JP5419455B2 - 自己免疫疾患治療のための乳酸菌の使用 - Google Patents
自己免疫疾患治療のための乳酸菌の使用 Download PDFInfo
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PCT/SE2006/001139 WO2007040446A1 (en) | 2005-10-06 | 2006-10-06 | Use of lactobacillus for treatment of autoimmune diseases |
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Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5019961B2 (ja) * | 2006-06-26 | 2012-09-05 | 株式会社ヤクルト本社 | インターロイキン10産生促進剤 |
DK2068899T3 (da) | 2006-10-02 | 2015-09-28 | Dupont Nutrition Biosci Aps | Lactobacillus acidophilus til anvendelse til reducering af forekomsten og varigheden af luftvejsinfektioner |
PL210465B1 (pl) | 2007-06-04 | 2012-01-31 | Inst Biotechnologii Surowic I Szczepionek Biomed Społka Akcyjna | Zastosowanie kompozycji szczepów z rodzaju Lactobacillus |
JP2009057346A (ja) * | 2007-09-03 | 2009-03-19 | Kirin Holdings Co Ltd | 免疫バランス調節用組成物 |
FR2922450B1 (fr) * | 2007-10-19 | 2014-06-13 | Lallemand Sas | Utilisation de bacteries lactique pour la prevention et/ou le traitement de pathologies cutanees |
WO2009062132A2 (en) | 2007-11-09 | 2009-05-14 | California Institute Of Technology | Immunomodulating compounds and related compositions and methods |
EP2153837A1 (en) * | 2008-08-14 | 2010-02-17 | Compagnie Gervais Danone | Compositions comprising Lactobacillus casei for improving resistance to common infectious diseases |
SE533778C2 (sv) | 2009-05-14 | 2011-01-11 | Probi Ab | Probiotisk fruktdryck |
US20100311686A1 (en) * | 2009-06-03 | 2010-12-09 | Kasper Lloyd H | Nutraceutical composition and methods for preventing or treating multiple sclerosis |
WO2011059332A2 (en) | 2009-11-16 | 2011-05-19 | Stichting Top Institute Food And Nutrition | Improved immunomodulation by probiotics |
KR20110082480A (ko) * | 2010-01-11 | 2011-07-19 | 포항공과대학교 산학협력단 | 포유동물 체내에서 유래된 세포밖 소포체를 포함하는 조성물 및 이의 용도 |
BR112012018813B1 (pt) * | 2010-01-28 | 2020-12-08 | Ab-Biotics S.A. | composição compreendendo cepas bacterianas com atividade anti-inflamatória, imunomoduladora, antiibs ou antidistensão abdominal, uso das mesmas, bem como produtos farmacêutico, veterinário e comestível compreendendo a referida composição |
DK2555753T3 (en) | 2010-04-07 | 2018-11-26 | California Inst Of Techn | Vesicle for delivering a compound to a mucosal membrane as well as corresponding compositions, methods and systems |
EP2571982A4 (en) | 2010-05-20 | 2014-01-01 | California Inst Of Techn | ANTIGEN-SPECIFIC TREGS AND CORRESPONDING COMPOSITIONS, METHODS AND SYSTEMS |
WO2012081650A1 (ja) * | 2010-12-16 | 2012-06-21 | 株式会社明治 | 遅延型過敏症軽減剤 |
CN103261165B (zh) | 2010-12-23 | 2015-08-26 | 辉瑞公司 | 胰高血糖素受体调节剂 |
WO2012093755A1 (ko) * | 2011-01-04 | 2012-07-12 | 포항공과대학교 산학협력단 | 발효식품에서 유래된 세포밖 소포체를 포함하는 조성물 및 이의 용도 |
KR101585840B1 (ko) | 2011-02-08 | 2016-01-15 | 화이자 인코포레이티드 | 글루카곤 수용체 조절자 |
WO2012133827A1 (ja) * | 2011-03-31 | 2012-10-04 | 森永乳業株式会社 | 新規乳酸菌、並びに新規乳酸菌を含有する医薬、飲食品、及び飼料 |
WO2012141540A2 (ko) * | 2011-04-13 | 2012-10-18 | 씨제이제일제당 (주) | 바이러스 감염 억제 활성을 갖는 신규 분리한 락토바실러스 퍼멘텀 균주 |
KR101279852B1 (ko) * | 2011-06-29 | 2013-07-09 | 주식회사 쎌바이오텍 | 골다공증 예방 또는 치료용 조성물 |
JP6273200B2 (ja) | 2011-07-12 | 2018-01-31 | ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド | 脂質含有psa組成物、その単離の方法および使用の方法 |
