EA200971053A1 - Способы лечения кожных язв - Google Patents
Способы лечения кожных язвInfo
- Publication number
- EA200971053A1 EA200971053A1 EA200971053A EA200971053A EA200971053A1 EA 200971053 A1 EA200971053 A1 EA 200971053A1 EA 200971053 A EA200971053 A EA 200971053A EA 200971053 A EA200971053 A EA 200971053A EA 200971053 A1 EA200971053 A1 EA 200971053A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- ulcers
- lead
- treatment
- skin ulcers
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01004—Phospholipase A2 (3.1.1.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
Abstract
Предложены способы лечения и/или профилактики кожных язв, отличающиеся введением фармацевтических композиций, включающих ингибиторы активности или экспрессии белка Лп-ФЛА, пациентам, страдающим кожными язвами, или с риском развития кожных язв.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92875907P | 2007-05-11 | 2007-05-11 | |
PCT/US2008/063239 WO2008141176A1 (en) | 2007-05-11 | 2008-05-09 | Methods of treatment of skin ulcers |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200971053A1 true EA200971053A1 (ru) | 2010-06-30 |
EA018101B1 EA018101B1 (ru) | 2013-05-30 |
Family
ID=40002610
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200971053A EA018101B1 (ru) | 2007-05-11 | 2008-05-09 | Способы лечения кожных язв |
Country Status (12)
Country | Link |
---|---|
US (2) | US9029383B2 (ru) |
EP (1) | EP2155225B1 (ru) |
JP (1) | JP5437996B2 (ru) |
KR (1) | KR101563753B1 (ru) |
CN (2) | CN105748480A (ru) |
AU (1) | AU2008251467B2 (ru) |
BR (1) | BRPI0810336A2 (ru) |
CA (1) | CA2687079A1 (ru) |
EA (1) | EA018101B1 (ru) |
ES (1) | ES2548878T3 (ru) |
MX (1) | MX2009012197A (ru) |
WO (1) | WO2008141176A1 (ru) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9029383B2 (en) | 2007-05-11 | 2015-05-12 | The Trustees Of The University Of Pennsylvania | Methods of treatment of skin ulcers |
AR084153A1 (es) | 2010-12-06 | 2013-04-24 | Glaxo Group Ltd | Derivados de pirimidinona |
JP2013545792A (ja) | 2010-12-17 | 2013-12-26 | グラクソ グループ リミテッド | 眼疾患の処置および防止方法 |
AU2012288865B2 (en) | 2011-07-27 | 2015-10-01 | Glaxo Group Limited | Bicyclic pyrimidone compounds |
BR112014001665A2 (pt) | 2011-07-27 | 2017-02-14 | Glaxo Group Ltd | compostos de 2,3-di-hidroimidazo[1,2-c]pirimidin-5(1h)-ona utilizados como inibidores de lp-plaz |
WO2013030374A1 (en) * | 2011-09-01 | 2013-03-07 | Glaxo Group Limited | Novel crystal form |
US9492682B2 (en) * | 2011-09-14 | 2016-11-15 | Medicis Pharmaceutical Corporation | Combination therapy with low dosage strength imiquimod and photodynamic therapy to treat actinic keratosis |
CA2899091A1 (en) | 2013-01-25 | 2014-07-31 | Glaxosmithkline Intellectual Property Development Limited | Compounds |
KR20150108896A (ko) | 2013-01-25 | 2015-09-30 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | Lp-pla2의 억제제로서의 비시클릭 피리미돈 화합물 |
US9296755B2 (en) | 2013-01-25 | 2016-03-29 | Glaxosmithkline Intellectual Property Development Limited | 3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one compounds and their therapeutic applications |
EP2764866A1 (en) | 2013-02-07 | 2014-08-13 | IP Gesellschaft für Management mbH | Inhibitors of nedd8-activating enzyme |
