JP5525729B2 - 組換え一価抗体およびその作製方法 - Google Patents

組換え一価抗体およびその作製方法 Download PDF

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JP5525729B2
JP5525729B2 JP2008541590A JP2008541590A JP5525729B2 JP 5525729 B2 JP5525729 B2 JP 5525729B2 JP 2008541590 A JP2008541590 A JP 2008541590A JP 2008541590 A JP2008541590 A JP 2008541590A JP 5525729 B2 JP5525729 B2 JP 5525729B2
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antibody
region
amino acid
monovalent
monovalent antibody
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JP2009517006A5 (enExample
JP2009517006A (ja
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パウル パーレン
ヤニネ スフールマン
トム フィンク
ウィレム カレル ブレーケル
デ ウィンケル ヤン ヘー． イェー． ファン
ベルケル パトリック ファン
フランク ブールスケンス
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Genmab AS
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K—PEPTIDES
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
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  • Pulmonology (AREA)
  • Hematology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
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JP2008541590A 2005-11-28 2006-11-28 組換え一価抗体およびその作製方法 Active JP5525729B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US74040305P 2005-11-28 2005-11-28
US60/740,403 2005-11-28
US85247906P 2006-10-17 2006-10-17
US60/852,479 2006-10-17
US85261106P 2006-10-18 2006-10-18
US60/852,611 2006-10-18
PCT/DK2006/000669 WO2007059782A1 (en) 2005-11-28 2006-11-28 Recombinant monovalent antibodies and methods for production thereof

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JP2009517006A JP2009517006A (ja) 2009-04-30
JP2009517006A5 JP2009517006A5 (enExample) 2011-01-06
JP5525729B2 true JP5525729B2 (ja) 2014-06-18

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JP2013266275A Active JP6039542B2 (ja) 2005-11-28 2013-12-25 組換え一価抗体およびその作製方法
JP2016129517A Active JP6341954B2 (ja) 2005-11-28 2016-06-30 組換え一価抗体およびその作製方法

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JP2016129517A Active JP6341954B2 (ja) 2005-11-28 2016-06-30 組換え一価抗体およびその作製方法

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US (3) US10155816B2 (enExample)
EP (1) EP1973576B1 (enExample)
JP (3) JP5525729B2 (enExample)
KR (2) KR101866623B1 (enExample)
AU (1) AU2006317242A1 (enExample)
BR (1) BRPI0619056A2 (enExample)
CA (1) CA2631184A1 (enExample)
EA (1) EA016609B1 (enExample)
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Cited By (1)

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JP2016182138A (ja) * 2005-11-28 2016-10-20 ゲンマブ エー／エス 組換え一価抗体およびその作製方法

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EP1960431B1 (en) 2005-12-15 2014-10-01 Genmab A/S Use of effector-function-deficient antibodies for treatment of auto-immune diseases
US20130004480A1 (en) 2006-07-04 2013-01-03 Paul Parren CD20 Binding Molecules for the Treatment of Copd
CN101627055A (zh) 2006-09-05 2010-01-13 梅达雷克斯公司 骨形成蛋白及其受体的抗体以及它们的使用方法
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AU2013202392B2 (en) * 2006-12-20 2016-02-25 Mmrglobal, Inc. Antibodies and methods for making and using them
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WO2008104803A2 (en) 2007-02-26 2008-09-04 Oxford Genome Sciences (Uk) Limited Proteins
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EP2626372B1 (en) 2007-03-29 2018-03-21 Genmab A/S Bispecific antibodies and methods for production thereof
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US20100255012A1 (en) * 2007-05-31 2010-10-07 Genmab A/S Recombinant fucose modified monovalent half-antibodies obtained by molecular engineering
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CA2689895A1 (en) * 2007-05-31 2008-12-04 Genmab A/S Non-glycosylated recombinant monovalent antibodies
EP2152751A1 (en) * 2007-05-31 2010-02-17 Genmab A/S Fusion or linked proteins with extended half life
EP2155238B1 (en) 2007-06-05 2016-04-06 Yale University Antibody against d4 domain of the kit receptor and use thereor
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