JP5539607B2 - ポリマー−ｖｉｉｉ因子部分結合体 - Google Patents

ポリマー−ｖｉｉｉ因子部分結合体 Download PDF

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Publication number
JP5539607B2
JP5539607B2 JP2006503916A JP2006503916A JP5539607B2 JP 5539607 B2 JP5539607 B2 JP 5539607B2 JP 2006503916 A JP2006503916 A JP 2006503916A JP 2006503916 A JP2006503916 A JP 2006503916A JP 5539607 B2 JP5539607 B2 JP 5539607B2
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factor viii
composition
poly
moiety
conjugate
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JP2006519238A5 (cg-RX-API-DMAC7.html
JP2006519238A (ja
Inventor
ジェイ． ボサード，メアリー
ディー． ベントレイ，マイケル
チャン，ピン
Original Assignee
ウェルズ ファーゴ バンク ナショナル アソシエイション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
JP2006503916A 2003-02-26 2004-02-26 ポリマー−ｖｉｉｉ因子部分結合体 Expired - Lifetime JP5539607B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45057803P 2003-02-26 2003-02-26
US60/450,578 2003-02-26
PCT/US2004/006034 WO2004075923A2 (en) 2003-02-26 2004-02-26 Polymer-factor viii moiety conjugates

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011156978A Division JP2012025747A (ja) 2003-02-26 2011-07-15 ポリマー−ｖｉｉｉ因子部分結合体

Publications (3)

Publication Number Publication Date
JP2006519238A JP2006519238A (ja) 2006-08-24
JP2006519238A5 JP2006519238A5 (cg-RX-API-DMAC7.html) 2007-02-08
JP5539607B2 true JP5539607B2 (ja) 2014-07-02

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Family Applications (2)

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JP2006503916A Expired - Lifetime JP5539607B2 (ja) 2003-02-26 2004-02-26 ポリマー−ｖｉｉｉ因子部分結合体
JP2011156978A Withdrawn JP2012025747A (ja) 2003-02-26 2011-07-15 ポリマー−ｖｉｉｉ因子部分結合体

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US (13) US7199223B2 (cg-RX-API-DMAC7.html)
EP (4) EP2572733A1 (cg-RX-API-DMAC7.html)
JP (2) JP5539607B2 (cg-RX-API-DMAC7.html)
KR (1) KR101085375B1 (cg-RX-API-DMAC7.html)
CN (2) CN1767857A (cg-RX-API-DMAC7.html)
AU (2) AU2004215912B2 (cg-RX-API-DMAC7.html)
BE (1) BE2022C541I2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0407882B1 (cg-RX-API-DMAC7.html)
CA (2) CA2517369C (cg-RX-API-DMAC7.html)
CY (1) CY1125235T1 (cg-RX-API-DMAC7.html)
DK (1) DK1596887T3 (cg-RX-API-DMAC7.html)
ES (1) ES2911435T3 (cg-RX-API-DMAC7.html)
FR (1) FR22C1043I2 (cg-RX-API-DMAC7.html)
HU (1) HUE058897T2 (cg-RX-API-DMAC7.html)
IL (1) IL170424A (cg-RX-API-DMAC7.html)
LT (1) LT1596887T (cg-RX-API-DMAC7.html)
MX (1) MXPA05009169A (cg-RX-API-DMAC7.html)
NL (1) NL301184I2 (cg-RX-API-DMAC7.html)
PT (1) PT1596887T (cg-RX-API-DMAC7.html)
SI (1) SI1596887T1 (cg-RX-API-DMAC7.html)
WO (1) WO2004075923A2 (cg-RX-API-DMAC7.html)

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