CN103789401A (zh) * | 2014-02-14 | 2014-05-14 | 苏州莱泰生物科技有限公司 | 用于特异测定蛋白磷脂酶pla2g7活性的化合物 |
WO2016012916A1 (en) | 2014-07-22 | 2016-01-28 | Glaxosmithkline Intellectual Property Development Limited | 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2 |
WO2016012917A1 (en) | 2014-07-22 | 2016-01-28 | Glaxosmithkline Intellectual Property Development Limited | 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2 |
RU2605286C1 (ru) * | 2015-11-22 | 2016-12-20 | Алексей Александрович Боклин | Способ лечения оперированных больных с синдромом диабетической стопы |
CN109289048B (zh) * | 2018-08-08 | 2021-05-25 | 南京工业大学 | 一种肿瘤血管阻断协同光治疗试剂及其合成方法与应用 |
WO2020121179A1 (en) * | 2018-12-11 | 2020-06-18 | Universita' Degli Studi Di Salerno | Composition for the treatment of skin lesions |
EP4056571A4 (en) | 2019-11-09 | 2024-01-24 | Shanghai Simr Biotechnology Co Ltd | TRICYCLIC DIHYDROIMIDAZOPYRIMIDONE DERIVATIVE, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF |
CN115304620A (zh) | 2021-05-07 | 2022-11-08 | 上海赛默罗生物科技有限公司 | 嘧啶酮衍生物、其制备方法、药物组合物和用途 |
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US9029383B2 (en) | 2007-05-11 | 2015-05-12 | The Trustees Of The University Of Pennsylvania | Methods of treatment of skin ulcers |
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2008
- 2008-05-09 US US12/599,601 patent/US9029383B2/en active Active
- 2008-05-09 CN CN201610072982.4A patent/CN105748480A/zh active Pending
- 2008-05-09 ES ES08769397.4T patent/ES2548878T3/es active Active
- 2008-05-09 KR KR1020097025753A patent/KR101563753B1/ko not_active IP Right Cessation
- 2008-05-09 CN CN200880024065A patent/CN101687009A/zh active Pending
- 2008-05-09 JP JP2010508514A patent/JP5437996B2/ja not_active Expired - Fee Related
- 2008-05-09 EA EA200971053A patent/EA018101B1/ru not_active IP Right Cessation
- 2008-05-09 MX MX2009012197A patent/MX2009012197A/es active IP Right Grant
- 2008-05-09 BR BRPI0810336-4A patent/BRPI0810336A2/pt not_active IP Right Cessation
- 2008-05-09 WO PCT/US2008/063239 patent/WO2008141176A1/en active Application Filing
- 2008-05-09 EP EP08769397.4A patent/EP2155225B1/en not_active Not-in-force
- 2008-05-09 AU AU2008251467A patent/AU2008251467B2/en not_active Ceased
- 2008-05-09 CA CA 2687079 patent/CA2687079A1/en not_active Abandoned
-
2015
- 2015-04-21 US US14/691,786 patent/US20150297597A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2008251467A1 (en) | 2008-11-20 |
KR20100017747A (ko) | 2010-02-16 |
JP2010526883A (ja) | 2010-08-05 |
EP2155225A1 (en) | 2010-02-24 |
MX2009012197A (es) | 2010-01-15 |
CN105748480A (zh) | 2016-07-13 |
EP2155225A4 (en) | 2010-09-01 |
WO2008141176A1 (en) | 2008-11-20 |
EP2155225B1 (en) | 2015-07-08 |
US9029383B2 (en) | 2015-05-12 |
JP5437996B2 (ja) | 2014-03-12 |
EA018101B1 (ru) | 2013-05-30 |
BRPI0810336A2 (pt) | 2019-03-19 |
CN101687009A (zh) | 2010-03-31 |
AU2008251467B2 (en) | 2014-07-31 |
US20150297597A1 (en) | 2015-10-22 |
ES2548878T3 (es) | 2015-10-21 |
US20100239565A1 (en) | 2010-09-23 |
KR101563753B1 (ko) | 2015-10-27 |
CA2687079A1 (en) | 2008-11-20 |
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