (en) 2015-06-22 2023-03-06 Arena Pharmaceuticals, Inc. Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid for use in s1p1 receptor-associated disorders
CN108290058B (en) * 2015-09-17 2023-05-16 美国安进公司 Predicting clinical response of IL23 antagonists using IL23 pathway biomarkers
CN110545848A (en) 2017-02-16 2019-12-06 艾尼纳制药公司 Compounds and methods for treating inflammatory bowel disease with extra-intestinal manifestations
CN110520124A (en) 2017-02-16 2019-11-29 艾尼纳制药公司 For treating the Compounds and methods for of primary biliary cholangitis
CA3120706A1 (en) * 2018-11-30 2020-06-04 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3024257A (en) 1961-04-10 1962-03-06 Frosst & Co Charles E Stable preparations of alkali metal salts of estrone sulfate
FR2340735A1 (en) 1976-02-11 1977-09-09 Roussel Uclaf NEW DERIVATIVES OF 3-QUINOLEINE CARBOXYLIC ACID, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS A MEDICINAL PRODUCT
IE52670B1 (en) 1981-03-03 1988-01-20 Leo Ab Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
DE3437232A1 (en) 1984-10-10 1986-04-17 Mack Chem Pharm STABILIZED INJECTION SOLUTIONS FROM PIROXICAM
US4782155A (en) 1986-03-19 1988-11-01 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, processes for their preparation and antibacterial agents
US5139878A (en) 1991-08-12 1992-08-18 Allied-Signal Inc. Multilayer film constructions
US5540934A (en) 1994-06-22 1996-07-30 Touitou; Elka Compositions for applying active substances to or through the skin
US5912349A (en) 1997-01-31 1999-06-15 Pharmacia & Upjohn Company Process for the preparation of roquinimex
US20030124187A1 (en) 1997-02-14 2003-07-03 Smithkline Beecham Laboratoires Pharmaceutiques, Pharmaceutical formulations comprising amoxycillin and clavulanate
US6696407B1 (en) 1997-03-21 2004-02-24 The Regents Of The University Of California Huntington's disease treatment comprising administering aldose reductase inhibitors to increase striatal CNTF
GB9726339D0 (en) 1997-12-13 1998-02-11 Zeneca Ltd Human-derived tissue-specific potassium channel
US6077851A (en) * 1998-04-27 2000-06-20 Active Biotech Ab Quinoline derivatives
SE9801474D0 (en) 1998-04-27 1998-04-27 Active Biotech Ab Quinoline Derivatives
US6133285A (en) 1998-07-15 2000-10-17 Active Biotech Ab Quinoline derivatives
US6121287A (en) 1998-07-15 2000-09-19 Active Biotech Ab Quinoline derivatives
SE9802550D0 (en) 1998-07-15 1998-07-15 Active Biotech Ab Quinoline derivatives
SE9802549D0 (en) 1998-07-15 1998-07-15 Active Biotech Ab Quinoline derivatives
US6395750B1 (en) 1999-10-25 2002-05-28 Active Biotech Ab Drugs for the treatment of malignant tumors
AU2001278981A1 (en) 2000-07-21 2002-02-05 Tom F Lue Prevention and treatment of sexual arousal disorders
US6307050B1 (en) 2000-08-29 2001-10-23 R. T. Alamo Venture I Llc Method of synthesizing flosequinan from 4-fluoroanthranilic acid
US6802422B2 (en) 2000-12-12 2004-10-12 Multi-Comp, Inc. Sealed blister assembly
US6706733B2 (en) 2001-05-08 2004-03-16 Dainippon Ink And Chemicals, Inc. Quinolinone derivative formulation and its production method
US20030119826A1 (en) 2001-09-24 2003-06-26 Pharmacia Corporation Neuroprotective treatment methods using selective iNOS inhibitors
US7560557B2 (en) 2002-06-12 2009-07-14 Active Biotech Ag Process for the manufacture of quinoline derivatives
SE0201778D0 (en) 2002-06-12 2002-06-12 Active Biotech Ab Process for the manufacture of quinoline derivatives
US6875869B2 (en) 2002-06-12 2005-04-05 Active Biotech Ab Process for the manufacture of quinoline derivatives
ES2282667T3 (en) * 2002-06-25 2007-10-16 Merck Frosst Canada Ltd. PDE4 INHIBITORS 8- (BIARIL) QUINOLINAS.
