FR22C1043I1 - Conjugues de groupe fonctionnel a facteur polymerique viii - Google Patents

Conjugues de groupe fonctionnel a facteur polymerique viii

Info

Publication number
FR22C1043I1
FR22C1043I1 FR22C1043C FR22C1043C FR22C1043I1 FR 22C1043 I1 FR22C1043 I1 FR 22C1043I1 FR 22C1043 C FR22C1043 C FR 22C1043C FR 22C1043 C FR22C1043 C FR 22C1043C FR 22C1043 I1 FR22C1043 I1 FR 22C1043I1
Authority
FR
France
Prior art keywords
polymeric
functional group
factor viii
group conjugates
viii functional
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR22C1043C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nektar Therapeutics
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32927670&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR22C1043(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of FR22C1043I1 publication Critical patent/FR22C1043I1/fr
Application granted granted Critical
Publication of FR22C1043I2 publication Critical patent/FR22C1043I2/fr
Active legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
FR22C1043C 2003-02-26 2022-08-11 Conjugues de groupe fonctionnel a facteur polymerique viii Active FR22C1043I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45057803P 2003-02-26 2003-02-26
PCT/US2004/006034 WO2004075923A2 (fr) 2003-02-26 2004-02-26 Conjugues de groupe fonctionnel a facteur polymerique viii

Publications (2)

Publication Number Publication Date
FR22C1043I1 true FR22C1043I1 (fr) 2022-09-30
FR22C1043I2 FR22C1043I2 (fr) 2023-12-15

Family

ID=32927670

Family Applications (1)

Application Number Title Priority Date Filing Date
FR22C1043C Active FR22C1043I2 (fr) 2003-02-26 2022-08-11 Conjugues de groupe fonctionnel a facteur polymerique viii

Country Status (20)

Country Link
US (13) US7199223B2 (fr)
EP (4) EP1596887B1 (fr)
JP (2) JP5539607B2 (fr)
KR (1) KR101085375B1 (fr)
CN (2) CN1767857A (fr)
AU (2) AU2004215912B2 (fr)
BE (1) BE2022C541I2 (fr)
BR (1) BRPI0407882B1 (fr)
CA (2) CA2788505C (fr)
DK (1) DK1596887T3 (fr)
ES (1) ES2911435T3 (fr)
FR (1) FR22C1043I2 (fr)
HU (1) HUE058897T2 (fr)
IL (1) IL170424A (fr)
LT (1) LT1596887T (fr)
MX (1) MXPA05009169A (fr)
NL (1) NL301184I2 (fr)
PT (1) PT1596887T (fr)
SI (1) SI1596887T1 (fr)
WO (1) WO2004075923A2 (fr)