US8927577B2 (en) | 2011-07-22 | 2015-01-06 | Pfizer Inc. | Quinolinyl glucagon receptor modulators |
JP5468183B2 (ja) | 2011-12-28 | 2014-04-09 | 株式会社山田養蜂場本社 | IgA産生促進作用を有する新規乳酸菌及びその用途 |
JP6028962B2 (ja) * | 2012-02-16 | 2016-11-24 | 国立大学法人金沢大学 | ウイルス感染予防乳酸菌組成物及びウイルス感染予防乳酸発酵食品 |
JP5995593B2 (ja) * | 2012-08-02 | 2016-09-21 | 丸善製薬株式会社 | 抗炎症剤 |
WO2014038929A1 (en) | 2012-09-07 | 2014-03-13 | N.V. Nutricia | Probiotics for producing antiviral factors |
FR2997960B1 (fr) * | 2012-11-09 | 2016-08-05 | Inst Nat De La Rech Agronomique (Inra) | Nouvelle souche bacterienne de lactobacillus plantarum et utilisation de cette souche |
WO2014077365A1 (ja) | 2012-11-16 | 2014-05-22 | カルピス株式会社 | 特定のラクトバチルス・ガセリ株又はその処理物を含有するストレス性腸障害の軽減剤 |
CN117064923A (zh) * | 2013-04-03 | 2023-11-17 | 普罗比公司 | 益生菌菌株用于治疗或预防骨质疏松 |
WO2014182966A1 (en) | 2013-05-10 | 2014-11-13 | California Institute Of Technology | Probiotic prevention and treatment of colon cancer |
KR101614262B1 (ko) * | 2013-07-12 | 2016-04-20 | 모리나가 뉴교 가부시키가이샤 | 신규 유산균, 그리고 신규 유산균을 함유하는 의약, 음식품 및 사료 |
TWI505831B (zh) * | 2013-11-15 | 2015-11-01 | Genmont Biotech Inc | 用於治療微小核糖核酸病毒感染的益生菌組合物及其用途 |
TWI505832B (zh) | 2014-02-21 | 2015-11-01 | Genmont Biotech Inc | 乳酸菌、其組合物與彼等於治療自體免疫疾病暨其倂發症之用途 |
KR101644595B1 (ko) * | 2014-07-11 | 2016-08-03 | 한국식품연구원 | 락토바실러스 파라카제이(Lactobacillus paracasei)를 유효성분으로 포함하는 Th1-매개 면역 질환 또는 Th2-매개 면역 질환의 예방, 개선 또는 치료용 조성물 |
US11331335B2 (en) | 2015-06-10 | 2022-05-17 | California Institute Of Technology | Sepsis treatment and related compositions methods and systems |
CN113637040A (zh) | 2015-08-19 | 2021-11-12 | 哈佛学院院长及董事 | 脂化psa组合物和方法 |
KR101749222B1 (ko) * | 2016-01-04 | 2017-06-21 | 주식회사 카브 | 젖산균을 유효성분으로 포함하는 인플루엔자 바이러스 예방 및 치료용 조성물 |
KR102852714B1 (ko) * | 2016-01-19 | 2025-08-29 | 시므라이즈 아게 | 구강 내 항-염증제로서 프로바이오틱스의 용도 |
GB201600975D0 (en) | 2016-01-19 | 2016-03-02 | Probi Ab | Novel strain of probiotic bacteria and compositions and uses thereof |
EP3196318A1 (en) | 2016-01-19 | 2017-07-26 | Symrise AG | Probiotics for altering the composition of oral biofilms |
EP3222282A1 (en) * | 2016-03-21 | 2017-09-27 | Bionou Research, S.L. | Use of probiotics in the treatment and/or prevention of psoriasis |
US11491181B2 (en) | 2016-07-15 | 2022-11-08 | President And Fellows Of Harvard College | Glycolipid compositions and methods of use |
CN106562462A (zh) * | 2016-11-04 | 2017-04-19 | 覃贤强 | 一种富硒保健汤圆及其制备方法 |
EP3568144B1 (en) * | 2017-01-12 | 2024-05-08 | Probi Ab | Probiotic compositions and uses thereof |
EP3351259A1 (en) | 2017-01-18 | 2018-07-25 | Symrise AG | Probiotics for aggregation with disease-associated species in the oral cavity |
EP3578637A4 (en) * | 2017-01-31 | 2020-12-16 | University - Industry Cooperation Group of Kyung Hee University | NEW LACTIC BACTERIA AND THEIR USE |
JP6839298B2 (ja) * | 2017-01-31 | 2021-03-03 | ユニバーシティ−インダストリー コーオペレイション グループ オブ キョンヒ ユニバーシティUniversity−Industry Cooperation Group Of Kyung Hee University | 新規乳酸菌およびその用途 |
GB201709763D0 (en) * | 2017-06-19 | 2017-08-02 | Probi Ab | Biological materials and methods |
JP6942030B2 (ja) * | 2017-11-02 | 2021-09-29 | 株式会社ヤクルト本社 | 抗アレルギー剤感受性判定マーカー |
