JP5525729B2 - 組換え一価抗体およびその作製方法 - Google Patents

組換え一価抗体およびその作製方法 Download PDF

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JP5525729B2
JP5525729B2 JP2008541590A JP2008541590A JP5525729B2 JP 5525729 B2 JP5525729 B2 JP 5525729B2 JP 2008541590 A JP2008541590 A JP 2008541590A JP 2008541590 A JP2008541590 A JP 2008541590A JP 5525729 B2 JP5525729 B2 JP 5525729B2
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antibody
region
amino acid
monovalent
monovalent antibody
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JP2009517006A5 (enExample
JP2009517006A (ja
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パウル パーレン
ヤニネ スフールマン
トム フィンク
ウィレム カレル ブレーケル
デ ウィンケル ヤン ヘー． イェー． ファン
ベルケル パトリック ファン
フランク ブールスケンス
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Genmab AS
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Diabetes (AREA)
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JP2008541590A 2005-11-28 2006-11-28 組換え一価抗体およびその作製方法 Active JP5525729B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US74040305P 2005-11-28 2005-11-28
US60/740,403 2005-11-28
US85247906P 2006-10-17 2006-10-17
US60/852,479 2006-10-17
US85261106P 2006-10-18 2006-10-18
US60/852,611 2006-10-18
PCT/DK2006/000669 WO2007059782A1 (en) 2005-11-28 2006-11-28 Recombinant monovalent antibodies and methods for production thereof

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JP2013266275A Division JP6039542B2 (ja) 2005-11-28 2013-12-25 組換え一価抗体およびその作製方法

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JP2009517006A JP2009517006A (ja) 2009-04-30
JP2009517006A5 JP2009517006A5 (enExample) 2011-01-06
JP5525729B2 true JP5525729B2 (ja) 2014-06-18

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JP2013266275A Active JP6039542B2 (ja) 2005-11-28 2013-12-25 組換え一価抗体およびその作製方法
JP2016129517A Active JP6341954B2 (ja) 2005-11-28 2016-06-30 組換え一価抗体およびその作製方法

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JP2016129517A Active JP6341954B2 (ja) 2005-11-28 2016-06-30 組換え一価抗体およびその作製方法

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US (3) US10155816B2 (enExample)
EP (1) EP1973576B1 (enExample)
JP (3) JP5525729B2 (enExample)
KR (2) KR20080090406A (enExample)
AU (1) AU2006317242A1 (enExample)
BR (1) BRPI0619056A2 (enExample)
CA (1) CA2631184A1 (enExample)
EA (1) EA016609B1 (enExample)
SG (1) SG10201600950TA (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016182138A (ja) * 2005-11-28 2016-10-20 ゲンマブ エー／エス 組換え一価抗体およびその作製方法

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US20070087005A1 (en) 2005-10-14 2007-04-19 Lazar Gregory A Anti-glypican-3 antibody
US9181344B2 (en) 2005-12-15 2015-11-10 Genmab A/S Use of effector-function-deficient antibodies for treatment of auto-immune diseases
EP2046383B1 (en) 2006-07-04 2014-11-19 Genmab A/S Cd20 binding molecules for the treatment of copd
WO2008030611A2 (en) 2006-09-05 2008-03-13 Medarex, Inc. Antibodies to bone morphogenic proteins and receptors therefor and methods for their use
SG178712A1 (en) 2006-10-02 2012-03-29 Medarex Inc Human antibodies that bind cxcr4 and uses thereof
CN103172743B (zh) 2006-12-01 2015-04-08 梅达雷克斯有限责任公司 结合cd22的人抗体及其用途
CL2007003622A1 (es) 2006-12-13 2009-08-07 Medarex Inc Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
US20100150950A1 (en) 2006-12-14 2010-06-17 Medarex, Inc. Human antibodies that bind cd70 and uses thereof
AU2013202392B2 (en) * 2006-12-20 2016-02-25 Mmrglobal, Inc. Antibodies and methods for making and using them
CA2832111A1 (en) * 2006-12-20 2008-07-03 Mmrglobal, Inc. Antibodies and methods for making and using them
EP3118221B1 (en) 2007-02-26 2019-08-21 Oxford BioTherapeutics Ltd Proteins
WO2008104803A2 (en) 2007-02-26 2008-09-04 Oxford Genome Sciences (Uk) Limited Proteins
AU2008234248C1 (en) * 2007-03-29 2015-01-22 Genmab A/S Bispecific antibodies and methods for production thereof
WO2008134046A1 (en) * 2007-04-27 2008-11-06 Genentech, Inc. Potent, stable and non-immunosuppressive anti-cd4 antibodies
WO2008145138A1 (en) * 2007-05-31 2008-12-04 Genmab A/S Recombinant fucose modified monovalent half-antibodies obtained by molecular engineering
WO2008145137A2 (en) * 2007-05-31 2008-12-04 Genmab A/S Recombinant non glycosylated monovalent half-antibodies obtained by molecular engineering
WO2008145142A1 (en) 2007-05-31 2008-12-04 Genmab A/S Stable igg4 antibodies
US20110045007A1 (en) * 2007-05-31 2011-02-24 Genmab A/S Fusion or linked proteins with extended half life
EP2167669A2 (en) * 2007-05-31 2010-03-31 Genmab A/S Transgenic animals producing monovalent human antibodies and antibodies obtainable from these animals
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