Families Citing this family (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008252B2 (en) * 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
US7214660B2 (en) * 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
AU2004236174B2 (en) 2001-10-10 2011-06-02 Novo Nordisk A/S Glycopegylation methods and proteins/peptides produced by the methods
US8048408B2 (en) * 2002-01-16 2011-11-01 Biocompatibles Uk Limited Polymer conjugates
MXPA04012496A (es) * 2002-06-21 2005-09-12 Novo Nordisk Healthcare Ag Glicoformos del factor vii pegilados.
GB0301014D0 (en) * 2003-01-16 2003-02-19 Biocompatibles Ltd Conjugation reactions
LT1596887T (lt) * 2003-02-26 2022-04-25 Nektar Therapeutics Polimero-faktoriaus viii fragmento konjugatai
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
PT2644206T (pt) * 2003-05-23 2019-07-10 Nektar Therapeutics Derivados de peg contendo duas cadeias de peg
US7947261B2 (en) 2003-05-23 2011-05-24 Nektar Therapeutics Conjugates formed from polymer derivatives having particular atom arrangements
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
WO2005039641A2 (fr) * 2003-10-15 2005-05-06 The Regents Of The University Of California Conjugues polymeres biomacromoleculaires
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US20060040856A1 (en) 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
US6887952B1 (en) * 2004-02-12 2005-05-03 Biosite, Inc. N-aryl-carbamic acid ester-derived and valeric acid ester-derived cross-linkers and conjugates, and methods for their synthesis and use
EP1725262B1 (fr) * 2004-03-15 2021-05-26 Nektar Therapeutics Compositions et conjugués polymères d'inhibiteurs d'entrée du VIH
US8470315B2 (en) 2004-04-13 2013-06-25 Quintessence Biosciences, Inc. Non-natural ribonuclease conjugates as cytotoxic agents
US20080300173A1 (en) 2004-07-13 2008-12-04 Defrees Shawn Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1]
DK2586456T3 (en) 2004-10-29 2016-03-21 Ratiopharm Gmbh Conversion and glycopegylation of fibroblast growth factor (FGF)
MX350293B (es) * 2004-11-12 2017-09-04 Bayer Healthcare Llc Modificacion dirigida al sitio del factor viii.
AU2016203693B2 (en) * 2004-11-12 2018-08-23 Bayer Healthcare Llc Site-directed modification of FVIII
AU2012203813B2 (en) * 2004-11-12 2013-10-24 Bayer Healthcare Llc Site-directed modification of FVIII
AU2013203348B2 (en) * 2004-11-12 2016-03-03 Bayer Healthcare Llc Site-directed modification of FVIII
US7884075B2 (en) 2004-12-27 2011-02-08 Baxter International Inc. Polymer-factor VIII-von Willebrand factor-conjugates
EP1858543B1 (fr) 2005-01-10 2013-11-27 BioGeneriX AG Facteur de stimulation de colonie de granulocytes glycopegylé
EP1848461A2 (fr) 2005-02-16 2007-10-31 Nektar Therapeutics Al, Corporation Conjugues d'une fraction d'epo et d'un polymere
US20060233740A1 (en) * 2005-03-23 2006-10-19 Bossard Mary J Conjugates of an hGH moiety and a polymer
WO2006103298A2 (fr) * 2005-04-01 2006-10-05 Novo Nordisk Health Care Ag Analogues du fviii de coagulation sanguine
EP2386571B1 (fr) 2005-04-08 2016-06-01 ratiopharm GmbH Compositions et méthodes utilisées pour la préparation de mutants par glycosylation de l'hormone de croissance humaine résistant à la protéase
EP1885403B1 (fr) 2005-04-12 2013-05-08 Nektar Therapeutics Conjugués de la lysostaphine et du poly(éthylène glycol)
US20080255026A1 (en) 2005-05-25 2008-10-16 Glycopegylated Factor 1X Glycopegylated Factor Ix