US20070292461A1 (en) 2003-08-04 2007-12-20 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US7820145B2 (en) 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US7790197B2 (en) 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US20050271717A1 (en) 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
AR044927A1 (en) 2003-06-25 2005-10-12 Elan Pharm Inc METHODS AND COMPOSITIONS TO TREAT REUMATOID ARTHRITIS
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
SE0400235D0 (en) 2004-02-06 2004-02-06 Active Biotech Ab New composition containing quinoline compounds
US8314124B2 (en) 2004-02-06 2012-11-20 Active Biotech Ab Crystalline salts of quinoline compounds and methods for preparing them
US20060004019A1 (en) 2004-04-01 2006-01-05 Ivan Lieberburg Steroid sparing agents and methods of using same
US20090048181A1 (en) 2004-09-02 2009-02-19 Schipper Hyman M Combination therapy with glatiramer acetate and n-acetylcysteine for the treatment of multiple sclerosis
PL1797109T3 (en) 2004-09-09 2016-11-30 Mixtures of polypeptides, compositions containing and processes for preparing same, and uses thereof
US20060205822A1 (en) 2004-12-22 2006-09-14 Forest Laboratories, Inc. 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect
WO2006076681A2 (en) 2005-01-13 2006-07-20 Sirtris Pharmaceuticals, Inc. Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders
JP2008545739A (en) 2005-06-02 2008-12-18 グレンマーク・ファーマシューティカルズ・エスエー Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and methods for their preparation
US9168286B2 (en) 2005-10-13 2015-10-27 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive disease
EA015860B1 (en) 2005-10-13 2011-12-30 Хьюман Дженом Сайенсиз, Инк. Methods for treatment of autoimmune diseases using neutrokine-alpha antagonist
UA92761C2 (en) 2005-10-19 2010-12-10 Тева Фармасьютикл Индастриз, Лтд. urn:schemas-microsoft-com:office:smarttagsCRYSTALSOF LAQUINIMOD SODIUM, AND PROCESS FOR THE MANUFACTURE THEREOF
SI1951674T1 (en) 2005-10-26 2012-01-31 Merck Serono Sa Sulfonamide derivatives and use thereof for the modulation of metalloproteinases
US20080108641A1 (en) 2006-02-08 2008-05-08 Ajami Alfred M Compounds for treating inflammatory disorders, demyelinating disdorders and cancers
US8367629B2 (en) 2006-02-14 2013-02-05 Noxxon Pharma Ag MCP-1 binding nucleic acids and use thereof
US8410115B2 (en) 2006-02-28 2013-04-02 Elan Pharmaceuticals, Inc. Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds
EP3620469A1 (en) 2006-02-28 2020-03-11 Biogen MA Inc. Methods of treating inflammatory and autoimmune diseases with natalizumab
MX2008011176A (en) 2006-03-03 2008-09-10 Elan Pharm Inc Methods of treating inflammatory and autoimmune diseases with natalizumab.
