PT2966083T - Método de preparação melhorado para produção de alto rendimento de conjugado de polipéptido fisiologicamente ativo - Google Patents
Método de preparação melhorado para produção de alto rendimento de conjugado de polipéptido fisiologicamente ativoInfo
- Publication number
- PT2966083T PT2966083T PT14760968T PT14760968T PT2966083T PT 2966083 T PT2966083 T PT 2966083T PT 14760968 T PT14760968 T PT 14760968T PT 14760968 T PT14760968 T PT 14760968T PT 2966083 T PT2966083 T PT 2966083T
- Authority
- PT
- Portugal
- Prior art keywords
- physiologically active
- active polypeptide
- polypeptide conjugate
- yield production
- improved preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20130023602 | 2013-03-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2966083T true PT2966083T (pt) | 2019-09-17 |
Family
ID=51491612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT14760968T PT2966083T (pt) | 2013-03-05 | 2014-03-05 | Método de preparação melhorado para produção de alto rendimento de conjugado de polipéptido fisiologicamente ativo |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US10660940B2 (pt) |
| EP (1) | EP2966083B1 (pt) |
| JP (1) | JP6374412B2 (pt) |
| KR (1) | KR102136336B1 (pt) |
| CN (2) | CN110590903A (pt) |
| AR (1) | AR094987A1 (pt) |
| AU (1) | AU2014226741B2 (pt) |
| BR (1) | BR112015021764B1 (pt) |
| CA (1) | CA2903365C (pt) |
| ES (1) | ES2743612T3 (pt) |
| HK (1) | HK1217717A1 (pt) |
| IL (1) | IL240869B (pt) |
| MX (1) | MX367817B (pt) |
| MY (1) | MY186423A (pt) |
| NZ (1) | NZ712948A (pt) |
| PH (1) | PH12015501952B1 (pt) |
| PT (1) | PT2966083T (pt) |
| RU (1) | RU2677796C9 (pt) |
| SA (1) | SA515360980B1 (pt) |
| SG (1) | SG11201506937RA (pt) |
| TW (1) | TWI647240B (pt) |
| WO (1) | WO2014137161A1 (pt) |
| ZA (1) | ZA201507312B (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR081755A1 (es) * | 2010-04-02 | 2012-10-17 | Hanmi Holdings Co Ltd | Formulacion de accion prolongada de la hormona estimuladora de los foliculos donde se usa un fragmento de inmunoglobulina, metodo de preparacion y metodo para tratar a un sujeto que sufre un trastorno reproductivo |
| KR20130049671A (ko) | 2011-11-04 | 2013-05-14 | 한미사이언스 주식회사 | 생리활성 폴리펩타이드 결합체 제조 방법 |
| AR090281A1 (es) * | 2012-03-08 | 2014-10-29 | Hanmi Science Co Ltd | Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo |
| EP3689914A4 (en) * | 2017-09-29 | 2021-08-25 | Hanmi Pharm. Co., Ltd. | PERSISTENT PROTEIN CONJUGATE WITH IMPROVED EFFICIENCY |
| JP7394207B2 (ja) | 2019-07-18 | 2023-12-07 | ハンミ ファーマシューティカル カンパニー リミテッド | 新規な中間体製造による持続型薬物結合体の製造方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8824591D0 (en) | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Fractionation process |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| DE69731289D1 (de) | 1996-03-18 | 2004-11-25 | Univ Texas | Immunglobulinähnliche domäne mit erhöhten halbwertszeiten |
| WO2001083525A2 (en) | 2000-05-03 | 2001-11-08 | Amgen Inc. | Modified peptides, comprising an fc domain, as therapeutic agents |
| US20040062748A1 (en) * | 2002-09-30 | 2004-04-01 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| ES2911435T3 (es) * | 2003-02-26 | 2022-05-19 | Nektar Therapeutics | Conjugados de polímero-resto de Factor VIII |
| ES2372495T3 (es) | 2003-11-13 | 2012-01-20 | Hanmi Holdings Co., Ltd | Método para la producción en masa de la región constante de inmunoglobulina. |
| KR101135244B1 (ko) * | 2007-11-29 | 2012-04-24 | 한미사이언스 주식회사 | 인슐린 분비 펩타이드 결합체를 포함하는 비만 관련질환 치료용 조성물 |
| CU23556A1 (es) * | 2005-11-30 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico |
| KR20160052812A (ko) * | 2008-04-14 | 2016-05-12 | 할로자임, 아이엔씨 | 히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도 |
| JP5563572B2 (ja) * | 2008-07-23 | 2014-07-30 | ハンミ サイエンス カンパニー リミテッド | 三末端官能基を有する非ペプチド性重合体を用いた生理活性ポリペプチド薬物結合体 |
| WO2010078376A2 (en) | 2008-12-30 | 2010-07-08 | Ventana Medical Systems, Inc. | Fc-specific polymer-conjugated antibodies and their diagnostic use |