EP1893632B1 (fr) * 2005-06-17 2015-08-12 Novo Nordisk Health Care AG Reduction et derivation séléctives de proteines facteur vii comprenant au moins une cysteine non native
WO2007019331A2 (fr) * 2005-08-04 2007-02-15 Nektar Therapeutics Al, Corporation Conjugues d'un groupe fonctionnel g-cfs et d'un polymere
US20070105755A1 (en) * 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
US20070141021A1 (en) * 2005-12-19 2007-06-21 Perry Rosen Methylmaleimidyl polymer derivatives
US8580746B2 (en) * 2006-03-30 2013-11-12 Palatin Technologies, Inc. Amide linkage cyclic natriuretic peptide constructs
WO2007115175A2 (fr) * 2006-03-30 2007-10-11 Palatin Technologies, Inc. Constructions de peptides natriurétiques cycliques
JP2009532385A (ja) * 2006-03-30 2009-09-10 パラティン・テクノロジーズ・インコーポレーテッド 線状ナトリウム利尿ペプチド構築物
US7982010B2 (en) * 2006-03-31 2011-07-19 Baxter International Inc. Factor VIII polymer conjugates
KR20080108147A (ko) 2006-03-31 2008-12-11 백스터 인터내셔널 인코포레이티드 페질화된 인자 ｖｉｉｉ
US7645860B2 (en) * 2006-03-31 2010-01-12 Baxter Healthcare S.A. Factor VIII polymer conjugates
US7985839B2 (en) * 2006-03-31 2011-07-26 Baxter International Inc. Factor VIII polymer conjugates
MX2008014685A (es) * 2006-05-24 2008-11-27 Novo Nordisk Healthcare Ag Analogos de factor ix con semivida prolongada in vivo.
JP2009541333A (ja) 2006-06-23 2009-11-26 クインテセンス バイオサイエンシーズ インコーポレーティッド 修飾リボヌクレアーゼ
EP2049151A4 (fr) 2006-07-17 2010-03-24 Quintessence Biosciences Inc Méthodes et compositions pour le traitement du cancer
EP2049144B8 (fr) 2006-07-21 2015-02-18 ratiopharm GmbH Glycosylation de peptides par l'intermédiaire de séquences de glycosylation à liaison o
US20100075375A1 (en) 2006-10-03 2010-03-25 Novo Nordisk A/S Methods for the purification of polypeptide conjugates
ES2521490T3 (es) * 2006-12-15 2014-11-12 Baxter International Inc. Conjugado de factor VIIa - ácido (poli)siálico con una vida media in vivo prolongada.
EP2097108B1 (fr) * 2006-12-27 2014-02-12 Nektar Therapeutics Conjugués polymère-fraction à activité facteur ix comprenant une liaison dégradable
EP2114458B1 (fr) * 2006-12-27 2014-02-26 Nektar Therapeutics Conjugués polymère-facteur viii et facteur von willebrand comprenant une liaison dégradable
CN101796063B (zh) 2007-04-03 2017-03-22 拉蒂奥法姆有限责任公司 使用糖聚乙二醇化g‑csf的治疗方法
ES2551123T3 (es) 2007-06-12 2015-11-16 Ratiopharm Gmbh Proceso mejorado para la producción de azúcares de nucleótido
WO2009045539A2 (fr) * 2007-10-05 2009-04-09 Nektar Therapeutics Al, Corporation Conjugués d'oligomères et corticostéroïdes
WO2009048909A1 (fr) 2007-10-08 2009-04-16 Quintessence Biosciences, Inc. Compositions et procédés pour des thérapies à base de ribonucléase
EP2222329A1 (fr) * 2007-11-09 2010-09-01 Baxter International Inc. Facteur viii et facteur de von willebrand recombinés modifiés et procédé d'utilisation
KR20170072365A (ko) * 2007-12-27 2017-06-26 백스터 인터내셔널 인코포레이티드 생리학적으로 수용가능한 중합체 분자를 특이적으로 검출하기 위한 방법 및 조성물
MX2010009154A (es) 2008-02-27 2010-09-09 Novo Nordisk As Moleculas conjugadas del factor viii.
TWI395593B (zh) 2008-03-06 2013-05-11 Halozyme Inc 可活化的基質降解酵素之活體內暫時性控制
US20100003238A1 (en) 2008-04-14 2010-01-07 Frost Gregory I Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions
TWI394580B (zh) 2008-04-28 2013-05-01 Halozyme Inc 超快起作用胰島素組成物
CA2726942A1 (fr) * 2008-06-04 2009-12-10 Bayer Healthcare Llc Muteines du facteur viii pour le traitement de la maladie de von willebrand
KR101507718B1 (ko) 2008-06-24 2015-04-10 체에스엘 베링 게엠베하 연장된 생체내 반감기를 갖는 인자 ｖｉｉｉ, 폰 빌레브란트 인자 또는 이들의 복합체