SG10202112104UA (en) | 2018-05-09 | 2021-12-30 | Ko Biolabs Inc | Lactobacillus paracasei strain and use thereof |
JP7088573B2 (ja) | 2018-05-23 | 2022-06-21 | コバイオラブズ・インコーポレイテッド | ラクトバチルス・ガッセリーkbl697株及びその使用 |
KR20210024014A (ko) * | 2018-06-18 | 2021-03-04 | 프로비 에이비 | 프로바이오틱스 조성물 및 이의 용도 |
KR102770563B1 (ko) * | 2018-06-18 | 2025-02-21 | 프로비 에이비 | 락토바실러스 플란타룸 조성물 및 이의 용도 |
WO2020001747A1 (en) | 2018-06-26 | 2020-01-02 | Symrise Ag | Lactobacillus plantarum for skin care |
WO2020084051A1 (en) | 2018-10-24 | 2020-04-30 | Novozymes A/S | Probiotic supplement for metabolic health comprising lactobacillus |
US11058634B2 (en) | 2018-11-19 | 2021-07-13 | Steven J. Edwards | Adherent oral pharmabiotic delivery strip |
WO2020118576A1 (zh) * | 2018-12-12 | 2020-06-18 | 生合生物科技股份有限公司 | 胚芽乳酸杆菌twk10在制备抗运动后发炎或降体脂组合物的用途 |
GB201905386D0 (en) * | 2019-04-16 | 2019-05-29 | Probi Ab | Probiotic compositions and uses thereof |
IT201900013740A1 (it) * | 2019-08-01 | 2021-02-01 | Nutrilinea S R L | Composition comprising S-adenosyl-L-methionine and a probiotic for use to treat depression |
JP7195714B2 (ja) * | 2020-10-19 | 2022-12-26 | 曽根ファーム株式会社 | 炎症性腸疾患用組成物 |
CN111035663B (zh) * | 2020-01-17 | 2023-07-14 | 广州医科大学附属口腔医院(广州医科大学羊城医院) | 酸鱼乳杆菌10851在制备治疗多发性硬化的药物中的应用 |
IT202000007675A1 (it) * | 2020-04-09 | 2021-10-09 | Sofar Spa | Ivermectina e sue composizioni per uso nel trattamento di infezioni da coronavirus principalmente a carico dell’apparato respiratorio |
EP4159839A4 (en) | 2020-05-29 | 2024-10-23 | Tohoku University | ANTIVIRAL AGENT |
CN116133669A (zh) * | 2020-06-06 | 2023-05-16 | 群体创新有限责任公司 | 用于抑制包括冠状病毒感染的病毒感染的材料和方法 |
KR20220091427A (ko) | 2020-12-23 | 2022-06-30 | 주식회사 리스큐어바이오사이언시스 | 락토바실러스 사케아이 유래 세포밖 소포체를 유효성분으로 포함하는 자가면역질환의 개선, 예방 또는 치료용 조성물 |
JP7594980B2 (ja) | 2021-06-22 | 2024-12-05 | 株式会社ヤクルト本社 | 単純ヘルペスウイルスの再活性化抑制用組成物 |
CN114085798B (zh) * | 2021-12-28 | 2023-10-31 | 杭州普元生物技术有限公司 | 一种植物乳杆菌及其在预防和/或治疗疾病中的应用 |
CN114317343A (zh) * | 2021-12-28 | 2022-04-12 | 杭州普元生物技术有限公司 | 一种植物乳杆菌及其在预防和/或治疗中枢神经系统疾病中的应用 |
CN116270763A (zh) * | 2023-04-04 | 2023-06-23 | 广东南芯医疗科技有限公司 | 发酵乳杆菌e15在制备预防或治疗肠道炎症药物中的应用 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4983163A (en) * | 1981-10-09 | 1991-01-08 | Science Research Center, Inc. | Method, compositions and articles for prevention and treatment of herpes simplex virus infections |
JPH092959A (ja) * | 1995-06-16 | 1997-01-07 | Yakult Honsha Co Ltd | IgE抗体産生抑制剤および抗アレルギー剤 |
JP4064481B2 (ja) | 1996-10-11 | 2008-03-19 | ハウスウェルネスフーズ株式会社 | 免疫賦活剤 |
JP4163276B2 (ja) * | 1998-02-05 | 2008-10-08 | 独立行政法人理化学研究所 | 機能性組成物 |
AU764011B2 (en) * | 1998-10-01 | 2003-08-07 | Probi Ab | Reduction of oxidative stress factors |
EP1020123A1 (en) * | 1999-01-18 | 2000-07-19 | Sitia-Yomo S.p.A. | Beverages containing live lactic bacteria |
EP1034787A1 (en) * | 1999-03-11 | 2000-09-13 | Société des Produits Nestlé S.A. | Lactobacillus strains preventing diarrhea caused by pathogenic bacteria |
RO121700B1 (ro) * | 1999-03-11 | 2008-02-28 | Societe Des Produits Nestle S.A. | Bacterii lactobacillus capabile să prevină diareea cauzată de bacterii patogene şi rotavirusuri |
IT1306716B1 (it) * | 1999-06-21 | 2001-10-02 | Mendes S U R L | Associazione di batteri lattici e suo uso per la prevenzione e/o iltrattamento terapeutico di infezioni e di stati infiammatori. |