EP2001510A4 (en) 2006-03-16 2010-06-09 Genentech Inc Methods of treating lupus using cd4 antibodies
EP2010214A4 (en) 2006-04-10 2010-06-16 Abbott Biotech Ltd Uses and compositions for treatment of rheumatoid arthritis
WO2007146331A1 (en) 2006-06-12 2007-12-21 Teva Pharmaceutical Industries, Ltd. Tannate salt form of polypeptide mixtures, their preparation and use
AU2007258366B2 (en) 2006-06-12 2012-10-25 Active Biotech, Ab Stable laquinimod preparations
JP2009543823A (en) 2006-07-17 2009-12-10 ノバルティス アクチエンゲゼルシャフト Sulfonylaminocarbonyl derivatives of bile acid amides for use as immunomodulators
EP1886996A1 (en) 2006-08-10 2008-02-13 Ferrer Internacional, S.A. 1H-Quinolin-4-one compounds, with affinity for the GABA receptor, processes, uses and compositions
WO2008021368A2 (en) 2006-08-11 2008-02-21 The Johns Hopkins University Compositions and methods for neuroprotection
BRPI0715950A2 (en) 2006-08-17 2013-07-30 Univ Chicago treatment of inflammatory diseases
WO2008085484A2 (en) 2006-12-28 2008-07-17 Jacobus Pharmaceutical Company, Inc. Treatment of inflammatory bowel disease with enteric coated formulations comprising 5-aminosalicylic acid or 4-aminosalicylic acid
EP2567699A1 (en) 2007-07-11 2013-03-13 MediciNova, Inc. Treatment of progressive neurodegenerative disease with ibudilast
WO2009053070A1 (en) 2007-10-23 2009-04-30 Schwarz Pharma Ag Compounds for treating demyelination conditions
SI2234485T1 (en) 2007-12-20 2014-03-31 Teva Pharmaceutical Industries Ltd. Stable laquinimod preparations
ES2329327B1 (en) 2008-03-19 2010-09-17 Proyecto De Biomedicina Cima, S.L. 5'-METHYLTIOADENOSINE SYNERGIC COMBINATIONS.
EA021227B1 (en) 2008-09-03 2015-05-29 Тева Фармасьютикал Индастриз Лтд. 2-oxo-1,2-dihydro-quinoline modulators of immune function
TW201438738A (en) 2008-09-16 2014-10-16 Genentech Inc Methods for treating progressive multiple sclerosis
TWI404721B (en) 2009-01-26 2013-08-11 Pfizer Amino-heterocyclic compounds
UY32427A (en) 2009-02-13 2010-09-30 Boheringer Ingelheim Internat Gmbh PHARMACEUTICAL COMPOSITION, PHARMACEUTICAL FORM, PROCEDURE FOR PREPARATION, METHODS OF TREATMENT AND USES OF THE SAME
NZ597378A (en) 2009-06-19 2014-08-29 Teva Pharma Treatment of multiple sclerosis with laquinimod
ES2564931T3 (en) * 2009-07-30 2016-03-30 Teva Pharmaceutical Industries Ltd. Crohn's disease treatment with laquinimod
DK2467372T3 (en) 2009-08-10 2016-08-22 Teva Pharma TREATMENT OF BDNF-RELATED DISEASES USING LAQUINIMOD
DE102010026879A1 (en) * 2010-02-11 2011-08-11 AMW GmbH, 83627 Transdermal system, useful for indicating and preventing multiple sclerosis, immunomodulator including quinolines or isoxazoles, metabolite forming groups, skin protective layer, a reservoir and a carrier impermeable to active substance
PT2542079E (en) 2010-03-03 2014-07-18 Teva Pharma Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate
SG183515A1 (en) 2010-03-03 2012-10-30 Teva Pharma Treatment of lupus arthritis using laquinimod
PE20130613A1 (en) 2010-03-03 2013-06-23 Teva Pharma TREATMENT OF LUPUS NEFRITIS USING LAQUINIMOD
KR20130092558A (en) 2010-07-09 2013-08-20 테바 파마슈티컬 인더스트리즈 리미티드 Deuterated n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof
US20120010239A1 (en) 2010-07-09 2012-01-12 Ulf Tomas Fristedt 5-chloro-4-hydroxy-1-methyl-2-oxo-n-phenyl-1,2-dihydroquinoline-3-carboxamide, salts and uses thereof
NZ611628A (en) 2010-12-07 2015-06-26 Teva Pharma Use of laquinimod for reducing fatigue, improving functional status, and improving quality of life in multiple sclerosis patients