WO2010014258A2 (fr) * 2008-08-01 2010-02-04 Nektar Therapeutics Al, Corporation Conjugués possédant une liaison libérable
MX2011001887A (es) * 2008-08-22 2011-04-04 Baxter Int Derivados de bencil carbonato polimericos.
CN102227443B (zh) 2008-10-01 2014-05-14 昆特森斯生物科学公司 治疗性核糖核酸酶
EP2349341B1 (fr) * 2008-10-15 2013-10-09 Baxter Healthcare SA Pégylation de facteurs de coagulation sanguine recombinants en présence d'anticorps liés
KR101929641B1 (ko) * 2008-10-17 2018-12-14 박스알타 인코퍼레이티드 낮은 수준의 수용성 중합체를 포함하는 개질된 혈액 인자
JP5281358B2 (ja) * 2008-10-27 2013-09-04 学校法人常翔学園 高分子、経上皮吸収促進剤、及び医薬用製剤
KR20110093775A (ko) * 2008-11-03 2011-08-18 바이엘 헬스케어 엘엘씨 혈우병 치료 방법
EP3037529B1 (fr) 2008-12-09 2019-03-27 Halozyme, Inc. Polypeptides ph20 solubles étendus et leurs utilisations
US20120121613A1 (en) * 2009-01-19 2012-05-17 Bayer Healthcare Llc Protein conjugate having an endopeptidase- cleavable bioprotective moiety
LT2393828T (lt) 2009-02-03 2017-01-25 Amunix Operating Inc. Prailginti rekombinantiniai polipeptidai ir juos apimančios kompozicijos
WO2010102886A1 (fr) * 2009-02-19 2010-09-16 Novo Nordisk A/S Modification du facteur viii
WO2010140148A1 (fr) 2009-06-01 2010-12-09 Yeda Research And Development Co . Ltd Promédicaments contenant une sonde se liant à l'albumine
US8809501B2 (en) 2009-07-27 2014-08-19 Baxter International Inc. Nucleophilic catalysts for oxime linkage
SG10201401194VA (en) 2009-07-27 2014-07-30 Lipoxen Technologies Ltd Glycopolysialylation of non-blood coagulation proteins
KR101832937B1 (ko) * 2009-07-27 2018-02-28 박스알타 인코퍼레이티드 혈액 응고 단백질 복합체
US8642737B2 (en) 2010-07-26 2014-02-04 Baxter International Inc. Nucleophilic catalysts for oxime linkage
ES2590679T3 (es) 2009-07-27 2016-11-23 Lipoxen Technologies Limited Glicopolisialilación de proteínas diferentes a proteínas de coagulación de la sangre
EP2470559B1 (fr) 2009-08-24 2017-03-22 Amunix Operating Inc. Compositions de facteur ix de coagulation et leurs procédés de fabrication et d'utilisation
MX2012003282A (es) 2009-09-17 2012-04-30 Baxter Healthcare Sa Co-formulacion estable de hialuronidasa e inmunoglobulina, y metodos de su uso.
ES2545893T3 (es) * 2010-04-20 2015-09-16 Octapharma Ag Nuevo agente estabilizante para proteínas farmacéuticas
GB201007357D0 (en) * 2010-04-30 2010-06-16 Leverton Licence Holdings Ltd Conjugated factor VIII
GB201007356D0 (en) 2010-04-30 2010-06-16 Leverton Licence Holdings Ltd Conjugated factor VIIa
WO2012006623A1 (fr) 2010-07-09 2012-01-12 Biogen Idec Hemophilia Inc. Systèmes pour le traitement du facteur viii et procédés associés
KR20130125753A (ko) 2010-07-20 2013-11-19 할로자임, 아이엔씨 항-히알루로난제 투여와 관련된 유해 부작용의 치료
TWI557135B (zh) 2010-11-03 2016-11-11 介控生化科技公司 經修飾之第九因子多胜肽及其用途
EA032056B1 (ru) 2010-12-22 2019-04-30 Баксалта Инкорпорейтид Конъюгат терапевтического белка и производного жирной кислоты, способы получения конъюгата терапевтического белка и производного жирной кислоты (варианты)
EP2907504B1 (fr) 2011-02-08 2017-06-28 Halozyme, Inc. Composition et formulation de lipides d'une enzyme de dégradation d'hyaluronan et leur utilisation pour le traitement de l'hyperplasie bénigne de la prostate
WO2012140647A2 (fr) 2011-04-11 2012-10-18 Yeda Research And Development Co. Ltd Sondes de liaison à l'albumine et conjugués de médicaments de celles-ci
WO2012140650A2 (fr) * 2011-04-12 2012-10-18 Hepacore Ltd. Conjugués de carboxy polysaccharides avec des facteurs de croissance des fibroblastes et variants de ceux-ci
KR101874401B1 (ko) 2011-06-17 2018-07-04 할로자임, 아이엔씨 히알루로난 분해 효소의 안정한 제형
