SG10201913738YA - Thrombin cleavable linker with xten and its uses thereof - Google Patents

Thrombin cleavable linker with xten and its uses thereof

Info

Publication number
SG10201913738YA
SG10201913738YA SG10201913738YA SG10201913738YA SG10201913738YA SG 10201913738Y A SG10201913738Y A SG 10201913738YA SG 10201913738Y A SG10201913738Y A SG 10201913738YA SG 10201913738Y A SG10201913738Y A SG 10201913738YA SG 10201913738Y A SG10201913738Y A SG 10201913738YA
Authority
SG
Singapore
Prior art keywords
xten
cleavable linker
thrombin cleavable
thrombin
linker
Prior art date
Application number
SG10201913738YA
Inventor
Ekta Seth Chhabra
John Kulman
Tongyao Liu
Original Assignee
Bioverativ Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioverativ Therapeutics Inc filed Critical Bioverativ Therapeutics Inc
Publication of SG10201913738YA publication Critical patent/SG10201913738YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
SG10201913738YA 2013-06-28 2014-06-27 Thrombin cleavable linker with xten and its uses thereof SG10201913738YA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361840872P 2013-06-28 2013-06-28

Publications (1)

Publication Number Publication Date
SG10201913738YA true SG10201913738YA (en) 2020-03-30

Family

ID=52142742

Family Applications (3)

Application Number Title Priority Date Filing Date
SG10201710616XA SG10201710616XA (en) 2013-06-28 2014-06-27 Thrombin cleavable linker with xten and its uses thereof
SG11201509313PA SG11201509313PA (en) 2013-06-28 2014-06-27 Thrombin cleavable linker with xten and its uses thereof
SG10201913738YA SG10201913738YA (en) 2013-06-28 2014-06-27 Thrombin cleavable linker with xten and its uses thereof

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SG10201710616XA SG10201710616XA (en) 2013-06-28 2014-06-27 Thrombin cleavable linker with xten and its uses thereof
SG11201509313PA SG11201509313PA (en) 2013-06-28 2014-06-27 Thrombin cleavable linker with xten and its uses thereof

Country Status (17)

Country Link
US (3) US20160251408A1 (en)
EP (2) EP3013358A4 (en)
JP (5) JP2016523919A (en)
KR (3) KR20230007555A (en)
CN (3) CN105392495A (en)
AU (3) AU2014302100B2 (en)
CA (1) CA2913078A1 (en)
CL (1) CL2015003710A1 (en)
EA (1) EA201592022A1 (en)
HK (1) HK1223302A1 (en)
IL (3) IL297611A (en)
MX (1) MX2015016567A (en)
NZ (1) NZ713904A (en)
PH (1) PH12015502614A1 (en)
SG (3) SG10201710616XA (en)
TW (2) TWI716340B (en)
WO (1) WO2014210558A1 (en)

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CN107428831A (en) * 2015-03-06 2017-12-01 瑞士杰特贝林生物制品重组设备股份公司 For the compound for the half-life period for improving vWF ELISA
JP6909203B2 (en) 2015-08-03 2021-07-28 バイオベラティブ セラピューティクス インコーポレイテッド Factor IX fusion proteins and their production and usage
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CN109922824A (en) * 2016-11-11 2019-06-21 康诺贝林伦瑙有限公司 For treating haemophiliachemophiliac truncated von Willebrand factor polypeptide
EP3793588A1 (en) 2018-05-18 2021-03-24 Bioverativ Therapeutics Inc. Methods of treating hemophilia a

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Also Published As

Publication number Publication date
KR20160023654A (en) 2016-03-03
MX2015016567A (en) 2016-03-31
IL242436B (en) 2019-05-30
CN105392495A (en) 2016-03-09
TW202045535A (en) 2020-12-16
EP4368194A2 (en) 2024-05-15
IL297611A (en) 2022-12-01
IL266462B2 (en) 2023-04-01
CL2015003710A1 (en) 2016-08-26
US20160251408A1 (en) 2016-09-01
JP2019010124A (en) 2019-01-24
AU2014302100B2 (en) 2020-02-13
KR20230007555A (en) 2023-01-12
AU2020203063B2 (en) 2023-05-25
NZ713904A (en) 2022-02-25
CN113831415A (en) 2021-12-24
PH12015502614A1 (en) 2016-02-29
TW201514204A (en) 2015-04-16
JP2016523919A (en) 2016-08-12
US20240083975A1 (en) 2024-03-14
SG10201710616XA (en) 2018-02-27
KR102666819B1 (en) 2024-05-23
JP7297837B2 (en) 2023-06-26
EA201592022A1 (en) 2016-05-31
AU2014302100A1 (en) 2015-11-26
JP2022000053A (en) 2022-01-04
IL266462B (en) 2022-12-01
TWI716340B (en) 2021-01-21
CN113817069A (en) 2021-12-21
EP4368194A3 (en) 2024-07-31
JP2023107932A (en) 2023-08-03
SG11201509313PA (en) 2016-01-28
CA2913078A1 (en) 2014-12-31
US20220106383A1 (en) 2022-04-07
AU2020203063A1 (en) 2020-05-28
EP3013358A1 (en) 2016-05-04
HK1223302A1 (en) 2017-07-28
JP7005800B2 (en) 2022-02-10
TW202313672A (en) 2023-04-01
JP2021072853A (en) 2021-05-13
EP3013358A4 (en) 2017-03-22
IL266462A (en) 2019-06-30
WO2014210558A1 (en) 2014-12-31
TWI770467B (en) 2022-07-11
KR20240023705A (en) 2024-02-22
BR112015031194A2 (en) 2017-09-19
AU2023219840A1 (en) 2023-09-14

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