| AR081066A1 (es) | 2010-04-02 | 2012-06-06 | Hanmi Holdings Co Ltd | Conjugado de insulina donde se usa un fragmento de inmunoglobulina |
| KR101330868B1 (ko) * | 2010-06-08 | 2013-11-18 | 한미사이언스 주식회사 | 면역글로불린 단편을 이용한 인슐린 유도체 약물 결합체 |
-
2014
- 2014-03-05 RU RU2015139510A patent/RU2677796C9/ru active
- 2014-03-05 WO PCT/KR2014/001818 patent/WO2014137161A1/ko active Application Filing
- 2014-03-05 KR KR1020140026256A patent/KR102136336B1/ko active IP Right Grant
- 2014-03-05 NZ NZ712948A patent/NZ712948A/en unknown
- 2014-03-05 ES ES14760968T patent/ES2743612T3/es active Active
- 2014-03-05 BR BR112015021764-8A patent/BR112015021764B1/pt active IP Right Grant
- 2014-03-05 AU AU2014226741A patent/AU2014226741B2/en active Active
- 2014-03-05 PT PT14760968T patent/PT2966083T/pt unknown
- 2014-03-05 EP EP14760968.9A patent/EP2966083B1/en active Active
- 2014-03-05 JP JP2015561270A patent/JP6374412B2/ja active Active
- 2014-03-05 MX MX2015011668A patent/MX367817B/es active IP Right Grant
- 2014-03-05 TW TW103107577A patent/TWI647240B/zh not_active IP Right Cessation
- 2014-03-05 US US14/772,493 patent/US10660940B2/en active Active
- 2014-03-05 AR ARP140100703A patent/AR094987A1/es active IP Right Grant
- 2014-03-05 CN CN201910874160.1A patent/CN110590903A/zh active Pending
- 2014-03-05 CA CA2903365A patent/CA2903365C/en active Active
- 2014-03-05 MY MYPI2015002182A patent/MY186423A/en unknown
- 2014-03-05 CN CN201480011914.6A patent/CN105143255B/zh active Active
- 2014-03-05 SG SG11201506937RA patent/SG11201506937RA/en unknown
-
2015
- 2015-08-27 IL IL240869A patent/IL240869B/en active IP Right Grant
- 2015-09-03 SA SA515360980A patent/SA515360980B1/ar unknown
- 2015-09-03 PH PH12015501952A patent/PH12015501952B1/en unknown
- 2015-10-02 ZA ZA2015/07312A patent/ZA201507312B/en unknown
-
2016
- 2016-05-18 HK HK16105703.9A patent/HK1217717A1/zh unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB2518547B (en) | Method for the preparation of high purity lignin | |
| HK1200466A1 (en) | Method for the preparation of surfactant peptides | |
| HK1201858A1 (en) | An improved process for preparation of physiologically active polypeptide complex | |
| ZA201403189B (en) | Method for preparing physiologically active polypeptide complex | |
| HK1217717A1 (zh) | 高產率製備生理活性多肽複合物的改進方法 | |
| SI3027634T1 (sl) | Proces za pripravo tulatromicina | |
| HK1209790A1 (en) | Method of producing recombinant iduronate-2-sulfatase -2- | |
| HK1198584A1 (en) | Process for the preparation of travoprost | |
| EP2834188A4 (en) | FORMATION OF A CONJUGATED PROTEIN BY ELECTROSTATIC WIRING | |
| IL236450A (en) | Process for making 5-fluoro-h1-pyrazoles | |
| HK1210225A1 (en) | Procedure for the production of tiacumicin | |
| EP3325496C0 (en) | METHOD FOR PRODUCING A PHYSIOLOGICALLY ACTIVE POLYPEPTIDE CONJUGATE | |
| HUE040536T2 (hu) | Eljárás halogén-N,N-dimetilbenzilaminok elõállítására | |
| HK1211789A1 (en) | Plants for production of therapeutic proteins | |
| EP3027739A4 (en) | MODIFIED CELLS FOR THE PRODUCTION OF BLOOD CELLS | |
| EP2976326A4 (en) | PROCESS FOR THE PREPARATION OF SOLID FORMS OF 2-CHLORO-N- (4-CHLORO-3- (PYRIDIN-2-YLPHENYL) -4-METHYLSULFONYLBENZAMIDE | |
| PL2883461T3 (pl) | Sposób wytwarzania aktywnej folistatyny | |
| EP2817305A4 (en) | IMPROVED METHOD FOR PREPARING APREPITANT | |
| HK1218295A1 (zh) | 由三氟乙酰乙酸製備 -三氟甲基吡啶- -羧酸衍生物的方法 | |
| IL229669A0 (en) | Process for the preparation of 1,2,3 triazole 4 carboxamide | |
| EP3049402A4 (en) | Process for preparation of alogliptin | |
| EP2906536A4 (en) | IMPROVED METHOD FOR PRODUCING A PERINDOPRIL INTERMEDIATE PRODUCT | |
| TH1501004995A (th) | วิธีการเตรียมที่ถูกปรับปรุงสำหรับการผลิตที่มีปริมาณผลิตผลที่สูงของโพลีเปปไทด์ คอนจูเกตที่มีฤทธิ์ทางเภสัชวิทยา | |
| GB201315268D0 (en) | Process for preparation of blood group antigen derivatives | |
| PL399603A1 (pl) | Sposób wytwarzania 3β,15α-dihydroksy-5α-androst-17-onu |