BR112013032265A2 (pt) 2011-06-17 2016-12-20 Halozyme Inc métodos de infusão de insulina subcutânea contínua com uma enzima de degradação do hialuronano
US20130011378A1 (en) 2011-06-17 2013-01-10 Tzung-Horng Yang Stable formulations of a hyaluronan-degrading enzyme
US20130071394A1 (en) 2011-09-16 2013-03-21 John K. Troyer Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and methods of use
EP2771028A2 (fr) 2011-10-24 2014-09-03 Halozyme, Inc. Diagnostic compagnon pour le traitement avec un agent anti-hyaluronane et procédés d'utilisation dudit diagnostic
JP6067746B2 (ja) 2011-12-30 2017-01-25 ハロザイム インコーポレイテッド Ｐｈ２０ポリペプチド変異体、その製剤および使用
LT2804623T (lt) 2012-01-12 2019-12-10 Bioverativ Therapeutics Inc Chimeriniai viii faktoriaus polipeptidai ir jų panaudojimas
PL2814502T3 (pl) 2012-02-15 2018-02-28 Csl Behring Gmbh Warianty czynnika von Willebranda mające ulepszone powinowactwo do wiązania czynnika VIII
RS63870B1 (sr) 2012-02-15 2023-01-31 Bioverativ Therapeutics Inc Sastavi faktora viii i postupci za pravljenje i upotrebu istih
WO2013123457A1 (fr) 2012-02-15 2013-08-22 Biogen Idec Ma Inc. Protéines de facteur viii de recombinaison
JP6042527B2 (ja) 2012-04-04 2016-12-14 ハロザイム インコーポレイテッド 抗ヒアルロナン剤と腫瘍標的タキサンの組み合わせ治療
IL235129B (en) * 2012-04-16 2022-06-01 Cantab Biopharmaceuticals Patents Ltd Therapeutic compounds for subcutaneous administration
US10202595B2 (en) 2012-06-08 2019-02-12 Bioverativ Therapeutics Inc. Chimeric clotting factors
CN104519897A (zh) 2012-06-08 2015-04-15 比奥根艾迪克Ma公司 促凝血化合物
US20140017265A1 (en) * 2012-07-05 2014-01-16 Mersana Therapeutics, Inc. Terminally Modified Polymers and Conjugates Thereof
ES2770501T3 (es) 2012-07-11 2020-07-01 Bioverativ Therapeutics Inc Complejo del factor VIII con XTEN y proteína del factor de Von Willebrand y sus usos
WO2014026954A1 (fr) * 2012-08-13 2014-02-20 Novo Nordisk A/S Formulations liquides de facteur viii
WO2014062856A1 (fr) 2012-10-16 2014-04-24 Halozyme, Inc. Hypoxie et hyaluronane et leurs marqueurs pour le diagnostic et la surveillance de maladies et de pathologies, et méthodes associées
US10391152B2 (en) 2012-10-18 2019-08-27 Bioverativ Therapeutics Inc. Methods of using a fixed dose of a clotting factor
KR102136336B1 (ko) 2013-03-05 2020-07-22 한미약품 주식회사 생리활성 폴리펩타이드 결합체의 고수율 생산을 위한 개선된 제조 방법
WO2014160272A1 (fr) * 2013-03-13 2014-10-02 Emory University Élimination ciblée de cellules immunitaires de facteur viii
TWI683666B (zh) 2013-03-15 2020-02-01 美商百歐維拉提夫治療公司 因子ｉｘ多肽調配物
US20200157159A1 (en) 2013-04-16 2020-05-21 The Board Of Regents Of The University Of Oklahoma Peptide compounds and compositions thereof
EP2796145B1 (fr) 2013-04-22 2017-11-01 CSL Ltd. Un complexe covalent de facteur von willebrand et de faktor viii conjugé par un pont disulfure
EP4368194A3 (fr) 2013-06-28 2024-07-31 Bioverativ Therapeutics Inc. Lieur clivable par thrombine ayant xten et ses utilisations
TW201534726A (zh) 2013-07-03 2015-09-16 Halozyme Inc 熱穩定ｐｈ２０玻尿酸酶變異體及其用途
TWI667255B (zh) 2013-08-14 2019-08-01 美商生物化學醫療公司 因子ｖｉｉｉ－ｘｔｅｎ融合物及其用途
US20160311885A1 (en) 2013-08-14 2016-10-27 Biogen Ma Inc. Recombinant factor viii proteins
SG11201605242YA (en) 2014-01-10 2016-07-28 Biogen Ma Inc Factor viii chimeric proteins and uses thereof
WO2015132724A1 (fr) 2014-03-05 2015-09-11 Pfizer Inc. Mutéines améliorées du facteur viii de coagulation
