FR22C1043I2 - Conjugues de groupe fonctionnel a facteur polymerique viii - Google Patents
Conjugues de groupe fonctionnel a facteur polymerique viiiInfo
- Publication number
- FR22C1043I2 FR22C1043I2 FR22C1043C FR22C1043C FR22C1043I2 FR 22C1043 I2 FR22C1043 I2 FR 22C1043I2 FR 22C1043 C FR22C1043 C FR 22C1043C FR 22C1043 C FR22C1043 C FR 22C1043C FR 22C1043 I2 FR22C1043 I2 FR 22C1043I2
- Authority
- FR
- France
- Prior art keywords
- conjugates
- polymeric
- functional group
- factor viii
- viii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229960000301 factor viii Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45057803P | 2003-02-26 | 2003-02-26 | |
PCT/US2004/006034 WO2004075923A2 (fr) | 2003-02-26 | 2004-02-26 | Conjugues de groupe fonctionnel a facteur polymerique viii |
Publications (2)
Publication Number | Publication Date |
---|---|
FR22C1043I1 FR22C1043I1 (fr) | 2022-09-30 |
FR22C1043I2 true FR22C1043I2 (fr) | 2023-12-15 |
Family
ID=32927670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR22C1043C Active FR22C1043I2 (fr) | 2003-02-26 | 2022-08-11 | Conjugues de groupe fonctionnel a facteur polymerique viii |
Country Status (20)
Country | Link |
---|---|
US (13) | US7199223B2 (fr) |
EP (4) | EP1596887B1 (fr) |
JP (2) | JP5539607B2 (fr) |
KR (1) | KR101085375B1 (fr) |
CN (2) | CN102139114A (fr) |
AU (2) | AU2004215912B2 (fr) |
BE (1) | BE2022C541I2 (fr) |
BR (1) | BRPI0407882B1 (fr) |
CA (2) | CA2517369C (fr) |
DK (1) | DK1596887T3 (fr) |
ES (1) | ES2911435T3 (fr) |
FR (1) | FR22C1043I2 (fr) |
HU (1) | HUE058897T2 (fr) |
IL (1) | IL170424A (fr) |
LT (1) | LT1596887T (fr) |
MX (1) | MXPA05009169A (fr) |
NL (1) | NL301184I2 (fr) |
PT (1) | PT1596887T (fr) |
SI (1) | SI1596887T1 (fr) |
WO (1) | WO2004075923A2 (fr) |
Families Citing this family (150)
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US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
US7214660B2 (en) * | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US8008252B2 (en) * | 2001-10-10 | 2011-08-30 | Novo Nordisk A/S | Factor VII: remodeling and glycoconjugation of Factor VII |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
WO2004099231A2 (fr) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Methode de glycopegylation et proteines/peptides produits au moyen de ces methodes |
EP1465933B1 (fr) * | 2002-01-16 | 2007-08-29 | Biocompatibles UK Limited | Conjugues polymeres |
MXPA04012496A (es) * | 2002-06-21 | 2005-09-12 | Novo Nordisk Healthcare Ag | Glicoformos del factor vii pegilados. |
GB0301014D0 (en) * | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
CN102139114A (zh) * | 2003-02-26 | 2011-08-03 | 尼克塔治疗公司 | 聚合物-因子viii部分缀合物 |
US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
MXPA05007628A (es) * | 2003-05-23 | 2005-10-19 | Nektar Therapeutics Al Corp | Derivados de polimeros que tienen arreglos de atomos particulares. |
US7947261B2 (en) | 2003-05-23 | 2011-05-24 | Nektar Therapeutics | Conjugates formed from polymer derivatives having particular atom arrangements |
US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
WO2005039641A2 (fr) * | 2003-10-15 | 2005-05-06 | The Regents Of The University Of California | Conjugues polymeres biomacromoleculaires |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
US6887952B1 (en) * | 2004-02-12 | 2005-05-03 | Biosite, Inc. | N-aryl-carbamic acid ester-derived and valeric acid ester-derived cross-linkers and conjugates, and methods for their synthesis and use |