EP1084709A1 (en) * | 1999-09-17 | 2001-03-21 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Oral recombinant lactobacilli vaccines |
US6696057B1 (en) * | 1999-09-22 | 2004-02-24 | Lacpro Industries, Inc. | Composition and method for treatment of gastrointestinal disorders and hyperlipidemia |
SE0003045D0 (sv) * | 2000-08-29 | 2000-08-29 | Probi Ab | New method |
SE0003100D0 (sv) * | 2000-09-01 | 2000-09-01 | Probi Ab | New strains |
FI109602B (fi) * | 2001-01-25 | 2002-09-13 | Valio Oy | Probioottiyhdistelmä |
WO2003022255A2 (en) | 2001-09-05 | 2003-03-20 | Vsl Pharmaceuticals, Inc. | Lactic acid bacteria comprising unmethylated cytosine-guanine dinucleotides for use in therapy |
RU2223774C2 (ru) * | 2002-04-11 | 2004-02-20 | Закрытое акционерное общество "Партнер" | Способ коррекции дисбиотических расстройств у детей раннего возраста с диареями |
US20040022775A1 (en) * | 2002-04-15 | 2004-02-05 | Gregor Reid | Methods of treating viral infections in mammals |
RU2247148C2 (ru) * | 2002-05-28 | 2005-02-27 | Пименов Евгений Васильевич | Штамм бактерий lactobacillus plantarum p4, штамм бактерий lactobacillus buchneri p0 и препарат-пробиотик на их основе для коррекции дисбактериозов различной этиологии у людей и животных |
US20040002275A1 (en) * | 2002-06-28 | 2004-01-01 | Niranjan Thakore | Fabric reinforced rubber product |
JP4034632B2 (ja) * | 2002-10-01 | 2008-01-16 | ハウスウェルネスフーズ株式会社 | 乳酸菌含有炊飯用組成物 |
SE526711C2 (sv) * | 2003-01-31 | 2005-10-25 | Probi Ab | Nya stammar av Bifidobacterium med förmåga att överleva i magtarmkanalen och producera glutamin in vivo, samt kompositioner och användningar därav |
WO2004076615A2 (en) | 2003-02-27 | 2004-09-10 | Bioneer A/S | Immunomodulating probiotic compounds |
SE527555C2 (sv) * | 2003-04-04 | 2006-04-11 | Probi Ab | Anti-inflammatorisk komposition innehållande tannasproducerande Lactobacillusstammar |
WO2004103083A1 (en) * | 2003-05-22 | 2004-12-02 | Synbiotics Ab | A probiotic composition comprising at least two lactic acid bacterial strains which are able to colonise the gastrointestinal tracts in combination with having intestinal survival property, intestinal binding property, an infection protection property and a fiber fermenting property |
AU2003247193A1 (en) * | 2003-07-23 | 2005-02-04 | M.D.Lab Corp. | Acid tolerant probiotic lactobacillus plantarum probio-38 that can suppress the growth of pathogenic microorganism and tge coronavirus |
ES2356315T3 (es) * | 2003-08-21 | 2011-04-06 | Otsuka Pharmaceutical Co., Ltd. | Bacterias ácido-lácticas que presentan un efecto de inmunopotenciación de las mucosas. |
RU2258524C2 (ru) * | 2003-10-23 | 2005-08-20 | Закрытое акционерное общество "Партнер" | Композиция для лечения острых респираторных заболеваний hib-этиологии у детей и способ лечения |
SE0400355D0 (sv) * | 2004-02-17 | 2004-02-17 | Synbiotics Ab | New synbiotec use |
SE528382C2 (sv) * | 2004-10-05 | 2006-10-31 | Probi Ab | Probiotiska lactobacillusstammar för förbättrad vaginal hälsa |
CN101128182B (zh) * | 2004-11-25 | 2011-11-16 | 荷兰联合利华有限公司 | 重链和结构域抗体 |
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