BR112016030950A2 (pt) 2014-07-02 2018-03-27 Csl Ltd polipeptídeo modificado que se liga ao fator viii, complexo, composição farmacêutica, métodos para tratar uma coagulopatia, para produzir um polipeptídeo que compreende um vwf modificado e para aumentar a afinidade de ligação ao fator viii do vwf e a meia-vida do fator viii, uso de um polipeptídeo modificado ou de um complexo, polinucleotídeo, plasmídeo ou vetor, e, célula hospedeira.
ES2727137T3 (es) 2014-08-28 2019-10-14 Halozyme Inc Terapia combinada con una enzima de degradación de hialuronano y un inhibidor de puntos de control inmunitario
CA3203273A1 (fr) 2014-10-14 2016-04-21 Halozyme, Inc. Compositions d'adenosine deaminase-2, variants et methodes d'utilisation
MA40835A (fr) 2014-10-23 2017-08-29 Biogen Ma Inc Anticorps anti-gpiib/iiia et leurs utilisations
MA40861A (fr) 2014-10-31 2017-09-05 Biogen Ma Inc Anticorps anti-glycoprotéines iib/iiia
CN107406493B (zh) 2015-03-06 2021-08-13 康诺贝林伦瑙有限公司 具有改善的半衰期的经修饰的血管性血友病因子
CA2986625A1 (fr) 2015-05-22 2016-12-01 Csl Behring Recombinant Facility Ag Procedes de preparation du facteur willebrand modifie
AU2016266627A1 (en) 2015-05-22 2018-01-18 CSL Behring Lengnau AG Truncated von Willebrand Factor polypeptides for treating hemophilia
UA126016C2 (uk) 2015-08-03 2022-08-03 Біовератів Терапеутікс Інк. Злитий білок фактора іх
CN108779165B (zh) 2016-01-07 2022-12-02 康诺贝林伦瑙有限公司 突变的冯·维勒布兰德因子
RU2018128582A (ru) 2016-01-07 2020-02-11 Цсл Беринг Ленгнау Аг Мутированный укороченный фактор фон виллебранда
JP7235511B2 (ja) * 2016-06-24 2023-03-08 モガム・インスティテュート・フォー・バイオメディカル・リサーチ 組換え型一本鎖ｆｖｉｉｉおよびその化学コンジュゲート
WO2018017923A1 (fr) 2016-07-22 2018-01-25 Nektar Therapeutics Conjugués de groupe fonctionnel à facteur viii ayant une liaison oxime
DK3538133T3 (da) 2016-11-11 2021-04-19 CSL Behring Lengnau AG Trunkeret von willebrand faktor polypeptider til behandling af hæmofili
EP3538134B1 (fr) 2016-11-11 2021-12-29 CSL Behring Lengnau AG Polypeptides du facteur von willebrand tronqué pour l'administration extravasculaire dans le traitement ou la prophylaxie d'un trouble de la coagulation sanguine
US20200085915A1 (en) 2016-12-02 2020-03-19 Bioverativ Therapeutics Inc. Methods of inducing immune tolerance to clotting factors
EP3548066A1 (fr) 2016-12-02 2019-10-09 Bioverativ Therapeutics Inc. Méthodes de traitement de l'arthropathie hémophilique à l'aide de facteurs de coagulation chimériques
MX2019015402A (es) 2017-06-22 2020-07-20 Catalyst Biosciences Inc Polipeptidos de serina proteasa 1 de tipo membrana modificada (mtsp-1) y metodos de uso.
US11491212B1 (en) 2017-09-27 2022-11-08 Catalyst Biosciences, Inc. Subcutaneous administration of modified factor IX polypeptides and treatment of hemophilia B
WO2019222435A1 (fr) 2018-05-16 2019-11-21 Halozyme, Inc. Procédés de sélection de sujets pour une polythérapie anticancéreuse avec un ph20 soluble conjugué à un polymère
TW202015723A (zh) 2018-05-18 2020-05-01 美商百歐維拉提夫治療公司 治療ａ型血友病的方法
CN112654562B (zh) * 2018-07-20 2023-06-02 赫尔克里士有限公司 水溶性或水分散性组合物
SG11202106244RA (en) 2018-12-28 2021-07-29 Catalyst Biosciences Inc Modified urokinase-type plasminogen activator polypeptides and methods of use
US11613744B2 (en) 2018-12-28 2023-03-28 Vertex Pharmaceuticals Incorporated Modified urokinase-type plasminogen activator polypeptides and methods of use
WO2021154414A2 (fr) 2020-01-29 2021-08-05 Catalyst Biosciences, Inc. Thérapie génique pour l'hémophilie b avec un vecteur de capside d'aav chimérique codant pour des polypeptides du facteur ix modifiés
US20220394450A1 (en) * 2021-06-03 2022-12-08 Apple Inc. Systems and methods for emergency service access by reduced capability radio frequency devices