WO2005089805A2 (fr) * | 2004-03-15 | 2005-09-29 | Nektar Therapeutics Al, Corporation | Compositions a base de polymeres et conjugues d'inhibiteurs d'entree du vih |
WO2005115477A2 (fr) | 2004-04-13 | 2005-12-08 | Quintessence Biosciences, Inc. | Conjugues de ribonuclease non naturelle utilises en tant qu'agents cytotoxiques |
EP1771066A2 (fr) | 2004-07-13 | 2007-04-11 | Neose Technologies, Inc. | Remodelage de peg ramifie et glycosylation de peptide-1 semblable a glucagon glp-1 |
US20080176790A1 (en) | 2004-10-29 | 2008-07-24 | Defrees Shawn | Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf) |
PT2371856T (pt) * | 2004-11-12 | 2022-08-12 | Bayer Healthcare Llc | Modificação de fviii direcionada a sítio |
AU2012203813B2 (en) * | 2004-11-12 | 2013-10-24 | Bayer Healthcare Llc | Site-directed modification of FVIII |
AU2013203348B2 (en) * | 2004-11-12 | 2016-03-03 | Bayer Healthcare Llc | Site-directed modification of FVIII |
AU2016203693B2 (en) * | 2004-11-12 | 2018-08-23 | Bayer Healthcare Llc | Site-directed modification of FVIII |
EP1835938B1 (fr) | 2004-12-27 | 2013-08-07 | Baxter International Inc. | Conjugues entre polymeres et facteurs von willebrand |
US9029331B2 (en) | 2005-01-10 | 2015-05-12 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
EP1848461A2 (fr) * | 2005-02-16 | 2007-10-31 | Nektar Therapeutics Al, Corporation | Conjugues d'une fraction d'epo et d'un polymere |
WO2006102659A2 (fr) * | 2005-03-23 | 2006-09-28 | Nektar Therapeutics Al, Corporation | Conjugues d'un fragment de hgh et d'un polymere |
WO2006103298A2 (fr) * | 2005-04-01 | 2006-10-05 | Novo Nordisk Health Care Ag | Analogues du fviii de coagulation sanguine |
EP1871795A4 (fr) | 2005-04-08 | 2010-03-31 | Biogenerix Ag | Compositions et méthodes utilisées pour la préparation de mutants par glycosylation de l'hormone de croissance humaine résistant à la protéase |
WO2006110776A2 (fr) | 2005-04-12 | 2006-10-19 | Nektar Therapeutics Al, Corporation | Compositions a base de polymere et conjugues d'agents antimicrobiens |
JP5216580B2 (ja) | 2005-05-25 | 2013-06-19 | ノヴォ ノルディスク アー/エス | グリコペグ化第ix因子 |
JP5335422B2 (ja) * | 2005-06-17 | 2013-11-06 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 少なくとも1つの非天然のシステインを含んでいる操作されたタンパク質の選択的な還元および誘導体化 |
CA2617064A1 (fr) * | 2005-08-04 | 2007-02-15 | Nektar Therapeutics Al, Corporation | Conjugues d'un groupe fonctionnel g-cfs et d'un polymere |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
WO2007056191A2 (fr) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Purification de sucre de nucleotide en utilisant des membranes |
US20070141021A1 (en) * | 2005-12-19 | 2007-06-21 | Perry Rosen | Methylmaleimidyl polymer derivatives |
US8580746B2 (en) * | 2006-03-30 | 2013-11-12 | Palatin Technologies, Inc. | Amide linkage cyclic natriuretic peptide constructs |
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US7795221B2 (en) * | 2006-03-30 | 2010-09-14 | Palatin Technologies, Inc. | Linear natriuretic peptide constructs |
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JP5606738B2 (ja) * | 2006-12-27 | 2014-10-15 | ウェルズ ファーゴ バンク ナショナル アソシエイション | 解離可能な連結を有する第ix因子部分−ポリマー共役体 |
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CA2715465C (fr) | 2008-02-27 | 2017-03-21 | Novo Nordisk A/S | Molecules de facteur viii conjuguees |
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