EP2691393B1 (en) 2011-03-31 2016-09-14 Pfizer Inc Novel bicyclic pyridinones
SG10201606204TA (en) 2011-07-28 2016-09-29 Teva Pharma Treatment Of Multiple Sclerosis With Combination Of Laquinimod And Interferon-Beta
PE20142319A1 (en) 2011-07-28 2015-01-24 Teva Pharma MULTIPLE SCLEROSIS TREATMENT WITH A COMBINATION OF LAQUINIMOD AND GLATIRAMER ACETATE
US8889627B2 (en) 2011-10-12 2014-11-18 Teva Pharmaceutical Industries, Ltd. Treatment of multiple sclerosis with combination of laquinimod and fingolimod
US9284276B2 (en) 2012-02-16 2016-03-15 Teva Pharmaceutical Industries, Ltd. N-ethyl-N-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide, preparation and uses thereof
US20130259856A1 (en) 2012-03-27 2013-10-03 Teva Pharmaceutical Industries, Ltd. Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate
TW201347762A (en) 2012-05-02 2013-12-01 Teva Pharma Use of high dose laquinimod for treating multiple sclerosis
TW201350467A (en) 2012-05-08 2013-12-16 Teva Pharma N-ethyl-4-hydroxyl-1-methyl-5-(methyl(2,3,4,5,6-pentahydroxyhexyl)amino)-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide
TW201400117A (en) 2012-06-05 2014-01-01 Teva Pharma Treatment of ocular inflammatory disease using laquinimod
US20130345257A1 (en) 2012-06-26 2013-12-26 The Regents Of The University Of California Composition for lupus nephritis and methods of making and using the same
AR091706A1 (en) 2012-07-11 2015-02-25 Teva Pharma LAQUINIMOD FORMULATIONS WITHOUT ALKALINIZING AGENTS
UY34896A (en) 2012-07-12 2014-02-28 Teva Pharma TREATMENT OF MULTIPLE SCLEROSIS WITH A COMBINATION OF LAQUINIMOD AND FAMPRIDINE
TW201410243A (en) 2012-08-13 2014-03-16 Teva Pharma Laquinimod for treatment of cannabinoid receptor type 1 (CB1) mediated disorders
TW201410244A (en) 2012-08-13 2014-03-16 Teva Pharma Laquinimod for treatment of GABA mediated disorders
EP2961406A4 (en) 2012-10-12 2017-01-04 Teva Pharmaceutical Industries Ltd. Laquinimod for reducing thalamic damage in multiple sclerosis
MX2015005632A (en) 2012-11-07 2016-02-05 Teva Pharma Amine salts of laquinimod.
AU2014216199A1 (en) 2013-02-15 2015-09-03 Teva Pharmaceutical Industries Ltd. Treatment of progressive forms of multiple sclerosis with laquinimod
NZ630427A (en) 2013-03-14 2017-06-30 Teva Pharma Crystals of laquinimod sodium and improved process for the manufacture thereof
EP2968203A1 (en) 2013-03-14 2016-01-20 Teva Pharmaceutical Industries Ltd. Transdermal formulations of laquinimod
EP3094330A4 (en) * 2014-01-17 2017-09-27 Teva Pharmaceutical Industries Ltd Treatment of crohn's disease using low doses of laquinimod

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MX2014009373A (en) 2014-08-27
JP2017200926A (en) 2017-11-09
AU2013214909A1 (en) 2014-09-18
CN106063787A (en) 2016-11-02
KR20140138694A (en) 2014-12-04
US9161935B2 (en) 2015-10-20
US20170290822A1 (en) 2017-10-12
BR112014018485A2 (en) 2017-06-20
BR112014018485A8 (en) 2017-07-11
US20150359788A1 (en) 2015-12-17
SG11201404214QA (en) 2014-08-28
HK1202776A1 (en) 2015-10-09
IL233557A0 (en) 2014-08-31
EP2811832A4 (en) 2015-09-23
TW201345527A (en) 2013-11-16
US20130203807A1 (en) 2013-08-08
EP2811832A1 (en) 2014-12-17
AR089862A1 (en) 2014-09-24
AU2017200472A1 (en) 2017-02-09
CN104093310A (en) 2014-10-08
JP2015505564A (en) 2015-02-23
CA2862865A1 (en) 2013-08-08
WO2013116657A1 (en) 2013-08-08

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