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS59172425A (ja) 1983-03-18 1984-09-29 Nippon Chemiphar Co Ltd 新規な血液凝固因子誘導体およびその製造法ならびにそれを含有する血液凝固促進剤
EP0148843B2 (fr) * 1983-03-21 1994-05-04 Novo Nordisk A/S Concentre du facteur antihemophilique viii et son procede de production
US4757006A (en) 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
DK525384D0 (da) * 1984-11-05 1984-11-05 Nordisk Insulinlab Praeparat paa basis af faktor viii til behandling af haemofili a inhibitorpatienter samt fremgangsmaade til fremstilling af et saadan praeparat
US4970300A (en) * 1985-02-01 1990-11-13 New York University Modified factor VIII
EP0218712B1 (fr) 1985-04-12 1992-02-26 Genetics Institute, Inc. Nouvelles proteines procoagulantes
AT387234B (de) 1987-03-05 1988-12-27 Vogelbusch Gmbh Vorrichtung zur zuechtung von dauerformen insbesondere filamentoeser mikroorganismen
US4994439A (en) * 1989-01-19 1991-02-19 California Biotechnology Inc. Transmembrane formulations for drug administration
SE465222C5 (sv) * 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
US5397771A (en) * 1990-05-10 1995-03-14 Bechgaard International Research And Development A/S Pharmaceutical preparation
IT1248723B (it) * 1990-06-12 1995-01-26 Scalvo S P A Processo per la purificazione del fattore viii e fattore viii ottenuto con tale processo
US5766897A (en) * 1990-06-21 1998-06-16 Incyte Pharmaceuticals, Inc. Cysteine-pegylated proteins
WO1992016555A1 (fr) * 1991-03-18 1992-10-01 Enzon, Inc. Conjuges de polypeptides et de glycopolypeptides associes a des polymeres, contenant de l'hydrazine
DE4111393A1 (de) * 1991-04-09 1992-10-15 Behringwerke Ag Stabilisierte faktor viii-praeparationen
US6376463B1 (en) * 1992-04-07 2002-04-23 Emory University Modified factor VIII
US6037452A (en) * 1992-04-10 2000-03-14 Alpha Therapeutic Corporation Poly(alkylene oxide)-Factor VIII or Factor IX conjugate
WO1994004193A1 (fr) * 1992-08-21 1994-03-03 Enzon, Inc. Nouvelle fixation d'oxydes de polyalkylene a des substances presentant une efficacite biologique
US5298643A (en) * 1992-12-22 1994-03-29 Enzon, Inc. Aryl imidate activated polyalkylene oxides
AU6029594A (en) 1993-01-15 1994-08-15 Enzon, Inc. Factor viii - polymeric conjugates
US5321095A (en) * 1993-02-02 1994-06-14 Enzon, Inc. Azlactone activated polyalkylene oxides
US5621039A (en) * 1993-06-08 1997-04-15 Hallahan; Terrence W. Factor IX- polymeric conjugates
SE504074C2 (sv) * 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
US5612039A (en) * 1994-03-14 1997-03-18 Nini E. Policappelli Dietary supplement
CA2204726A1 (fr) * 1994-11-09 1996-12-27 Robin E. Offord Polymeres fonctionnalises destines a une ligation dirigee
US5569596A (en) * 1995-01-04 1996-10-29 The Board Of Regents Of The University Of Oklahoma Method for bacterial reduction of chromium (VI)
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
SE9503380D0 (sv) * 1995-09-29 1995-09-29 Pharmacia Ab Protein derivatives
US6158888A (en) 1996-09-05 2000-12-12 University Of Florida Materials and methods for improved radiography
US5804420A (en) * 1997-04-18 1998-09-08 Bayer Corporation Preparation of recombinant Factor VIII in a protein free medium
WO1998051341A1 (fr) 1997-05-14 1998-11-19 The University Of Manitoba CONJUGUES ANTIGENE-mPEG SUPPRIMANT DES REPONSES IMMUNITAIRES HUMORALES ET A MEDIATION CELLULAIRE
WO1999005333A1 (fr) 1997-07-22 1999-02-04 Nippon Steel Corporation Acier cemente particulierement capable d'empecher la recristallisation secondaire des particules pendant la cementation, procede de fabrication, et matiere brute formee pour pieces cementees
US5985263A (en) 1997-12-19 1999-11-16 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
US6358703B1 (en) 1998-12-10 2002-03-19 Bayer Corporation Expression system for factor VIII
BR122013003013B8 (pt) 1999-01-14 2021-07-06 Bolder Biotechnology Inc proteína isolada monopeguilada do hormônio do crescimento e método para sua obtenção
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
AU2001238595A1 (en) 2000-02-22 2001-09-03 Shearwater Corporation N-maleimidyl polymer derivatives
IL152804A0 (en) 2000-05-16 2003-06-24 Bolder Biotechnology Inc Methods for refolding proteins containing free cysteine residues
KR100396983B1 (ko) 2000-07-29 2003-09-02 이강춘 고반응성의 가지 달린 고분자 유도체 및 고분자와 단백질또는 펩타이드의 접합체
TW593427B (en) * 2000-12-18 2004-06-21 Nektar Therapeutics Al Corp Synthesis of high molecular weight non-peptidic polymer derivatives
CN101045166A (zh) * 2001-05-21 2007-10-03 耐科塔医药公司 化学修饰胰岛素的肺部给药
US6546159B1 (en) 2001-08-22 2003-04-08 Avanex Corporation Method and apparatus for compensating differential group delay
AU2004236174B2 (en) 2001-10-10 2011-06-02 Novo Nordisk A/S Glycopegylation methods and proteins/peptides produced by the methods
WO2003037385A1 (fr) * 2001-10-30 2003-05-08 Nektar Therapeutics Al, Corporation Conjugues polymeres hydrosolubles d'acide retinoique
US7569214B2 (en) 2002-09-09 2009-08-04 Nektar Therapeutics Al, Corporation Method for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid
RS20050202A (en) * 2002-09-09 2007-08-03 Nektar Therapeuticals Al.Corporation, Water-soluble polymer alkanals
ATE400602T1 (de) * 2002-12-31 2008-07-15 Nektar Therapeutics Al Corp Verfahren zur herstellung von hydrogelen aus thiosulfonat-zusammensetzungen und ihre verwendungen
US7208145B2 (en) 2002-12-31 2007-04-24 Nektar Therapeutics Al, Corporation Polymeric reagents comprising a ketone or a related functional group
US7910661B2 (en) * 2003-01-06 2011-03-22 Nektar Therapeutics Thiol-selective water-soluble polymer derivatives
LT1596887T (lt) 2003-02-26 2022-04-25 Nektar Therapeutics Polimero-faktoriaus viii fragmento konjugatai
CA2530725A1 (fr) 2003-03-28 2004-10-07 Biopolymed Inc. Materiau biologiquement actif conjugue avec un polymere biocompatible avec un complexe 1:1, technique de preparation de celui-ci et composition pharmaceutique comprenant celui-ci
EP1613261A4 (fr) 2003-04-09 2011-01-26 Novo Nordisk As Formation intracellulaire de conjugues de peptides
PT2644206T (pt) 2003-05-23 2019-07-10 Nektar Therapeutics Derivados de peg contendo duas cadeias de peg
KR102612902B1 (ko) 2016-04-22 2023-12-18 삼성디스플레이 주식회사 투명 전도막 및 이를 포함하는 전자 소자

Also Published As

Publication number Publication date
US20120244597A1 (en) 2012-09-27
BRPI0407882B1 (pt) 2021-07-27
US20120178692A1 (en) 2012-07-12
EP2338523A1 (fr) 2011-06-29
AU2009201308B2 (en) 2011-06-02
FR22C1043I2 (fr) 2023-12-15
US9999657B2 (en) 2018-06-19
US20100125049A1 (en) 2010-05-20
US8247536B2 (en) 2012-08-21
US8618259B2 (en) 2013-12-31
US8889831B2 (en) 2014-11-18
EP1596887B1 (fr) 2022-03-23
JP2006519238A (ja) 2006-08-24
US8519102B2 (en) 2013-08-27
WO2004075923A2 (fr) 2004-09-10
JP5539607B2 (ja) 2014-07-02
US20150038422A1 (en) 2015-02-05
BE2022C541I2 (fr) 2023-08-09
US20100120689A1 (en) 2010-05-13
EP2572733A1 (fr) 2013-03-27
KR20050105497A (ko) 2005-11-04
EP1596887A2 (fr) 2005-11-23
CN1767857A (zh) 2006-05-03
CA2517369C (fr) 2013-06-04
US7199223B2 (en) 2007-04-03
CA2788505C (fr) 2018-09-04
AU2004215912A1 (en) 2004-09-10
DK1596887T3 (da) 2022-06-20
US20090041714A1 (en) 2009-02-12
US7858749B2 (en) 2010-12-28
US20080058504A1 (en) 2008-03-06
EP2572732A1 (fr) 2013-03-27
KR101085375B1 (ko) 2011-11-21
US20210401948A1 (en) 2021-12-30
LT1596887T (lt) 2022-04-25
CN102139114A (zh) 2011-08-03
US20120245289A1 (en) 2012-09-27
HUE058897T2 (hu) 2022-09-28
US8143378B2 (en) 2012-03-27
US20160175402A1 (en) 2016-06-23
WO2004075923A3 (fr) 2005-02-24
US8133977B2 (en) 2012-03-13
US20040235734A1 (en) 2004-11-25
BRPI0407882A (pt) 2006-03-01
ES2911435T3 (es) 2022-05-19
US11141465B2 (en) 2021-10-12
SI1596887T1 (sl) 2022-05-31
US20180250367A1 (en) 2018-09-06
IL170424A (en) 2010-02-17
EP2338523B1 (fr) 2024-01-17
MXPA05009169A (es) 2005-11-17
JP2012025747A (ja) 2012-02-09
US20100130427A1 (en) 2010-05-27
AU2004215912B2 (en) 2009-03-26
AU2009201308A1 (en) 2009-04-23
CA2788505A1 (fr) 2004-09-10
CA2517369A1 (fr) 2004-09-10
US7863421B2 (en) 2011-01-04
NL301184I2 (nl) 2022-07-21
PT1596887T (pt) 2022-04-14

Similar Documents

Publication Publication Date Title
FR22C1043I1 (fr) Conjugues de groupe fonctionnel a facteur polymerique viii
FR17C1054I2 (fr) Conjugues de type vecteur-derive de calicheamicine
FR2863502B1 (fr) Implant textile adhesif de refection parietale
ATE390099T1 (de) Zwischenwirbelkunststoffimplantat
DE602004018601D1 (de) Schiebedach
FI6928U1 (fi) Peliautomaatti
DE602004006541D1 (de) Gassack
DE502004005223D1 (de) Verteileranschlussmodul
DE50111423D1 (de) Sitzmodul
MA26998A1 (fr) Conjugues peg de hgt-nk4
AU2003241279A8 (en) Antimicrobial polymer conjugates
DE502004001525D1 (de) Gassackmodul
FR2861758B1 (fr) Element de caniveau
DE50304046D1 (de) Gassackmodul
DE502004001328D1 (de) Gassackmodul
DE50305833D1 (de) Gassackmodul
DE502004002074D1 (de) Airbagmodul
DE602004003909D1 (de) Kombiniertes schaltmodul
FR2852611B1 (fr) Article de lingerie calecon-boxer
DE502004000459D1 (de) Gasgeneratorbaugruppe
FR2853526B1 (fr) Support de biberon
DE50306814D1 (de) Gassackmodul
DE602004012316D1 (de) Schaltanordnung
DE602004027818D1 (de) Mehrteiliger büstenhalter
ES1055334Y (es) Buzon de correos